Introduction to an alternate view of acid/base balance: The strong ion difference or stewart approach

2002 ◽  
Vol 15 (1) ◽  
pp. 14-20 ◽  
Author(s):  
Martin Boyle ◽  
Ian Baldwin
Keyword(s):  
Strong Ion Difference ◽  
Acid Base Balance ◽  
Acid Base ◽  
Stewart Approach ◽  
Base Balance

Cardiorespiratory effects of prolonged angiotensin II block in resting conscious dogs

2001 ◽  
Vol 79 (9) ◽  
pp. 825-830
Author(s):  
Donald B Jennings
Keyword(s):  
Angiotensin Ii ◽  
Salt Water ◽  
Respiratory Control ◽  
Conscious Dogs ◽  
Chow Diet ◽  
Strong Ion Difference ◽  
Ang Ii ◽  
Acid Base Balance ◽  
Acid Base ◽  
Base Balance

Intravenous (iv) infusion of the angiotensin II (ANG II) receptor blocker saralasin in resting conscious dogs during physiological pertubations, such as hypotension and prolonged hypoxia, indicates the presence of an ANG II drive to increase respiration and decrease the arterial partial pressure of CO2 (PaCO2). In contrast, in eupneic resting dogs on a regular chow diet, iv infusion of saralasin for short periods (up to 30 min) provides no evidence of a tonic effect of circulating levels of ANG II on acid-base balance, respiration, metabolism, or circulation. However, ANG II influences physiological processes involving salt, water, and acid-base balances, which are potentially expressed beyond a 30 min time period, and could secondarily affect respiration. Therefore, we tested the hypothesis that blocking ANG II with iv saralasin would affect respiration and circulation over a 4-h period. Contrary to the hypothesis, iv infusion of saralasin in resting conscious eupneic dogs on a regular chow diet over a 4-h period had no effects on plasma strong ions, osmolality, acid-base balance, respiration, metabolism, or circulation when compared with similar control studies in the same animals. Thus, ANG II does not play a tonic modulatory role in respiratory control under "normal" physiological conditions.Key words: acid-base balance, arginine vasopressin, saralasin, strong ions, strong ion difference.

Effect of chronic acetazolamide administration on gas exchange and acid-base control after maximal exercise

1994 ◽  
Vol 76 (3) ◽  
pp. 1211-1219 ◽  
Author(s):  
J. M. Kowalchuk ◽  
G. J. Heigenhauser ◽  
J. R. Sutton ◽  
N. L. Jones
Keyword(s):  
Gas Exchange ◽  
Muscle Power ◽  
Strong Ion Difference ◽  
Acid Base Balance ◽  
Acid Base ◽  
Arterial Lactate ◽  
Arterial Pco2 ◽  
Co2 Output ◽  
Base Balance ◽  
Arterial Plasma

The interaction between systems regulating acid-base balance (i.e., CO2, strong ions, week acids) was studied in six subjects for 10 min after 30 s of maximal isokinetic cycling during control conditions (CON) and after 3 days of chronic acetazolamide (ChACZ) administration (500 mg/8 h po) to inhibit carbonic anhydrase (CA). Gas exchange was measured; arterial and venous forearm blood was sampled for acid-base variables. Muscle power output was similar in ChACZ and CON, but peak O2 intake was lower in ChACZ; peak CO2 output was also lower in ChACZ (2,207 +/- 220 ml/min) than in CON (3,238 +/- 87 ml/min). Arterial PCO2 was lower at rest, and its fall after exercise was delayed in ChACZ. In ChACZ there was a higher arterial [Na+] and lower arterial [lactate-] ([La-]) accompanied by lower arterial [K+] and higher arterial [Cl-] during the first part of recovery, resulting in a higher arterial plasma strong ion difference (sigma [cations] - sigma [anions]). Venoarterial (v-a) differences across the forearm showed a similar uptake of Na+, K+, Cl-, and La- in ChACZ and CON. Arterial [H+] was higher and [HCO3-] was lower in ChACZ. Compared with CON, v-a [H+] was similar and v-a [HCO3-] was lower in ChACZ. Chronic CA inhibition impaired the efflux of CO2 from inactive muscle and its excretion by the lungs and also influenced the equilibration of strong ions.(ABSTRACT TRUNCATED AT 250 WORDS)

Calculation of physiological acid-base parameters in multicompartment systems with application to human blood

2003 ◽  
Vol 95 (6) ◽  
pp. 2333-2344 ◽  
Author(s):  
E. Wrenn Wooten
Keyword(s):  
Base Change ◽  
Strong Ion Difference ◽  
Acid Base Balance ◽  
Acid Base ◽  
Base Parameters ◽  
Present Formalism ◽  
Base Balance ◽  
Multicompartment Systems ◽  
Relationship Of ◽  
The Relationship

A general formalism for calculating parameters describing physiological acid-base balance in single compartments is extended to multicompartment systems and demonstrated for the multicompartment example of human whole blood. Expressions for total titratable base, strong ion difference, change in total titratable base, change in strong ion difference, and change in Van Slyke standard bicarbonate are derived, giving calculated values in agreement with experimental data. The equations for multicompartment systems are found to have the same mathematical interrelationships as those for single compartments, and the relationship of the present formalism to the traditional form of the Van Slyke equation is also demonstrated. The multicompartment model brings the strong ion difference theory to the same quantitative level as the base excess method.

