Sibling Risk of Anxiety Based on Hospitalizations in Sweden

2009 ◽  
Vol 24 (S1) ◽  
pp. 1-1
Author(s):  
X. Li ◽  
J. Sundquist ◽  
K. Sundquist
Keyword(s):  
Anxiety Disorder ◽  
Family Relationships ◽  
Depressive Disorders ◽  
Case Control Studies ◽  
Social Phobias ◽  
Gene Environment ◽  
Increased Risk ◽  
Gender And Age ◽  
Gender And Age Differences ◽  
Heritable Effects

Background:Familial risks of anxiety have been assessed in small case-control studies, usually based on reported, but not medically verified anxiety in family members; thus the degree of familial clustering for this disease remains to be established.Methods:This 1 January 1973 to 31 December 2004 study of the entire population of Sweden linked information on family relationships from the nationwide Multi-Generation Register with information from the nationwide Swedish Hospital Discharge Register on first diagnoses of anxiety. Standardized incidence ratios (SIRs) were calculated by comparing risk in siblings of persons hospitalized for anxiety with risk in persons whose siblings had no hospital diagnosis of anxiety.Results:The sibling risk was 3.02, which was independent of gender and age differences between siblings. The SIR was highest in siblings < 20 years of age (3.99). Analysis of subtype risk showed that having a sibling diagnosed with any anxiety disorder resulted in increased risk of a number of disorders; highest increased risk was of social phobias (SIR 4.70, 95% CI, 1.96-11.0). Risk of Panic disorder, generalized anxiety disorder, and mixed anxiety and depressive disorders was raised in female but not male siblings.Conclusions:Heritable effects likely play an important role in the etiology of anxiety disorders, but the extent of their role remains to be established. Important contributions could be made by studies of gene-environment interactions that have sufficient sample sizes to produce reliable results.

Assessing interactions between HLA-DRB1*15 and infectious mononucleosis on the risk of multiple sclerosis

2013 ◽  
Vol 19 (10) ◽  
pp. 1355-1358 ◽  
Author(s):  
Giulio Disanto ◽  
Carolina Hall ◽  
Robyn Lucas ◽  
Anne-Louise Ponsonby ◽  
Antonio J Berlanga-Taylor ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Infectious Mononucleosis ◽  
Additive Model ◽  
Causal Process ◽  
Case Control Studies ◽  
Logistic Regression Models ◽  
Gene Environment ◽  
Increased Risk ◽  
History Of ◽  
Additive Scale

Gene–environment interactions may shed light on the mechanisms underlying multiple sclerosis (MS). We pooled data from two case-control studies on incident demyelination and used different methods to assess interaction between HLA-DRB1*15 (DRB1-15) and history of infectious mononucleosis (IM). Individuals exposed to both factors were at substantially increased risk of disease (OR=7.32, 95% CI=4.92–10.90). In logistic regression models, DRB1-15 and IM status were independent predictors of disease while their interaction term was not (DRB1-15*IM: OR=1.35, 95% CI=0.79–2.23). However, interaction on an additive scale was evident (Synergy index=2.09, 95% CI=1.59–2.59; excess risk due to interaction=3.30, 95%CI=0.47–6.12; attributable proportion due to interaction=45%, 95% CI=22–68%). This suggests, if the additive model is appropriate, the DRB1-15 and IM may be involved in the same causal process leading to MS and highlights the benefit of reporting gene–environment interactions on both a multiplicative and additive scale.

scholarly journals High-temperature requirement factor A1 rs11200638 polymorphism and age-related macular degenerative from a comprehensive analysis about 15316 subjects

2020 ◽  
Author(s):  
Ying Liu ◽  
Huipeng Jin ◽  
Dong Wei ◽  
Wenxiu Li
Keyword(s):  
High Temperature ◽  
Meta Analysis ◽  
Case Control ◽  
Dominant Model ◽  
Case Control Studies ◽  
Temperature Requirement ◽  
Age Related ◽  
Gene Environment ◽  
Increased Risk ◽  
Taqman Pcr

