More than amnesia: prospective cohort study of an integrated novel assessment of the cognitive and behavioural features of PTA

2021 ◽  
pp. 1-18
Author(s):  
Maria J. Hennessy ◽  
Lorryn Delle Baite ◽  
Laurence A. G. Marshman
Keyword(s):  
Processing Speed ◽  
Verbal Memory ◽  
Visual Learning ◽  
Full Range ◽  
Clinical Syndrome ◽  
Self Monitoring ◽  
Traumatic Amnesia ◽  
Severe Tbi ◽  
Post Traumatic ◽  
Significant Stage

Abstract Background and Objective: Post-traumatic amnesia (PTA) is an early significant stage of recovery from traumatic brain injury (TBI). Current prospective PTA scales do not assess the full range of PTA symptomatology. This study conducted a novel integrated assessment of cognition and behaviour during PTA. Method: Twenty-four moderate-to-severe TBI participants in PTA and 23 TBI controls emerged from PTA were matched for age, gender, and years of education. All completed PTA measures (Galveston Orientation and Amnesia Test: GOAT, Westmead Post-traumatic Amnesia Scale: WPTAS), a cognitive battery; and behaviour ratings scored by 2 independent raters (informant and staff). Results: Significantly poorer performance was found during PTA for attention, processing speed, delayed verbal free recall and recognition, and visual learning. A large effect size was found for category fluency only. Behaviour ratings were significantly higher during PTA. Five behaviours were rated as high frequency (>50%) by both raters: Inattention, Impulsivity, Sleep Disturbance, Daytime Arousal, and Self-Monitoring. Prospective PTA measures produced significantly different duration estimates from 2 days (GOAT vs. WPTAS 1st day) to 9 days (WPTAS 1st day vs. 3-day). The WPTAS correlated most highly with processing speed and language tasks; whilst the GOAT correlated most highly with language and executive control of verbal memory. Conclusion: New prospective measures are needed that integrate core cognitive and behavioural features are brief, easy to administer, and capable of measuring emergence. The term PTA is a misnomer that requires revision to better accommodate the clinical syndrome.

APOE genotype and verbal memory recovery during and after emergence from post-traumatic amnesia

Brain Injury ◽  
2010 ◽  
Vol 24 (6) ◽  
pp. 886-892 ◽  
Author(s):  
E. Noé ◽  
J. Ferri ◽  
C. Colomer ◽  
B. Moliner ◽  
J. Chirivella
Keyword(s):  
Verbal Memory ◽  
Apoe Genotype ◽  
Memory Recovery ◽  
Traumatic Amnesia ◽  
Post Traumatic

scholarly journals Associations between total MRI-visible small vessel disease burden and domain-specific cognitive abilities in a community-dwelling older-age cohort

2021 ◽  
Author(s):  
OKL Hamilton ◽  
SR Cox ◽  
L Ballerini ◽  
ME Bastin ◽  
J Corley ◽  
...  
Keyword(s):  
Cognitive Ability ◽  
Processing Speed ◽  
Verbal Memory ◽  
Cognitive Abilities ◽  
Small Vessel Disease ◽  
Full Range ◽  
Community Dwelling ◽  
Small Vessel ◽  
General Cognitive Ability ◽  
Vessel Disease

AbstractCerebral small vessel disease (SVD) is a leading cause of vascular cognitive impairment, however the precise nature of SVD-related cognitive deficits, and their associations with structural brain changes, remain unclear. We combined computational volumes and visually-rated MRI markers of SVD to quantify total SVD burden, using data from the Lothian Birth Cohort 1936 (n=540; age:72.6±0.7 years). We found negative associations between total SVD burden and general cognitive ability (standardised β: −0.363; 95%CI: [−0.49, −0.23]; p(FDR)<0.001), processing speed (−0.371 [−0.50, −0.24]; p(FDR)<0.001), verbal memory (−0.265; [−0.42, −0.11]; p(FDR)=0.002), and visuospatial ability (−0.170; [−0.32, −0.02]; p(FDR)=0.029). Only the association between SVD burden and processing speed remained after accounting for covariance with general cognitive ability (−0.325; [−0.61, −0.04]; p(FDR)=0.029). This suggests that SVD’s association with poorer processing speed is not driven by, but is independent of its association with poorer general cognitive ability. Tests of processing speed may be particularly sensitive to the cognitive impact of SVD, but all major cognitive domains should be tested to determine the full range of SVD-related cognitive characteristics.

