P294 The level of physical activity, lung function and exercise capacity of children and adolescents with cystic fibrosis compared to healthy controls

2020 ◽  
Vol 19 ◽  
pp. S138
Author(s):  
P.M. Rovedder ◽  
M. Cardoso ◽  
G. Motter ◽  
C. Taffarel ◽  
A.P. Kasten ◽  
...  
Keyword(s):  
Physical Activity ◽  
Cystic Fibrosis ◽  
Lung Function ◽  
Children And Adolescents ◽  
Exercise Capacity ◽  
Healthy Controls

scholarly journals Heart rate variability, exercise capacity and levels of daily physical activity in children and adolescents with mild-to-moderate cystic fibrosis

2021 ◽  
pp. 1-10
Author(s):  
Pitiguara de Freitas Coelho ◽  
Roberta Ribeiro Batista Barbosa ◽  
Rodrigo dos Santos Lugao ◽  
Fernanda Mayrink Gonçalves Liberato ◽  
Pâmela Reis Vidal ◽  
...  
Keyword(s):  
Physical Activity ◽  
Cystic Fibrosis ◽  
Heart Rate ◽  
Heart Rate Variability ◽  
Lung Function ◽  
Children And Adolescents ◽  
Exercise Capacity ◽  
Pancreatic Insufficiency ◽  
Daily Physical Activity ◽  
Rr Intervals

Background: Autonomic nervous system balance is altered in cystic fibrosis (CF), although its influence on physical fitness has been poorly explored. Objective: This study aimed to evaluate the association of heart rate variability (HRV) with exercise capacity and levels of daily physical activity in children and adolescents with mild-to-moderate CF. Methods: A cross-sectional study including individuals with CF aged 6–18 years, not under CFTR modulator therapy, was performed. Sociodemographic (age, sex) and clinical information (airway colonization, pancreatic insufficiency, and genotyping) were collected. In addition, exercise capacity (modified shuttle test — MST), lung function (spirometry), body composition (bioimpedance), levels of daily physical activity (5-day accelerometer), and HRV (both at rest and during the MST) were evaluated. Results: 30 individuals (20 females) aged [Formula: see text] years, mean FEV[Formula: see text]%, were included. A sympathovagal balance (LF/HF) increase ([Formula: see text]) during the MST was shown, indicating a predominance of sympathetic modulation. The standard deviation of all RR intervals (SDNN) and the high frequency (HF) index during exercise correlated significantly with FEV1 ([Formula: see text], [Formula: see text] and [Formula: see text], [Formula: see text]; respectively). MST distance also correlated positively and significantly with SDNN ([Formula: see text], [Formula: see text]), square root of the mean of the sums of squares of frequencies between RR intervals greater than 50[Formula: see text]ms — RMSSD ([Formula: see text], [Formula: see text]), low frequency — LF ([Formula: see text], [Formula: see text]), HF ([Formula: see text], [Formula: see text]), dispersion of points perpendicular to the short-term identity line — SD1 ([Formula: see text], [Formula: see text]) and negatively with LF/HF ([Formula: see text], [Formula: see text]). Regarding daily physical activity, SDNN at rest ([Formula: see text], [Formula: see text]) and exercise ([Formula: see text], [Formula: see text]) showed positive correlations with time in moderate-to-vigorous activities. When normalizing the SDNN and classifying individuals as normal or altered, those presenting altered SDNN showed poorest FEV1 ([Formula: see text]) and lower exercise capacity ([Formula: see text]). Conclusion: HRV correlates with lung function, exercise capacity and levels of daily physical activity in children and adolescents with CF. The study highlights the influence of CF on autonomic function and suggests HRV measurement as an easy tool to be used in clinical settings as an alternative marker to monitor CF individuals.

scholarly journals The Level of Physical Activity, Lung Function and Exercise Capacity of Children and Adolescents With Cystic Fibrosis Compared to Healthy Controls

2020 ◽  
Author(s):  
Marjane Cardoso ◽  
Caroline Jacoby Schmidt ◽  
Gabriela Motter ◽  
Gabrielle Costa Borba ◽  
Tatiana Helena Rech ◽  
...  
Keyword(s):  
Physical Activity ◽  
Cystic Fibrosis ◽  
Lung Function ◽  
Children And Adolescents ◽  
Functional Capacity ◽  
Control Group ◽  
Healthy Children ◽  
Healthy Controls ◽  
Cross Sectional ◽  
Significant Difference

Abstract Background : people with Cystic Fibrosis (CF) have progressive limitation to physical exercise and reduced daily living activities. Regular physical activity (PA) and exercise contribute to the quality of live of people with CF. The objective of this study was to evaluate level of PA , lung function and functional capacity in children and adolescents diagnosed with CF and compare them with those of healthy children and adolescents. Methodology: the study had a cross-sectional design with a control group. Patients with CF were followed at the Children’s Pneumology Outpatient Clinic, and were matched for age and sex with healthy controls from a local public school. The evaluations included daily step count, the shuttle walk test and spirometry. Results: 70 children and adolescents were evaluated, 35 diagnosed with CF and 35 healthy controls. The overall mean age was 11.6±2.9 years. There was no significant difference in level of PA between the patient and control groups. Gender analysis revealed no significant difference in level of PA between the groups or within the CF group. The CF group values were significantly lower than the control group for BMI (p=0.04), percentage of predicted FEV 1 and FEV 1 Z-score (p=0.02 and p=0.010). Conclusion: In this sample, children and adolescents with CF had the same level of PA as their healthy peers. Boys and girls with CF had similar level of PA when stratified by sex, as well as when compared to healthy peers of the same gender. Differences were observed between BMI, FEV 1 and some functional capacity test variables between the groups.