Abstract Background The high-temperature requirement factor A1 (HTRA1) gene at the 10q26 locus has been associated with age-related macular degenerative (AMD) risk, with the significantly associated polymorphism being (rs11200638, -625G/A), however, above association is not consistent. We investigated an updated meta-analysis to evaluate the association between rs11200638 polymorphism and AMD risk thoroughly addressing this issue. Methods An identification was covered with the Pubmed and Chinese Wanfang databases through 27th Jan, 2020. Odds ratios (OR) and 95% confidence intervals (CI) were used to assess the strength of associations. After a thorough and meticulous search, 35 different articles (33 case-control studies with HWE, 22 case-control studies about wet/dry AMD) were retrieved. Results Individuals carrying A-allele or AA genotype may have an increased risk to be AMD disease. For example, there has a significantly increased relationship between rs11200638 polymorphism and AMD both for Asians (OR: 2.50, 95%CI: 2.22-2.80 for A-allele vs. G-allele) and Caucasians (OR: 2.11, 95%CI: 1.43-3.13 for A-allele vs. G-allele). Moreover, a similar trend in the source of control subgroup was detected. To classify the type of AMD, increased association was also observed in both wet (OR: 3.40, 95%CI: 2.90-3.99 for dominant model) and dry (OR: 2.08, 95%CI: 1.24-3.48 for dominant model) AMD. Finally, based on the different genotyping methods, increased relationships were identified by sequencing, TaqMan, PCR-RFLP. Conclusions Our present meta-analysis suggests that the HTRA1 rs11200638 polymorphism are potentially associated with the risk of AMD development, especially about individuals carrying A-allele or AA genotype, who may be as identified targets to detect and intervene in advance. Further studies using larger sample sizes and including information about gene-environment interactions should be conducted to elucidate.

scholarly journals High-temperature requirement factor A1 rs11200638 polymorphism and age-related macular degenerative from a comprehensive analysis about 15316 subjects

2020 ◽  
Author(s):  
Ying Liu ◽  
Huipeng Jin ◽  
Dong Wei ◽  
Wenxiu Li
Keyword(s):  
High Temperature ◽  
Meta Analysis ◽  
Case Control ◽  
Dominant Model ◽  
Case Control Studies ◽  
Temperature Requirement ◽  
Age Related ◽  
Gene Environment ◽  
Increased Risk ◽  
Taqman Pcr

Abstract Background: The high-temperature requirement factor A1 (HTRA1) gene at the 10q26 locus has been associated with age-related macular degenerative (AMD) risk, with the significantly associated polymorphism being (rs11200638, -625G/A), however, above association is not consistent. We investigated an updated meta-analysis to evaluate the association between rs11200638 polymorphism and AMD risk thoroughly addressing this issue. Methods: An identification was covered with the Pubmed and Chinese Wanfang databases through 27th Jan, 2020. Odds ratios (OR) and 95% confidence intervals (CI) were used to assess the strength of associations. After a thorough and meticulous search, 35 different articles (33 case-control studies with HWE, 22 case-control studies about wet/dry AMD) were retrieved. Results: Individuals carrying A-allele or AA genotype may have an increased risk to be AMD disease. For example, there has a significantly increased relationship between rs11200638 polymorphism and AMD both for Asians (OR: 2.51, 95%CI: 2.22-2.83 for A-allele vs. G-allele) and Caucasians (OR: 2.63, 95%CI: 2.29-3.02 for A-allele vs. G-allele). Moreover, a similar trend in the source of control subgroup was detected. To classify the type of AMD, increased association was also observed in both wet (OR: 3.40, 95%CI: 2.90-3.99 for dominant model) and dry (OR: 2.08, 95%CI: 1.24-3.48 for dominant model) AMD. Finally, based on the different genotyping methods, increased relationships were identified by sequencing, TaqMan, PCR-RFLP and RT-PCR. Conclusions: Our present meta-analysis suggests that the HTRA1 rs11200638 polymorphism are potentially associated with the risk of AMD development, especially about individuals carrying A-allele or AA genotype, who may be as identified targets to detect and intervene in advance. Further studies using larger sample sizes and including information about gene-environment interactions should be conducted to elucidate.

