5107 POSTER Association of Serum Level of 25 Hydroxy-vitamin D With Prognostic Factors of Breast Cancer

Background. Besides the extensive regulatory role in growing number of biologic processes, vitamin D has been recently considered essential for lungs function as well as protective against exacerbation of chronic obstructive pulmonary diseases. We assessed the correlation between vitamin D serum levels with pulmonary function in healthy individuals. Methods. In a cross-sectional study, healthy volunteer (n=92) participants underwent the following laboratory procedures: a blood test, a 24-hour urine collection test, and the serum level of 25-hydroxy vitamin D before undergoing spirometry. Linear correlation coefficient was calculated to detect the association between serum level of 25-hydroxy vitamin D and pulmonary volumes. Results. The mean age of participants was 39.95±9.98 years. 48% of participants showed different levels of 25-hydroxy vitamin D deficiency. We recognized a consistent direct positive correlation between serum levels of 25-hydroxy vitamin D and lung function volumes. The coefficient for forced vital capacity, forced expiratory volume in 1 second, forced expiratory flow 25–75%, and forced expiratory volume in 1 second/forced vital capacity ratio were 0.610, 0.509, 0.454, and 0.551, respectively. Conclusions. Our findings suggest correlation between higher serum levels of 25-hydroxy vitamin D and improved pulmonary function. Accordingly, supplemental vitamin D might significantly improve treatment response.

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Circulating 25-hydroxy vitamin D correlates with serum level of anti-Müllerian hormone in male patients with chronic kidney disease

Andrologia ◽

10.1111/and.12972 ◽

2018 ◽

Vol 50 (4) ◽

pp. e12972

Author(s):

F. F. Abdel Hamid ◽

A. F. Soliman ◽

F. E. S. Lashin

Keyword(s):

Chronic Kidney Disease ◽

Vitamin D ◽

Kidney Disease ◽

Serum Level ◽

25 Hydroxy Vitamin D ◽

Male Patients

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Association Between Vitamin D Deficiencies in Sarcoidosis with Disease Activity, Course of Disease and Stages of Lung Involvements

Journal of Medical Biochemistry ◽

10.1515/jomb-2017-0041 ◽

2018 ◽

Vol 37 (2) ◽

pp. 103-109 ◽

Cited By ~ 7

Author(s):

Arda Kiani ◽

Atefeh Abedini ◽

Ian M. Adcock ◽

Maryam Sadat Mirenayat ◽

Kimia Taghavi ◽

...

Keyword(s):

Vitamin D ◽

Serum Level ◽

Pulmonary Function ◽

Disease Activity ◽

Vitamin D Deficiency ◽

Calcium Level ◽

Significant Negative Correlation ◽

Urine Calcium ◽

Chronic Respiratory Diseases ◽

25 Hydroxy Vitamin D

SummaryBackground:Despite negative association between 25-hydroxy vitamin D and incidence of many chronic respiratory diseases, this feature was not well studied in sarcoidosis. Current study investigated the association between 25-hydroxy vitamin D deficiency with sarcoidosis chronicity, disease activity, extra-pulmonary skin manifestations, urine calcium level and pulmonary function status in Iranian sarcoidosis patients. Results of this study along with future studies, will supply more effective programs for sarcoidosis treatment.Methods:Eighty sarcoidosis patients in two groups of insufficient serum level and sufficient serum level of 25-hydroxy vitamin D were studied. Course of sarcoidosis was defined as acute and chronic sarcoidosis. Pulmonary function test (PFT) was assessed by spirometry. Skin involvements were defined as biopsy proven skin sarcoidosis. 24-hour urine calcium level was used to specify the disease activity. Stages of lung involvements were obtained by CT-scan and chest X-ray. The statistical analyses were evaluated using Statistical Package for the Social Sciences.Results:A significant negative correlation was obtained between vitamin D deficiency in sarcoidosis patients and disease chronic course and stages two to four of lung involvements. Considering other parameters of the disease and vitamin D deficiency, no significant correlation was detected.Conclusions:In conclusion, results of the current study implies in the role of vitamin 25(OH)D deficiencies in predicting the course of chronic sarcoidosis. Furthermore, it was concluded that vitamin 25(OH)D deficiency can direct pulmonary sarcoidosis toward stage 2–4 of lung involvements.

