The relationship between body mass index and pulse pressure in older adults with isolated systolic hypertension

Background: High levels of intramuscular adipose tissue and low levels of capillarization are both predicative of low muscle and mobility function in older adults, however little is known about their relationship. Objectives: The purpose of this study was to examine the relationship of intramuscular adipose tissue and capillarization in older adults. Setting: An outpatient medical center. Participants: Forty-seven sedentary adults (age 59.9 ± 1.0 years, BMI 32.0 ± 0.7 kg/m2, VO2max 22.4 ± 0.7 ml/kg/min); Measurements: All participants underwent CT scans to determine intramuscular adipose tissue and muscle biopsies to determine capillarization in the mid-thigh. A step-wise hierarchical linear regression analysis was used to examine the contributions of age, sex, race, body mass index, 2-hour postprandial glucose, VO2max, and muscle capillarization, to the variability in intramuscular adipose tissue. Results: The predictors as a group accounted for 38.1% of the variance in intramuscular adipose tissue, with body mass index and capillarization each significantly contributing to the final model (P<0.001). The part correlation of body mass index with intramuscular adipose tissue was r = 0.47, and the part correlation of capillarization with intramuscular adipose tissue was r = 0.39, indicating that body mass index and capillarization explained 22.1%, and 15.2% of the variance in intramuscular adipose tissue. Conclusions: While increased muscle capillarization is typically thought of as a positive development, in some clinical conditions, such as tendinopathies, an increase in capillarization is part of the pathological process related to expansion of the extracellular matrix and fibrosis. This may also be an explanation for the surprising finding that high capillarization is related to high levels of intramuscular adipose tissue. Future studies are necessary to determine the relationship of changes in both capillarization and intramuscular adipose tissue after interventions, such as exercise.

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Negative Interaction and Body Weight in Later Life

The International Journal of Aging and Human Development ◽

10.2190/qf0f-98g4-3jvk-nuxe ◽

1997 ◽

Vol 45 (4) ◽

pp. 305-321 ◽

Cited By ~ 2

Author(s):

Neal Krause ◽

Estina Thompson

Keyword(s):

Older Adults ◽

Body Mass Index ◽

Body Weight ◽

Body Mass ◽

Elderly Women ◽

Later Life ◽

Older Men ◽

Negative Interaction ◽

Individual Variations ◽

The Relationship

This study assesses the relationship between negative interaction and body mass index values among older adults. Throughout, an emphasis is placed on probing for individual differences in response to unpleasant encounters with significant others. Individual variations in personality (introversion-extraversion) as well as social status (gender) are evaluated within this context. Tests of the complex three-way interaction between negative interaction, gender, and introversion reveal that more negative interaction is associated with higher body mass index values among elderly women who are introverted. In contrast, a significant relationship between negative interaction, introversion, and body mass failed to emerge for older men.

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Body Mass Index, Weight Change, and Death in Older Adults: The Systolic Hypertension in the Elderly Program

American Journal of Epidemiology ◽

10.1093/aje/kwf019 ◽

2002 ◽

Vol 156 (2) ◽

pp. 132-138 ◽

Cited By ~ 75

Author(s):

G. W. Somes

Keyword(s):

Older Adults ◽

Body Mass Index ◽

Body Mass ◽

Weight Change ◽

Systolic Hypertension ◽

The Elderly ◽

Index Weight

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The relationship between increased body mass index and frailty on falls in community dwelling older adults

BMC Geriatrics ◽

10.1186/1471-2318-13-132 ◽

2013 ◽

Vol 13 (1) ◽

Cited By ~ 27

Author(s):

Katie J Sheehan ◽

Matthew DL O’Connell ◽

Clodagh Cunningham ◽

Lisa Crosby ◽

Rose Anne Kenny

Keyword(s):

Older Adults ◽

Body Mass Index ◽

Body Mass ◽

Community Dwelling ◽

Community Dwelling Older Adults ◽

The Relationship

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Association of Body Mass Index and Waist Circumference with Hypertension in Older Adults

10.21203/rs.3.rs-65456/v1 ◽

2020 ◽

Author(s):

Wenli Zhang ◽

Kun He ◽

Hao Zhao ◽

Xueqi Hu ◽

Chunyu Yin ◽

...

