PP1.7 – 1983 Quality of life one year after arterial ischaemic stroke in a population-based cohort

2013 ◽  
Vol 17 ◽  
pp. S33
Author(s):  
AA Mallick ◽  
V Ganesan ◽  
FJ Kirkham ◽  
P Fallon ◽  
T Hedderly ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Ischaemic Stroke ◽  
Population Based ◽  
Arterial Ischaemic Stroke ◽  
One Year

P125 HEALTH-RELATED QUALITY OF LIFE ONE YEAR AFTER THE DIAGNOSIS OF OESOPHAGEAL AND JUNCTIONAL CANCER: A POPULATION-BASED STUDY FROM THE SWEDISH NATIONAL REGISTRY FOR ESOPHAGEAL AND GASTRIC CANCER

2019 ◽  
Vol 32 (Supplement_2) ◽  
Author(s):  
Sunde Berit ◽  
Lindblad Mats ◽  
Malmström Marlene ◽  
Hedberg Jakob ◽  
Lagergren Pernilla ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Population Based ◽  
Health Related Quality ◽  
Definitive Chemoradiotherapy ◽  
Curative Intent ◽  
Palliative Intent ◽  
Related Quality ◽  
Health Related ◽  
One Year

Abstract Aim The aim of this study is to describe and analyse patient reported HRQoL one year after the diagnosis of oesophageal and junctional carcinoma in an unselected cohort comprising both palliative and curative intent patients. Background & Methods Short and long-term health-related quality of life (HRQoL) has been extensively described in operated oesophageal cancer patients in several population-based studies. However, the knowledge of HRQoL in patients with palliative intent management is not well described, and further, documentation of HRQoL in curative intent patients treated with definitive chemoradiotherapy is also quite scarce. A nation-wide population-based cohort, of patients diagnosed between 2009 and 2016 collected in the Swedish National Registry for Esophageal and Gastric Cancer (NREV) with prospectively registered exposure data and Health-related quality of life (HRQoL) outcome data. Validated instruments from the European Organisation for Research and Treatment of Cancer QLQ-C30 and QLQ-OG25 were used, and data was analysed with means and adjusted mean differences. Results In patients alive one year after diagnosis, 1,156 responded to the HRQOL questionnaires and were included in the analyses. Both curative and palliative intent patients reported severe symptoms of problems in oesophageal specific domains. In the comparison between the curative and palliative intent groups, more prominent symptoms among palliative patients were detected regarding dysphagia (MD 11; 95% ci: 7-15) and anxiety (MD 10; 95% ci: 6 -15). Levels of anxiety were reported with high levels in all groups analysed and problems with dysphagia was also more common in patients treated with definitive chemoradiotherapy compared with surgically treated patients (MD 11; 95% ci: 4 -18) diagnosed in locally advanced disease stages. Conclusion One year after diagnosis high levels of anxiety were reported in all subgroups of oesophageal and junctional cancer patients, and problems with dysphagia are a major problem in the palliative intent subcohort and in patients treated with definitive chemoradiotherapy.

Quality-of-life and psychosocial outcome following childhood arterial ischaemic stroke

Brain Injury ◽  
2012 ◽  
Vol 26 (9) ◽  
pp. 1072-1083 ◽  
Author(s):  
Fiadhnait O’Keeffe ◽  
Vijeya Ganesan ◽  
John King ◽  
Tara Murphy
Keyword(s):  
Quality Of Life ◽  
Ischaemic Stroke ◽  
Psychosocial Outcome ◽  
Arterial Ischaemic Stroke

scholarly journals Health-related quality of life one year after the diagnosis of oesophageal cancer: a population-based study from the Swedish National Registry for Oesophageal and Gastric Cancer

