The Most Severe Somatic Disorders Treated with Excitaloprim

2009 ◽  
Vol 24 (S1) ◽  
pp. 1-1
Author(s):  
S. Kaludjerovic
Keyword(s):  
Cytochrome P450 ◽  
Major Depression ◽  
List Type ◽  
Weak Inhibitor ◽  
Liver Cytochrome ◽  
Icd 10 ◽  
Persistent Depression ◽  
Somatic Disorders ◽  
The Moment ◽  
Almost All

Almost all of patients treated for cancers, experience episodes of persistent depression. Which moment is the most terrible? The moment patients hear their diagnosis,or time suffer while getting chemotherapy?The time on controls tumor markers or when their relatives give up on them? When mirror reflects damaged body and face. Or felt useless in the presence of their children?•diagnosis of cancers C00,E05 are difficult to accept, and go hand in hand with major depression F33/ according to ICD-10.•why excitaloprim as choice?Patients age 27 to 37 need antidepressant with pharmacokinetic superiority. Excitaloprim works faster than any other antidepressant, and it is strong, thanks to its dual serotonergic bonding on primar part as well as alosteric part bonding. It is weak inhibitor of the well defined liver cytochrome P450 isoenzym, CYP2D6., EEg .EKG is ok, so its safe drug/.In this study, I followed the results of excitaloprim treatment on 30 patients (20 females, 10 males).During 2 months, 20 patients were diagnosed with cancer (mostly colon and breast). All this patients have already been operated. Some have anus praeternaturalis.Other patients have AIDSinitial phase, and autoimmune dg/On Hamilton scale, 45, points, MADRS on 10 items, 40, on Becks scale 65.Zung self rating index o,6. In this project, patients without children were much more suicidal.Cancer patients got 20 mg excitaloprim pro die, other 10 mg pro die. After 2 mothsscales showed statistically important improvements despite severity.

scholarly journals Determining the IC50 Values for Vorozole and Letrozole, on a Series of Human Liver Cytochrome P450s, to Help Determine the Binding Site of Vorozole in the Liver

2015 ◽  
Vol 2015 ◽  
pp. 1-4 ◽  
Author(s):  
Lendelle Raymond ◽  
Nikita Rayani ◽  
Grace Polson ◽  
Kylie Sikorski ◽  
Ailin Lian ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
High Throughput Screening ◽  
Human Liver ◽  
Potent Inhibitor ◽  
Cytochrome P450s ◽  
Third Generation ◽  
Weak Inhibitor ◽  
Liver Cytochrome ◽  
Ic50 Values ◽  
Screening Assays

Vorozole and letrozole are third-generation aromatase (cytochrome P450 19A1) inhibitors. [11C]-Vorozole can be used as a radiotracer for aromatase in living animals but when administered by IV, it collects in the liver. Pretreatment with letrozole does not affect the binding of vorozole in the liver. In search of finding the protein responsible for the accumulation of vorozole in the liver, fluorometric high-throughput screening assays were used to test the inhibitory capability of vorozole and letrozole on a series of liver cytochrome P450s (CYP1A1, CYP1A2, CYP2A6, and CYP3A4). It was determined that vorozole is a potent inhibitor of CYP1A1 (IC50 = 0.469 μM) and a moderate inhibitor of CYP2A6 and CYP3A4 (IC50 = 24.4 and 98.1 μM, resp.). Letrozole is only a moderate inhibitor of CYP1A1 and CYP2A6 (IC50 = 69.8 and 106 μM) and a very weak inhibitor of CYP3A4 (<10% inhibition at 1 mM). Since CYP3A4 makes up the majority of the CYP content found in the human liver, and vorozole inhibits it moderately well but letrozole does not, CYP3A4 is a good candidate for the protein that [11C]-vorozole is binding to in the liver.

scholarly journals Universal Qudit Hamiltonians

2021 ◽  
Author(s):  
Stephen Piddock ◽  
Ashley Montanaro
Keyword(s):  
State Energy ◽  
Entangled State ◽  
Quantum Computers ◽  
List Type ◽  
Universal Family ◽  
Finite Dimensional ◽  
Universal Quantum ◽  
Aklt Model ◽  
Almost All ◽  
Natural Way

AbstractA family of quantum Hamiltonians is said to be universal if any other finite-dimensional Hamiltonian can be approximately encoded within the low-energy space of a Hamiltonian from that family. If the encoding is efficient, universal families of Hamiltonians can be used as universal analogue quantum simulators and universal quantum computers, and the problem of approximately determining the ground-state energy of a Hamiltonian from a universal family is QMA-complete. One natural way to categorise Hamiltonians into families is in terms of the interactions they are built from. Here we prove universality of some important classes of interactions on qudits (d-level systems): We completely characterise the k-qudit interactions which are universal, if augmented with arbitrary Hermitian 1-local terms. We find that, for all $$k \geqslant 2$$ k ⩾ 2 and all local dimensions $$d \geqslant 2$$ d ⩾ 2 , almost all such interactions are universal aside from a simple stoquastic class. We prove universality of generalisations of the Heisenberg model that are ubiquitous in condensed-matter physics, even if free 1-local terms are not provided. We show that the SU(d) and SU(2) Heisenberg interactions are universal for all local dimensions $$d \geqslant 2$$ d ⩾ 2 (spin $$\geqslant 1/2$$ ⩾ 1 / 2 ), implying that a quantum variant of the Max-d-Cut problem is QMA-complete. We also show that for $$d=3$$ d = 3 all bilinear-biquadratic Heisenberg interactions are universal. One example is the general AKLT model. We prove universality of any interaction proportional to the projector onto a pure entangled state.

Increased serum drug concentrations in concomitant treatment with citalopram, clomipramine and alprazolam

1994 ◽  
Vol 9 (6) ◽  
pp. 312-314
Author(s):  
U Lepola ◽  
E Leinonen ◽  
H Koponen
Keyword(s):  
Cytochrome P450 ◽  
Major Depression ◽  
Obsessive Compulsive Disorder ◽  
Oxidative Metabolism ◽  
Competitive Inhibition ◽  
High Serum ◽  
Concomitant Treatment ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
Drug Concentrations

SummaryWe report the case of a patient with major depression and obsessive-compulsive disorder who had simultaneously high serum citalopram, clomipramine, and alprazolam concentrations probably due to the reciprocal competitive inhibition of the cytochrome P450-catalyzed oxidative metabolism.

Identification of Human Liver Cytochrome P450 Enzymes Involved in Biotransformation of Vicriviroc, a CCR5 Receptor Antagonist

2007 ◽  
Vol 35 (12) ◽  
pp. 2186-2195 ◽  
Author(s):  
Anima Ghosal ◽  
Ragu Ramanathan ◽  
Yuan Yuan ◽  
Neil Hapangama ◽  
Swapan K. Chowdhury ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Receptor Antagonist ◽  
Human Liver ◽  
Cytochrome P450 Enzymes ◽  
Liver Cytochrome ◽  
Ccr5 Receptor
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