Molecular Big Data in Sports Sciences: State-of-Art and Future Prospects of OMICS-Based Sports Sciences

Together with environment and experience (that is to say, diet and training), the biological and genetic make-up of an athlete plays a major role in exercise physiology. Sports genomics has shown, indeed, that some DNA single nucleotide polymorphisms (SNPs) can be associated with athlete performance and level (such as elite/world-class athletic status), having an impact on physical activity behavior, endurance, strength, power, speed, flexibility, energetic expenditure, neuromuscular coordination, metabolic and cardio-respiratory fitness, among others, as well as with psychological traits. Athletic phenotype is complex and depends on the combination of different traits and characteristics: as such, it requires a “complex science,” like that of metadata and multi-OMICS profiles. Several projects and trials (like ELITE, GAMES, Gene SMART, GENESIS, and POWERGENE) are aimed at discovering genomics-based biomarkers with an adequate predictive power. Sports genomics could enable to optimize and maximize physical performance, as well as it could predict the risk of sports-related injuries. Exercise has a profound impact on proteome too. Proteomics can assess both from a qualitative and quantitative point of view the modifications induced by training. Recently, scholars have assessed the epigenetics changes in athletes. Summarizing, the different omics specialties seem to converge in a unique approach, termed sportomics or athlomics and defined as a “holistic and top-down,” “non-hypothesis-driven research on an individual’s metabolite changes during sports and exercise” (the Athlome Project Consortium and the Santorini Declaration) Not only sportomics includes metabonomics/metabolomics, but relying on the athlete’s biological passport or profile, it would enable the systematic study of sports-induced changes and effects at any level (genome, transcriptome, proteome, etc.). However, the wealth of data is so huge and massive and heterogenous that new computational algorithms and protocols are needed, more computational power is required as well as new strategies for properly and effectively combining and integrating data.

Genetic diversity and selection in Puerto Rican horses

Since the first Spanish settlers brought horses to America centuries ago, several local varieties and breeds have been established in the New World. These were generally a consequence of the admixture of the different breeds arriving from Europe. In some instances, local horses have been selectively bred for specific traits, such as appearance, endurance, strength, and gait. We looked at the genetics of two breeds, the Puerto Rican Non-Purebred (PRNPB) (also known as the “Criollo”) horses and the Puerto Rican Paso Fino (PRPF), from the Caribbean Island of Puerto Rico. While it is reasonable to assume that there was a historic connection between the two, the genetic link between them has never been established. In our study, we started by looking at the genetic ancestry and diversity of current Puerto Rican horse populations using a 668 bp fragment of the mitochondrial DNA D-loop (HVR1) in 200 horses from 27 locations on the island. We then genotyped all 200 horses in our sample for the “gait-keeper” DMRT3 mutant allele previously associated with the paso gait especially cherished in this island breed. We also genotyped a subset of 24 samples with the Illumina Neogen Equine Community genome-wide array (65,000 SNPs). This data was further combined with the publicly available PRPF genomes from other studies. Our analysis show an undeniable genetic connection between the two varieties in Puerto Rico, consistent with the hypothesis that PRNPB horses represent the descendants of the original genetic pool, a mix of horses imported from the Iberian Peninsula and elsewhere in Europe. Some of the original founders of PRNRB population must have carried the “gait-keeper” DMRT3 allele upon arrival to the island. From this admixture, the desired traits were selected by the local people over the span of centuries. We propose that the frequency of the mutant “gait-keeper” allele originally increased in the local horses due to the selection for the smooth ride and other characters, long before the PRPF breed was established. To support this hypothesis, we demonstrate that PRNPB horses, and not the purebred PRPF, carry a signature of selection in the genomic region containing the DMRT3 locus to this day. The lack of the detectable signature of selection associated with the DMRT3 in the PRPF would be expected if this native breed was originally derived from the genetic pool of PRNPB horses established earlier and most of the founders already had the mutant allele. Consequently, selection specific to PRPF later focused on allels in other genes (including CHRM5, CYP2E1, MYH7, SRSF1, PAM, PRN and others) that have not been previously associated with the prized paso gait phenotype in Puerto Rico or anywhere else.