scholarly journals The Effect of Curcumin Differs on Individual Cognitive Domains across Different Patient Populations: A Systematic Review and Meta-Analysis

2021 ◽  
Vol 14 (12) ◽  
pp. 1235
Author(s):  
I-Chen Tsai ◽  
Chih-Wei Hsu ◽  
Chun-Hung Chang ◽  
Ping-Tao Tseng ◽  
Ke-Vin Chang
Keyword(s):  
Working Memory ◽  
Placebo Group ◽  
Cognitive Function ◽  
Processing Speed ◽  
Verbal Memory ◽  
Meta Analysis ◽  
Visual Learning ◽  
Clinical Effectiveness ◽  
Cognitive Domains ◽  
Significant Difference

Curcumin is a polyphenol with strong antioxidant and anti-inflammatory effects that has been shown to be effective in ameliorating cognitive decline in animal studies. However, its clinical effectiveness is inconclusive, and relevant gastrointestinal adverse events (AEs) have been reported. The aim of this meta-analysis was to summarize the existing evidence from randomized controlled trials (RCTs) of effects of curcumin on overall cognitive function, individual cognitive domains, and gastrointestinal AE. The study includes 8 RCTs and 389 participants. A random-effects model was used for the meta-analysis. Compared with the placebo group, the curcumin group was associated with an improvement in working memory (Hedges’ g = 0.396, 95% confidence interval (CI) = 0.078 to 0.714, p = 0.015) and a borderline benefit in processing speed (Hedges’ g = 0.303, 95% CI = ‒0.013 to 0.619, p = 0.06). In the domains of language, episodic memory/visual learning, verbal memory, cognitive flexibility/problem solving, and overall cognitive function, no significant difference existed for the comparison between the curcumin and placebo groups. The curcumin group had a significantly higher risk of gastrointestinal AEs than the placebo group (odds ratio = 3.019, 95% CI = 1.118 to 8.150, p = 0.029). In the future, the effects of curcumin on working memory, processing speed, and gastrointestinal AE should be further investigated.

Retrograde Personal Semantic Memory During Post-Traumatic Amnesia and Following Emergence

2018 ◽  
Vol 24 (10) ◽  
pp. 1064-1072 ◽  
Author(s):  
Caroline M. Roberts ◽  
Gershon Spitz ◽  
Matthew Mundy ◽  
Jennie L. Ponsford
Keyword(s):  
Traumatic Brain Injury ◽  
Repeated Measures ◽  
Memory Performance ◽  
Memory Deficit ◽  
Healthy Controls ◽  
Repeated Measures Design ◽  
Traumatic Amnesia ◽  
Severe Tbi ◽  
Post Traumatic ◽  
Negative Gradient

AbstractObjectives:Anecdotal reports suggest that following traumatic brain injury (TBI) retrograde memories are initially impaired and recover in order of remoteness. However, there has been limited empirical research investigating whether a negative gradient in retrograde amnesia—relative preservation of remote over recent memory—exists during post-traumatic amnesia (PTA) compared with the acute phase post-emergence. This study used a repeated-measures design to examine the pattern of personal semantic (PS) memory performance during PTA and within two weeks of emergence to improve understanding of the nature of the memory deficit during PTA and its relationship with recovery.Methods:Twenty patients with moderate-severe TBI and 20 healthy controls (HCs) were administered the Personal Semantic Schedule of the Autobiographical Memory Interview. The TBI group was assessed once during PTA and post-emergence. Analysis of variance was used to compare the gradient across lifetime periods during PTA relative to post-emergence, and between groups.Results:PS memory was significantly lower during PTA than post-emergence from PTA, with no relative preservation of remote memories. The TBI group was still impaired relative to HCs following emergence from PTA. Lower overall PS memory scores during PTA were associated with increased days to emerge from PTA post-interview.Conclusions:These results suggest a global impairment in PS memory across lifetime periods particularly during PTA, but still present within 2 weeks of emergence from PTA. PS memory performance may be sensitive to the diffuse nature of TBI and may, therefore, function as a clinically valuable indicator of the likely time to emerge from PTA. (JINS, 2018,24, 1064–1072)

scholarly journals Relationship between post-traumatic amnesia and white matter integrity in traumatic brain injury using tract-based spatial statistics