630: Strong ion difference in fetal cord blood - A novel comprehensive approach to acid-base balance

2007 ◽  
Vol 197 (6) ◽  
pp. S182
Author(s):  
Yoni Cohen ◽  
Jessica Ascher Landsberg ◽  
Michael Kupferminc ◽  
Joseph B. Lessing ◽  
Adi Nimrod ◽  
...  
Keyword(s):  
Cord Blood ◽  
Comprehensive Approach ◽  
Strong Ion Difference ◽  
Acid Base Balance ◽  
Acid Base ◽  
Fetal Cord Blood ◽  
Base Balance

scholarly journals Acid-Base Balance in Callinectes Sapidus During Acclimation from High to Low Salinity

1982 ◽  
Vol 101 (1) ◽  
pp. 255-264 ◽  
Author(s):  
RAYMOND P. HENRY ◽  
JAMES N. CAMERON
Keyword(s):  
Carbonic Anhydrase ◽  
Blue Crab ◽  
Callinectes Sapidus ◽  
Weak Acid ◽  
Strong Ion Difference ◽  
Acid Base Balance ◽  
Acid Base ◽  
Ion Regulation ◽  
Low Salinity ◽  
Base Balance

When transferred from 865 to 250 m-osmol salinity, the blue crab C. sapidus maintains its blood Na+ and Cl− concentrations significantly above those in the medium. When branchial carbonic anhydrase is inhibited by acetazolamide, ion regulation fails and the animals do not survive the transfer. An alkalosis occurs in the blood at low salinity, indicated by an increase in HCO3− and pH at constant PCO2. The alkalosis is closely correlated with an increase in the Na+-Cl− difference, a convenient indicator of the overall strong ion difference. The contribution of changes in PCO2 to acid-base changes was negligible, but the change in the total weak acid (proteins) may be important. It is suggested that the change in blood acidbase status with salinity is related to an increase in the strong ion difference, which changes during the transition from osmoconformity to osmoregulation in the blue crab, and which is related to both carbonic anhydrase and ionactivated ATPases. Note:

scholarly journals The Physiology of Dehydration Stress in the Land Crab, Cardisoma Carnifex: Respiration, Ionoregulation, Acid-Base Balance and Nitrogenous Waste Excretion

1986 ◽  
Vol 126 (1) ◽  
pp. 271-296 ◽  
Author(s):  
CHRIS M. WOOD ◽  
R. G. BOUTILIER ◽  
D. J. RANDALL
Keyword(s):  
Metabolic Alkalosis ◽  
Ammonia Excretion ◽  
French Polynesia ◽  
Strong Ion Difference ◽  
Acid Base Balance ◽  
Acid Base ◽  
Land Crab ◽  
Base Balance ◽  
Ion Shifts ◽  
Total Body

Air-breathing Cardisoma carnifex, collected in Moorea, French Polynesia, were held in fresh water similar in chemical composition to that in their burrows. Under control conditions, which allowed branchial chamber flushing but not ventilation of the medium, crabs demonstrated net Na+ and Cl− uptake, and ammonia, urea and base excretion (= acidic equivalent uptake). Throughout 192 h of water deprivation, crabs dehydrated slowly at a rate of 0.55 g H2O kg−1 h−1, eventually reaching a near lethal 18% loss of total body water. Increases in haemolymph osmolytes were quite variable (0–29%); electrolyte excretion was negligible. MOO2 and MCOCO2 both decreased by approximately 55%, maintaining an unusually low gas exchange ratio (R = 0.53), and suggesting general metabolic depression. There was no evidence of internal hypoxia as haemolymph lactate remained at hydrated levels and PaOO2 actually increased. The dominant acid-base response was a progressive metabolic alkalosis accompanied by a partially compensating rise in PaCOCO2. Alkalosis was probably caused by blockage of the normal aquatic excretion of base produced by the metabolism of this herbivore. Other possible causes were eliminated: i.e. alkalaemia due to contraction of the ECFV; entrainment via strong ion shifts; CaCO3 mobilization; and ammonia accumulation in the haemolymph. In the absence of water, net ammonia production and excretion both appeared to cease, and alternate end products (urea, uric acid) did not generally accumulate. Within 2h of rehydration, crabs regained more than half the lost water, MOO2 and MCOCO2 increased above control levels, and ammonia excretion and haemolymph concentration both exhibited a prolonged (56 h) 4- to 6-fold rise. At the same time, metabolic alkalosis was reversed in association with elevated net base excretion into the water; the latter was correlated with an increase in the strong ion difference (SID) flux ([Na+ + K+ + Ca2+ + Mg2+ - Cl−]). Note:

