The Correlations of Suicide Attempts in Major Depressive Disorder

2009 ◽  
Vol 24 (S1) ◽  
pp. 1-1
Author(s):  
S. Nastase ◽  
D. Ivanovici ◽  
M. Vrabie ◽  
I.M. Dumitrescu ◽  
A. Mihailescu
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Suicide Attempts ◽  
Individual Characteristics ◽  
Categorical Variables ◽  
Control Group ◽  
Major Depressive ◽  
Historical Case ◽  
Suicidal Attempts ◽  
The Individual

Objective:We have pursued the association between clinical and socio-demographic characteristics and the suicide attempts at inpatients with major depressive disorder.Method:We ran an historical case control study to analyse the individual characteristics associated with suicide attempts in the depression inpatients admitted into the 9th Department of the Clinical Psychiatric Hospital “Al. Obregia” between 01 January 2007 - 01 January 2008. A total of 168 subjects with major depressive disorder (MDD) were included in the study. The patients were separated into two subgroups: “S” - the group with suicide attempt as reason of the present admission into hospital and the comparative group “C” - those without a suicidal attempt at the present admission (used as control group). The two groups were compared with respect to the individual characteristics, following their possible association with the suicidal attempts risk. We used the chi-square (x2) statistic for categorical variables.Results:Our findings suggest that the most robust predictors of suicide attempts in depression are the younger age of the depression onset, previous psychiatric hospitalizations, low socio-economic status, “single” marital status (widowed/divorced), with no children, heredocolateral history of suicidal attempts and the comorbidity with the problematic alcohol consumption.Conclusion:The risk factors associated with the suicidal attempts are useful for the screening, finding, prediction and prophylaxis of suicide attempts in major depression.

scholarly journals Clinical and Socio-Demographic Correlates in Depressive Patients with Suicidal Ideas & Suicidal Attempts

2017 ◽  
Vol 4 (2) ◽  
Author(s):  
Dr. Syed Ummer. I ◽  
Dr. Sushith Sugathan. C
Keyword(s):  
Major Depressive Disorder ◽  
Suicidal Ideation ◽  
Depressive Disorder ◽  
Tamil Nadu ◽  
Suicide Attempts ◽  
Suicidal Attempt ◽  
Major Depressive ◽  
Clinical Correlates ◽  
Suicidal Attempts ◽  
Suicidal Ideas

Background: Suicide has a strong association with mental disorder and contributes to the excess mortality of the mentally ill. Suicidal ideation is prevalent and appears to be a precondition for suicide attempts among psychiatric patients with Major Depressive disorder. Though ideas and attempts may overlap there are studies that show the two are separate clinical entities with unique psycho-socio demographic profile. Aim: To study correlates in patients with suicidal ideation and those with suicide attempts in a cohort of major depressive disorder patients. Methodology:  Study was conducted at the Inpatient psychiatry unit at a private medical college in Coimbatore, Tamil Nadu. It was a Cross sectional study design. Patients consecutively admitted with major depressive disorder (DSM IV TR) were recruited. Severity of suicidal ideations and attempts were rated on validated scales and the socio demographic and clinical correlates were analyzed. Results: Clinical correlates like severity of depression, severity of suicidal ideation and history of past suicidal attempt were positively correlated with severity of suicidal ideation as well as severity of current suicidal attempts in the cohort of depressive disorder patients. Conclusion: Assessment of current episode severity of both suicidal ideation as well as suicidal attempt is important in identifying high risk patients with major depressive disorder.

scholarly journals Preventive Effect of Liothyronine on Electroconvulsive Therapy-Induced Memory Deficit in Patients with Major Depressive Disorder: A Double-Blind Controlled Clinical Trial

2015 ◽  
Vol 2015 ◽  
pp. 1-5 ◽  
Author(s):  
Arash Mohagheghi ◽  
Asghar Arfaie ◽  
Shahrokh Amiri ◽  
Masoud Nouri ◽  
Salman Abdi ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Electroconvulsive Therapy ◽  
Visual Memory ◽  
Memory Deficit ◽  
Control Group ◽  
Major Depressive ◽  
Double Blind ◽  
The Impact

Introduction and Objective. Despite the effectiveness of electroconvulsive therapy (ECT) in treating major depressive disorder (MDD), its cognitive side effects make it less popular. This study investigated the impact of liothyronine on ECT-induced memory deficit in patients with MDD.Methodology. This is a double-blind clinical trial, in which 60 patients with MDD who were referred for ECT were selected. The diagnosis was based on the criteria of DSM-IV-TR. Patients were divided randomly into two groups to receive either liothyronine (50 mcg every morning) or placebo. After the assessment with Wechsler Memory Scale-Revised (WMS-R) before first session of ECT, posttests were repeated again, two months after the completion of ECT.Findings. By controlling the pretest scores, the mean scores of the experimental group were higher than the control group in delayed recall, verbal memory, visual memory, general memory, and attention/concentration scales (P<0.05).Conclusion. Liothyronine may prevent ECT-induced memory impairment in patients with MDD. This study has been registered in IRCT underIRCT201401122660N2.

