HLA-DQB1 Subtypes Predict Diabetic Retinopathy in Patients with Type I Diabetes Mellitus

2009 ◽  
Vol 19 (4) ◽  
pp. 638-645 ◽  
Author(s):  
Mohammad Hassan Khazaee ◽  
Jalil Tavakol Afshari ◽  
Bahram Khazaee ◽  
Ramin Daneshvar ◽  
Javad Akbarzadeh ◽  
...  
Keyword(s):  
Diabetic Retinopathy ◽  
Type I Diabetes ◽  
Disease Onset ◽  
Human Leukocyte ◽  
Hla Typing ◽  
Diabetic Patients ◽  
Type I ◽  
Study Type ◽  
Type 1 Diabetic Patients

Purpose To investigate if diabetic patients without diabetic retinopathy despite long disease duration have different human leukocyte antigen (HLA) status vs those with an early onset of retinopathy. Methods Retrospective, nonrandomized, masked comparative study. Type 1 diabetic patients with a disease onset before age 30 were recruited to the study. The study population consisted of two groups of diabetic patients: those with normal retinopathy course (retinopathy developed during the first 20 years of diabetes onset) (23 patients) and those with postponed retinopathy (no obvious retinopathy in spite of passing 20 years of diabetes) (19 patients). These groups were matched with regard to level of glycemic control, blood pressure, and lipid profile. A group of 23 healthy patients served as controls. HLA-DQB1 typing of blood samples was done using a polymerase chain reaction with sequence-specific primer (PCR-SSP) method. Results HLA-DQB1*0201/HLA-DQB1*0501 and HLA-DQB1*0201/HLA-DQB1*0504 haplotypes were more common among type 1 diabetic patients with normal retinopathy course than those with postponed retinopathy (26.1% vs 0.0%; p=0.019). HLA-DQB1*0301 and HLA-DQB1*0304 were less common among those diabetic patients with normal retinopathy course than those with a postponed retinopathy (63.2% vs 34.8%; p=0.067). Conclusions Some haplotypes seem to predispose diabetic patients to diabetic retinopathy. HLA typing may be beneficial for predicting the prognosis of diabetic retinopathy in younger diabetic patients.

Kinetics of sodium-lithium countertransport activity in patients with uncomplicated type I diabetes

1992 ◽  
Vol 82 (3) ◽  
pp. 291-299 ◽  
Author(s):  
Peter A. Rutherford ◽  
Trevor H. Thomas ◽  
Susan J. Carr ◽  
Roy Taylor ◽  
Robert Wllklnson
Keyword(s):  
Type 1 Diabetes ◽  
Essential Hypertension ◽  
Type I Diabetes ◽  
Plasma Lipid ◽  
Maximum Velocity ◽  
Diabetic Patients ◽  
Type I ◽  
High Sodium ◽  
Type 1 Diabetic Patients

1. Increased erythrocyte sodium-lithium countertransport activity has been reported to be associated with nephropathy in type 1 diabetes and linked to a family history of essential hypertension. 2. This study aimed to determine the mechanism of increased sodium-lithium countertransport activity. Sodium-lithium countertransport kinetics were measured in uncomplicated and hyperlipidaemic type 1 diabetic patients. 3. In the nine out of 31 uncomplicated type 1 diabetic patients who had high sodium-lithium countertransport activity, the sodium affinity (Km) was normal but the maximum velocity (Vmax.) was increased. 4. Hyperlipidaemia, when present in diabetic patients, was associated with increased sodium-lithium countertransport activity, but could not explain the high activity in uncomplicated type 1 diabetic patients in whom plasma lipid concentrations were normal. 5. Sodium-lithium countertransport activity is increased in type 1 diabetes by a mechanism different to that in essential hypertension, where the mechanism is a low Km (increased sodium affinity). Hence familial hypertension cannot explain the raised sodium-lithium countertransport activity in type 1 diabetes.

scholarly journals Nigella Sativa (Ns) Could it be a New Remedy for Type 1 Diabetic Patients

2018 ◽  
Vol 3 (3) ◽  
Keyword(s):  
Type I Diabetes ◽  
Nigella Sativa ◽  
Fasting Blood Glucose ◽  
Diabetic Patients ◽  
Type I ◽  
Mortality And Morbidity ◽  
Regular Treatment ◽  
Wide Range ◽  
Type 1 Diabetic Patients

Nigella sativa (NS) is a widely used medicinal plant throughout the world. Seeds and oil have a long history of folklore usage in various aspects of medicines and food. It has been used to treat a wide range of diseases including diabetes mellitus (DM). DM is a chronic incurable disease with high mortality and morbidity and increasing prevalence. The aim of this study was to investigate the hypoglycemic effect of (NS) in type 1 diabetic patients. 30 patients with type I diabetes aged 5 to 17 years were included in the study after consenting their parents. Their medical history was taken to confirm that they were fit in the last month and their FBG was measured. They were given NS (2gm per day) with yogurt, beside their regular treatment (insulin) without changing their dose or diet for 30 days. Fasting blood glucose (FBG) was rechecked after that and compared with the initial FBG paired t-test in Statistical Package for the Social Sciences (SPSS) 22 software. The mean levels of FBS before and one month after the intervention were 259 ± 102 and 134 ± 70 mg/dl respectively. There was significant reduction in FBS after treatment with NS (P =0.000). In conclusion NS, a natural product, showed a significant improvement in FBG in type 1 diabetic patients. More studies are recommended in the future to determine the optimal dose, duration and frequency of NS as an antidiabetic drug, its mechanism of action in type1 diabetes and to search for the active antidiabetic ingredient as well as to study the effect of NS in prevention of diabetic complications.

