The effect of metformin use and the incidence of prostate cancer in type 2 diabetes mellitus patients: A nationwide population-based study

2017 ◽  
Vol 16 (3) ◽  
pp. e609
Author(s):  
S.J. Yun ◽  
S.Y. Kim ◽  
J.-H. Park ◽  
I.-C. Cho ◽  
P. Jeong ◽  
...  
2015 ◽  
Vol 17 (8) ◽  
pp. 1001-1010 ◽  
Author(s):  
Manel Mata-Cases ◽  
Marc Casajuana ◽  
Josep Franch-Nadal ◽  
Aina Casellas ◽  
Conxa Castell ◽  
...  

2020 ◽  
Vol 29 (10) ◽  
pp. 105173
Author(s):  
Orwa Albitar ◽  
Sabariah Noor Harun ◽  
Nur Ezzati Abidin ◽  
Balamurugan Tangiisuran ◽  
Hadzliana Zainal ◽  
...  

2020 ◽  
Vol 44 (1) ◽  
pp. 113 ◽  
Author(s):  
Ji Hee Yu ◽  
Kyungdo Han ◽  
Sanghyun Park ◽  
Hanna Cho ◽  
Da Young Lee ◽  
...  

2021 ◽  
Author(s):  
E Lin ◽  
Hans Garmo ◽  
Mieke Hemelrijck ◽  
Jan Adolfsson ◽  
Pär Stattin ◽  
...  

Abstract Background: Gonadotropin Releasing Hormones agonists (GnRH), which are first line treatment for metastatic prostate cancer (PCa), increase risk of type 2 diabetes mellitus (T2DM). This study aims to quantify the association of use of GnRH with diabetes control in PCa men with T2DM.Methods: Nationwide population-based cohort study in the Swedish National Diabetes Register and Prostate Cancer data Base Sweden 4.1, on the association between GnRH and diabetes control in T2DM men with PCa by comparing T2DM men with PCa vs. without PCa, as well as comparing T2DM men with PCa on or not on GnRH. The primary exposure was use of GnRH. Worsening diabetes control was the primary outcome, defined as: 1) increase of HbA1c to 58 mmol/mol or higher; 2) HbA1c increase by 10 mmol/mol or more; 3) Start of antidiabetic drugs or switch to insulin; 4) combine all definitions above. Cox proportional hazards regression was used to analyze the association. Results: There were 5,714 T2DM men with PCa of whom 692 were on GnRH and 28,445 PCa-free men with T2DM with similar baseline characteristics. Diabetes control was worse in men with GnRH vs. PCa-free men (HR: 1.24, 95% CI: 1.13-1.34) as well as compared with PCa men without GnRH (HR:1.58, 95% CI: 1.39-1.80). Conclusion: Use of GnRH in T2DM men with PCa was associated with worse glycemic control. The findings highlight the need to closely monitor diabetes control in men with T2DM and PCa starting GnRH agonists and to limit the duration of their use when possible.


Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 1503-P
Author(s):  
DAISUKE MATSUTANI ◽  
MASAYA SAKAMOTO ◽  
SOICHIRO MINATO ◽  
YUKI TSUJIMOTO ◽  
YOSUKE KAYAMA ◽  
...  

2017 ◽  
Vol 40 ◽  
pp. 46-53 ◽  
Author(s):  
Ailin Falkmo Hansen ◽  
Anica Simić ◽  
Bjørn Olav Åsvold ◽  
Pål Richard Romundstad ◽  
Kristian Midthjell ◽  
...  

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