ePS1.03 Sleep disorders, exercise capacity and daily physical activity levels in children and adolescents with cystic fibrosis

2020 ◽  
Vol 19 ◽  
pp. S37-S38
Author(s):  
F.M. Vendrusculo ◽  
N. Evangelista Campos ◽  
R. Ribeiro Batista Barbosa ◽  
P. de Freitas Coelho ◽  
P. dos Reis Vidal ◽  
...  
Keyword(s):  
Physical Activity ◽  
Cystic Fibrosis ◽  
Children And Adolescents ◽  
Sleep Disorders ◽  
Exercise Capacity ◽  
Daily Physical Activity ◽  
Activity Levels ◽  
Physical Activity Levels

scholarly journals Children and Adolescents Treated for Valvular Aortic Stenosis Have Different Physical Activity Patterns Compared to Healthy Controls: A Methodological Study in a National Cohort

2021 ◽  
Author(s):  
Pia Skovdahl ◽  
Cecilia Kjellberg Olofsson ◽  
Jan Sunnegårdh ◽  
Jonatan Fridolfsson ◽  
Mats Börjesson ◽  
...  
Keyword(s):  
Physical Activity ◽  
High Resolution ◽  
Aortic Stenosis ◽  
Children And Adolescents ◽  
Sedentary Time ◽  
Heart Defects ◽  
Sports Participation ◽  
Accelerometer Data ◽  
Healthy Controls ◽  
Valvular Aortic Stenosis

AbstractPrevious research in children and adolescents with congenital heart defects presents contradictory findings concerning their physical activity (PA) level, due to methodological limitations in the PA assessment. The aim of the present cross-sectional study was to compare PA in children and adolescents treated for valvular aortic stenosis with healthy controls using an improved accelerometer method. Seven-day accelerometer data were collected from the hip in a national Swedish sample of 46 patients 6–18 years old treated for valvular aortic stenosis and 44 healthy controls matched for age, gender, geography, and measurement period. Sports participation was self-reported. Accelerometer data were processed with the new improved Frequency Extended Method and with the traditional ActiGraph method for comparison. A high-resolution PA intensity spectrum was investigated as well as traditional crude PA intensity categories. Children treated for aortic stenosis had a pattern of less PA in the highest intensity spectra and had more sedentary time, while the adolescent patients tended to be less physically active in higher intensities overall and with less sedentary time, compared to the controls. These patterns were evident using the Frequency Extended Method with the detailed PA intensity spectrum, but not to the same degree using the ActiGraph method and traditional crude PA intensity categories. Patients reported less sports participation than their controls in both age-groups. Specific differences in PA patterns were revealed using the Frequency Extended Method with the high-resolution PA intensity spectrum in Swedish children and adolescents treated for valvular aortic stenosis.

WS04.3 Lung function as a determinant of the evolution of exercise capacity over a three-year follow-up period in patients with cystic fibrosis

2021 ◽  
Vol 20 ◽  
pp. S7-S8
Author(s):  
N. Evangelista Campos ◽  
F.M. Vendrusculo ◽  
I. Silveira de Almeida ◽  
N. Acosta Becker ◽  
M.V. Fagundes Donadio
Keyword(s):  
Cystic Fibrosis ◽  
Lung Function ◽  
Exercise Capacity

scholarly journals Effects of aerobic interval training on glucose tolerance in children and adolescents with cystic fibrosis: a randomized trial protocol

Trials ◽  
2019 ◽  
Vol 20 (1) ◽  
Author(s):  
Karolinne Souza Monteiro ◽  
Matheus de Paiva Azevedo ◽  
Lucas Menescal Jales ◽  
Fernanda Elizabeth Pereira da Silva ◽  
Ricardo Fernando Arrais ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Cystic Fibrosis ◽  
Lung Function ◽  
Glucose Tolerance ◽  
Children And Adolescents ◽  
Interval Training ◽  
Moderate Intensity ◽  
Registration System ◽  
Aerobic Interval Training

Abstract Background Individuals with cystic fibrosis (CF) may develop CF-related diabetes (CFDR). This comorbidity is related to a poorer quality of life, microvascular complications, a decline in lung function, and an increase in exacerbations, as well as delayed growth and puberty. Evidence exists that physical exercise contributes to glycemic control in individuals with non-CF-related diabetes. This exercise is usually continuous with moderate intensity and long duration, which can cause muscle dyspnea and fatigue in CF individuals. Aerobic interval training (AIT) emerges as a safe and effective alternative for treating these individuals. The objective of this study is to evaluate the effects of AIT on glucose tolerance in children and adolescents with CF. Methods This study will be a two-arm, prospectively registered, randomized controlled trial with blind assessors and twenty 6- to 18-year-old individuals with cystic fibrosis (CF) from two different Brazilian states. People with CF will be randomly allocated to either the experimental or control group using block randomization, stratified by puberty stage,. Participants from both groups will receive an educational intervention and will be asked to continue their usual daily treatment for the full duration of the study. Those in the experimental group will perform AIT on a cycle ergometer at home three times a week, for 8 consecutive weeks. The sample characterization will include an assessment of puberty stage, socioeconomic status, dyspnea, and anthropometry. The primary outcome will be the change in glucose tolerance, while the secondary outcomes will include lung function, exercise tolerance, respiratory muscle strength, quality of life, and CF exacerbations. All outcomes will be assessed at baseline, week 9, and week 17. Discussion This is the first study to evaluate the effects of AIT on glucose tolerance in children and adolescents with CF. This study will serve as a basis for guiding clinical practice and decision-making in treating glucose intolerance and CF-related diabetes (CFRD) in children and adolescents with CF. Trial registration ClinicalTrials.gov Protocol Registration System: NCT03653949. Registered on August 31, 2018.

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