scholarly journals ABNORMAL GLOBAL LONGITUDINAL STRAIN PREDICTS ADVERSE CARDIAC EVENTS IN SARCOIDOSIS

2016 ◽  
Vol 67 (13) ◽  
pp. 1604
Author(s):  
Ahmed Ibrahim ◽  
Brett Sperry ◽  
Balaji Tamarappoo
Keyword(s):  
Longitudinal Strain ◽  
Global Longitudinal Strain ◽  
Cardiac Events ◽  
Adverse Cardiac Events

scholarly journals Strain Echocardiography Is a Promising Tool for the Prognostic Assessment of Sarcoidosis

Life ◽  
2021 ◽  
Vol 11 (10) ◽  
pp. 1065
Author(s):  
Paolo Cameli ◽  
Maria Concetta Pastore ◽  
Giulia Elena Mandoli ◽  
Mariangela Vigna ◽  
Giuseppe De Carli ◽  
...  
Keyword(s):  
Longitudinal Strain ◽  
Pulmonary Function Tests ◽  
Global Longitudinal Strain ◽  
Left Ventricular ◽  
Cardiac Events ◽  
Prognostic Assessment ◽  
Promising Tool ◽  
Adverse Cardiac Events

Sarcoidosis is a systemic chronic granulomatous disease with significant morbidity and mortality. Although basic transthoracic echocardiography (TTE) is not recommended for the assessment of sarcoidosis, speckle tracking echocardiography (STE) has emerged as more sensitive for the early detection of cardiac sarcoidosis and its outcome. The aim of the study was to assess the utility of left atrial and left ventricular longitudinal STE for the prediction of major adverse cardiac events (MACE) and sarcoidosis relapses. We enrolled 172 consecutive patients with sarcoidosis who underwent TTE and pulmonary function tests (PFTs). All patients were followed for a sarcoidosis relapse and MACE. During a median follow-up of 2217 days, 8 deaths, 23 MACE and 36 sarcoidosis relapses were observed. LV global longitudinal strain (GLS) was significantly lower in patients with MACE (p = 0.025). LV-GLS < 17.13% (absolute value) was identified as a fair predictor of MACE. Concerning the sarcoidosis control, TTE revealed a reduction of the LV ejection fraction (p = 0.0432), tricuspid annular plane systolic excursion (p = 0.0272) and global peak atrial longitudinal strain (PALS, p = 0.0012) in patients with relapses. PALS < 28.5% was the best predictor of a sarcoidosis relapse. Our results highlight a potential role of LV-GLS and PALS as prognostic markers in sarcoidosis, supporting the use of STE in the clinical management of these patients.

scholarly journals Left ventricular global longitudinal strain predicts elevated cardiac pressures and poor clinical outcomes in patients with non-ischemic dilated cardiomyopathy

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Ieva Kažukauskienė ◽  
Giedrė Balčiūnaitė ◽  
Vaida Baltrūnienė ◽  
Jelena Čelutkienė ◽  
Vytė Valerija Maneikienė ◽  
...  
Keyword(s):  
Dilated Cardiomyopathy ◽  
Clinical Outcomes ◽  
Longitudinal Strain ◽  
Global Longitudinal Strain ◽  
Hemodynamic Parameters ◽  
Cardiac Events ◽  
Adverse Cardiac Events ◽  
Short And Long Term ◽  
Non Ischemic Dilated Cardiomyopathy

Abstract Background Risk stratification in patients with non-ischemic dilated cardiomyopathy (NI-DCM) is essential to treatment planning. Global longitudinal strain (GLS) predicts poor prognosis in various cardiac diseases, but it has not been evaluated in a cohort of exclusively NI-DCM. Although deformation parameters have been shown to reflect diastolic function, their association with other hemodynamic parameters needs further elucidation. We aimed to evaluate the association between GLS and E/GLS and invasive hemodynamic parameters and assess the prognostic value of GLS and E/GLS in a prospective well-defined pure NI-DCM cohort. Methods and results Forty-one patients with NI-DCM were enrolled in the study. They underwent a standard diagnostic workup, including transthoracic echocardiography and right heart catheterization. During a five-year follow-up, 20 (49%) patients reached the composite outcome measure: LV assist device implantation, heart transplantation, or cardiovascular death. Pulmonary capillary wedge pressure (PCWP), mean pulmonary artery pressure, pulmonary vascular resistance (PVR) correlated with GLS and E/GLS (p < 0.05). ROC analysis revealed that GLS and E/GLS could identify elevated PCWP (≥ 15 mmHg) and PVR (> 3 Wood units). Survival analysis showed GLS and E/GLS to be associated with short- and long-term adverse cardiac events (p < 0.05). GLS values above thresholds of –5.34% and -5.96% indicated 18- and 12-fold higher risk of poor clinical outcomes at one and five years, respectively. Multivariate Cox regression analysis revealed that GLS is an independent long-term outcome predictor. Conclusion GLS and E/GLS correlate with invasive hemodynamics parameters and identify patients with elevated PCWP and high PVR. GLS and E/GLS predict short- and long-term adverse cardiac events in patients with NI-DCM. Worsening GLS is associated with incremental risk of long-term adverse cardiac events and might be used to identify high-risk patients.