scholarly journals Cannabis Use and Prospective Long-Term Association with Anxiety: A Systematic Review and Meta-Analysis of Longitudinal Studies: Usage du cannabis et association prospective à long terme avec l’anxiété: une revue systématique et une méta-analyse d’études longitudinales

2020 ◽  
pp. 070674372095225
Author(s):  
Siqi Xue ◽  
M. Ishrat Husain ◽  
Haoyu Zhao ◽  
Arun V. Ravindran
Keyword(s):  
Anxiety Disorder ◽  
Longitudinal Studies ◽  
Depressive Disorders ◽  
Meta Analysis ◽  
Cannabis Use ◽  
Hand Search ◽  
Published Evidence ◽  
Increased Risk ◽  
The Relationship

Objectives: Cannabis use is proposed as a risk factor for psychosis and is associated with depressive disorders. However, the relationship between recreational cannabis use and its longitudinal implications on anxiety conditions is less studied. The aim of this investigation is to systematically evaluate published literature and perform a meta-analysis of the data. Methods: A systematic search was performed of MEDLINE, Embase, and PsychINFO from inception to May 31, 2020, in addition to a hand search. Longitudinal studies that evaluated the relationship of cannabis use and development of anxiety were included. Where applicable, adjusted odds ratios ( ORs) were extracted, pooled, and evaluated using random-effects meta-analysis. Results: After screening of unique abstracts ( n = 6835), the final evaluation included 24 studies, of which 10 reported ORs that were analyzed quantitatively. Cannabis use was significantly associated with increased odds of developing any anxiety conditions ( OR = 1.25; 95% CI, 1.01 to 1.54). Cannabis use was not significantly associated with developing generalized anxiety disorder, panic disorder, or social anxiety disorder. Review of studies not reporting OR revealed mixed results but are suggestive of a link between cannabis use and increased rates/severity of anxiety. Conclusions: Published evidence suggests that cannabis use is likely associated with increased risk of anxiety in the long term but variability of study designs precludes declaration of a causal relationship. Awareness of this association is of relevance for both clinical practice and mental health policy implementation.

scholarly journals Association between eNOS rs1799983 Polymorphism and Hypertension: a Meta-analysis involving 14,185 Cases and 13,407 Controls

2021 ◽  
Author(s):  
Jikang Shi ◽  
Siyu Liu ◽  
Yanbo Guo ◽  
Sainan Liu ◽  
Jiayi Xu ◽  
...  
Keyword(s):  
Complex Disease ◽  
Web Of Science ◽  
Genetic Model ◽  
Meta Analysis ◽  
Case Control Studies ◽  
R Software ◽  
Gene Environment ◽  
Increased Risk ◽  
Genetic And Environmental Factors ◽  
Insight Into

Abstract Background: Essential hypertension (EH) is a complex disease determined by the interaction of genetic and environmental factors, eNOS is considered to be one of the susceptible genes for hypertension. Our study aimed to evaluate the association between eNOS rs1799983 polymorphism and hypertension, and to provide evidence for the etiology of hypertension. Methods: Case-control studies of eNOS rs1799983 polymorphism and hypertension were included by searching PubMed, Embase, Web of Science, Medline, Scopus, WanFang datebase, Vip datebase, and CNKI database. Eligible data were extracted and pooled, and were analyzed using R software based on five different genetic models. Results: A total of 60 eligible articles involving 14,185 cases and 13,407 controls were finally selected. We found significant association between eNOS rs1799983 polymorphism and hypertension under any genetic model (T vs G: OR=1.44, 95% CI=1.26-1.63; GT vs GG: OR=1.34, 95% CI=1.18-1.52; TT vs GG: OR=1.80, 95% CI=1.41-2.31; GT+TT vs GG: OR=1.42, 95% CI=1.25-1.63; TT vs GG+GT: OR=1.68, 95% CI=1.35-2.08; GT vs GG+TT: OR=1.24, 95% CI=1.11-1.40). Conclusions: We found that eNOS rs1799983 polymorphism is associated with the increased risk of hypertension under any genetic model. Moreover, investigations of gene-gene and gene-environment interactions are needed to give more insight into the association between eNOS rs1799983 polymorphism and hypertension.