The effect of insulin pump therapy in retinal vasculature in type 1 diabetic patients

2021 ◽  
pp. 112067212199057
Author(s):  
Tomás de Oliveira Loureiro ◽  
João Nobre Cardoso ◽  
Carlos Diogo Pinheiro Lima Lopes ◽  
Ana Rita Carreira ◽  
Sandra Rodrigues-Barros ◽  
...  
Keyword(s):  
Diabetic Retinopathy ◽  
Metabolic Control ◽  
Insulin Pump Therapy ◽  
Vascular Density ◽  
Diabetic Patients ◽  
Retinal Vasculature ◽  
Increased Risk ◽  
The Mean ◽  
Type 1 Diabetic Patients

Background/objectives: Continuous subcutaneous insulin infusion (CSII) is a treatment for type 1 diabetes that improves metabolic control and reduces micro and macrovascular complications. The aim of this study was to compare the effect of CSII versus traditional multiple daily injections (MDI) therapy on retinal vasculature. Methods: We performed a prospective study with type 1 diabetic patients with no prior history of ocular pathology other than mild diabetic retinopathy. The patients were divided into two groups according to their therapeutic modality (CSII vs MDI). The retinal nerve fiber layers thickness and vascular densities were compared between groups in both macula and optic disc. The correlations between vascular density and clinical features were also determined. Statistical significance was defined as p < 0.05. Results: The study included 52 eyes, 28 in the insulin CSII group. The mean age was 36.66 ± 12.97 years, with no difference between groups ( p = 0.49). The mean glycated hemoglobin (HbA1c) was found to be lower in the CSII group (7.1% ± 0.7 vs 7.5% ± 0.7 p < 0.01). The parafoveal vascular density was found to be higher in the CSII group (42.5% ± 0.4 vs 37.7% ± 0.6, p < 0.01). We found an inverse correlation between HbA1c value and parafoveal vascular densities ( p < 0.01, r = −0.50). Conclusion: We found that CSII provided better metabolic control than MDI and this seemed to result in higher parafoveal vascular density. As lower vascular density is associated with an increased risk of diabetic retinopathy, these results suggest that CSII could be the safest therapeutic option to prevent retinopathy.

Associations Between Diabetic Retinopathy and Plasma Levels of High-sensitive C-reactive Protein or Von Willebrand Factor in Long-term Type 1 Diabetic Patients

2012 ◽  
Vol 38 (1) ◽  
pp. 174-179 ◽  
Author(s):  
Jonas Vejvad Nørskov Laursen ◽  
Stine Skovbo Hoffmann ◽  
Anders Green ◽  
Mads Nybo ◽  
Anne Katrin Sjølie ◽  
...  
Keyword(s):  
Diabetic Retinopathy ◽  
Diabetic Patients ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Von Willebrand ◽  
Type 1 Diabetic Patients ◽  
Willebrand Factor ◽  
Term Type

scholarly journals Selective Loss of Inner Retinal Layer Thickness in Type 1 Diabetic Patients with Minimal Diabetic Retinopathy

2009 ◽  
Vol 50 (7) ◽  
pp. 3404 ◽  
Author(s):  
Hille W. van Dijk ◽  
Pauline H. B. Kok ◽  
Mona Garvin ◽  
Milan Sonka ◽  
J. Hans DeVries ◽  
...  
Keyword(s):  
Diabetic Retinopathy ◽  
Layer Thickness ◽  
Diabetic Patients ◽  
Retinal Layer ◽  
Selective Loss ◽  
Type 1 Diabetic Patients

scholarly journals The Implications of Hyperoxia, Type 1 Diabetes and Sex on Cardiovascular Physiology in Mice

2021 ◽  
Author(s):  
Katarina Bojkovic ◽  
Jennifer Rodgers ◽  
Riddhi Vichare ◽  
Asmita Nandi ◽  
Hussein Mansour ◽  
...  
Keyword(s):  
Cardiac Remodeling ◽  
Type I Diabetes ◽  
Comorbid Condition ◽  
Diabetic Patients ◽  
Type I ◽  
Wild Type ◽  
Cardiac Pathophysiology ◽  
Provision Of Care ◽  
Akita Mice

Abstract Oxygen supplementation, although a cornerstone of emergency and cardiovascular medicine, often results in hyperoxia, a condition characterized by excessive tissue oxygen which results in adverse cardiac remodeling and subsequent injurious effects to physiological function. Cardiac remodeling is further influenced by various risk factors, including pre-existing conditions and sex. Thus, the purpose of this experiment was to investigate cardiac remodeling in Type I Diabetic (Akita) mice subjected to hyperoxic treatment. Overall, we demonstrated that Akita mice experience distinct challenges from wild type (WT) mice. Specifically, Akita males at both normoxia and hyperoxia showed significant decreases in body and heart weights, prolonged PR, QRS, and QTc intervals, and reduced %EF and %FS at normoxia compared to WT controls. Moreover, Akita males largely resemble female mice (both WT and Akita) with regards to the parameters studied. Finally, statistical analysis revealed hyperoxia to have the greatest influence on cardiac pathophysiology, followed by sex, and finally genotype. Taken together, our data suggest that Type I diabetic patients may have distinct cardiac pathophysiology under hyperoxia compared to uncomplicated patients, with males being at high risk. These findings can be used to enhance provision of care in ICU patients with Type I diabetes as a comorbid condition.

Sign in / Sign up

Export Citation Format

Share Document