scholarly journals THE IMPACT OF NATURAL CHIOS MASTIC SUPPLEMENTATION ON ENDOTHELIAL FUNCTION AND ARTERIAL STIFFNESS IN SMOKERS

2017 ◽  
Vol 69 (11) ◽  
pp. 2021
Author(s):  
Vasiliki Tsigkou ◽  
Gerasimos Siasos ◽  
Evangelos Oikonomou ◽  
Konstantinos Mourouzis ◽  
George-Angelo Papamikroulis ◽  
...  
Keyword(s):  
Arterial Stiffness ◽  
Endothelial Function ◽  
The Impact

Abstract 4688: The Impact of Marfan Syndrome on Arterial Stiffness and Endothelial Function: The Role of Matrix Metalloproteinases

Circulation ◽  
2008 ◽  
Vol 118 (suppl_18) ◽  
Author(s):  
Stella Brilli ◽  
Dimitris Tousoulis ◽  
Charalambos Antoniades ◽  
George Hatzis ◽  
Nikos Ioakeimidis ◽  
...  
Keyword(s):  
Matrix Metalloproteinases ◽  
Arterial Stiffness ◽  
Endothelial Function ◽  
Marfan Syndrome ◽  
Augmentation Index ◽  
Flow Mediated Dilation ◽  
Arterial Tree ◽  
Augmentation Pressure ◽  
The Impact

Background: Marfan syndrome is characterised by high risk of aortic dissections and increased cardiovascular risk. However, the impact of Marfan syndrome on endothelial function and arterial stiffness is unclear, while the role of matrix metalloproteinases is unknown. We examined the impact of Marfan syndrome on the elastic properties of the arterial tree, and vascular endothelial function, and we evaluated the potential role of matrix metalloproteinases in these effects. Methods: The study population consisted of 17 subjects with Marfan syndrome, aged 26.6±2.3 years old, with BMI 20.5±1.03Kg/m2 and 22 healthy individuals matched for gender, age (26.4±0.78 years old, p=NS) and BMI (22.4±0.86 Kg/m2). Arterial stiffness was evaluated by measuring carotid-femoral pulse wave velocity (PWV), while augmentation pressure and augmentation index (AIx) were also determined, as measures of arterial wave reflections. Endothelial function was evaluated by determining flow mediated dilation (FMD) in the brachial artery while matrix metalloproteinase 9 (MMP-9) levels were determined by ELISA. Results: Patients with Marfan syndrome had significantly lower pulse pressure in the radial artery (41.0±1.07mmHg) compared to controls (51.3±4.4mmHg). In addition, patients had higher AIx (17.6±2.4%) and augmentation pressure (5.44±0.65mmHg) compared to controls (7.72±3.43% and 2.41±1.14mmHg respectively, p<0.05 for both). However, the difference in PWV between patients and controls did not reach statistical significance (6.33±0.33 vs 5.96±0.23m/s respectively, p=NS). Patients with Marfan syndrome had lower FMD (2.05±1.13%) and higher plasma MMP-9 (827±70ng/ml) compared to controls (6.8±2.3% p<0.05 and 326±50ng/ml, p<0.01). Conclusions: Marfan syndrome is associated with increased MMP-9 levels, as well as with elevated augmentation index and augmentation pressure compared to healthy individuals, matched for age, gender and body mass index. Moreover, flow-mediated dilation is also impaired in these subjects. These findings suggest that Marfan syndrome directly affects the elastic properties and endothelial function of the arterial tree, with matrix metalloproteinases being important mediators in the pathophysiology of this syndrome.

scholarly journals Endurance Training Depletes Antioxidant System but Does Not Affect Endothelial Functions in Women with Abdominal Obesity: A Randomized Trial with a Comparison to Endurance-Strength Training

2021 ◽  
Vol 10 (8) ◽  
pp. 1639
Author(s):  
Małgorzata Jamka ◽  
Paweł Bogdański ◽  
Patrycja Krzyżanowska-Jankowska ◽  
Anna Miśkiewicz-Chotnicka ◽  
Joanna Karolkiewicz ◽  
...  
Keyword(s):  
Arterial Stiffness ◽  
Endothelial Function ◽  
Strength Training ◽  
Endurance Training ◽  
Antioxidant Status ◽  
Systolic Pressure ◽  
Obese Women ◽  
Anthropometric Parameters ◽  
Endurance Strength ◽  
The Impact