Resequencing three candidate genes discovers seven potentially deleterious variants susceptibility to major depressive disorder and suicide attempts in Chinese

Gene ◽  
2017 ◽  
Vol 603 ◽  
pp. 34-41 ◽  
Author(s):  
Shitao Rao ◽  
Cherry She Ting Leung ◽  
Macro Hb Lam ◽  
Yun Kwok Wing ◽  
Mary Miu Yee Waye ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Candidate Genes ◽  
Suicide Attempts ◽  
Major Depressive

Optical Coherence Tomography and Pattern Electroretinography Changes in Egyptian Patients with Major Depressive Disorder

QJM ◽  
2021 ◽  
Vol 114 (Supplement_1) ◽  
Author(s):  
Mostafa S ElShaarawi ◽  
Ayman A Gaafar ◽  
Hisham S. Saad Eldin ◽  
Randa H Ali
Keyword(s):  
Optical Coherence Tomography ◽  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Control Group ◽  
Ophthalmological Examination ◽  
Optical Coherence ◽  
Fiber Layer ◽  
Major Depressive ◽  
Cross Sectional ◽  
Pattern Electroretinography

Abstract Background Major depressive disorder (MDD) is a common psychiatric disorder that affects nearly 11.1-14.6 % of the population in their lifetime. Pathophysiology and brain imaging findings show that degenerative and inflammatory processes may play a role. Meta-analysis of voxel-based morphometry studies in MDD demonstrated significant gray matter loss. From anatomical and embryological perspectives, the retina can be considered a unique extension of the brain and is able to reflect axonal histopathology. Being unmyelinated, it can provide insight into the pathophysiological processes of diseases with a neurodegenerative element. Aim to compare retinal optical coherence tomography (OCT) parameters in a group of MDD patients with a healthy control group and to correlate OCT parameters with pattern electroretinography (PERG) parameters. Method a controlled cross sectional study was conducted on 30 MDD patients and 28 age and sex matched controls. Both groups had a full ophthalmological examination, OCT imaging and 7 patients and 11 controls have PERG recorded. Results Thinning of the superior retinal nerve fiber layer, thinning of most of the ganglion cell inner plexiform (GCIP) layer, thinning of most of the macular thickness and thinning of macular volume in both eyes were detected. There was a statistically significant positive correlation between the left GCIP layer and the amplitude of the N95 wave. Also a statistically significant negative correlation existed between MDD duration in years with the left eye's average volume of the outer ring of the macula. Conclusion Significant retinal changes were detected by OCT in MDD patients supporting the theory of neurodegeneration as a pathophysiology of MDD.

THE PATTERN OF IRRATIONAL BELIEFS ASSOCIATED WITH MAJOR DEPRESSIVE DISORDER

1992 ◽  
Vol 20 (3) ◽  
pp. 199-212 ◽  
Author(s):  
Lyne Prud'homme ◽  
Pierre Barron
Keyword(s):  
Major Depressive Disorder ◽  
Discriminant Analysis ◽  
Depressive Disorder ◽  
Symptom Severity ◽  
Irrational Beliefs ◽  
Irrational Belief ◽  
Normal Control Group ◽  
Control Group ◽  
Major Depressive ◽  
Normal Controls

In light of Rational-Emotive Theory, this study was undertaken to determine the pattern of irrational beliefs underlying Major Depressive Disorder (MDD). A total of 126 subjects (50 males, 76 females) volunteered to participate. Patients clinically diagnosed with MDD (unipolar type) and a control group of non-depressed patients were solicited from the inpatient and outpatient facilities of several Ottawa and Montreal hospitals; the normal control group comprised students and civil servants. The subjects completed questionnaires to measure irrational belief endorsement (IBT, RBI) and symptom severity (STAI, BDI) and to verify the depression diganosis (IDD). Multivariate statistics were used to determine the pattern of beliefs which best discriminates between the MDD group, the psychiatric control group, and the normal controls. Discriminant analysis of the IBT revealed a pattern of four irrational beliefs generally known as demand for approval, frustration reactivity, anxious overconcern, and helplessness over past. The implications of such findings for RET theory are discussed.

scholarly journals The effects of intramuscular administration of scopolamine augmentation in moderate to severe major depressive disorder: a randomized, double-blind, placebo-controlled trial

