The role of antileukotriene therapy in seasonal allergic rhinitis: a systematic review of randomized trials

Background Controversies persist regarding whether exposure to cat or dog increases the risk of asthma and allergic rhinitis. Objective This meta-analysis aimed to assess the associations between exposure to cats or dogs and the development of asthma and allergic rhinitis. Methods A systematic review was performed to identify case-control and cohort studies before May 2019, evaluating the association between exposure to cats and dogs and the risk of asthma and rhinitis. The risk of bias was assessed using the Newcastle–Ottawa Scale. The odds ratios (ORs) and risk ratios (RRs) were pooled for case-control and cohort studies, respectively. Subgroup analyses were performed on prespecified study-level characteristics. Results The meta-analysis of 34 cohort studies showed a protective role of exposure to cats [RR: 0.88, 95% confidence interval (CI): 0.77–0.99] or dogs (RR: 0.85, 95% CI: 0.73–0.97) in the development of asthma. The subgroup analysis of birth cohort (RR: 0.74, 95% CI: 0.56–0.93) and children population (RR: 0.83, 95% CI: 0.70–0.96) also suggested a favorable role of exposure to dogs in the development of asthma. Pooled evidence from 13 case-control studies indicated no significant impact of cats (OR: 1.66, 95% CI: 0.39–2.94) and dogs (OR: 1.22, 95% CI: 0.92–1.52) on the development of asthma. A pooled analysis of five cohort studies showed a favorable effect of exposure to cats (RR: 0.60, 95% CI: 0.33–0.86) or dogs (RR: 0.68, 95% CI 0.44–0.90) on the development of allergic rhinitis. Conclusion The findings indicated a protective effect of exposure to cats and dogs, especially ownership, on the development of asthma and allergic rhinitis.

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Intramuscular corticosteroid injections in seasonal allergic rhinitis: A systematic review

Laryngoscope Investigative Otolaryngology ◽

10.1002/lio2.645 ◽

2021 ◽

Author(s):

Ahmed B. Bayoumy ◽

Felicia van Schie ◽

Inge Stegeman ◽

Esther B. Blijleven ◽

Erwin L. van der Veen ◽

...

Keyword(s):

Systematic Review ◽

Allergic Rhinitis ◽

Seasonal Allergic Rhinitis ◽

Corticosteroid Injections

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Chemoradiotherapy in the Management of Locally Advanced Pancreatic Carcinoma: A Qualitative Systematic Review

Journal of Clinical Oncology ◽

10.1200/jco.2008.19.7921 ◽

2009 ◽

Vol 27 (13) ◽

pp. 2269-2277 ◽

Cited By ~ 168

Author(s):

Florence Huguet ◽

Nicolas Girard ◽

Clotilde Séblain-El Guerche ◽

Christophe Hennequin ◽

Françoise Mornex ◽

...

Keyword(s):

Systematic Review ◽

Pancreatic Carcinoma ◽

Induction Chemotherapy ◽

Randomized Trials ◽

Locally Advanced ◽

Phase Iii ◽

Level Of Evidence ◽

Qualitative Systematic Review ◽

Survival Level

PurposePancreatic carcinoma is one of the leading causes of cancer-related mortality. At time of diagnosis, 30% of patients present with a locally advanced unresectable but nonmetastatic pancreatic carcinoma (LAPC). The French program Standards, Options, and Recommendations was promoted to conduct a qualitative systematic review to evaluate the role of radiotherapy in patients with LAPC.MethodsA search to identify eligible studies was undertaken using the MEDLINE database. All phase III randomized trials and systematic reviews evaluating the role of radiotherapy in LAPC were included, together with some noncontrolled studies if no phase III trials were retrieved. The quality and clinical relevance of the studies were evaluated using validated checklists, which allowed associating each result with a level of evidence.ResultsTwenty-one studies were included, as follows: two meta-analyses, 13 randomized trials, and six nonrandomized trials. Chemoradiotherapy increases overall survival when compared with best supportive care (level of evidence C) or with exclusive radiotherapy (level B1), but is more toxic (level B1). Chemoradiotherapy is not superior to chemotherapy in terms of survival (level B1) and increases toxicity (level A). Recent data favor limited irradiation to the tumor volume (level C). Fluorouracil is still the reference chemotherapy in association with radiotherapy (level B1). Induction chemotherapy before chemoradiotherapy improves survival (level C).ConclusionNo standard treatment exists, but there are two options for treatment of LAPC; these are gemcitabine-based chemotherapy and chemoradiotherapy. Induction chemotherapy followed by a chemoradiotherapy is a promising strategy for selection of patients without early metastatic/progressing disease.

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Efficacy of sublingual immunotherapy with grass allergens for seasonal allergic rhinitis: A systematic review and meta-analysis

Journal of Allergy and Clinical Immunology ◽

10.1016/j.jaci.2010.06.013 ◽

2010 ◽

Vol 126 (3) ◽

pp. 558-566 ◽

Cited By ~ 75

Author(s):

Danilo Di Bona ◽

Antonella Plaia ◽

Valeria Scafidi ◽

Maria Stefania Leto-Barone ◽

Gabriele Di Lorenzo

Keyword(s):

Systematic Review ◽

Allergic Rhinitis ◽

Seasonal Allergic Rhinitis ◽

Sublingual Immunotherapy ◽

Meta Analysis

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Can musical intervention improve memory in Alzheimer’s patients? Evidence from a systematic review

Dementia & Neuropsychologia ◽

10.1590/1980-57642018dn12-020005 ◽

2018 ◽

Vol 12 (2) ◽

pp. 133-142 ◽

Cited By ~ 7

Author(s):

Shirlene Vianna Moreira ◽

Francis Ricardo dos Reis Justi ◽

Marcos Moreira

Keyword(s):

Systematic Review ◽

Randomized Controlled Trials ◽

Randomized Trials ◽

Positive Outcome ◽

Memory Deficit ◽

Cochrane Library ◽

Controlled Trials ◽

Exclusion Criteria ◽

Randomized Controlled

ABSTRACT Treatment with music has shown effectiveness in the treatment of general behavioural and cognitive symptoms of patients with various types of dementia. Objective: To assess the effectiveness of treatment with music on the memory of patients with Alzheimer’s disease (AD). Methods: A systematic search was performed on PubMed (Medline), Cochrane Library, PsycINFO and Lilacs databases up to June 2017 and included all randomized controlled trials that assessed memory using musical interventions in patients with AD. Results: Forty-two studies were identified, and 24 studies were selected. After applying the exclusion criteria, four studies involving 179 patients were included. These studies showed the benefits of using music to treat memory deficit in patients with AD. Conclusion: To the best of our knowledge, this is the first systematic review focusing on randomized trials found in the literature that analysed the role of musical interventions specifically in the memory of patients with AD. Despite the positive outcome of this review, the available evidence remains inconsistent due to the small number of randomized controlled trials.

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