scholarly journals Blood gas analysis, anion gap, and strong ion difference in horses treated with polyethylene glycol balanced solution (PEG 3350) or enteral and parenteral electrolyte solutions

2014 ◽  
Vol 44 (6) ◽  
pp. 1086-1092 ◽  
Author(s):  
Cláudio Luís Nina Gomes ◽  
José Dantas Ribeiro Filho ◽  
Rafael Resende Faleiros ◽  
Fernanda Timbó D'el Rey Dantas ◽  
Lincoln da Silva Amorim ◽  
...  
Keyword(s):  
Blood Gas Analysis ◽  
Electrolyte Solutions ◽  
Gas Analysis ◽  
Strong Ion Difference ◽  
Acid Base Balance ◽  
Acid Base ◽  
Ringer’S Solution ◽  
Base Balance ◽  
Lactated Ringer's Solution ◽  
Balanced Solution

Large volumes of different electrolytes solutions are commonly used for ingesta hydration in horses with large colon impaction, but little is known about their consequences to blood acid-base balance. To evaluate the effects of PEG 3350 or enteral and parenteral electrolyte solutions on the blood gas analysis, anion gap and strong ion difference, five adult female horses were used in a 5x5 latin square design. The animals were divided in five groups and distributed to each of the following treatments: NaCl (0.9% sodium chloride solution); EES (enteral electrolyte solution), EES+LR (EES plus lactated Ringer's solution); PEG (balanced solution with PEG 3350) and PEG+LR (PEG plus lactated Ringer's solution). Treatments PEG or PEG + LR did not change or promoted minimal changes, while the EES caused a slight decrease in pH, but its association with lactated Ringer's solution induced increase in AG and SID values, as well as caused hypernatremia. In turn, the treatment NaCl generated metabolic acidosis. PEG 3350 did not alter the acid-base balance. Despite it's slight acidifying effect, the enteral electrolyte solution (EES) did not cause clinically relevant changes.

Simplified strong ion difference approach to acid-base balance in healthy foals

2016 ◽  
Vol 26 (4) ◽  
pp. 549-558 ◽  
Author(s):  
Judit Viu ◽  
Lara Armengou ◽  
José Ríos ◽  
Anna Muñoz ◽  
Eduard Jose-Cunilleras
Keyword(s):  
Strong Ion Difference ◽  
Acid Base Balance ◽  
Acid Base ◽  
Base Balance

Acid-base balance in ducks (Anas platyrhynchos) during involuntary submergence

1987 ◽  
Vol 252 (2) ◽  
pp. R348-R352 ◽  
Author(s):  
M. Shimizu ◽  
D. R. Jones
Keyword(s):  
Protein Content ◽  
Total Protein ◽  
Recovery Period ◽  
Lactate Production ◽  
Weak Acid ◽  
Total Protein Content ◽  
Strong Ion Difference ◽  
Acid Base Balance ◽  
Acid Base ◽  
Base Balance

Measurements of all the major independent variables [arterial CO2 tension (PaCO2); strong-ion difference ([SID]), and total protein content, which approximate total weak acid concentration in plasma] are essential for understanding changes in acid-base balance in plasma. During involuntary submergence of 1, 2, or 4 min, PaCO2 in ducks increased and arterial pH (pHa) decreased. During 1-min dives there were no significant changes in any strong ions. In both 2- and 4-min dives, there was a significant increase in [lactate-], but because of an increase in equal magnitude of [Na+], [SID] did not change. During recovery from all dives the plasma remained acidotic for several minutes, although PaCO2 fell below predive levels in less than 1 min. [Lactate-] increased in the recovery period. There were no changes in total protein content during submergence or recovery. Breathing 100% O2 before 2-min dives caused a reduction in [lactate-] production and release during and after the dive, although due to a marked increased in PaCO2, pHa fell as low as in 4-min dives after breathing air. After 1 min of recovery, pHa returned to normal along with the restoration of the predive level of PaCO2. We conclude that the acidosis during involuntary submergence is due solely to an increase in PaCO2, whereas in recovery it is caused by decreased [SID].

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