Insulin-like Growth Factor Binding Protein 3 (IGFBP-3) modifies Epidermal Growth Factor (EGF)-related breast cancer growth depending upon the extracellular matrix (ECM)

2004 ◽  
Vol 2 (3) ◽  
pp. 102-103 ◽  
Author(s):  
J McIntosh ◽  
C.M Perks ◽  
J.M.P Holly ◽  
Z.E Winters
Keyword(s):  
Breast Cancer ◽  
Extracellular Matrix ◽  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Cancer Growth ◽  
Insulin Like Growth Factor ◽  
Factor Binding ◽  
Epidermal Growth ◽  
Breast Cancer Growth ◽  
Igfbp 3

Epidermal growth factor stimulates production of insulin-like growth factor-binding protein-1 in human granulosa-luteal cells

1992 ◽  
Vol 134 (1) ◽  
pp. 127-131 ◽  
Author(s):  
M. Angervo ◽  
R. Koistinen ◽  
M. Seppälä
Keyword(s):  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Granulosa Cells ◽  
Binding Protein ◽  
Viable Cell ◽  
Insulin Like Growth Factor ◽  
Luteal Cells ◽  
Factor Binding ◽  
Igf I ◽  
Epidermal Growth

ABSTRACT Insulin-like growth factor-I (IGF-I) enhances and epidermal growth factor (EGF) inhibits gonadotrophin-induced aromatization in granulosa cells. Our previous studies have shown that human ovarian granulosa cells synthesize insulin-like growth factor-binding protein-1 (IGFBP-1) which inhibits IGF-stimulated DNA synthesis. The present study addresses the effect of EGF and gonadotrophins in the regulation of IGFBP-1 release by human granulosa cells cultured in serum-free medium. At concentrations of 1–100 μg/l EGF was found to stimulate IGFBP-1 secretion. This was not due to cell proliferation, as the viable cell count remained unaffected. Growth hormone and gonadotrophins had no effect on IGFBP-1 secretion when added alone to culture medium. These results suggest that EGF regulates IGFBP-1 secretion in human granulosa-luteal cells. Journal of Endocrinology (1992) 134, 127–131

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