Diffuse White Matter Differences Between Gulf War Syndrome II and Control Subjects Revealed by Diffusion Tensor MRI

NeuroImage ◽  
2009 ◽  
Vol 47 ◽  
pp. S105
Author(s):  
R McColl ◽  
S Li ◽  
R Briggs ◽  
R Haley
Keyword(s):  
White Matter ◽  
Diffusion Tensor ◽  
Gulf War ◽  
Diffusion Tensor Mri ◽  
Gulf War Syndrome ◽  
Control Subjects ◽  
Diffuse White Matter ◽  
And Control

scholarly journals Fatigue and cognitive function in systemic lupus erythematosus: associations with white matter microstructural damage. A diffusion tensor MRI study and meta-analysis

Lupus ◽  
2016 ◽  
Vol 26 (6) ◽  
pp. 588-597 ◽  
Author(s):  
S J Wiseman ◽  
M E Bastin ◽  
I F Hamilton ◽  
D Hunt ◽  
S J Ritchie ◽  
...  
Keyword(s):  
Cognitive Function ◽  
White Matter ◽  
Lupus Erythematosus ◽  
Diffusion Tensor ◽  
Meta Analysis ◽  
Mean Diffusivity ◽  
Diffusion Tensor Mri ◽  
Systemic Lupus ◽  
Diffuse White Matter ◽  
Brain White Matter

Objective The objective of this study was to investigate fatigue and cognitive impairments in systemic lupus erythematous (SLE) in relation to diffuse white matter microstructural brain damage. Methods Diffusion tensor MRI, used to generate biomarkers of brain white matter microstructural integrity, was obtained in patients with SLE and age-matched controls. Fatigue and cognitive function were assessed and related to SLE activity, clinical data and plasma biomarkers of inflammation and endothelial dysfunction. Results Fifty-one patients with SLE (mean age 48.8 ± 14.3 years) were included. Mean diffusivity (MD) was significantly higher in all white matter fibre tracts in SLE patients versus age-matched healthy controls ( p < 0.0001). Fatigue in SLE was higher than a normal reference range ( p < 0.0001) and associated with lower MD ( ß = −0.61, p = 0.02), depression ( ß = 0.17, p = 0.001), anxiety ( ß = 0.13, p = 0.006) and higher body mass index ( ß = 0.10, p = 0.004) in adjusted analyses. Poorer cognitive function was associated with longer SLE disease duration ( p = 0.003) and higher MD ( p = 0.03) and, in adjusted analysis, higher levels of IL-6 ( ß = −0.15, p = 0.02) but not with MD. Meta-analysis (10 studies, n = 261, including the present study) confirmed that patients with SLE have higher MD than controls. Conclusion Patients with SLE have more microstructural brain white matter damage for age than the general population, but this does not explain increased fatigue or lower cognition in SLE. The association between raised IL-6 and worse current cognitive function in SLE should be explored in larger datasets.

Diffusion tensor imaging of cerebral white matter in patients with myotonic dystrophy

2005 ◽  
Vol 46 (1) ◽  
pp. 104-109 ◽  
Author(s):  
H. Fukuda ◽  
J. Horiguchi ◽  
C. Ono ◽  
T. Ohshita ◽  
J. Takaba ◽  
...  
Keyword(s):  
Diffusion Tensor Imaging ◽  
White Matter ◽  
Myotonic Dystrophy ◽  
Normal Control ◽  
Diffusion Tensor ◽  
Age At Onset ◽  
Mean Diffusivity ◽  
Magnetic Resonance Images ◽  
Microstructural Changes ◽  
Control Subjects

Purpose: To determine whether myotonic dystrophy (MyD) patients have diffusion tensor abnormalities suggestive of microstructural changes in normal‐appearing white matter (NAWM). Material and Methods: Conventional and diffusion tensor magnetic resonance images of the brain were obtained in 19 MyD patients and 19 age‐matched normal control subjects. Fractional anisotropy (FA) and mean diffusivity (MD) values were calculated in white matter lesions (WMLs) and NAWM in MyD patients and in the white matter of normal control subjects. Differences between WML and NAWM values and between MyD patient and control subject values were analyzed statistically. Results: Significantly lower FA and higher MD values were found in all regions of interest in the NAWM of MyD patients than in the white matter of control subjects ( P<0.01), as well as significantly lower FA and higher MD values in WMLs than in NAWM of MyD patients ( P<0.05). There was no significant correlation of mean FA or MD values in NAWM with patient age, age at onset, or duration of illness ( P>0.1). Conclusion: Diffusion tensor imaging analysis suggests the presence of diffuse microstructural changes in NAWM of MyD patients that may play an important role in the development of disability.

