PP291 TAC REGIMEN INDUCED METABOLIC SYNDROME-X IN BREAST CANCER PATIENTS

One of the most serious cancers among women is breast cancer. This disease is the first reason for the death of women due to cancer. Increasing breast cancer risk may associate with many factors including genetic, reproductive factors, people's lifestyle, metabolic syndrome (MS) and hormones. MS has been known as a risk factor for prostate, pancreatic, breast and colorectal cancers. The purpose of this review is to identify the relationship between MS components and breast cancer individually. This study was performed by researching electronic database references including PubMed, Google Scholar, CINAHL ProQuest, and web of science through 2019. The effect of MS with its components and breast cancer was reported in many studies.Nevertheless, a thorough understanding of the mechanisms involved remains a challenge.However, one can take several preventive measures, including a proper diet, which is one of the most important determinants of metabolic status. Also, general preventive recommendations are including reducing alcohol consumption, red meat and total fat in the diet. Moreover, increasing the consumption of vegetable and fruit reduce the proportion of MS patients to improve the outcome of breast cancer patients.

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Abstract P6-01-02: Adipose tissue from breast cancer patients with the metabolic syndrome promotes proliferation and invasion of tumor cells and influences expression of genes involved in carcinogenesis.

10.1158/0008-5472.sabcs12-p6-01-02 ◽

2012 ◽

Author(s):

SA McGarrigle ◽

PA Carroll ◽

LA Healy ◽

T Boyle ◽

GP Pidgeon ◽

...

Keyword(s):

Breast Cancer ◽

Metabolic Syndrome ◽

Adipose Tissue ◽

Cancer Patients ◽

Tumor Cells ◽

Breast Cancer Patients ◽

The Metabolic Syndrome ◽

Expression Of Genes ◽

Proliferation And Invasion

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Abstract P4-10-05: Changes in metabolic syndrome components in breast cancer patients receiving neoadjuvant or adjuvant chemotherapy

10.1158/1538-7445.sabcs15-p4-10-05 ◽

2016 ◽

Author(s):

CM Dieli-Conwright ◽

L Wong ◽

S Waliany ◽

L Bernstein ◽

B Salehian ◽

...

Keyword(s):

Breast Cancer ◽

Metabolic Syndrome ◽

Adjuvant Chemotherapy ◽

Cancer Patients ◽

Breast Cancer Patients ◽

Metabolic Syndrome Components

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Effect of Body Mass Index on Survival in Breast Cancer Patients According to Subtype, Metabolic Syndrome, and Treatment

Clinical Breast Cancer ◽

10.1016/j.clbc.2018.04.010 ◽

2018 ◽

Vol 18 (5) ◽

pp. e1141-e1147 ◽

Cited By ~ 8

Author(s):

Won Kyung Cho ◽

Doo Ho Choi ◽

Won Park ◽

Hyejung Cha ◽

Seok Jin Nam ◽

...

Keyword(s):

Breast Cancer ◽

Metabolic Syndrome ◽

Body Mass Index ◽

Cancer Patients ◽

Body Mass ◽

Breast Cancer Patients

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Identification of Subclinical Myocardial Dysfunction in Breast Cancer Patients With Metabolic Syndrome After Cancer Related Comprehensive Therapy

10.21203/rs.3.rs-129387/v1 ◽

2020 ◽

Author(s):

Feng Zhang ◽

Siyuan Wang ◽

Siying Liang ◽

Chao Yu ◽

Sufang Li ◽

...

