Re-wiring and gene expression changes of AC025034.1 and ATP2B1 play complex roles in early-to-late breast cancer progression

Background Elucidating the dynamic topological changes across different stages of breast cancer, called stage re-wiring, could lead to identifying key latent regulatory signatures involved in cancer progression. Such dynamic regulators and their functions are mostly unknown. Here, we reconstructed differential co-expression networks for four stages of breast cancer to assess the dynamic patterns of cancer progression. A new computational approach was applied to identify stage-specific subnetworks for each stage. Next, prognostic traits of genes and the efficiency of stage-related groups were evaluated and validated, using the Log-Rank test, SVM classifier, and sample clustering. Furthermore, by conducting the stepwise VIF-feature selection method, a Cox-PH model was developed to predict patients’ risk. Finally, the re-wiring network for prognostic signatures was reconstructed and assessed across stages to detect gain/loss, positive/negative interactions as well as rewired-hub nodes contributing to dynamic cancer progression. Results After having implemented our new approach, we could identify four stage-specific core biological pathways. We could also detect an essential non-coding RNA, AC025034.1, which is not the only antisense to ATP2B1 (cell proliferation regulator), but also revealed a statistically significant stage-descending pattern; Moreover, AC025034.1 revealed both a dynamic topological pattern across stages and prognostic trait. We also identified a high-performance Overall-Survival-Risk model, including 12 re-wired genes to predict patients’ risk (c-index = 0.89). Finally, breast cancer-specific prognostic biomarkers of LINC01612, AC092142.1, and AC008969.1 were identified. Conclusions In summary new scoring method highlighted stage-specific core pathways for early-to-late progressions. Moreover, detecting the significant re-wired hub nodes indicated stage-associated traits, which reflects the importance of such regulators from different perspectives.

Evaluation of Reclaimed Asphalt Mixtures Modified by Nanoclay Powder on Moisture Damage

Recycling asphalt is a significant stage in pavement industry, yet it can be unfavorable to the durability of the recycled mix due to the loss of binder charachteristics, thus the mixture will be weaker to the external factors like moisture. This study aims to evaluate the influence of nanoclay montmorillonite k10 powder (MMT) on Marshall’s characteristics and moisture resistance in Reclaimed Asphalt Pavement (RAP) mixtures. Three percentages of rejuvenated RAP were used, 30%, 40%, and 50% of the total mixture, these percentages were modified with 0%, 1%, 3%, and 5% nanoclay (MMT) of the neat binder’s weight. Asphalt Cement AC(85-100) was used to rejuvenate the RAP. The Marshall test was conducted on modified RAP to detect the effect on the Marshall stability and flow and air void, indirect tensile strength tests (ITS) were also conducted before and after nanoclay powder addition to compare and assess the resistance of moisture to rejuvenated RAP mixtures. The results of the laboratory tests have shown that the use of 5% nanoclay in the regenerated RAP mixes offers superior performance than without it, where it enhanced stability by 15%, reduced flow by 14.3%, and increased moisture damage resistance by 3.66% all for 50% RAP mixtures.

Quality Control Methods for Turkey Meat Products

The article under discussion considers methods of quality control of turkey meat products. The author believes that the quality control of food raw materials and food products is a significant stage in the production of food products. It is important to organize research aimed at improving the quality and safety of turkey meat products, using accurate, rapid, and highly effective methods of infrared spectroscopy and chromato-mass spectrometry to determine its chemical composition to develop methods to determine the correctness of HS codes.

Nikolay Karazin’s Graphic Series for the Amu Darya and Samara Expeditions of 1874 and 1879

The article examines the drawings and watercolors by the artist Nikolay Nikolayevich Karazin (1842—1908), based on the materials of the Amu Darya and Samara expeditions of 1874 and 1879. The paper aims at reviewing the graphic series “Amu Darya Scientific Expedition”, published in the magazine “Niva” in 1874—1875, and a series of watercolor portraits made during the Samara expedition, in comparison with the pencil portraits by Vasily Vasilyevich Vereshchagin (1842—1904) in the album of photographs “Russian Turkestan”, published in 1874. This collection of artworks has not previously been the subject of a special art history study. Their examination introduces into the field of specialists’ view a significant stage of Nikolay Karazin’s creative path. The relevance of the article, in view of the investigations of recent years, lies in the representation of the image of an artist-traveler, a draftsman during expeditions in the second half of the 19th century.The study of the first series is based on the nature and national types of the Amu Darya delta. The analysis of individual examples of journal graphics is accompanied by a description of some of the author’s simultaneous graphic originals, as well as works of other artists interested in Central Asian ethnography. The article uses a comparative methodological principle, with the analysis of fragments of N.N. Karazin’s literary works — travel essays with a pronounced ethnographic component.The artist’s series of watercolors based on the Samara expedition also presents several images of the ethnotypes of Russian Turkestan, a region of Central Asia in its western part. As a result, there are identified the similarities and differences in the artistic methods and manners, as well as the conditions of creative work, of the two artists — Nikolay Karazin and Vasily Vereshchagin. The analysis is carried out using a comparative method and a socio-historical background.The Amu Darya and Samara graphic cycles represent N.N. Karazin as a mature creator who intuitively used the means of the approaching new time and modern style. At the same time, he did not leave the boundaries of the literary and artistic genre “voyage pittoresque”, overall successfully combining realistic tendencies with the vision of a romantic.