Limited data suggested that inclusion of a strength component into endurance exercises might intensify the beneficial effect of training. However, the available data is limited. Therefore, we aimed to compare the effect of endurance and endurance-strength training on anthropometric parameters, endothelial function, arterial stiffness, antioxidant status, and inflammatory markers in abdominally obese women without serious comorbidities. A total of 101 women were recruited and randomly divided into endurance (n = 52) and endurance-strength (n = 49) groups. During the three-month intervention, both groups performed supervised sixty-minute training three times a week. All studied parameters were measured pre- and post-intervention period. In total, 85 women completed the study. Both training significantly decreased anthropometric parameters. Besides, endurance training decreased endothelial nitric oxide synthase, central aortic systolic pressure, pulse wave velocity, glutathione (GSH), total antioxidant status (TAS), interleukin (IL) 8, matrix metalloproteinase (MMP) 9, and tumor necrosis factor alpha, while endurance-strength training decreased MMP-2 concentrations, and increased IL-6, monocyte chemoattractant protein-1, and MMP-9 levels. We observed significant differences between groups for GSH, TAS, and MMP-9 levels. In summary, endurance and endurance-strength training did not differ in the impact on endothelial function and arterial stiffness. However, endurance training significantly depleted the antioxidant defense, simultaneously reducing MMP-9 levels. The study was retrospectively registered with the German Clinical Trials Register within the number DRKS00019832.

scholarly journals THE IMPACT OF DIFFERENT TYPES OF AEROBIC EXERCISE ON ENDOTHELIAL FUNCTION AND ARTERIAL STIFFNESS

2015 ◽  
Vol 65 (10) ◽  
pp. A1199
Author(s):  
Gerasimos Siasos ◽  
Dimitrios Athanasiou ◽  
Gerasimos Terzis ◽  
Aggeliki Stasinaki ◽  
Panagiotis Tourikis ◽  
...  
Keyword(s):  
Arterial Stiffness ◽  
Endothelial Function ◽  
Aerobic Exercise ◽  
Different Types ◽  
The Impact

scholarly journals THE IMPACT OF CYP2C19*2 POLYMORPHISM ON ENDOTHELIAL FUNCTION AND ARTERIAL STIFFNESS IN PATIENTS WITH CORONARY ARTERY DISEASE RECEIVING CLOPIDOGREL

2012 ◽  
Vol 59 (13) ◽  
pp. E1409
Author(s):  
Marina Zaromitidou ◽  
Gerasimos Siasos ◽  
Dimitris Tousoulis ◽  
Stamatios Kioufis ◽  
Evangelos Oikonomou ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Arterial Stiffness ◽  
Endothelial Function ◽  
Artery Disease ◽  
The Impact

scholarly journals Lipoprotein-associated phospholipase A2 levels, endothelial dysfunction and arterial stiffness in patients with stable coronary artery disease

2020 ◽  
Vol 41 (Supplement_2) ◽  
Author(s):  
K Mourouzis ◽  
G Siasos ◽  
E Oikonomou ◽  
M Zaromitidou ◽  
V Tsigkou ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Endothelial Dysfunction ◽  
Arterial Stiffness ◽  
Endothelial Function ◽  
Phospholipase A2 ◽  
Linear Regression Analysis ◽  
Serum Levels ◽  
Artery Disease ◽  
The Impact

Abstract Background Lipoprotein-associated Phospholipase A2 (Lp-PLA2), has inflammatory and atherogenic actions in the vascular wall. We investigate the impact of high Lp-PLA2 levels on endothelial function and arterial stiffness on patients with coronary artery disease (CAD). Methods We enrolled 374 consecutive patients with stable CAD (mean age 61±11 years). Endothelial function was evaluated by flow-mediated dilation (FMD) and reflected waves with augmentation index (AIx) of the central aortic pressure. Serum levels of Lp-PLA2 were measured with ELISA. Results In the studied population the median values of Lp-PLA2 levels was 125 (96–152) μg/L. There was no difference between subjects with Lp-PLA2 levels above and below 125μg/L concerning classical risk factors for CAD. Importantly, subjects with Lp-PLA2 values ≥125μg/L had significantly impaired FMD (4.44±2.19% vs. 4.89±2.07%, p=0.04) and AIx values (25.21±8.70% vs. 23.06±9.47%, p=0.03), compared to participants with lower Lp-PLA2 serum levels. A linear regression analysis revealed that Lp-PLA2 ≥125μg/L negatively relates to impaired FMD [b=−0.54 (95% CI: −1.05 to −0.02), p=0.04] and AIx values [b=2.14 (95% CI: 0.18–4.01), p=0.03] independently of cofounders. Conclusions Elevated Lp-PLA2 relates to endothelial dysfunction and arterial stiffness in CAD patients. These findings highlight the significant role of Lp-PlA2 in the process of atherosclerosis. Funding Acknowledgement Type of funding source: None

The Effect of DPP-4i on Endothelial Function and Arterial Stiffness in Patients with Type 2 Diabetes: A Systematic Review of Randomized Placebo-controlled Trials

2020 ◽  
Vol 26 (46) ◽  
pp. 5980-5987
Author(s):  
Stavroula A. Paschou ◽  
Gerasimos Siasos ◽  
Evanthia Bletsa ◽  
Panagiota K. Stampouloglou ◽  
Evangelos Oikonomou ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Arterial Stiffness ◽  
Endothelial Function ◽  
Vascular Function ◽  
Dipeptidyl Peptidase 4 ◽  
Atherosclerosis Progression ◽  
Dipeptidyl Peptidase 4 Inhibitors ◽  
The Impact ◽  
Neutral Effect