BMC Cancer ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Berit Sunde ◽  
Mats Lindblad ◽  
Marlene Malmström ◽  
Jakob Hedberg ◽  
Pernilla Lagergren ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Oesophageal Cancer ◽  
Reference Population ◽  
Population Based ◽  
National Registry ◽  
Palliative Intent ◽  
Related Quality ◽  
Health Related ◽  
One Year

Abstract Background Population-based patient reported outcome data in oesophageal cancer are rare. The main purpose of this study was to describe health-related quality of life (HRQOL) 1 year after the diagnosis of oesophageal cancer, comparing subgroups of curatively and palliatively managed patients. Methods This is a nationwide population-based cohort study, based on the Swedish National Registry for Oesophageal and Gastric Cancer (NREV) with prospectively registered data, including HRQOL instruments from the European Organisation for Research and Treatment of Cancer including the core and disease specific questionnaires (EORTC QLQ-C30 and QLQ-OG25). Patients diagnosed with oesophageal cancer between 2009 and 2016 and with complete HRQOL data at 1 year follow-up were included. HRQOL of included patients was compared to a reference population matched by age and gender to to a previous cohort of unselected Swedish oesophageal cancer patients. Linear regression was performed to calculate mean scores with 95% confidence intervals (CI) and adjusted linear regression analysis was used to calculate mean score differences (MD) with 95% CI. Results A total of 1156 patients were included. Functions and global health/quality of life were lower in both the curative and palliative cohorts compared to the reference population. Both curatively and palliatively managed patients reported a severe symptom burden compared to the reference population. Patients who underwent surgery reported more problems with diarrhoea compared to those treated with definitive chemoradiotherapy (dCRT) (MD -14; 95% CI − 20 to − 8). Dysphagia was more common in patiens treated with dCRT compared to surgically treated patients (MD 11; 95% CI 4 to 18). Those with palliative intent due to advanced tumour stage reported more problems with dysphagia compared to those with palliative intent due to frailty (MD -18; 95% CI − 33 to − 3). Conclusions One year after diagnosis both curative and palliative intent patients reported low function scores and severe symptoms. Dysphagia, choking, and other eating related problems were more pronounced in palliatively managed patients and in the curative intent patients treated with dCRT.

Health-related quality of life and its determinants in paediatric arterial ischaemic stroke survivors

2018 ◽  
Vol 103 (10) ◽  
pp. 930-936 ◽  
Author(s):  
Satvinder K Ghotra ◽  
Jeffrey A Johnson ◽  
Weiyu Qiu ◽  
Amanda S Newton ◽  
Carmen Rasmussen ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Socioeconomic Status ◽  
Ischaemic Stroke ◽  
Stroke Survivors ◽  
Health Related Quality ◽  
Patient Reported ◽  
Related Quality ◽  
Health Related ◽  
Arterial Ischaemic Stroke

ObjectiveHealth-related quality of life (HRQL) instruments are patient or proxy-reported outcome measures that provide a comprehensive and subjective assessment of patient’s well-being and hence vital for health outcomes evaluation. A clear and thorough understanding of HRQL and its determinants is especially important to appropriately guide health-improving interventions. In this study, HRQL of paediatric arterial ischaemic stroke survivors was assessed using guidelines recommended for interpretation and reporting of the patient-reported outcome data. Determinants of HRQL were also explored.MethodsChildren diagnosed with arterial ischaemic stroke between 2003 and 2012 were assessed at least 1 year poststroke using the parent–proxy report versions of the Pediatric Quality of Life Inventory 4.0 and Pediatric Stroke Recurrence and Recovery Questionnaire. HRQL data were compared with population norms and used as outcome in multiple linear regression analysis.Results59 children were evaluated. Mean age at diagnosis of stroke was 2.2 years. Mean age at assessment and time elapsed since stroke was 7 years and 5 years, respectively. A total of 41% children had normal global outcome, whereas 51% had moderate to severe deficits. A lower overall HRQL was observed in both self and proxy reports. Parents reported the maximum impairment in emotional domain, whereas children indicated physical functioning to be the most affected. Neurological outcome, site of stroke and socioeconomic status were independently associated with overall HRQL.ConclusionsLower HRQL was demonstrated in children who survived arterial ischaemic stroke. Socioeconomic status of families was an important determinant of HRQL, over and above clinical parameters.