Formation of mathematical education and science at the Belarusian State University (1919–1920s)

On the basis of archival materials and other sources, the complex process of formation at the Belarusian State University of mathematical education and scientific research in various fields of science is considered. Particular attention is paid to the years that did not stop in 1919–1921 discussions among officials and scientists about the legality of creating a separate mathematics faculty specifically for the opening of the Belarusian State University. In this case, for the first time, the position of an outstanding mathematician and organiser of mathematical education, a native of Belarus, I. R. Braitsev, is presented in detail. The author defines the 1920s as an undoubtedly significant stage not only in the formation of the mathematical component in the general character of Belarusian State University, but also in the formation of the foundations of the future high level of university mathematics.

Advancements in Intravesical Chemotherapy in Non-Muscle Invasive Bladder cancer

The treatment for non-muscle-invasive bladder cancer is transurethral resection of bladder cancer followed by intravesical chemotherapy or BCG. There have been various advancements in low risk, intermediate risk, high risk, and BCG failure cases of non-muscle invasive bladder cancer. There has been increased research on hyperthermia and intravesical chemotherapy, new agents like apaziquone, use of gemcitabine in low-risk cases, and combination chemotherapy in cases of BCG failure. Combining docetaxel and gemcitabine has taken a significant stage because of BCG shortage in some parts of the world. This chapter will discuss the latest advancements in intravesical chemotherapy in low, intermediate, and high-risk patients.

Measuring Adolescent Participation: Results from a Qualitative Pretest in Cote D’Ivoire and Indonesia

Adolescence, or the period of transition between childhood and adulthood, is a significant stage in human development. Not only is it a time of physical growth and neurological development, but it is also a time when many young people begin to expand their networks beyond their family, form close ties with their peers, develop and express their views, and have a greater desire to be involved in decisions that affect them. This act of forming and expressing their views and influencing matters that concern them is sometimes referred to as adolescent participation. When viewed through an international human rights lens, adolescent participation is considered a fundamental right, and consequently, there is a need for reliable and valid measures that accurately assess adolescent participation and allow for internationally comparable data. The purpose of this study was to qualitatively test a draft questionnaire designed to measure adolescent participation. The goal was to gain insight into both how the items would perform cross-culturally and how adolescents’ comprehension and interpretation of different constructs related to adolescent participation. Cognitive interviews were conducted with 123 adolescents aged 10 to 19 in Côte d’Ivoire and Indonesia. This paper describes the development of the draft questionnaire, presents the methods used to pretest the questionnaire, and summarizes the findings. This study reveals important considerations for researchers and practitioners interested in qualitatively pretesting questionnaires with adolescents and in measuring and understanding adolescent participation across a range of international contexts.

Study on Microbial Community Succession and Functional Analysis during Biodegradation of Mushroom Residue

In this study, 16S rRNA high-throughput sequencing technology was used to analyze the composition and diversity of bacterial and fungal communities in mushroom residue samples at different composting stages. During the composting process, the maximum temperature in the center of the pile can reach 52.4°C, and the temperature above 50°C has been maintained for about 8 days. The results showed that Actinobacteria, Firmicutes, Proteobacteria, Bacteroidetes, and Chloroflexi were the main microorganisms in the composting process, accounting for 98.9%-99.7% of the total bacteria. Furthermore, in order to obtain the protein expressed in each stage of composting, the nonstandard quantitative method (label free) was used to analyze it quantitatively by mass spectrometry, anda total of 22815 proteins were identified. It indicated that the number of identified proteins related to cellulose decomposition and the number of differentially expressed proteins were significantly enriched, and the functional proteins related to cellulose decomposition had significant stage correspondence.

Requirements Elicitation Techniques in Mobile Applications

The common view of requirements engineering consists of requirement elicitation, specification, validation, and evolution. Requirement elicitation is a significant stage to assure the quality of the requirement documentations and would affect the project success or failure. There are different techniques to elicit the requirements. Each technique has its advantages and disadvantages. Thus, it is important to adopt more than one kind of technique to describe a system clearly from different viewpoints. This study prospected some of the research papers in the same field to display the requirements elicitation techniques that are used in developing mobile applications from a variety of research disciplines. It suggests some requirements elicitation concepts to guide software engineers in selecting the techniques according to customers' needs and to show the common challenges that they face.

Interpersonal Intelligence: A Strengthening in Efforts to Improve Student Learning Achievement

The purpose of this study was to determine the relationship between interpersonal intelligence and student learning outcomes so that there is an increase and strengthening of student achievement. The method used in this research is field research with a correlational quantitative approach which aims to analyze the relationship between interpersonal intelligence and student achievement. The results of this study found that there is a significant relationship between interpersonal intelligence and student achievement. This can be proven from statistical calculations, namely r count is greater than r table (0.995> 0.347) with a significant stage of 5%. Thus the alternative hypothesis (Ha) in this study is accepted and the hypothesis (H0) in this study is rejected.