scholarly journals High-temperature requirement factor A1 rs11200638 polymorphism and age-related macular degenerative from a comprehensive analysis about 15316 subjects

2020 ◽  
Author(s):  
Ying Liu ◽  
Huipeng Jin ◽  
Dong Wei ◽  
Wenxiu Li
Keyword(s):  
High Temperature ◽  
Meta Analysis ◽  
Case Control ◽  
Dominant Model ◽  
Case Control Studies ◽  
Temperature Requirement ◽  
Age Related ◽  
Gene Environment ◽  
Increased Risk ◽  
Taqman Pcr

Abstract Background: The high-temperature requirement factor A1 (HTRA1) gene at the 10q26 locus has been associated with age-related macular degenerative (AMD) risk, with the significantly associated polymorphism being (rs11200638, -625G/A), however, above association is not consistent. We investigated an updated meta-analysis to evaluate the association between rs11200638 polymorphism and AMD risk thoroughly addressing this issue. Methods: An identification was covered with the Pubmed and Chinese Wanfang databases through 27th Jan, 2020. Odds ratios (OR) and 95% confidence intervals (CI) were used to assess the strength of associations. After a thorough and meticulous search, 35 different articles (33 case-control studies with HWE, 22 case-control studies about wet/dry AMD) were retrieved. Results: Individuals carrying A-allele or AA genotype may have an increased risk to be AMD disease. For example, there has a significantly increased relationship between rs11200638 polymorphism and AMD both for Asians (OR: 2.51, 95%CI: 2.22-2.83 for A-allele vs. G-allele) and Caucasians (OR: 2.63, 95%CI: 2.29-3.02 for A-allele vs. G-allele). Moreover, a similar trend in the source of control subgroup was detected. To classify the type of AMD, increased association was also observed in both wet (OR: 3.40, 95%CI: 2.90-3.99 for dominant model) and dry (OR: 2.08, 95%CI: 1.24-3.48 for dominant model) AMD. Finally, based on the different genotyping methods, increased relationships were identified by sequencing, TaqMan, PCR-RFLP and RT-PCR. Conclusions: Our present meta-analysis suggests that the HTRA1 rs11200638 polymorphism are potentially associated with the risk of AMD development, especially about individuals carrying A-allele or AA genotype, who may be as identified targets to detect and intervene in advance. Further studies using larger sample sizes and including information about gene-environment interactions should be conducted to elucidate.

scholarly journals High-temperature requirement factor A1 rs11200638 polymorphism and age-related macular degenerative from a comprehensive analysis about 15316 subjects

2020 ◽  
Author(s):  
Ying Liu ◽  
Huipeng Jin ◽  
Dong Wei ◽  
Wenxiu Li
Keyword(s):  
High Temperature ◽  
Meta Analysis ◽  
Case Control ◽  
Dominant Model ◽  
Case Control Studies ◽  
Temperature Requirement ◽  
Age Related ◽  
Gene Environment ◽  
Increased Risk ◽  
Taqman Pcr

