S.06.04 NGF and BDNF as neuroendocrine factors involved in the response to early life stress and susceptibility to psychopathology: evidence from animal models

2010 ◽  
Vol 20 ◽  
pp. S170-S171
Author(s):  
F. Cirulli ◽  
L. Aloe ◽  
N. Francia ◽  
A. Berry ◽  
E. Alleva ◽  
...  
Keyword(s):  
Animal Models ◽  
Life Stress ◽  
Early Life ◽  
Early Life Stress ◽  
Neuroendocrine Factors

scholarly journals Early-life stress origins of gastrointestinal disease: animal models, intestinal pathophysiology, and translational implications

2015 ◽  
Vol 309 (12) ◽  
pp. G927-G941 ◽  
Author(s):  
Calvin S. Pohl ◽  
Julia E. Medland ◽  
Adam J. Moeser
Keyword(s):  
Animal Models ◽  
Life Stress ◽  
Early Life ◽  
Disease Susceptibility ◽  
Gastrointestinal Disease ◽  
Adult Life ◽  
Early Life Stress ◽  
Early Postnatal Development ◽  
Disease States ◽  
Fundamental Understanding

Early-life stress and adversity are major risk factors in the onset and severity of gastrointestinal (GI) disease in humans later in life. The mechanisms by which early-life stress leads to increased GI disease susceptibility in adult life remain poorly understood. Animal models of early-life stress have provided a foundation from which to gain a more fundamental understanding of this important GI disease paradigm. This review focuses on animal models of early-life stress-induced GI disease, with a specific emphasis on translational aspects of each model to specific human GI disease states. Early postnatal development of major GI systems and the consequences of stress on their development are discussed in detail. Relevant translational differences between species and models are highlighted.

scholarly journals Animal models of early life stress: Implications for understanding resilience

2010 ◽  
Vol 52 (5) ◽  
pp. 402-410 ◽  
Author(s):  
David M. Lyons ◽  
Karen J. Parker ◽  
Alan F. Schatzberg
Keyword(s):  
Animal Models ◽  
Life Stress ◽  
Early Life ◽  
Early Life Stress

Early life stress paradigms in rodents: potential animal models of depression?

2010 ◽  
Vol 214 (1) ◽  
pp. 131-140 ◽  
Author(s):  
Mathias V. Schmidt ◽  
Xiao-Dong Wang ◽  
Onno C. Meijer
Keyword(s):  
Animal Models ◽  
Life Stress ◽  
Early Life ◽  
Early Life Stress ◽  
Animal Models Of Depression

scholarly journals Maternal Separation Induces Sex-Specific Differences in Sensitivity to Traumatic Stress

2021 ◽  
Vol 15 ◽  
Author(s):  
Dayan Knox ◽  
Stephanie A. Stout-Oswald ◽  
Melissa Tan ◽  
Sophie A. George ◽  
Israel Liberzon
Keyword(s):  
Risk Factors ◽  
Sex Differences ◽  
Animal Models ◽  
Traumatic Stress ◽  
Life Stress ◽  
Early Life ◽  
Maternal Separation ◽  
Early Life Stress ◽  
Female Rats ◽  
Male Rats

Post-traumatic stress disorder (PTSD) is a debilitating psychiatric disorder with a high economic burden. Two risk factors for increasing the chances of developing PTSD are sex (being female) and early life stress. These risk factors suggest that early life stress-induced changes and sex differences in emotional circuits and neuroendocrinological systems lead to susceptibility to traumatic stress. Exploring mechanisms via which stress leads to specific effects can be accomplished in animal models, but reliable animal models that allow for an examination of how early life stress interacts with sex to increase susceptibility to traumatic stress is lacking. To address this, we examined the effects of early life stress [using the maternal separation (MS) model] and late adolescence/early adult traumatic stress [using the single prolonged stress (SPS) model] on startle reactivity, anxiety-like behavior in the open field (OF), and basal corticosterone levels in male and female rats. Female rats exposed to MS and SPS (MS/SPS) showed enhanced startle reactivity relative to MS/control female rats. Enhanced startle reactivity was not observed in MS/SPS male rats. Instead, non-maternally separated male rats that were exposed to SPS showed enhanced startle reactivity relative to controls. Female rats had enhanced locomotor activity in the OF and higher basal corticosterone levels in comparison to males, but measures in the OF and basal corticosterone were not affected by MS or SPS. Overall the results suggest that the combined MS and SPS models can be used to explore how changes in maternal care during infancy lead to sex differences in sensitivity to the effects of traumatic stress as adolescents and adults.

scholarly journals Animal Models and Their Contribution to Our Understanding of the Relationship Between Environments, Epigenetic Modifications, and Behavior

Genes ◽  
2019 ◽  
Vol 10 (1) ◽  
pp. 47 ◽  
Author(s):  
Natalia Ledo Husby Phillips ◽  
Tania L. Roth
Keyword(s):  
Animal Models ◽  
Environmental Factors ◽  
Life Stress ◽  
Early Life ◽  
Early Life Stress ◽  
Human Biology ◽  
Environmental Toxicants ◽  
Immune Challenges ◽  
And Behavior ◽  
The Relationship

The use of non-human animals in research is a longstanding practice to help us understand and improve human biology and health. Animal models allow researchers, for example, to carefully manipulate environmental factors in order to understand how they contribute to development, behavior, and health. In the field of behavioral epigenetics such approaches have contributed novel findings of how the environment physically interacts with our genes, leading to changes in behavior and health. This review highlights some of this research, focused on prenatal immune challenges, environmental toxicants, diet, and early-life stress. In conjunction, we also discuss why animal models were integral to these discoveries and the translational relevance of these discoveries.

Sign in / Sign up

Export Citation Format

Share Document