Keyword(s):

Breast Cancer ◽

Metabolic Syndrome ◽

Cancer Patients ◽

Myocardial Dysfunction ◽

Left Ventricular ◽

Left Ventricular Ejection ◽

Breast Cancer Patients ◽

Ventricular Ejection Fraction ◽

Comprehensive Therapy ◽

After Cancer

Abstract Background: Breast cancer patients with metabolic syndrome have an increased risk of cardiovascular disease. These patients are more prone to suffer from cardiotoxicity after anti-cancer therapy. Patients after completion of cancer related comprehensive therapy, who show normal myocardial function, may already have subclinical myocardial dysfunction. We sought to evaluate the subclinical myocardial dysfunction in breast cancer patients with metabolic syndrome after cancer related comprehensive therapy.Methods: In this study, 45 breast cancer patients with metabolic syndrome after completion of cancer related comprehensive therapy and 45 non-breast cancer patients with metabolic syndrome were enrolled. Left ventricular ejection fraction (LVEF) and global longitudinal strain (GLS) were measured using echocardiogram. Results: All the patients have normal LVEF. However, nine breast cancer patients (20%) had GLS that was lower than -17%, while all the non-cancer patients have normal GLS. Breast cancer patients with metabolic syndrome had a decrease of GLS and LVEF, compared with non-cancer patients with metabolic syndrome. Furthermore, we found that decrease of age was associated with reduction of LVEF, and that use of trastuzumab for 1 year was a significant factor that associated with reduction of GLS.Conclusions: Breast cancer patients with metabolic syndrome after completion of cancer related comprehensive therapy suffered from subclinical myocardial dysfunction. GLS should be routinely performed to early identify subclinical myocardial damage of patients, in order to prevent the cardiotoxicity of cancer related comprehensive therapy.Trial registration: the Medical Ethics Committee of Peking University People’s Hospital, 2018PHB032-02, Registered 23 November 2018, http://www.chictr.org.cn/showproj.aspx?proj=35202

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The Effects of 15 Week`s Rehabilitation Program on Health-related Physical Fitness and Metabolic Syndrome Factors for Stomach Cancer and Breast Cancer Patients

Journal of Sport and Leisure Studies ◽

10.51979/kssls.2010.05.40.611 ◽

2010 ◽

Vol 40 ◽

pp. 611-620

Author(s):

Ki Hyung Ryu ◽

Mi Sook Kim

Keyword(s):

Breast Cancer ◽

Metabolic Syndrome ◽

Physical Fitness ◽

Cancer Patients ◽

Stomach Cancer ◽

Rehabilitation Program ◽

Breast Cancer Patients ◽

Health Related

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Weight Gain, Metabolic Syndrome, and Breast Cancer Recurrence: Are Dietary Recommendations Supported by the Data?

International Journal of Breast Cancer ◽

10.1155/2012/506868 ◽

2012 ◽

Vol 2012 ◽

pp. 1-9 ◽

Cited By ~ 46

Author(s):

Colin E. Champ ◽

Jeff S. Volek ◽

Joshua Siglin ◽

Lianjin Jin ◽

Nicole L. Simone

Keyword(s):

Breast Cancer ◽

Metabolic Syndrome ◽

Weight Gain ◽

Cancer Patients ◽

Randomized Trials ◽

Cancer Recurrence ◽

Dietary Factors ◽

Breast Cancer Recurrence ◽

Breast Cancer Patients ◽

Long Term Outcome

Metabolic syndrome, which can include weight gain and central obesity, elevated serum insulin and glucose, and insulin resistance, has been strongly associated with breast cancer recurrence and worse outcomes after treatment. Epidemiologic and prospective data do not show conclusive evidence as to which dietary factors may be responsible for these results. Current strategies employ low-fat diets which emphasize supplementing calories with increased intake of fruit, grain, and vegetable carbohydrate sources. Although results thus far have been inconclusive, recent randomized trials employing markedly different dietary strategies in noncancer patients may hold the key to reducing multiple risk factors in metabolic syndrome simultaneously which may prove to increase the long-term outcome of breast cancer patients and decrease recurrences. Since weight gain after breast cancer treatment confers a poor prognosis and may increase recurrence rates, large-scale randomized trials are needed to evaluate appropriate dietary interventions for our breast cancer patients.

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