Abstract Background The high-temperature requirement factor A1 (HTRA1) gene at the 10q26 locus has been associated with age-related macular degenerative (AMD) risk, with the significantly associated polymorphism being (rs11200638, -625G/A), however, above association is not consistent. We investigated an updated meta-analysis to evaluate the association between rs11200638 polymorphism and AMD risk thoroughly addressing this issue. Methods An identification was covered with the Pubmed and Chinese Wanfang databases through 27th Jan, 2020. Odds ratios (OR) and 95% confidence intervals (CI) were used to assess the strength of associations. After a thorough and meticulous search, 35 different articles (33 case-control studies with HWE, 22 case-control studies about wet/dry AMD) were retrieved. Results Individuals carrying A-allele or AA genotype may have an increased risk to be AMD disease. For example, there has a significantly increased relationship between rs11200638 polymorphism and AMD both for Asians (OR: 2.50, 95%CI: 2.22-2.80 for A-allele vs. G-allele) and Caucasians (OR: 2.11, 95%CI: 1.43-3.13 for A-allele vs. G-allele). Moreover, a similar trend in the source of control subgroup was detected. To classify the type of AMD, increased association was also observed in both wet (OR: 3.40, 95%CI: 2.90-3.99 for dominant model) and dry (OR: 2.08, 95%CI: 1.24-3.48 for dominant model) AMD. Finally, based on the different genotyping methods, increased relationships were identified by sequencing, TaqMan, PCR-RFLP. Conclusions Our present meta-analysis suggests that the HTRA1 rs11200638 polymorphism are potentially associated with the risk of AMD development, especially about individuals carrying A-allele or AA genotype, who may be as identified targets to detect and intervene in advance. Further studies using larger sample sizes and including information about gene-environment interactions should be conducted to elucidate.

scholarly journals Association of GSTP1 Ile105Val polymorphism with the risk of coronary heart disease: An updated meta-analysis

PLoS ONE ◽  
2021 ◽  
Vol 16 (7) ◽  
pp. e0254738
Author(s):  
Yadong Song ◽  
Xiaoli Liu ◽  
Cheng Luo ◽  
Liangkai Chen ◽  
Lin Gong ◽  
...  
Keyword(s):  
Meta Analysis ◽  
Pooled Analysis ◽  
Sensitivity Analyses ◽  
Case Control Studies ◽  
Chd Risk ◽  
Gene Environment ◽  
Increased Risk ◽  
Gstp1 Ile105val ◽  
Or Gene

Background Numerous case-control studies have investigated the association between GSTP1 Ile105Val polymorphism and CHD risk, but the results from published studies were inconclusive. The present meta-analysis was performed to derive a more precise estimation. Methods PubMed, EMBASE, and Web of Science database searches were conducted to retrieve relevant articles. Results Ultimately, 5,451 CHD cases and 5,561 controls from 15 studies were included. Pooled analysis did not yield any statistically significant association between GSTP1 Ile105Val polymorphism and CHD risk for the overall population (Val vs. Ile: OR, 1.05; 95% CI, 0.93 to 1.18; Val/Val vs. Ile/Ile: OR, 1.09; 95% CI, 0.83 to 1.42; Val/Ile vs. Ile/Ile: OR, 1.09; 95% CI, 0.93 to 1.28; Val/Val vs. Val/Ile+Ile/Ile: OR, 1.04; 95% CI, 0.83 to 1.30; Val/Val+Val/Ile vs. Ile/Ile: OR, 1.14; 95% CI, 0.97 to 1.33). Subgroup analyses and sensitivity analyses indicated that GSTP1 Ile105Val polymorphism was still not associated with an increased risk of CHD. After excluding studies detected by Galbraith plots as major sources of heterogeneity, these relationships were still not significant. Conclusions The overall results did not reveal a major role of the GSTP1 Ile105Val polymorphism in modulating CHD risk. Well-designed studies with large sample sizes are needed to validate our findings and explore the possible gene-gene or gene-environment interactions.

scholarly journals Association between eNOS rs1799983 polymorphism and hypertension: a meta-analysis involving 14,185 cases and 13,407 controls

