The parameters of gas discharge visualization (biophotonics) correlated with parameters of acupuncture points, EEG, HRV and hormones

Background. Previously we have been shown that exist strong canonical correlation between parameters of GDV and principal neuroendocrine factors of adaptation as well as parameters of leukocytogram, immunity and phagocytosis. This study, conducted on a much expanded contingent, will analyze the relationships between GDV parameters, on the one hand, and the parameters of acupuncture points (APs), EEG, HRV and adaptation hormones, on the other. Material and Methods. We observed twice 31 women and 29 men aged 26-76 years with dysfunction of neuroendocrine-immune complex. In the morning in basal conditions at first registered kirlianogram by the method of GDV by the device “GDV Chamber” (“Biotechprogress”, SPb, RF). Than we registered simultaneously EEG and HRV and recorded electrical conductivity of three pairs of Aps. Finally, a blood sample was taken to determine the plasma levels of the main hormones of adaptation: cortisol, testosterone and triiodothyronine. Results processed by method of canonical analysis, using the software package “Statistica 64”. Results. The coefficient of canonical correlation between the electrical conductivity of APs and gas-discharge image (GDI) parameters is 0,635; between APs and virtual Chakras parameters – 0,614; instead, between APs and GDV parameters as a whole – 0,707. The autonomic-endocrine constellation is somewhat more strongly associated with GDI parameters than with virtual Chakras parameters (0,769 vs 0,712). Additional inclusion of EEG parameters in the neuroendocrine set increases the strength of the canonical correlation to 0,869. Conclusion. The above data, taken together with the previous ones, state that between parameters of neuroendocrine-immune complex and GDV exist strong canonical correlation suggesting suitability of the latter method.

Causal relationships between the parameters of gas discharge visualization and leukocytogram

Background. Previously we have been shown that between parameters of GDV and principal neuroendocrine factors of adaptation exist strong canonical correlation. In the next study, we detected very strong (R=0,994) integral canonical correlation between the parameters of GDV and Immunity. This study, conducted in the same contingent, will analyze the relationships between GDV parameters, on the one hand, and Phagocytosis and Leukocytogram parameters, on the other. Material and Methods. We observed twice ten women and ten men aged 33-76 years without clinical diagnose. In the morning in basal conditions at first registered kirlianogram by the method of GDV by the device “GDV Chamber” (“Biotechprogress”, SPb, RF). Than we counted up the Leukocytogram and determined Interleukin-1 serum level. Results processed by method of canonical analysis, using the software package “Statistica 5.5”. Results. According to the value of the canonical correlation coefficient R with GDV parameters, the components of the Leukocytogram are arranged in this order: proportion of monocytes (0,769) and eosinophils (0,703), entropy of Leukocytogram (0,636), total leukocytes level (0,558), proportion of lymphocytes (0,492), stub neutrophils (0,374) and polymorphonuclear neutrophils (0,307). Coefficient of canonical correlation between parameters of GDV, on the one hand, and, on the other hand, Leukocytogram, makes 0,904; Leukocytary Strain&Adaptation Indices-1 – 0,756; Leukocytary Strain&Adaptation Indices-2 – 0,783; Interleukin-1 – 0,798. Conclusion. The above data, taken together with the previous ones, state that between parameters of Neuroendocrine-Immune complex and GDV exist strong canonical correlation suggesting suitability of the latter method.

Causal relationships between the parameters of gas discharge visualization and phagocytosis

