scholarly journals 33 Sodium 4-phenylbutyrate induces IL-8 expression in CF lung epithelial cells through an ERK1/2-dependent pathway

2006 ◽  
Vol 5 ◽  
pp. S8
Author(s):  
E. Boncoeur ◽  
T. Roque ◽  
O. Tabary ◽  
E. Bonvin ◽  
A. Clement ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Lung Epithelial Cells ◽  
Lung Epithelial ◽  
Dependent Pathway

Bacterial neuraminidase increases IL-8 production in lung epithelial cells via NF-κB-dependent pathway

2009 ◽  
Vol 379 (3) ◽  
pp. 754-759 ◽  
Author(s):  
Akira Kuroiwa ◽  
Akinori Hisatsune ◽  
Yoichiro Isohama ◽  
Hiroshi Katsuki
Keyword(s):  
Epithelial Cells ◽  
Lung Epithelial Cells ◽  
Lung Epithelial ◽  
Dependent Pathway

Resveratrol inhibits Staphylococcus aureus-induced TLR2/MyD88/NF-κB-dependent VCAM-1 expression in human lung epithelial cells

2014 ◽  
Vol 127 (6) ◽  
pp. 375-390 ◽  
Author(s):  
I-Ta Lee ◽  
Chih-Chung Lin ◽  
Chih-Kai Hsu ◽  
Ming-Yen Wu ◽  
Rou-Ling Cho ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Epithelial Cells ◽  
Human Lung ◽  
Alveolar Epithelial Cells ◽  
Lung Epithelial Cells ◽  
Polyphenolic Compound ◽  
Alveolar Epithelial ◽  
Lung Epithelial ◽  
Dependent Pathway ◽  
Human Lung Epithelial Cells

In the present study, we found that S. aureus induced VCAM-1 expression in human pulmonary alveolar epithelial cells via a TLR2/MyD88/NF-κB-dependent pathway, which was inhibited by treatment with the polyphenolic compound resveratrol.

cAMP stimulates Na+ transport in rat fetal pneumocyte: involvement of a PTK- but not a PKA-dependent pathway

1999 ◽  
Vol 277 (4) ◽  
pp. L727-L736 ◽  
Author(s):  
Naomi Niisato ◽  
Yasushi Ito ◽  
Yoshinori Marunaka
Keyword(s):  
Epithelial Cells ◽  
Tyrosine Phosphorylation ◽  
Short Circuit ◽  
Lung Epithelial Cells ◽  
Cell Shrinkage ◽  
Inhibitory Peptide ◽  
Stimulatory Action ◽  
Lung Epithelial ◽  
Distal Lung ◽  
Dependent Pathway

To study a cAMP-mediated signaling pathway in the regulation of amiloride-sensitive Na+ transport in rat fetal distal lung epithelial cells, we measured an amiloride-sensitive short-circuit current (Na+ transport). Forskolin, which increases the cytosolic cAMP concentration, stimulated the Na+ transport. Forskolin also activated cAMP-dependent protein kinase (PKA). A β-adrenergic agonist and cAMP mimicked the forskolin action. PKA inhibitors KT-5720, H-8, and myristoylated PKA-inhibitory peptide amide-(14—22) did not influence the forskolin action. These results suggest that forskolin stimulates Na+ transport through a PKA-independent pathway. Furthermore, forskolin increased tyrosine phosphorylation of ∼70- to 80-, ∼97-, and ∼110- to 120-kDa proteins. Protein tyrosine kinase (PTK) inhibitors (tyrphostin A23 and genistein) abolished the forskolin action. Moreover, 5-nitro-2-(3-phenylpropylamino)benzoate (a Cl−-channel blocker) prevented the stimulatory action of forskolin on Na+ transport via abolishment of the forskolin-induced cell shrinkage and tyrosine phosphorylation. Based on these results, we conclude that forskolin (and cAMP) stimulates Na+ transport in a PTK-dependent but not a PKA-dependent pathway by causing cell shrinkage, which activates PTK in rat fetal distal lung epithelial cells.

Legionella pneumophila induced microRNA expression in human lung epithelial cells

Pneumologie ◽  
2010 ◽  
Vol 64 (S 03) ◽  
Author(s):  
B Schmeck ◽  
B Dolniak ◽  
I Pollock ◽  
C Schulz ◽  
W Bertrams ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Legionella Pneumophila ◽  
Human Lung ◽  
Microrna Expression ◽  
Lung Epithelial Cells ◽  
Lung Epithelial ◽  
Human Lung Epithelial Cells

Microscopy study on the interaction of silica nanoparticles with lung epithelial cells

Pneumologie ◽  
2013 ◽  
Vol 67 (12) ◽  
Author(s):  
H Peuschel ◽  
T Ruckelshausen ◽  
C Cavelius ◽  
A Kraegeloh
Keyword(s):  
Epithelial Cells ◽  
Silica Nanoparticles ◽  
Microscopy Study ◽  
Lung Epithelial Cells ◽  
Lung Epithelial
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