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Jikang Shi ◽  
Siyu Liu ◽  
Yanbo Guo ◽  
Sainan Liu ◽  
Jiayi Xu ◽  
...  
Keyword(s):  
Complex Disease ◽  
Web Of Science ◽  
Genetic Model ◽  
Meta Analysis ◽  
Case Control Studies ◽  
R Software ◽  
Gene Environment ◽  
Increased Risk ◽  
Genetic And Environmental Factors ◽  
Insight Into

Abstract Background Essential hypertension is a complex disease determined by the interaction of genetic and environmental factors, eNOS is considered to be one of the susceptible genes for hypertension. Our study aimed to evaluate the association between eNOS rs1799983 polymorphism and hypertension, and to provide evidence for the etiology of hypertension. Methods Case–control studies of eNOS rs1799983 polymorphism and hypertension were included by searching PubMed, Embase, Web of Science, Medline, Scopus, WanFang datebase, Vip datebase, and CNKI database according to PRISMA guideline. Eligible data were extracted and pooled, and were analyzed using R software based on five different genetic models. Results A total of 60 eligible articles involving 14,185 cases and 13,407 controls were finally selected. We found significant association between eNOS rs1799983 polymorphism and hypertension under any genetic model (T vs G: OR = 1.44, 95% CI 1.26–1.63; GT vs GG: OR 1.34, 95% CI 1.18–1.52; TT vs GG: OR 1.80, 95% CI 1.41–2.31; GT + TT vs GG: OR 1.42, 95% CI 1.25–1.63; TT vs GG + GT: OR 1.68, 95% CI 1.35–2.08; GT vs GG + TT: OR 1.24, 95% CI 1.11–1.40). Conclusions We found that eNOS rs1799983 polymorphism is associated with the increased risk of hypertension under any genetic model. Moreover, investigations of gene–gene and gene-environment interactions are needed to give more insight into the association between eNOS rs1799983 polymorphism and hypertension.

The Relationship between Life Events and Personality Style to the Development of Depressive and Anxiety Disorders Among Adolescents

2020 ◽  
Vol 10 ◽  
Author(s):  
Noga Oschry-Bernstein ◽  
Netta Horesh-Reinman ◽  
Adar Avnon ◽  
Tomer Mevorach ◽  
Alan Apter ◽  
...  
Keyword(s):  
Anxiety Disorder ◽  
Life Events ◽  
Depressive Disorders ◽  
Multinomial Logistic Regression ◽  
Statistical Correlation ◽  
Personality Characteristics ◽  
Dominant Factor ◽  
Anxiety And Depression ◽  
Unique Contribution ◽  
Early Trauma

Background:: The separateness of anxiety disorder and depressive disorder as two distinct disorders is often questioned. The aim of the current study is to examine whether there is a different profile of life events and personality characteristics for anxiety and depression disorders in adolescents. Methods:: One hundred forty-six adolescents participated in the study, 57 boys and 89 girls, ranging in age from 11-18 years (mean=15.08+1.97). The study group included 92 adolescents with a clinical diagnosis of depression or anxiety, and the comparison group included 54 teenagers with no known psychopathology. Results:: Multinomial logistic regression produced different predictive profiles for anxiety disorder and for depressive disorders. Life event variables, especially minor life events and early traumas, were found to be predictors for depression. Furthermore, interaction was found between early trauma and minor life events in the prediction of depression, such that the existence of trauma weakened the statistical correlation between minor life events and the onset of depression. In addition, contrary to the literature regarding adults, it was found that during adolescence personality variables have a unique contribution as predictive factors for vulnerability to the onset of anxiety and depression, thus reducing the significance of life events. Conclusion:: Our findings suggest that different profile of life events and personality characteristics can be identified for the two disorders. In addition, it appears that early traumas are a dominant factor that overshadows more recent life events at the onset of depression among adolescents.

Sign in / Sign up

Export Citation Format

Share Document