Keyword(s):

Older Adults ◽

Body Mass Index ◽

Waist Circumference ◽

Body Mass ◽

Interaction Analysis ◽

Synergistic Effects ◽

Cubic Spline ◽

Additive Interaction ◽

Males And Females ◽

The Relationship

Abstract Background: The relationship between obesity and prevalent hypertension in older adults has predominantly been estimated using categorical measures of body mass index (BMI) and waist circumference (WC), masking the shape of the dose-response relationship. We aimed to examine the precise relationship of BMI, WC with hypertension, and to assess the appropriate level of BMI and WC for hypertension. Methods: We examined data for 126,123 individuals in Xinzheng city aged ≥60 years from a population based study from January to December 2019. Logistic regression and restricted cubic spline models were applied to assess the relationship and the appropriate level of BMI and WC for hypertension. An additive interaction analysis was used to test synergistic effects between a higher BMI and WC for hypertension. Results: The full-adjusted odds ratios (ORs) with 95% confidence intervals (CIs) of an increase of 1 kg/m2 in BMI and 1 cm in WC for hypertension were 1.084 (1.080-1.087) and 1.025 (1.024-1.027), respectively. Multivariable adjusted restricted cubic spline analyses showed the nonlinear relationships of BMI and WC with hypertension in both men and women (all P<0.001). The risk of hypertension increased steeply with increasing BMI from ≥25 kg/m2 and WC ≥ 88 cm or 86 cm for males and females, respectively. And we observed a significant additive interaction between a higher BMI and WC such that the prevalence of hypertension was significantly enhanced. Conclusion: These findings suggest increased hypertension prevalence in the elderly population with increased BMI and WC. BMI ≤ 25 kg/m2 and WC ≤ 88 cm or 86 cm for males and females may be the best suggestion with regard to primary prevention of hypertension in older adults.

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Effects of body mass index, plasma glucose and cholesterol levels on isolated systolic hypertension

International Journal of Cardiology ◽

10.1016/j.ijcard.2004.03.059 ◽

2005 ◽

Vol 101 (3) ◽

pp. 429-433 ◽

Cited By ~ 8

Author(s):

Gary T.C. Ko ◽

Clive S. Cockram ◽

Chun-Chung Chow ◽

Wing-Bun Chan ◽

Wing-Yee So ◽

...

Keyword(s):

Body Mass Index ◽

Body Mass ◽

Plasma Glucose ◽

Systolic Hypertension ◽

Isolated Systolic Hypertension ◽

Cholesterol Levels

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The relationship between body mass index and quality of life in community-living older adults living in the United States

The journal of nutrition health & aging ◽

10.1007/s12603-013-0022-y ◽

2013 ◽

Vol 17 (6) ◽

pp. 495-501 ◽

Cited By ~ 19

Author(s):

Frank G. Bottone ◽

K. Hawkins ◽

S. Musich ◽

Y. Cheng ◽

R. J. Ozminkowski ◽

...

Keyword(s):

Quality Of Life ◽

United States ◽

Older Adults ◽

Body Mass Index ◽

Body Mass ◽

The United States ◽

Community Living ◽

The Relationship

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A U-Shaped Relationship between the Prevalence of Frailty and Body Mass Index in Community-Dwelling Japanese Older Adults: The Kyoto–Kameoka Study

Journal of Clinical Medicine ◽

10.3390/jcm9051367 ◽

2020 ◽

Vol 9 (5) ◽

pp. 1367 ◽

Cited By ~ 4

Author(s):

Daiki Watanabe ◽

Tsukasa Yoshida ◽

Yuya Watanabe ◽

Yosuke Yamada ◽

Misaka Kimura

Keyword(s):

Older Adults ◽

Body Mass Index ◽

Body Mass ◽

Cross Sectional Study ◽

Community Dwelling ◽

Assessment Tools ◽

Cross Sectional ◽

Frailty Assessment ◽

Japanese Older Adults ◽

The Relationship

The relationship between body mass index (BMI) and frailty remains unclear. Using two validated frailty assessment tools, this study aimed to investigate the relationship between the prevalence of frailty and BMI in Japanese older adults. This cross-sectional study used baseline data of 7191 individuals aged ≥65 years, living in Kameoka City, Kyoto, Japan. The BMI was calculated based on self-reported height and body weight, and classified into six categories. Frailty was defined using two validated assessment tools, the Fried phenotype (FP) model and Kihon Checklist (KCL). We evaluated the relationship between frailty and BMI using a multivariate restricted cubic spline logistic regression. The prevalence of frailty defined using the FP model was 25.3%, 19.6%, 14.3%, 12.4%, 12.6%, and 19.4% for each BMI category of <18.5, 18.5–19.9, 20.0–22.4, 22.5–24.9, 25.0–27.4, and ≥27.5 kg/m2, respectively. The spline model showed a significant U-shaped relationship between BMI and the prevalence of frailty defined using both, KCL and FP models. This study found that the BMI range corresponding to lowest prevalence of frailty defined using both tools was 21.4–25.7 kg/m2. Thus, a healthy BMI may reduce the prevalence of frailty, and the risk of frailty needs to be evaluated in individuals who are underweight or overweight.

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