4P-1009 A clinico-biochemical profile of young patients of coronary artery disease in national capital region of India

2003 ◽  
Vol 4 (2) ◽  
pp. 296
Author(s):  
S. Giri ◽  
B. Rajagopalan ◽  
S. Dwivedi ◽  
D.K. Srivastava ◽  
S. Singh ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Young Patients ◽  
Biochemical Profile ◽  
National Capital Region ◽  
Capital Region ◽  
National Capital ◽  
Artery Disease

scholarly journals Lipoprotein (a) and Comprehensive Lipid Tetrad Index in Young Patients of Coronary Artery Disease

2004 ◽  
Vol 3 (3) ◽  
pp. 8-9
Author(s):  
S Giri ◽  
B Rajgopalan ◽  
S Dwivedi ◽  
DK Shrivastaba ◽  
S Singh ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Special Reference ◽  
Young Patients ◽  
Biochemical Profile ◽  
Lipoprotein A ◽  
Artery Disease

To compare the clinico-biochemical profile of young patients (< 40 years) having coronary artery disease (CAD) with age-sex matched controls with a special reference to lipoprotein (a) [Lp(a)] and comprehensive lipid tetrad index (CLTI).

scholarly journals Angiographic profile of young patients (≤ 40 years) in a tertiary care center of Nepal

2020 ◽  
Vol 11 (6) ◽  
pp. 68-71
Author(s):  
Binay Kumar Rauniyar ◽  
Arun Kadel ◽  
Kiran Prasad Acharya ◽  
Kartikesh Kumar Thakur ◽  
Rakesh Bahadur Adhikari ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Tertiary Care ◽  
Significant Coronary Artery Disease ◽  
Young Patients ◽  
Vessel Disease ◽  
Single Vessel ◽  
Triple Vessel Disease ◽  
Artery Disease ◽  
Single Vessel Disease

Background: With rise in prevalence of conventional risk factors like diabetes, hypertension, smoking, dyslipidemia and obesity the incidence of coronary artery disease in young patients have increased in the recent decades even in developing world. There have been multiple studies done in Nepal studying the angiographic profile of coronary disease in general population. However, only few studies has been done till date on the angiographic profile in the young population in our country. Aims and Objectives: In this study, we aim to determine the angiographic profile of young patient ≤ 40 years in a tertiary care centre of Nepal. Materials and Methods: A retrospective analytic study was done in Shahid Gangalal National Heart Centre from January 2019 to December 2019. Individuals of both genders with age ≤ 40 years who underwent coronary angiography were included. Results: Total 109 patients were included. Out of 109, 89 were male and 20 were female. The mean age for male was 35.55 ± 4.31 and for female was 38.55 ± 1.90 (P = 0.003). Among 61 (55.96%) patients who had significant coronary artery disease, 33 patients (30.27%) with single vessel disease, 15 patients (13.76%) had double vessel disease, and 13 patients (11.92%) had triple vessel disease. Left anterior descending (LAD) artery was found to be most frequently involved in all patterns of Coronary artery disease (CAD). Smoking was the most common coronary risk factor present in 29.3% of patients followed by hypertension, family history of premature CAD and diabetes in 14.6%, 7.5% and 5.5% of patients respectively. Overall, the prevalence of smoking was more in males (31.4%) than in females (20%). Conclusion: Single vessel disease (SVD) was most prevalent in young patients with significant CAD. LAD is the most commonly involved coronary artery followed by Right coronary artery (RCA) and Left Circumflex (LCX).

scholarly journals Serum Trans-Fatty Acid Concentration Is Elevated in Young Patients With Coronary Artery Disease in Japan

2015 ◽  
Vol 79 (9) ◽  
pp. 2017-2025 ◽  
Author(s):  
Kenta Mori ◽  
Tatsuro Ishida ◽  
Tomoyuki Yasuda ◽  
Minoru Hasokawa ◽  
Tomoko Monguchi ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Fatty Acid ◽  
Coronary Artery ◽  
Acid Concentration ◽  
Trans Fatty Acid ◽  
Young Patients ◽  
Fatty Acid Concentration ◽  
Artery Disease

P4455The controversial role of genetics behind premature CAD: a plausible excuse for the young?