Corpus Callosum Microstructural Alterations In Children With Memory Related Learning Disability: A Diffusion Tensor Imaging Study

QJM ◽  
2021 ◽  
Vol 114 (Supplement_1) ◽  
Author(s):  
Abeer Maghawry Abd elhameed ◽  
Shaimaa Abdelsattar Mohammad ◽  
Neveen Hassan Nashaat ◽  
Amgad Samy Abdel-Rahman ◽  
Ehab Ragaa Abdol Raouf
Keyword(s):  
Learning Disabilities ◽  
White Matter ◽  
Corpus Callosum ◽  
Learning Disability ◽  
Diffusion Tensor ◽  
Digit Span ◽  
Clinical Test ◽  
Control Subjects ◽  
Healthy Control ◽  
With Memory

Abstract Purpose The purpose of this study is to assess the corpus callosum microstructural changes in children with memory related learning disability. Methods DTI was performed in 20 patients with memory related learning disabilities (MRLD +) and 22 matched healthy control subjects (MRLD -) aged 7– 13 years. Fractional anisotropy (FA), axial diffusivity, radial diffusivity (RD) and trace were calculated for corpus callosum. Comparison between patients with memory related learning disabilities (MRLD +) and healthy control subjects (MRLD -) was performed. DTI metrics were correlated to clinical digit span backward scores in (MRLD +) group. A pvalue less than .05 was considered significant. Results The corpus callosum showed a highly significant higher FA and lower diffusivity indices in (MRLD +) group compared to the (MRLD -) group (p &lt; 0.001). No significant correlation between the clinical test “digit span backward” scores and DTI metrics of the corpus callosum was found. Conclusion Changes in DTI metrics of corpus callosum in patients with memory related learning disabilities reflects white matter micro-structural changes. Higher FA values and lower diffusivity indices do not necessarily indicate healthier white matter but, can indicate pathology.

Normal-appearing white matter in ischemic leukoaraiosis: A diffusion tensor MRI study

Neurology ◽  
2001 ◽  
Vol 57 (12) ◽  
pp. 2307-2310 ◽  
Author(s):  
M. O'Sullivan ◽  
P. E. Summers ◽  
D. K. Jones ◽  
J. M. Jarosz ◽  
S. C.R. Williams ◽  
...  
Keyword(s):  
White Matter ◽  
Diffusion Tensor ◽  
Diffusion Tensor Mri ◽  
Normal Appearing White Matter ◽  
Mri Study

White matter structure and clinical characteristics of stroke patients: A diffusion tensor MRI study

2016 ◽  
Vol 1635 ◽  
pp. 61-70 ◽  
Author(s):  
Ryo Ueda ◽  
Naoki Yamada ◽  
Wataru Kakuda ◽  
Masahiro Abo ◽  
Atsushi Senoo
Keyword(s):  
White Matter ◽  
Clinical Characteristics ◽  
Diffusion Tensor ◽  
Diffusion Tensor Mri ◽  
Stroke Patients ◽  
Mri Study

Segmenting brain white matter, gray matter and cerebro-spinal fluid using diffusion tensor-MRI derived indices

2001 ◽  
Vol 19 (9) ◽  
pp. 1167-1172 ◽  
Author(s):  
Mara Cercignani ◽  
Matilde Inglese ◽  
Malgorzata Siger-Zajdel ◽  
Massimo Filippi
Keyword(s):  
White Matter ◽  
Gray Matter ◽  
Diffusion Tensor ◽  
Spinal Fluid ◽  
Diffusion Tensor Mri ◽  
Brain White Matter

Diffusion Tensor Imaging Abnormalities in the Cerebral White Matter Correlate with Sex-Dependent Neurobehavioral Deficits in Adult Mice with Neonatal Ischemia

2016 ◽  
Vol 38 (2) ◽  
pp. 83-95 ◽  
Author(s):  
Markus Breu ◽  
Jiangyang Zhang ◽  
Michael Porambo ◽  
Mikhail V. Pletnikov ◽  
Katharina Goeral ◽  
...  
Keyword(s):  
Cerebral Palsy ◽  
Diffusion Tensor Imaging ◽  
White Matter ◽  
Diffusion Tensor ◽  
Behavioral Testing ◽  
Behavioral Alterations ◽  
Neonatal Ischemia ◽  
And Control

Background: Neonatal white matter injury (NWMI) is the leading cause of cerebral palsy in prematurely born children. In order to develop a test bed for therapeutics, we recently reported a mouse model of NWMI by using a modified Rice-Vannucci model of neonatal ischemia on postnatal day 5 (P5) in CD-1 mice. We have previously shown that these mice illustrate initial neuroinflammation and oligodendroglial differentiation arrest followed by long-term dysmyelination, periventricular astrogliosis and axonal injury, resembling human NWMI. The objective of this study was to determine the sex-dependent long-term effects of neonatal brain injury on neurobehavioral and advanced in vivo neuroimaging indices in this mouse model, and to correlate these variables with histopathology. Methods: After right common artery ligation on P5, in vivo T2-weighted imaging and diffusion tensor imaging (DTI) were performed on ligated and control animals at 4 and 8 weeks. Common sets of regions of interest were used to compare fractional anisotropy (FA) values between ischemic and control mice. Behavioral testing (open field, startle response and grip strength) was performed at adult age. Finally, the animals were sacrificed for immunohistochemical (IHC) assessment of major white matter tracts. Results: DTI revealed significant sex-dependent changes in FA values ipsi- and contralateral to the ligation. Behavioral testing showed decreased reaction to acoustic stimuli in males but not females. Similarly, increased number of rearings and lack of novelty-induced habituation in the open field were encountered only in the male subgroup. Several regional correlations were found between FA values and these behavioral alterations. IHC studies revealed degeneration of mature oligodendrocytes and damage of white matter tracts in ligated animals, as previously reported in this model, and showed regional correlation with in vivo FA values and behavioral alterations. Conclusions: Our findings suggest structural sex-dependent long-term abnormalities after neonatal ischemia. These changes lead to behavioral deficits resembling common problems of patients with cerebral palsy.

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