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Min Jye Cho ◽  
Sung Ho Jang
Keyword(s):  
Traumatic Brain Injury ◽  
White Matter ◽  
Patient Group ◽  
Injury Severity ◽  
White Matter Integrity ◽  
Superior Cerebellar Peduncle ◽  
Uncinate Fasciculus ◽  
Traumatic Amnesia ◽  
Post Traumatic ◽  
Cerebellar Peduncle

AbstractThis study used tract-based spatial statistics to examine the relationship between post-traumatic amnesia (PTA) and white matter integrity in patients with a traumatic brain injury (TBI). Forty-seven patients with TBI in the chronic stage and 47 age- and sex-matched normal control subjects were recruited to the study. Correlation coefficients were calculated to observe the relationships among the PTA duration, white matter fractional anisotropy (FA) values, and mini-mental state examination (MMSE) results in the patient group. Both before and after Benjamini–Hochberg (BH) corrections, FA values of 46 of the 48 regions of interests of the patient group were lower than those of the control group. The FA values of column and body of fornix, left crus of fornix, left uncinate fasciculus, right hippocampus part of cingulum, left medial lemniscus, right superior cerebellar peduncle, left superior cerebellar peduncle, and left posterior thalamic radiation (after BH correction: the uncinate fasciculus and right hippocampus part of cingulum) in the patient group were negatively correlated with PTA duration. PTA duration was related to the injury severity of eight neural structures, each of which is involved in the cognitive functioning of patients with TBI. Therefore, PTA duration can indicate injury severity of the above neural structures in TBI patients.

Post-traumatic amnesia

2013 ◽  
Vol 20 (11) ◽  
pp. 1475-1481 ◽  
Author(s):  
Laurence A.G. Marshman ◽  
David Jakabek ◽  
Maria Hennessy ◽  
Frances Quirk ◽  
Eric P. Guazzo
Keyword(s):  
Traumatic Amnesia ◽  
Post Traumatic

scholarly journals Post-traumatic amnesia: still a valuable yardstick.

1994 ◽  
Vol 57 (2) ◽  
pp. 198-201 ◽  
Author(s):  
J T Wilson ◽  
G M Teasdale ◽  
D M Hadley ◽  
K D Wiedmann ◽  
D Lang
Keyword(s):  
Traumatic Amnesia ◽  
Post Traumatic

scholarly journals Longitudinal Associations Between Loneliness and Cognitive Ability in the Lothian Birth Cohort 1936

2018 ◽  
Vol 74 (8) ◽  
pp. 1376-1386 ◽  
Author(s):  
Judith A Okely ◽  
Ian J Deary
Keyword(s):  
Cognitive Ability ◽  
Birth Cohort ◽  
Processing Speed ◽  
Verbal Memory ◽  
Cognitive Abilities ◽  
Birth Cohort Study ◽  
Visuospatial Ability ◽  
Lothian Birth Cohort ◽  
Longitudinal Associations ◽  
Reciprocal Associations

Abstract Objectives Loneliness is associated with poorer cognitive function in old age; however, the direction of this association is unknown. We tested for reciprocal associations between loneliness and the cognitive ability domains of processing speed, visuospatial ability, verbal memory, and crystallized ability. Method We used three triennial waves of longitudinal data from the Lothian Birth Cohort Study 1936, and tested for cross-lagged associations between loneliness and cognitive abilities using cross-lagged panel models. Results Better processing speed, visuospatial ability, or crystallized ability at age 73, was associated with less positive changes in loneliness between ages 73 and 76; however, these associations were not replicated between ages 76 and 79. Loneliness at ages 73 and 76 did not predict subsequent changes in cognitive abilities. Discussion Our findings indicate an association between cognitive ability and loneliness, such that individuals with lower cognitive abilities at age 73 may be at a slightly higher risk of becoming lonely. However, we did not find support for the hypothesis that loneliness causes a decline in cognitive health.

Language and cognitive communication disorder during post-traumatic amnesia: Profiles of recovery after TBI from three cases

Brain Injury ◽  
2017 ◽  
Vol 31 (13-14) ◽  
pp. 1889-1902 ◽  
Author(s):  
Joanne Steel ◽  
Alison Ferguson ◽  
Elizabeth Spencer ◽  
Leanne Togher
Keyword(s):  
Communication Disorder ◽  
Traumatic Amnesia ◽  
Post Traumatic
Sign in / Sign up

Export Citation Format

Share Document