Endometrial cancer: prevention, screening, and early detection

2004 ◽  
pp. 293-310
Author(s):  
Ellen Sakornbut
Keyword(s):  
Endometrial Cancer ◽  
Early Detection ◽  
Cancer Prevention

scholarly journals Metabolomic Biomarkers for the Detection of Obesity-Driven Endometrial Cancer

Cancers ◽  
2021 ◽  
Vol 13 (4) ◽  
pp. 718
Author(s):  
Kelechi Njoku ◽  
Amy E. Campbell ◽  
Bethany Geary ◽  
Michelle L. MacKintosh ◽  
Abigail E. Derbyshire ◽  
...  
Keyword(s):  
Endometrial Cancer ◽  
Early Detection ◽  
Minimally Invasive ◽  
Cancer Detection ◽  
Test Performance ◽  
Female Genital Tract ◽  
Screening Tools ◽  
Normal Endometrium ◽  
Endometrioid Endometrial Cancer ◽  
Post Menopausal

Endometrial cancer is the most common malignancy of the female genital tract and a major cause of morbidity and mortality in women. Early detection is key to ensuring good outcomes but a lack of minimally invasive screening tools is a significant barrier. Most endometrial cancers are obesity-driven and develop in the context of severe metabolomic dysfunction. Blood-derived metabolites may therefore provide clinically relevant biomarkers for endometrial cancer detection. In this study, we analysed plasma samples of women with body mass index (BMI) ≥ 30 kg/m2 and endometrioid endometrial cancer (cases, n = 67) or histologically normal endometrium (controls, n = 69), using a mass spectrometry-based metabolomics approach. Eighty percent of the samples were randomly selected to serve as a training set and the remaining 20% were used to qualify test performance. Robust predictive models (AUC > 0.9) for endometrial cancer detection based on artificial intelligence algorithms were developed and validated. Phospholipids were of significance as biomarkers of endometrial cancer, with sphingolipids (sphingomyelins) discriminatory in post-menopausal women. An algorithm combining the top ten performing metabolites showed 92.6% prediction accuracy (AUC of 0.95) for endometrial cancer detection. These results suggest that a simple blood test could enable the early detection of endometrial cancer and provide the basis for a minimally invasive screening tool for women with a BMI ≥ 30 kg/m2.

Abstract 2608: Lung cancer prevention and an early detection educational intervention in minority and underserved communities

2021 ◽  
Author(s):  
Samantha J. Sojourner ◽  
Marlo M. Vernon ◽  
Ghadeer Albashir ◽  
Justin X. Moore ◽  
Stephen W. Looney ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Early Detection ◽  
Cancer Prevention ◽  
Educational Intervention ◽  
Underserved Communities ◽  
Lung Cancer Prevention

scholarly journals Controversies in the Management of Endometrial Carcinoma: An Update

2012 ◽  
Vol 2012 ◽  
pp. 1-10 ◽  
Author(s):  
Mohamed K. Mehasseb ◽  
John A. Latimer
Keyword(s):  
Radiation Therapy ◽  
Endometrial Cancer ◽  
Early Detection ◽  
Endometrial Carcinoma ◽  
Genital Tract ◽  
Female Genital Tract ◽  
Developed Countries ◽  
Changing Roles ◽  
The Developed Countries ◽  
Female Genital

Endometrial carcinoma is the commonest type of female genital tract malignancy in the developed countries. Endometrial carcinoma is usually confined to the uterus at the time of diagnosis and as such usually carries an excellent prognosis with high curability. Our understanding and management of endometrial cancer have continuously developed. Current controversies focus on screening and early detection, the extent of nodal surgery, and the changing roles of radiation therapy and chemotherapy and will be discussed in this paper.

Skin cancer prevention: a link between primary prevention and early detection?

2010 ◽  
Vol 18 (4) ◽  
pp. 417-420 ◽  
Author(s):  
Peter J. Anderson ◽  
John B. Lowe ◽  
Warren R. Stanton ◽  
Kevin P. Balanda
Keyword(s):  
Primary Prevention ◽  
Skin Cancer ◽  
Early Detection ◽  
Cancer Prevention ◽  
Skin Cancer Prevention ◽  
Prevention And Early Detection

scholarly journals Knowledge, attitudes, and practices of oral cancer prevention among students, interns, and faculty members at the college of dentistry of Jazan University