Global longitudinal strain from resting echocardiogram is associated with long-term adverse cardiac outcomes in patients with suspected coronary artery disease

Perfusion ◽  
2017 ◽  
Vol 32 (7) ◽  
pp. 529-537 ◽  
Author(s):  
Ajay Yadlapati ◽  
Timothy R. Maher ◽  
James D. Thomas ◽  
Mark Gajjar ◽  
Kofo O. Ogunyankin ◽  
...  
Keyword(s):  
Stress Echocardiography ◽  
Longitudinal Strain ◽  
Global Longitudinal Strain ◽  
Myocardial Strain ◽  
Regional Wall Motion ◽  
Major Adverse Cardiac Events ◽  
Cardiac Events ◽  
Adverse Cardiac Events ◽  
Cardiac Testing

Purpose: Measuring myocardial strain using two-dimensional speckle tracking echocardiography has emerged as a new tool to identify subclinical ventricular dysfunction. Abnormal strain has been shown to have superior sensitivity compared with dobutamine stress echocardiography for viability assessment; however, there is a paucity of data regarding the prediction of long-term major adverse cardiac events. We compared the prognostic ability of both global longitudinal strain (GLS) from resting echocardiograms to regional wall motion score index (WMSI) from stress echocardiograms in their ability to predict long-term major adverse cardiac events. Methods: Patients referred for stress echocardiography, who also underwent coronary angiography within 3 months of stress echo (n=122), were enrolled. Patients with reduced ejection fractions (<40%) were excluded. Patients were followed for a median of 3.4 years for major adverse cardiac events, readmissions and repeat cardiac testing. Results: Patients with abnormal GLS (GLS <16.8%) from the resting echocardiogram obtained as part of the exercise echocardiogram experienced a significantly shorter time to major adverse cardiac events (p=0.026), first cardiovascular hospitalization and repeat cardiac testing (p=0.0011) compared to those with normal GLS. Abnormal GLS appears to be a better predictor than abnormal WMSI in predicting major adverse cardiac events (p=0.174) and time to first cardiovascular hospitalization or repeat cardiac testing (p=0.0093). Conclusion: GLS may be a better predictor of long-term major adverse cardiac events, readmissions and repeat cardiac testing than WMSI in patients undergoing stress echocardiography.

scholarly journals P1386 A change in left ventricular global longitudinal strain is a prognostic indicator in congestive heart failure patients with preserved ejection fraction

2020 ◽  
Vol 21 (Supplement_1) ◽  
Author(s):  
E Sakaguchi ◽  
A Yamada ◽  
M Hoshino ◽  
K Takada ◽  
N Hoshino ◽  
...  
Keyword(s):  
Heart Failure ◽  
Congestive Heart Failure ◽  
Ejection Fraction ◽  
Longitudinal Strain ◽  
Global Longitudinal Strain ◽  
Stable Condition ◽  
Left Ventricular ◽  
Operating Characteristics ◽  
Cardiac Events

