Abstract #1021: Abnormal Thyroid Ultrasound Findings in Pediatric Patients with Pten Mutation During Endocrinology Surveillance

AbstractCongenital hypothyroidism is a main congenital endocrine disorder, affecting 1 in 4000 births. It is not well described in sub-Saharan countries, and to draw attention to that issue, we decided to describe affected pediatric patients. We retrospectively analyzed the records of eight patients over a period of 6 years. We analyzed clinical sings of hypothyroidism and psychomotor development; hormonal assays and thyroid ultrasound were performed. We included four boys and four girls aged from 3 to 84 months at diagnosis with a median thyroid-stimulating hormone (TSH) level of 156.5 mUI/L. All except one present with a moderate psychomotor delay. Other clinical signs were classical for hypothyroidism. Thyroid ultrasound performed showed a goiter in half of patients, a normal gland in three of them and a hypoplasic gland in the last one, consonant with dyshormonogenesis. We therefore concluded that dyshormonogenesis seems to be more frequent in our context, and this raised the issue of neonatal screening of hypothyroidism in Africa.

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Predictors of prognosis in children with portal venous gas detected by ultrasound

Medical Ultrasonography ◽

10.11152/mu-1727 ◽

2019 ◽

Vol 21 (1) ◽

pp. 30 ◽

Cited By ~ 5

Author(s):

Takahiro Hosokawa ◽

Yoshitake Yamada ◽

Yutaka Tanami ◽

Yumiko Sato ◽

Mayumi Hosokawa ◽

...

Keyword(s):

Large Bowel ◽

Pediatric Patients ◽

Surgical Interventions ◽

Intestinal Pneumatosis ◽

Portal Venous Gas ◽

Free Air ◽

Significant Difference ◽

Ultrasound Findings ◽

Life Threatening ◽

Underlying Diseases

Aims: To evaluate ultrasound findings in order to determine potential predictors of prognosis in pediatric patients with portal venous gas (PVG) detected by ultrasound.Materials and methods: Thirty-nine children were included and divided into two groups: benign PVG (n=24) and life-threatening PVG (n=15; 6 surgical interventions and 9 deaths). Possible predictors, i.e., the location of PVG in the liver, the distribution of intestinal pneumatosis, ascites and free air were compared between the two groups.Results: A significant difference was noted between the two groups in terms of the distribution of intestinal pneumatosis (limited to the large bowel, benign vs life-threatening = 60.9% (14/23):21.4% (3/14), p=0.040), the absence of ascites (benign vs life-threatening = 79.1% (19/24):40.0% (6/15), p=0.019) and patient age (benign vs life-threatening = 52.5±65.3 months vs 19.7±44.0 months, p=0.019). No significant difference was observed in the location of PVG in the liver, the presence of free air, and sex between the two groups.Conclusions: In pediatric patients with PVG, including various ages and underlying diseases, intestinal pneumatosis limited to the large bowel and absence of ascites were predictors of a benign prognosis. However, despite the presence of these predictors, some patients with PVG required surgical intervention, therebysuggesting that the cause of PVG, such as necrotizing enterocolitis, volvulus, or pancreatitis, must be also carefully evaluated.

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Use of ultrasound findings to predict bowel ischemic changes in pediatric patients with intestinal volvulus

Journal of Ultrasound in Medicine ◽

10.1002/jum.15145 ◽

2019 ◽

Vol 39 (4) ◽

pp. 683-692 ◽

Cited By ~ 2

Author(s):

Takahiro Hosokawa ◽

Mayumi Hosokawa ◽

Yutaka Tanami ◽

Yumiko Sato ◽

Tetsuya Ishimaru ◽

...

Keyword(s):

Pediatric Patients ◽

Intestinal Volvulus ◽

Ultrasound Findings

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Thyroid Ultrasound Findings and Its Associated Parameters in Saudi People

10.26420/annalsthyroidres.2021.1078 ◽

2021 ◽

Vol 7 (2) ◽

Author(s):

Mogahed MM ◽

◽

El-Awady MA ◽

Samih TA ◽

◽

...

Keyword(s):

Uric Acid ◽

Thyroid Gland ◽

Total Cholesterol ◽

Thyroid Nodules ◽

Thyroid Stimulating Hormone ◽

Thyroid Ultrasound ◽

Height Measurement ◽

Cross Sectional ◽

Ultrasound Findings ◽

Thyroid Lesions

Background: Thyroid abnormalities are the most common endocrine abnormalities in Saudi Arabia (KSA). Ultrasonography (USG) is the commonest method of thyroid gland imaging. Thyroid lesions prevalence depends on factors such as sex, age, iodine intake, and other metabolic parameters. Objectives: Investigating different thyroid lesions and their associated clinical parameters. Subjects and Methods: This is a cross-sectional study of adult residents who visited Internal Medicine Clinic in Riyadh, KSA. 206 participants were subjected to thyroid USG, weight and height measurement, laboratory investigations including FBG, HbA1C, ALT, AST, creatinine, uric acid, lipid profile, thyroid stimulating hormone (TSH), and FT4. Results: Thyroid nodules were found in 27.2%, 30.1% had thyroiditis, and 6.8% had pure cysts. There was a significant prevalence of thyroid ultrasound findings within different age groups, (P = 0.002). The highest BMI was found in subjects with nodular size ≤1cm. Subjects with thyroid nodules had higher level of FBG, HbA1c, ALT, AST, uric acid, total cholesterol, HDL-C, LDL-C and TSH. The most frequent thyroid status was euthyroid, followed by subclinical hypothyroidism which had higher frequency in subjects with nodular size ≤1cm (30.8%). Conclusion: Imaging, particularly USG, plays an important role in classifying thyroid gland abnormalities. We found that thyroid lesions, including nodules, pure cysts, and thyroiditis, were non-significantly positively associated with disturbed metabolic profile such as high FBS, HBA1C, ALT, AST, total cholesterol, and LDL levels. Our results for biochemical parameters do not allow inferences on whether they are independent factors associated with thyroid lesions or not.

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