Combined Effects of Citrulline Plus Nitrate-Rich Beetroot Extract Co-Supplementation on Maximal and Endurance-Strength and Aerobic Power in Trained Male Triathletes: A Randomized Double-Blind, Placebo-Controlled Trial

Citrulline (CIT) and nitrate-rich beetroot extract (BR) are ergogenic aids and nitric oxide (NO) precursors. In addition, both supplements seem to have other actions at the level of muscle metabolism that can benefit strength and aerobic power performance. Both supplements have been studied in numerous investigations in isolation. However, scientific evidence combining both supplements is scarce, and to the best of the authors’ knowledge, there is no current study of endurance athletes. Therefore, the main purpose of this study was to determine the effect of 9 weeks of CIT plus BR supplementation on maximal and endurance-strength performance and aerobic power in male triathletes. This study was a randomized double-blind, placebo-controlled trial where participants (n = 32) were randomized into four different groups: placebo group (PLG; n = 8), CIT plus BR group (CIT- BRG; 3 g/kg/day of CIT plus 3 mg/kg/day of nitrates (NO3−); n = 8), CIT group (CITG; 3 g/kg/day; n = 8) and BR group (BRG; 3 mg/kg/day of NO3−; n = 8). Before (T1) and after 9 weeks (T2), four physical condition tests were carried out in order to assess sport performance: the horizontal jump test (HJUMP), handgrip dynamometer test, 1-min abdominal tests (1-MAT) and finally, the Cooper test. Although, no significant interactions (time × supplementation groups) were found for the strength tests (p > 0.05), the CIT- BRG supplementation presented a trend on HJUMP and 1-MAT tests confirmed by significant increase between two study moments in CIT-BRG. Likewise, CIT-BRG presented significant interactions in the aerobic power test confirmed by this group’s improve estimated VO2max during the study with respect to the other study groups (p = 0.002; η2p = 0.418). In summary, supplementing with 3 g/day of CIT and 2.1 g/day of BR (300 mg/day of NO3−) for 9 weeks could increase maximal and endurance strength. Furthermore, when compared to CIT or BR supplementation alone, this combination improved performance in tests related to aerobic power.

Physical Activity and Social Relationships on Social Engagement Among Community-Dwelling Older Adults

This study examined physical activity (FITNESS) and social relationships (FRIENDS) on social engagement among community older adults. Members from two Florida aging-in-village programs participated. Three five-Likert scales were used: A 5-item FITNESS (weight, endurance, strength, flexibility, health), 4-item FRIEND (family, friends, neighbors, communication), and a 3-item social engagement scales (social-leisure activities, stay involved, healthy independent) (Cronbach alphas: .82~.92). Among the 96 participants, 79% were females, 91% were whites, 56% were married, 86% had college education, and 46% living alone. Mean age was 70.7 (SD=10.10). Participants reported at least 30-min. physical activity about 4.2 days per week. Overall social engagement was high (mean=4.38), FITNESS was median (mean=3.46), and FRINED was high (mean=4.19). FITNESS was significant to more 30-min. physical activity. Yet, higher FITNESS, FRIENDS, age, and volunteers were all significant to social engagement. Results has implications on promoting social engagement among older adults participating in aging-in-community programs.

FEATURES OF PHYSICAL CULTURE AND MASS WORK AT THE UNIVERSITY WITH THE USE OF FITNESS TECHNOLOGIES

Physical education and mass work at the university has always been based on the needs of students in classes in sports sections after school. The practice of physical activity of students included fitness, and with it appeared the sport "fitness aerobics", in which competitions are held within the framework of the sports Contest of universities. Fitness programs based on aerobics have a complex effect on the body of those involved. At the same time, in fact, in any form of aerobics, you can achieve the main goals of wellness fitness - to develop cardiorespiratory endurance, strength, strength endurance, flexibility.

Child programs infusion of the sportlife club system children's activity

Modern life is quite comfortable. Less and less physical effort a human spends to meet every day needs. A sedentary lifestyle is becoming habitual for many, but it is important to remember that a young body needs exercise to grow and develop. In order to maintain good physical shape, you should do exercise. As a result, physical qualities develop: endurance, strength, agility, speed, flexibility. First of all physical activity improves not only the physical form, but also promotes the harmonious development of the child, strengthening his health. It is easier to raise a healthy child it quickly acquires the necessary skills and abilities, better adapts to changes in environmental conditions. It is easier to raise a healthy child, which quickly acquires the necessary skills and abilities, better adapts to changes in environmental conditions. An active healthy child is always strong and cheerful. Insufficient motor activity, vice versa, leads to weakness, weakens the body and its resistance to various diseases. Hypodynamia has an negatively affects mental development, reduces efficiency. This indicates a close relationship between mental and physical development. Daily exercise, participation in moving games; long walks are necessary condition for creating an optimal motor that meets the biological needs of the child's body.