2019 ◽  
Vol 40 (Supplement_1) ◽  
Author(s):  
J Sousa ◽  
M Mendonca ◽  
A Pereira ◽  
F Mendonca ◽  
M Neto ◽  
...  
Keyword(s):  
Risk Factors ◽  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Risk Score ◽  
Genetic Risk ◽  
Genetic Risk Score ◽  
Young Patients ◽  
Premature Cad ◽  
Artery Disease ◽  
Group B

Abstract Introduction The complex interaction between genes and environmental factors contribute to individual-level risk of coronary artery disease (CAD), often resulting in premature CAD. The role for genetic risk scores in premature CAD is still controversial. Objective To evaluate the importance of conventional risk factors and of a genetic risk score in younger and older patients with coronary artery disease Methods From a group of 1619 pts with angiographic documented CAD from the GENEMACOR study, we selected 1276 pts admitted for ACS and analysed them in 2 groups (group A: ≤50 years, n=491 pts, 87.2% male, mean age 44±4.9 and group B: >50 years, n=785 pts, 75.2% male, mean age 57±4.2). Univariate analysis was used to characterize the traits of each group and we used ROC curves and respective AUCs to evaluate the power of genetics in the prediction of CAD, through a Genetic Risk Score (GRS). Results 99.3% of the young patients had at least one modifiable risk factor, 18.4% had 2 modifiable risk factors and 75.2% had 3 or more modifiable risk factors. The pattern of risk factors contributing to CAD were different among groups: family history (A: 27.5%, B: 21.4%, p=0.015) and smoking habits (A: 64.8%, B: 42.9%, p<0.001) were more frequent among patients under 50, and traditional age-linked factors like hypertension (A: 58%, B: 75.7%, p<0.001), diabetes (A: 21.6%, B: 38.6%, p<0.001) were more common in the older group. Acute ST-elevation myocardial infarction was more frequent among the young (A: 55.4%, B: 47.4%, p=0.006), as non-ST clinical presentation was higher among elder patients. Regarding angiographic presentation, single vessel CAD was higher in group A (A: 50.3%, B: 40.9%, p<0.001), while multivessel diasease was higher in group B (A: 33.3%, B: 53.9%, p<0.001). At a mean follow-up of 5 years, older patients had a worst prognosis, registering a higher rate of cardiovascular death (A: 4.1%, B: 8.6%, p=0.002) and higher MACE (A: 26.8%, B: 31%, p=0.128),. Adding the genetic risk score (GRS), we achieved only a slight improvement in the AUC for predicting CAD (0.796->0.805, p=0.0178 and 0.748->0.761, p=0.0007 in patients under and over 50, respectively). Conclusion Coronary artery disease is not all the same, as premature CAD shares a unique and specific pattern of risk factors, clinical presentation, angiographic severity and prognosis. Genetics should not be used as an excuse to justify premature CAD, as there is frequently more than one potentially reversible risk factor present even in young patients and the additive predictive value of GRS is modest.

Plasma levels and leucocyte RNA expression of adipokines in young patients with coronary artery disease, in metabolic syndrome and healthy controls

Cytokine ◽  
2019 ◽  
Vol 122 ◽  
pp. 154017 ◽  
Author(s):  
Aleš Smékal ◽  
Jan Václavík ◽  
David Stejskal ◽  
Klára Benešová ◽  
Jiří Jarkovský ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Metabolic Syndrome ◽  
Coronary Artery ◽  
Plasma Levels ◽  
Young Patients ◽  
Rna Expression ◽  
Healthy Controls ◽  
Artery Disease

scholarly journals Association of High Density Lipoprotein with Platelet to Lymphocyte and Neutrophil to Lymphocyte Ratios in Coronary Artery Disease Patients

2014 ◽  
Vol 2014 ◽  
pp. 1-8 ◽  
Author(s):  
Jayesh H. Prajapati ◽  
Sibasis Sahoo ◽  
Tushar Nikam ◽  
Komal H. Shah ◽  
Bhumika Maheriya ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
High Density Lipoprotein ◽  
Young Patients ◽  
Density Lipoprotein ◽  
High Density ◽  
Lymphocyte Ratio ◽  
Coronary Syndrome ◽  
Low Hdl ◽  
Artery Disease

Background. We aimed to evaluate a relationship between platelet-lymphocyte ratio (PLR) and neutrophil-lymphocyte ratio (NLR) with high density lipoprotein (HDL) cholesterol levels in coronary artery disease (CAD) patients.Methods. A total of 354 patients with angiographically confirmed coronary blockages were enrolled in the study. Hematological indices and lipid profiling data of all the patients were collected.Results. We have observed significant association between HDL and PLR (P=0.008) and NLR (P=0.009); however no significant relationship was obtained with HDL and isolated platelet (P=0.488), neutrophil (P=0.407), and lymphocyte (P=0.952) counts in CAD patients. The association was subjected to gender specific variation as in males PLR (P=0.024) and NLR (P=0.03) were highly elevated in low HDL patients, whereas in females the elevation could not reach the statistically significant level. The PLR (217.47 versus 190.3;P=0.01) and NLR (6.33 versus 5.10;P=0.01) were significantly higher among the patients with acute coronary syndrome. In young patients the PLR (P=0.007) and NLR (P=0.001) were inversely associated with HDL, whereas in older population only NLR (P=0.05) had showed a significant association.Conclusion. We conclude that PLR and NLR are significantly elevated in CAD patients having low HDL levels.

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