Background. Previously we have been shown that between parameters of GDV and principal neuroendocrine factors of adaptation exist strong canonical correlation. In the next study, we detected very strong (R=0,994) integral canonical correlation between the parameters of GDV and Immunity. This study, conducted in the same contingent, will analyze the relationships between GDV parameters, on the one hand, and Phagocytosis parameters, on the other. Material and Methods. We observed twice ten women and ten men aged 33-76 years without clinical diagnose. In the morning in basal conditions at first registered kirlianogram by the method of GDV by the device “GDV Chamber” (“Biotechprogress”, SPb, RF). Than we estimated the parameters of Phagocytic function of neutrophils. Results processed by method of canonical analysis, using the software package “Statistica 5.5”. Results. According to the value of the canonical correlation coefficient R with GDV parameters, the registered Phagocytosis parameters are arranged in the following order: activity (0,616), bactericidal capacity (0,493), completeness (0,489) and intensity (0,484) of Phagocytosis of E. coli; completeness (0,482), bactericidal capacity (0,448), activity (0,364) and intensity (0,338) of Phagocytosis of Staph. aureus. Coefficient of canonical correlation between parameters of GDV, on the one hand, and Phagocytosis, on the other hand, makes 0,847. Conclusion. The above data, taken together with the previous ones, state that between parameters of Neuroendocrine-Immune complex and GDV exist strong canonical correlation suggesting suitability of the latter method.

The Effects of Androstenone on the Plasma Serotonin, β-Endorphin, and Cortisol Concentrations in Thoroughbred Horses

Androstenone influences the changing behaviors of animals. Previous studies discovered that an androstenone receptor was expressed in horses and treatment with androstenone induced horses to be more compliant. As changes in the level of neuroendocrine factors result in animal behavioral changes, the objective of the study was to monitor the changes in the concentrations of 5-HT, β-endorphin, and cortisol in response to androstenone. Eight thoroughbred horses (five mares and three geldings) were treated with androstenone diluted in jojoba oil (10 µg/mL) and only oil for a control cross-overly. A handler applied the treatments to the horses′ nostril and rubbed for 5 s. Blood samples were collected before, 15, 30, and 60 min after each treatment. The concentrations of each neurotransmitter were analyzed by enzyme-linked immunosorbent assay. The concentrations of each neurotransmitter after the treatment were compared to its baseline concentration. The concentration of 5-HT of the androstenone-treated horses remained consistent throughout the experiment, while the concentration of the control group significantly decreased over time. The plasma concentration of β-endorphin in the androstenone-treated group also remained constant, whereas the concentration increased in the control group. Cortisol levels did not change in either the treated or untreated groups. An androstenone treatment triggers changes in the secretion of 5-HT and β-endorphin in horses.

Appetite and weight inducing and inhibiting neuroendocrine factors in Prader-Willi syndrome, Bardet-Biedl syndrome and craniopharyngioma versus anorexia nervosa

Obesity is reaching endemic state and has a major impact on health and economy. In most cases obesity is caused by life style factors. However, the risk of becoming obese differs highly between people. Individual differences in life style, genetic, and neuroendocrine factors play a role in satiety, hunger and regulation of body weight. In a small percentage of children and adults with obesity, an underlying hormonal or genetic cause can be found. The aim of this review is to present and compare data on the extreme ends of the obesity and undernutrition spectrum in patients with Prader-Willi syndrome (PWS), Bardet-Biedl syndrome (BBS), acquired hypothalamic obesity in craniopharyngioma patients, and anorexia nervosa. This may give more insight in the role of neuroendocrine factors and might give direction for future research in conditions of severe obesity and underweight.

Oxytocin modulates human chemosensory decoding of sex in a dose-dependent manner

There has been accumulating evidence of human social chemo-signaling, but the underlying mechanisms remain poorly understood. Considering the evolutionarily conserved roles of oxytocin and vasopressin in reproductive and social behaviors, we examined whether the two neuropeptides are involved in the subconscious processing of androsta-4,16,-dien-3-one and estra-1,3,5 (10),16-tetraen-3-ol, two human chemosignals that convey masculinity and femininity to the targeted recipients, respectively. Psychophysical data collected from 216 heterosexual and homosexual men across five experiments totaling 1056 testing sessions consistently showed that such chemosensory communications of masculinity and femininity were blocked by a competitive antagonist of both oxytocin and vasopressin receptors called atosiban, administered nasally. On the other hand, intranasal oxytocin, but not vasopressin, modulated the decoding of androstadienone and estratetraenol in manners that were dose-dependent, nonmonotonic, and contingent upon the recipients’ social proficiency. Taken together, these findings establish a causal link between neuroendocrine factors and subconscious chemosensory communications of sex-specific information in humans.