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Mosa A. Shubayr ◽  
Ahmed M. Bokhari ◽  
Afnan A. Essa ◽  
Ali M. Nammazi ◽  
Dania E. Al Agili
Keyword(s):  
Oral Health ◽  
Oral Cancer ◽  
Early Detection ◽  
Cancer Prevention ◽  
Dental Students ◽  
Faculty Members ◽  
Attitudes And Practices ◽  
The Past ◽  
Health Practitioners ◽  
Knowledge Attitudes And Practices

Abstract Background Oral cancer awareness among current and future dental practitioners plays a substantial role in the early detection and prevention of oral cancer. Therefore, this study aimed to assess the knowledge, attitudes, and practices (KAP) of oral cancer prevention (OCP) among oral health practitioners in the College of Dentistry at Jazan University, Saudi Arabia, and to determine factors that facilitate, or limit practices related to oral cancer prevention. Methods A self-administered questionnaire survey was done among dental students (n = 274), interns (n = 81), and faculty members (n = 117) in the College of Dentistry at Jazan University between May 2019 to February 2020. The questionnaire was developed in English and modified from a previously validated and published questionnaire into Arabic. It covered every KAP of oral cancer prevention that was useful in accomplishing the study's objectives. Logistic regression analysis was utilized to determine the factors associated with the practice of oral cancer prevention in the past year. Results Only 29.7% reported having participated in any OCP activities in the past 12 months while about 42% and 53% of participants referred suspected oral cancer patients to the departments of maxillofacial surgery and oral medicine, respectively. Most of the participants had poor knowledge (71.9%), unfavourable attitudes towards OCP (83.6%) and poor levels of practice (62.9%). The study found that the attitude of the participants was significant in influencing their practices of OCP in the previous 12 months, after adjusting for all other factors. Conclusion It was concluded that the level of knowledge, attitudes, and practices of OCP among the sample population was poor. The survey findings suggest that oral health practitioners in Jazan are inexperienced in the methods to adopt for prevention and early detection of oral cancer, despite the high prevalence of oral cancer among province residents. Further research should investigate effective educational strategies and training for improving the participation of students, interns, and faculty members in oral cancer prevention activities.

scholarly journals Enhancing the Knowledge of Cervical Cancer Screening among Female Nursing Students: An Interventional Educational Program

2020 ◽  
Author(s):  
Hayam Fathey A. Eittah ◽  
Khalid Abdullah S. Aljohani ◽  
Mohammed Saeed E. Aljohani
Keyword(s):  
Cervical Cancer ◽  
Saudi Arabia ◽  
Nursing Students ◽  
Early Detection ◽  
Cancer Prevention ◽  
Educational Intervention ◽  
Educational Program ◽  
Pap Smear ◽  
Cervical Cancer Prevention ◽  
Study Results

Background: Cervical cancer is a growing health risk facing women worldwide with the human papillomavirus (HPV) as the primary underlying cause. Pap smear is a simple screening test that can detect early changes in cervical cells, which might develop into cancer cells. Raising awareness of cervical cancer prevention has a significant impact on decreasing the burden of the disease. The aim of the study is to assess female nursing students' knowledge on early detection and screening of cervical cancer, and to determine the effectiveness of an educational program. Methods: A quasi-experimental research design (one group for pre- and post-tests) was utilized with a convenience sample of 130 female nursing students in one of the nursing colleges in Saudi Arabia. The study’s educational intervention included information about anatomy of genital tract and the importance of regular check-ups. The pre- and post-tests were applied to identify changes after intervention measures. Results: The mean age of the participants were 21.32 years (SD: 1.34). The findings revealed a significant improvement of post-test students’ knowledge in all items related to risk factors, signs and symptoms, occurrence, identification of HPV as causative agent, vaccination against HPV, and finally Pap smear for early detection and screening of cervical cancer. Conclusion: The study results support implementing educational intervention to improve nursing students' knowledge and awareness about cervical cancer prevention. Furthermore, it is imperative that cervical cancer awareness education modules should be developed and integrated within the nursing curriculum. Further studies with large sample size are recommended to increase generalization of the results.  Key words: cervical cancer, education program, primary prevention, nursing students, Saudi Arabia

Cancer Prevention, Screening, and Early Detection

2014 ◽  
pp. 322-359.e12
Author(s):  
Therese B. Bevers ◽  
Powel H. Brown ◽  
Karen Colbert Maresso ◽  
Ernest T. Hawk
Keyword(s):  
Early Detection ◽  
Cancer Prevention
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