High Incidence of Occult Leptomeningeal Disease Detected by Flow Cytometry in Newly Diagnosed Aggressive B-cell Lymphomas at Risk for Central Nervous System Involvement: The Role of Flow Cytometry Versus Cytology

Abstract We assessed the cerebrospinal fluid (CSF) by flow cytometry and cytology in 51 newly diagnosed and 9 treated aggressive B-cell lymphomas at risk for central nervous system (CNS) involvement to examine the utility of flow cytometry, incidence of CSF disease, and clinical surrogates of CNS spread. Multicolor flow cytometry using multiple antibody panels for light chains and B- and T-cell antigens identified neoplastic clones that constituted as little as 0.2% of total CSF lymphocytes. Among 51 newly diagnosed patients, 11 (22%) had occult CSF involvement. All 11 were detected by flow cytometry but only 1 by cytology (P = .002). Among 9 treated patients, CSF involvement was detected by flow cytometry alone in 2 and also by cytology in 1 case. CSF chemistry and cell counts were similar in patients with and without CSF lymphoma. Only the number of extranodal sites was associated with occult CSF lymphoma in newly diagnosed patients by univariate (P = .006) or logistic regression analysis (P = .012). We hypothesize that the biologic phenotype associated with colonization of extranodal sites leads to CNS spread, possibly related to the microenvironment. Patients at risk for CNS spread should undergo staging CSF evaluation by flow cytometry.

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A Diffuse Large B cell Lymphoma (DLBCL) With Central Nervous System Involvement in a HIV Positive Patient

La Prensa Medica ◽

10.4172/lpma.1000173 ◽

2015 ◽

Vol 105 (05) ◽

Author(s):

Amelia Maria Gaman ◽

Mihnea Alexandru Gaman

Keyword(s):

Central Nervous System ◽

Nervous System ◽

B Cell ◽

Cell Lymphoma ◽

Central Nervous System Involvement ◽

B Cell Lymphoma ◽

Hiv Positive ◽

System Involvement ◽

Large B Cell Lymphoma ◽

Large B Cell

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Central Nervous System Involvement in Systemic Lupus Erythematosus in a Hospital-Based Study of 171 Cases The Possible Therapeutic Role of Intrathecal Therapy

JCR Journal of Clinical Rheumatology ◽

10.1097/00124743-199912000-00003 ◽

1999 ◽

Vol 5 (6) ◽

pp. 314-319 ◽

Cited By ~ 6

Author(s):

Zhang Xuan ◽

Dong Yi ◽

Tang Fu-Lin ◽

Zhang Fen-Chun

Keyword(s):

Systemic Lupus Erythematosus ◽

Central Nervous System ◽

Nervous System ◽

Lupus Erythematosus ◽

Central Nervous System Involvement ◽

Intrathecal Therapy ◽

Systemic Lupus ◽

Therapeutic Role ◽

System Involvement

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Critical role of multidimensional flow cytometry in detecting occult leptomeningeal disease in newly diagnosed aggressive B-cell lymphomas

Leukemia Research ◽

10.1016/j.leukres.2007.12.016 ◽

2008 ◽

Vol 32 (8) ◽

pp. 1196-1199 ◽

Cited By ~ 29

Author(s):

R. Di Noto ◽

G. Scalia ◽

G. Abate ◽

M. Gorrese ◽

C. Pascariello ◽

...

Keyword(s):

Flow Cytometry ◽

B Cell ◽

Critical Role ◽

Leptomeningeal Disease ◽

Newly Diagnosed ◽

B Cell Lymphomas

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Transient Global Amnesia as the First Clinical Symptom for Malignant B-Cell Lymphoma with Central Nervous System Involvement

Case Reports in Neurological Medicine ◽

10.1155/2015/191709 ◽

2015 ◽

Vol 2015 ◽

pp. 1-4

Author(s):

Atif Zafar ◽

Ghulam Ishaq Khan ◽

Sahrish Abdin ◽

Muhammad Taimoor Khan

Keyword(s):

Central Nervous System ◽

Nervous System ◽

B Cell ◽

Cell Lymphoma ◽

Central Nervous System Involvement ◽

B Cell Lymphoma ◽

Transient Global Amnesia ◽

Imaging Protocol ◽

System Involvement ◽

Global Amnesia

We present the case of an elderly male who was diagnosed with transient global amnesia (TGA), only to be diagnosed with B-cell lymphoma with central nervous system involvement a few weeks later. This is the first ever case reported in literature with lymphoma presenting as TGA. Literature review and pertinent points regarding high-yield imaging protocol for presumed TGA patients are discussed.

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