Features of physical training of students based on the use of the method of interval training according to the “Tabata” system

The article highlights the problem of physical training of student youth in the conditions of non-physical culture education. The features of the influence of the method of interval training according to the “Tabata” system on the physical fitness of students have been investigated. Revealed significant differences in the level of physical fitness of students after the pedagogical experiment. It was found that the implementation of the method of interval training according to the Tabata system within the framework of physical education of students of non-physical culture institutions of higher education affects the education of endurance, strength, speed-strength qualities, speed and dexterity, which contributes to the improvement of physical fitness and the formation of a harmoniously developed personality. In the course of the study, the results were obtained that allow expanding and supplementing the existing data on the increase in the effectiveness of the process of physical education in the HEI based on the implementation of the method of interval training according to the “Tabata” system, which is observed in a significant increase in the indicators of physical fitness of students. The analysis of scientific literature made it possible to determine the actual factors of using the method of interval training according to the Tabata system for physical training of students. The results of the pedagogical experiment allow to expand and supplement the existing data to increase the efficiency of the process of physical education of students based on the implementation of the method of interval training system “Tabata”, which is observed in a significant increase in physical fitness of students in the experimental group.

Candidate genes associated with athletes' skeletal muscle functions regulation

It is generally recognized that an elite athlete's status is a multifactorial phenotype depending on many environmental and genetic factors. Variations in the sequence of nucleotides in deoxyribonucleic acid (DNA), in particular, single-nucleotide variants (SNVs) act as key internal factors associated with achieving high results in sports. The determination of specific individuals' genetic characteristics allows us to identify athletes who have the greatest genetically determined potential for certain sports that require speed, strength or endurance manifestation. Of course, peculiarities of the structure and function of skeletal muscles are among the most important characteristics in sports results context, in sports associated with the development of power / strength or endurance phenotypes. The composition and function of skeletal muscles are controlled by many different genes, and their SNVs can serve as strength or endurance athletes' status biomarkers. (1) Background: to conduct a thematic review of candidate genes studies and their single-nucleotide variants (SNVs) associated with the functioning of skeletal muscles in athletes. (2) Methods: A search for articles for the period from 2010 to 2020 was conducted in the databases SCOPUS, Web of Science, Google Calendar, Clinical keys, PubMed, e-LIBRARY using keywords and their combinations; (3) Conclusions: The identification of genetic biomarkers associated with muscular system regulation can help neurologists, sports doctors and coaches in developing personalized strategies for selecting children, adolescents and young adults for endurance, strength and speed sports (for example, running short, medium or long distances). Such a personalized approach will increase sports performance and reduce the risk of sports injuries of the musculoskeletal system.

Investigation of The Effect of Concurrent Training Strength and Endurance Training on Physical, Physiological and Psychological Parameters in Young Football Players

Background: Football is a versatile team sport that requires a range of physical characteristics, including flexibility, power, strength, endurance, speed, repetitive sprinting, quickness-agility and technique-tactics. Developing all these features at the same time, especially in the pre-season, when players are in a deconditioning state, returning to training after a rest period; it is quite difficult for coaches and performance trainers. Aim: The aim of this study is to examine the effects of strength and endurance training applied simultaneously on some physical, physiological and psychological parameters in young football players. Methods: U19 age group players were included in the research group, 24 male football players who played amateur or professionally licensed football for at least 5 years and trained for an average of 2 hours a day, 5 days a week; (Endurance+Strength Group n=12, Strength+Endurance Group n=12). In the study, 1 RM strength test, agility, speed, technique, decision-making skills and endurance tests were taken from the participants. In our study, with the pretest-posttest measurement method; Yo-Yo test, Loughborough Soccer Passing Test (LSPT), Illinois Agility Test, 30 meters Speed Test, Maximal (1RM) Strength Test, Jumping Test (CMJ) were applied. Results: The findings obtained when the performance values of football players within and between groups were evaluated statistically; It has been determined that the positive increase in endurance, strength, sprint, agility/speediness, jump and lspt pass test values as a percentage (%) was seen in the group that applied strength training before endurance training. Conclusion: The application of strength training before endurance training in 'concurrent' training model applications in young football players; on performance values; It has been determined that endurance training has more effect than applying it before strength training. According to these results, it is thought that designing the programs by taking this situation into consideration in the training program adjustments can contribute more to the coaches and the player group in terms of sportive efficiency. Keywords: Football, concurrent, strength, endurance, LSPT.