2020 ◽  
Vol 10 ◽  
pp. 204512532093855
Author(s):  
Jingjing Zhou ◽  
Jian Yang ◽  
Xuequan Zhu ◽  
Tarek Zghoul ◽  
Lei Feng ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Dose Group ◽  
Response Rate ◽  
Secondary Outcome ◽  
Control Group ◽  
Placebo Control ◽  
High Dose ◽  
Major Depressive ◽  
Double Blind

Introduction: Major depressive disorder (MDD) is a common affective disorder. Currently established pharmacotherapies lack rapid clinical response, thereby limiting their ability to bring instant relief to patients. A series of clinical trials has demonstrated the antidepressant effects of scopolamine, yet few have studied the effects of add-on scopolamine to currently available antidepressants. It is not known whether conventional antidepressant treatment with a 3-day scopolamine injection could speed up oral antidepressant efficacy. The main focus of this study is to detect the capacity of the rapid-onset efficacy of such a treatment option. Methods and analysis: This study consisted of a single-centre, double-blind, three-arm randomized trial with a 4-week follow-up period. Sixty-six participants meeting entry criteria were randomly allocated to three treatment groups: a high-dose group, a low-dose group and a placebo control group. Psychiatric rating scales were administered at baseline and seven viewing points following the administration of intramuscular injections. The primary outcome measure was length of time from randomization (baseline) to early improvement. Results: Both primary and secondary outcome measures consistently showed no differences among the three groups. The cumulative response rate and the remission rate were 72.7% (48/66) and 47.0% (31/66). Intramuscular scopolamine treatment was relatively well tolerated. Two subjects with high-dose injections dropped out because of a drug-related side effect. Conclusion: Contrary to our prediction, we found that, compared to placebo (0.9% saline i.m.), scopolamine was not associated with a significantly faster antidepressant response rate. Trial registration: ClinicalTrials.gov, NCT03131050. Registered on 18 April 2017.

scholarly journals Incidence and Risk Factors for Suicide Attempts in Patients Diagnosed with Major Depressive Disorder

2020 ◽  
Vol Volume 13 ◽  
pp. 1147-1157
Author(s):  
Angélica Gonçalves Peter ◽  
Mariane Lopez Molina ◽  
Taiane de Azevedo Cardoso ◽  
Thaíse Campos Mondin ◽  
Ricardo Azevedo da Silva ◽  
...  
Keyword(s):  
Risk Factors ◽  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Suicide Attempts ◽  
Major Depressive ◽  
Risk Factors For Suicide

Pre-adult versus adult onset major depressive disorder in a naturalistic patient sample: the Leiden Routine Outcome Monitoring Study

2010 ◽  
Vol 41 (7) ◽  
pp. 1407-1417 ◽  
Author(s):  
M. S. van Noorden ◽  
S. E. Minkenberg ◽  
E. J. Giltay ◽  
M. E. den Hollander-Gijsman ◽  
Y. R. van Rood ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Suicide Attempts ◽  
Age Of Onset ◽  
Signs And Symptoms ◽  
Diagnostic Interview ◽  
Adult Onset ◽  
Major Depressive ◽  
Logistic Regression Models ◽  
Outcome Monitoring

BackgroundPre-adult onset of major depressive disorder (MDD) may predict a more severe phenotype of depression. As data from naturalistic psychiatric specialty care settings are scarce, we examined phenotypic differences between pre-adult and adult onset MDD in a large sample of consecutive out-patients.MethodAltogether, 1552 out-patients, mean age 39.2±11.6 years, were diagnosed with current MDD on the Mini-International Neuropsychiatric Interview Plus diagnostic interview as part of the usual diagnostic procedure. A total of 1105 patients (71.2%) had complete data on all variables of interest. Pre-adult onset of MDD was defined as having experienced the signs and symptoms of a first major depressive episode before the age of 18 years. Patients were stratified according to the age at interview (20–40/40–65 years). Correlates of pre-adult onset were analysed using logistic regression models adjusted for age, age squared and gender.ResultsUnivariate analyses showed that pre-adult onset of MDD had a distinct set of demographic (e.g. less frequently living alone) and clinical correlates (more co-morbid DSM-IV – Text Revision diagnoses, more social phobia, more suicidality). In the multivariate model, we found an independent association only for a history of suicide attempts [odds ratio (OR) 3.15, 95% confidence intervals (CI) 1.97–5.05] and current suicidal thoughts (OR 1.81, 95% CI 1.26–2.60) in patients with pre-adult versus adult onset MDD.ConclusionsPre-adult onset of MDD is associated with more suicidality than adult onset MDD. Age of onset of depression is an easy to ascertain characteristic that may help clinicians in weighing suicide risk.

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