: We systematically reviewed the literature regarding the impact of dipeptidyl peptidase-4 inhibitors (DPP-4i) on vascular function, including endothelial function and arterial stiffness, as predictors of atherosclerosis progression and cardiovascular disease in patients with type 2 diabetes mellitus (T2DM). We searched PubMed in order to identify clinical trials that investigated the effect of DPP-4i on vascular function in patients with T2DM when compared with placebo. Although 168 articles were initially found, only 6 studies (total 324 patients) investigated the effect of DPP-4i in comparison with placebo, specifically linagliptin and sitagliptin, and satisfied the inclusion criteria. There are scarce data to indicate that linagliptin may enhance endothelial function and exert a slight beneficial effect on arterial wall properties. Sitagliptin seems to have a neutral effect on these variables. Further trials are needed to elucidate the topic. The standards of reporting were in accordance with the PRISMA guidelines.

The impact of the 24-hour movement spectrum on vascular remodeling in older men and women: a review.

2021 ◽  
Author(s):  
Jennifer S. Williams ◽  
Emily C. Dunford ◽  
Jem L. Cheng ◽  
Kevin Moncion ◽  
Sydney E. Valentino ◽  
...  
Keyword(s):  
Physical Activity ◽  
Older Adults ◽  
Resistance Training ◽  
Arterial Stiffness ◽  
Endothelial Function ◽  
Aerobic Training ◽  
Poor Sleep ◽  
Cerebrovascular Function ◽  
Increased Risk ◽  
The Impact

Aging is associated with increased risk of cardiovascular and cerebrovascular events, which are preceded by early, negative remodeling of the vasculature. Low physical activity is a well-established risk factor associated with the incidence and development of disease. However, recent physical activity literature indicates the importance of considering the 24-hour movement spectrum. Therefore, the purpose of this review was to examine the impact of the 24-hour movement spectrum, specifically physical activity (aerobic and resistance training), sedentary behaviour, and sleep, on cardiovascular and cerebrovascular outcomes in older adults, with a focus on recent evidence (<10 years) and sex-based considerations. The review identified that both aerobic training and being physically active (compared to sedentary) are associated with improvements in endothelial function, arterial stiffness, and cerebrovascular function. Additionally, there is evidence of sex-based differences in endothelial function: a blunted improvement in aerobic training in postmenopausal women compared to men. While minimal research has been conducted in older adults, resistance training does not appear to influence arterial stiffness. Poor sleep quantity or quality are associated with both impaired endothelial function and increased arterial stiffness. Finally, the review highlights mechanistic pathways involved in the regulation of vascular and cerebrovascular function - specifically the balance between pro- and anti-atherogenic factors, which mediate the relationship between the 24-hour movement spectrum and vascular outcomes. Finally, this review proposes future research directions: examining the role of duration and intensity of training, combining aerobic and resistance training, and exploration to sex-based differences in cardiovascular and cerebrovascular outcomes.

Arterial Stiffness Assessed by Cardio-Ankle Vascular Index in Patients With Abdominal Aortic Aneurysm and Its Alterations After Treatment

2021 ◽  
pp. 153857442110232
Author(s):  
Spyridon N. Mylonas ◽  
Konstantinos G. Moulakakis ◽  
Nikolaos Kadoglou ◽  
Constantinos Antonopoulos ◽  
Thomas E. Kotsis ◽  
...  
Keyword(s):  
Arterial Stiffness ◽  
Surgical Repair ◽  
Open Repair ◽  
Abdominal Aortic ◽  
Gender And Age ◽  
Baseline Values ◽  
The Difference ◽  
The Impact ◽  
Repair Group

Purpose: The aim of the present study was to investigate a potential difference on the arterial stiffness among aneurysm patients and non-aneurysm controls, as well as to explore potential changes between patients treated either with endovascular or open repair. Materials and Methods: A 110 patients with an infrarenal AAA were prospectively enrolled in this study. Fifty-six patients received an EVAR, whereas 54 patients received an open surgical repair. Moreover, 103 gender and age-matched subjects without AAA served as controls. The cardio-ankle vascular index (CAVI) was applied for measurement of the arterial stiffness. Results: CAVI values were statistically higher in the AAA patients when compared with control subjects. Although at 48 hours postoperatively the CAVI values were increased in both groups when compared to baseline values, the difference in CAVI had a tendency to be higher in the open group compared to the endovascular group. At 6 months of follow up the CAVI values returned to the baseline for the patients of the open repair group. However, in the endovascular group CAVI values remained higher when compared with the baseline values. Conclusion: Patients with AAAs demonstrated a higher value of CAVI compared to healthy controls. A significant increase of arterial stiffness in both groups during the immediate postoperative period was documented. The increase in arterial stiffness remained significant at 6 months in EVAR patients. Further studies are needed to elucidate the impact of a decreased aortic compliance after stentgraft implantation on the cardiac function of patients with AAA.

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