scholarly journals Quality of life heart-disease children who have suffered from an arterial ischaemic stroke

2018 ◽  
Vol 88 (3) ◽  
pp. 167-169
Author(s):  
María Vázquez López ◽  
Pedro Castro de Castro ◽  
Nuria Gil Villanueva ◽  
Andrés José Alcaraz Romero ◽  
Samuel Ignacio Pascual Pascual
Keyword(s):  
Quality Of Life ◽  
Heart Disease ◽  
Ischaemic Stroke ◽  
Arterial Ischaemic Stroke

Abstract 166: One-month Modified Rankin Scale (mRS) Score Predicts Five-year Disability, Death, Quality-of-Life, and Healthcare Costs in Ischaemic Stroke: A Prospective Cohort Study

Stroke ◽  
2017 ◽  
Vol 48 (suppl_1) ◽  
Author(s):  
Aravind Ganesh ◽  
Ramon Luengo-Fernandez ◽  
Rose M Wharton ◽  
Sergei A Gutnikov ◽  
Louise E Silver ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Cohort Study ◽  
Ischaemic Stroke ◽  
Acute Stroke ◽  
Healthcare Costs ◽  
Independent Predictor ◽  
Population Based ◽  
Step Change ◽  
Short Term

Background: Outcome in acute stroke trials is often based on short-term mRS, but there are few data from prospective population-based studies on how this measure translates into long-term outcomes. We evaluated the relationship between 1-month mRS and 5-year disability, death, quality of life, and healthcare cost in a population-based cohort study. Methods: In 3-month survivors of ischaemic stroke in the Oxford Vascular Study (2002-2014), we used logistic regression to determine predictors of 5-year death/disability, including mRS score at 1 month, age, and sex. The analyses were repeated for different subgroups, including thrombectomy-eligible, atrial fibrillation-related, and lacunar strokes. Hospital resource use and institutionalization data up to 31 August 2015 were collected, and mean censor-adjusted costs were reported with 95% CIs from 1000 bootstrap estimates. A general gamma linear model was used with 1-month mRS controlling for age, sex, and comorbidities. 5-year quality-adjusted life expectancies (QALE) generated from survival data and EQ-5D-derived utility scores were stratified by 1-month mRS. Results: Among 1,425 survivors, mRS score was a strong independent predictor of 5-year death/disability, with a step-change from mRS 2 to 3: adjusted odds ratio for mRS 3-5 vs 0-2: 35.57, 95%CI 17.40-72.71, p<0.0001. This step-change was also seen for 5-year mortality: adjusted hazard ratio for mRS 3-5 vs 0-2: 1.84, 95%CI 1.59-2.14, p<0.0001. Trends were consistent across the stroke subgroups. mRS score was the only independent predictor of 5-year healthcare costs (p<0.0001) aside from age, again with a step-change from mRS 2 to 3: £8,817.67 (95%CI 6,207.98-10,688.86) vs 29,692.73 (95%CI 21,117.18-31,367.53). 5-year QALE dropped incrementally with rising mRS: mRS=0 - 3.47 (95%CI 3.25-3.66); 1 - 2.91 (2.77-3.04); 2 - 2.64(2.46-2.81); 3 - 1.72 (1.52-1.91); 4 - 1.23 (1.03-1.45); 5 - 0.31 (0.02-0.76). Conclusions: Our results reaffirm the practice in acute stroke trials of using short-term mRS as the primary outcome measure. The step change between mRS 2 and 3 for both death/disability and healthcare costs supports the traditional dichotomous outcome, but the incremental drop in QALE with each mRS grade shows that ordinal analysis is also valid.

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