635 POSTER Synthesis and cytotoxic activity of novel water-soluble peptide-based paclitaxel conjugates

2006 ◽  
Vol 4 (12) ◽  
pp. 191
Author(s):  
K. Gurbanov ◽  
M. Huttunen ◽  
A. Koivistoinen ◽  
K. Karisalmi ◽  
H. Peräkylä ◽  
...  
Keyword(s):  
Cytotoxic Activity ◽  
Water Soluble ◽  
Soluble Peptide

Facile template synthesis of water-soluble triazine-based Schiff base ligand bridged-coordination polymers of Co(ii), Ni(ii), and Cu(ii): structure, biomolecular interactions, and cytotoxic activity

2019 ◽  
Vol 43 (34) ◽  
pp. 13371-13380 ◽  
Author(s):  
Sheikdawood Parveen ◽  
Thathan Premkumar ◽  
Hung Huy Nguyen ◽  
Subbiah Govindarajan
Keyword(s):  
Schiff Base ◽  
Cytotoxic Activity ◽  
Coordination Polymers ◽  
Schiff Base Ligand ◽  
Template Synthesis ◽  
Water Soluble ◽  
Biomolecular Interactions ◽  
First Time ◽  
Ct Dna

For the first time, a new hydrazone Schiff base ligand and its Co(ii), Ni(ii), and Cu(ii) complexes were synthesised and characterised. Their antioxidant and binding activities towards CT-DNA and BSA were evaluated.

Structural investigation and comparative cytotoxic activity of water-soluble polysaccharides from fruit bodies of the medicinal fungus quinine conk

2020 ◽  
Vol 175 ◽  
pp. 112313
Author(s):  
Victoria V. Golovchenko ◽  
Shinen Naranmandakh ◽  
Jamsranjav Ganbaatar ◽  
Artur Yu. Prilepskii ◽  
Gennady L. Burygin ◽  
...  
Keyword(s):  
Cytotoxic Activity ◽  
Structural Investigation ◽  
Water Soluble ◽  
Medicinal Fungus

Cytotoxic peptide conjugates of dinuclear arene ruthenium trithiolato complexes

MedChemComm ◽  
2015 ◽  
Vol 6 (2) ◽  
pp. 347-350 ◽  
Author(s):  
Federico Giannini ◽  
Marco Bartoloni ◽  
Lydia E. H. Paul ◽  
Georg Süss-Fink ◽  
Jean-Louis Reymond ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Cancer Cells ◽  
Resistant Mutant ◽  
Water Soluble ◽  
Ovarian Cancer Cells ◽  
Human Ovarian Cancer ◽  
Peptide Conjugates ◽  
Soluble Peptide ◽  
Peptide Moiety ◽  
Cytotoxic Peptide

Novel dinuclear arene ruthenium trithiolato complexes containing a water-soluble peptide moiety in one of the three thiolato bridges were designed and evaluated against A2780 human ovarian cancer cells and against their cisplatin-resistant mutant A2780cisR.

Green Synthesis, Characterization and Cytotoxic Activity of Gold and Silver Nanoparticles Using Kaempferol-3′-sulfonate

2020 ◽  
Vol 42 (3) ◽  
pp. 440-440
Author(s):  
Xin Bin Yang Xin Bin Yang ◽  
Chun Mei Wang Chun Mei Wang ◽  
Yu Huang Yu Huang
Keyword(s):  
Gold Nanoparticles ◽  
Silver Nanoparticles ◽  
Cytotoxic Activity ◽  
Room Temperature ◽  
Water Soluble ◽  
Ftir Analysis ◽  
Spherical Nanoparticles ◽  
Gold And Silver Nanoparticles ◽  
Stabilizing Agents ◽  
Mcf 7

Gold nanoparticles (AuNPs) and silver nanoparticles (AgNPs) were synthesized by using water-soluble Kaempferol–3′–sulfonate acid sodium (KS) alone as the reducing agent. The UV-vis spectra confirmed the formation of the ks-AuNPs and ks-AgNPs which were stable for up to 3 months without any other stabilizing agents at room temperature. The TEM studies exhibited monodispersed and mainly spherical nanoparticles with the size in the range of 15-30 nm and 20-50 nm for ks-AuNPs and ks-AgNPs, respectively. The XRD revealed crystallinity of nanoparticles. The chemical state of Au and Ag on the surface of nanoparticles was analyzed by XPS. The FTIR analysis indicated that the hydroxyl of KS were responsible for the reduction of Au3+ and Ag+ to ks-AuNPs and ks-AgNPs, respectively. Cytotoxic activity of ks-AuNPs and ks-AgNPs on MCF-7 cells is higher than the KS.

Phenolic Compound Profile and Functionality of Aqueous Overripe Tempe Extracts

2019 ◽  
Vol 7 (2) ◽  
pp. 382-392
Author(s):  
Zatil Afrah Athaillah ◽  
Dian Muzdalifah ◽  
Asri Lestari ◽  
Anastasia Fitria Devi ◽  
Linar Zalinar Udin ◽  
...  
Keyword(s):  
Cytotoxic Activity ◽  
Cancer Cell ◽  
Radical Scavenging Activity ◽  
Health Benefits ◽  
Radical Scavenging ◽  
Water Extract ◽  
Cancer Cell Line ◽  
Water Soluble ◽  
Total Phenols ◽  
Fermentation Time

Tempe is a soy fermentation product and has been associated with many health benefits. It is usually consumed after 48 hours of fermentation; however extended fermentation is sometimes favoured. Since cooking involves water, it is of interest to study the health benefits of tempe water extract. In this study, we focused our study on total phenols, total flavonoids, DPPH free radical scavenging activity, cytotoxic activity, and identification of the main flavonoids. Our findings demonstrated that concentration of water-soluble flavonoids in tempe increased as fermentation time was prolonged. Fermentation for 60 hr resulted in extracts with very noticeable cytotoxic activity against MCF-7 cancer cell line (IC50 of 8.70 µg/ml). The cytotoxic activity of the extracts was fermentation time-dependent following non-linear relationship. The activity showed strong inverse correlation with total phenols and flavonoids in the extracts. LC-MS/MS data suggested that extracts from control and 24-hr fermented tempe demonstrated the highest responses for genistein, genistin, daidzein, daidzin, and glycitein, compared to those of other treatments and therefore suggested that excessive amount of the isoflavones, particularly genistein, induced cancer cell proliferation but lesser yet optimum concentration (observed at 60 hr-fermentation) contributed to otherwise effect.

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