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Association of 25-hydroxyvitamin D, Cyclooxygenase-2 and Prostaglandin E2 Serum Levels in Breast Cancer Patients

The Indonesian Biomedical Journal ◽

10.18585/inabj.v13i4.1684 ◽

2021 ◽

Vol 13 (4) ◽

pp. 426-32

Author(s):

Theresia Ilyan ◽

Dwi Retnoningrum ◽

Meita Hendrianingtyas ◽

Dian Widyaningrum ◽

Banundari Rachmawati

Keyword(s):

Breast Cancer ◽

Vitamin D ◽

Serum Level ◽

Prostaglandin E2 ◽

Serum Vitamin ◽

Serum Levels ◽

Cyclooxygenase 2 ◽

Hydroxyvitamin D ◽

Serum Vitamin D ◽

25 Hydroxyvitamin D

BACKGROUND: Serum levels of 25-hydroxyvitamin D (25(OH)D), prostaglandin E2 (PGE2), and cyclooxygenase 2 (COX2) expression differ between breast cancer stages. Since, previous studies showed mixed results, in this study, we aimed to analyze vitamin D levels related to breast cancer stages and serum levels of COX2 and PGE2 in Indonesia.METHODS: This was a cross sectional study involving 75 breast cancer patients. Subjects were divided into 3 groups, namely operable early stage (K1), locally advanced stage (K2), and advanced stage (K3). Venous blood samples were taken from each subject, then were analyzed for the 25(OH)D, COX2, and PGE2 serum levels by enzyme-linked immunosorbent assay (ELISA) method.RESULTS: There were significant differences in 25(OH)D among groups (p=0.012); between K1 and K2 (p=0.009) and between K1 and K3 (p=0.023). However, there was no significant difference in serum COX2 level (p=0.328). There were significant differences of PGE2 among groups (p=0.002); between K1 and K2 (p=0.036) and between K1 and K3 (p=0.001). Correlation test showed that there were differences between 25(OH)D serum levels and PGE2 serum level (r=0.306, p=0.008) and also between 25(OH)D serum level and breast cancer stage (r=-0.229; p=0.048).CONCLUSION: There were differences in serum Vitamin D and PGE2 levels at various stages of breast cancer. Serum 25(OH)D levels had weak correlation with breast cancer stage and PGE2 serum level. Serum vitamin D level in advanced breast cancer were lower than early stage breast cancer and indicate a poor prognosis.KEYWORDS: breast cancer, 25-hydroxyvitamin D, cyclooxygenase 2, prostaglandin E2

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Evaluation of Serum Level of Vitamin D in Patients with Female Pattern Hair Loss Thesis

Journal of Advances in Medicine and Medical Research ◽

10.9734/jammr/2021/v33i1931091 ◽

2021 ◽

pp. 157-162

Author(s):

Manar Elsayed Taha Sadoma ◽

Ghada Fawzy Rezk Hassan ◽

Manal Mohamed ALI Elbatsh ◽

Zeinab AbdElsamd Ibrahim

Keyword(s):

Vitamin D ◽

Serum Level ◽

Hair Loss ◽

Vitamin D3 ◽

Serum Vitamin ◽

Serum Levels ◽

Common Cause ◽

Female Pattern Hair Loss ◽

Vitamin D Levels ◽

25 Hydroxy Vitamin D

Background: Female pattern hair loss (FPHL) is the most common cause of alopecia in women, characterized by diffuse non-scarring hair loss in frontal, central, and parietal areas of the scalp. Vitamin D is a factor that has recently been considered in dealing with these patients. Objective: The aim of this work was to evaluate the serum level of 25 hydroxy vitamin D in patients with FPHL to elucidate its possible role in the pathogenesis of the disease. Methods: This study included 45 patients with female pattern hair loss; Evaluation of vitamin D level by Elisa was done for both control and patients. Results: Regarding vitamin D levels, mean ± SD. 18.0 ± 11.97. Conclusion: This study indicated the correlation between FPHL and decreased serum levels of Vitamin D3. It is recommended to evaluate serum Vitamin D3 levels as well as other hormone assays in these patients.

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