Abstract Purposes We examined how changes in left ventricular (LV) global longitudinal strain (GLS) were associated with prognosis in patients with preserved LV ejection fraction (LVEF) after congestive heart failure (HF) admission. Methods We studied 123 consecutive patients (age 70 ± 15 years, 55% male) who had been hospitalized due to congestive HF with preserved LVEF (&gt; 50%). The exclusion criteria were atrial fibrillation and inadequate echo image quality for strain analyses. The patients underwent speckle-tracking echocardiography and measurement of plasma NT-ProBNP levels on the same day at the time of hospital admission as well as in the stable condition after discharge. Differences in GLS, LVEF and NT-ProBNP (delta GLS, LVEF and NT-ProBNP ; 2nd – 1st measurements) were calculated. The study end points were all-cause mortality and cardiac events. Results Mean periods of echo performance after hospitalization were 2 ±１days (1st echo) and 240 ± 289 days (2nd echo), respectively. During the follow-up (974 ± 626 days), 12 patients died and 25 patients were hospitalized because of HF worsening. In multivariate analysis, delta GLS and follow-up GLS were prognostic factors, whereas baseline and follow-up LVEF, NT-ProBNP, changes in LVEF and NT-ProBNP could not predict cardiac events. Delta GLS (p = 0.002) turned out to be the best independent prognosticator. Receiver operating characteristics analysis revealed that -0.6% of delta GLS was the optimal cut-off value to predict cardiac events and mortality (sensitivity 76%, specificity 67%, AUC 0.75). Kaplan-Meier analysis showed that patients with delta GLS more than -0.6% experienced significantly less cardiac events during the follow-up period (p &lt; 0.0001, log-rank). Conclusion A change in LV GLS after congestive HF admission was a predictor of the prognosis in patients with preserved LVEF. It would be useful to check the changes in GLS in those with preserved LVEF after discharge.

scholarly journals Global Longitudinal Strain and Cardiac Events in Patients With Immune Checkpoint Inhibitor-Related Myocarditis

2020 ◽  
Vol 75 (5) ◽  
pp. 467-478 ◽  
Author(s):  
Magid Awadalla ◽  
Syed S. Mahmood ◽  
John D. Groarke ◽  
Malek Z.O. Hassan ◽  
Anju Nohria ◽  
...  
Keyword(s):  
Immune Checkpoint ◽  
Longitudinal Strain ◽  
Immune Checkpoint Inhibitor ◽  
Checkpoint Inhibitor ◽  
Global Longitudinal Strain ◽  
Cardiac Events

Влияние величины локальной продольной систолической деформации миокарда левого желудочка на риск возникновения сердечно-сосудистых осложнений после острого коронарного синдрома

2019 ◽  
pp. 60-69
Keyword(s):  
Acute Coronary Syndrome ◽  
Cardiovascular Risk ◽  
Longitudinal Strain ◽  
Major Adverse Cardiac Events ◽  
Cardiac Events ◽  
Survival Curves ◽  
Coronary Syndrome ◽  
Kaplan Meier ◽  
Adverse Cardiac Events

Целью исследования было изучение влияния величины локальной продольной систолической деформации миокарда левого желудочка на риск возникновения сердечно-сосудистых осложнений после острого коронарного синдрома. Обследовано 146 больных с верифицированным острым коронарным синдромом, которые были разделены на две группы. Критерием разделения на группы было появление большого кардиоваскулярного события (major adverse cardiac events (MACE)) на протяжении периода наблюдения после выписки больного из стационара. 1-ю группу составили 45 больных с осложненным течением ишемической болезни сердца, 2-ю группу - 101 больной с неосложненным течением. Медиана срока наблюдения составила 47 мес, 25-75-й процентили - 32-60 мес. Измерение продольной систолической деформации передне-перегородочной, нижней и нижне-перегородочной стенок левого желудочка проводилось в апикальных сечениях методом двухмерного отслеживания пятен серой шкалы ультразвукового изображения. Анализ выживаемости больных по методу Каплана-Майера показал, что при использовании исходных показателей деформации средних сегментов нижней и нижне-перегородочной стенок левого желудочка можно на протяжении 5 лет после перенесенного острого коронарного синдрома оценивать риск сердечно-сосудистых осложнений (P = 0,01 и P = 0,002 соответственно). При снижении величины продольной систолической деформации нижней и нижне-перегородочной стенок менее 14% вероятность осложненного течения ИБС у больных через 5 лет после острого коронарного синдрома увеличивается на более 20 и 30% соответственно. Таким обра зом, среди исследуемых пациентов с острым коронарным синдромом сниженная величина продольной систолической деформации среднего сегмента нижней и нижне-перегородочной стенок левого желудочка (14%) является неблагоприятным фактором, свидетельствующим о повышенном риске сердечно-сосудистых осложнений на протяжении длительного периода наблюдения. Ключевые слова: ультразвуковое исследование сердца (эхокардиография), острый коронарный синдром, продольная деформация, сердечно-сосудистый риск, кривые выживаемости Каплана-Майера, echocardiography, acute coronary syndrome, longitudinal strain, cardiovascular risk, Kaplan Meier survival curves

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