Pregnant patients with comorbid diseases

Abstract Purpose The recent outbreak of COVID-19 rapidly spread worldwide. Comorbid diseases are determinants of the severity of COVID-19 infection and mortality. The aim of this study was to explore the potential association between chronic kidney disease (CKD) and the severity of COVID-19 infection. Methods The study included 609 consecutive adult patients (male: 54.52%, mean age: 59.23 ± 15.55 years) hospitalized with the diagnosis of COVID-19 in a tertiary level hospital. Data were collected from the electronic health records of the hospital. The patients were separated into two groups: Group I included COVID-19-positive patients with CKD stage 1–2, and Group II included COVID-19-positive with CKD stage 3–5. The relationships were examined between CKD stage, laboratory parameters and mortality. Results Significant differences were determined between the groups in respect of the inflammation parameters and the parameters used in prognosis. In Group II, statistically significantly higher rates were determined of comorbid diseases [hypertension (p < 0.001) and diabetes mellitus (p < 0.001), acute kidney injury (AKI), which was found to be associated with mortality (p < 0.001), and mortality (p < 0.001)]. In multivariate regression analysis, CKD stage 3–5, AKI, male gender, hypertension, DM and malignancy were found to be significant independent variables increasing mortality. Conclusion The prevelance of CKD stage 3–5 on admission is associated with a high risk of in-hospital mortality in patients with COVID-19. Close follow-up can be recommended for patients with a reduced glomerular filtration rate (GFR).

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Clinical Efficacy of Endoscopic Submucosal Dissection in Patients with Comorbid Diseases

Gastrointestinal Endoscopy ◽

10.1016/j.gie.2008.03.802 ◽

2008 ◽

Vol 67 (5) ◽

pp. AB283

Author(s):

Beom Jin Kim ◽

Jae J. Kim ◽

Byung-Hoon Min ◽

Won Kyoung Yun ◽

Hoi Jin Kim ◽

...

Keyword(s):

Endoscopic Submucosal Dissection ◽

Clinical Efficacy ◽

Submucosal Dissection ◽

Comorbid Diseases

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Hepatocorbidity in psoriasis

Medical alphabet ◽

10.33667/2078-5631-2021-9-7-11 ◽

2021 ◽

pp. 7-11

Author(s):

M. A. Koroleva

Keyword(s):

Diabetes Mellitus ◽

Psoriatic Arthritis ◽

Mental Disorders ◽

Cardiovascular System ◽

Liver Damage ◽

Liver Diseases ◽

Hepatobiliary System ◽

Immunological Mechanisms ◽

Bowel Diseases ◽

Comorbid Diseases

Тhe well-known manifestations in psoriasis include psoriatic arthritis and psoriasis of the nails, however, at present, other conditions comorbid to psoriasis have begun to be actively studied: such as liver diseases, diabetes mellitus, diseases of the cardiovascular system, obesity, mental disorders, inflmmatory bowel diseases. and joints. In addition to similar immunological mechanisms, genes have been found that are common to psoriasis and the comorbid diseases associated with it. The article provides data on dysfunctions of the hepatobiliary system in patients with psoriasis. The article reveals the results of studies conducted by foreign and domestic authors, which have shown signifiant relationships in the severity of liver damage in psoriasis.

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Molecular Relationships between Bronchial Asthma and Hypertension as Comorbid Diseases

Journal of Integrative Bioinformatics ◽

10.1515/jib-2018-0052 ◽

2018 ◽

Vol 15 (4) ◽

Cited By ~ 4

Author(s):

Elena Yu. Bragina ◽

Irina A. Goncharova ◽

Anna F. Garaeva ◽

Evgeniy V. Nemerov ◽

Anastasija A. Babovskaya ◽

...

Keyword(s):

Bronchial Asthma ◽

Genetic Background ◽

Regulation Of Gene Expression ◽

Common Phenomenon ◽

Nucleotide Polymorphisms ◽

Single Nucleotide ◽

Multiple Factors ◽

Comorbid Diseases ◽

Set Up ◽

Molecular Relationships

AbstractComorbidity, a co-incidence of several disorders in an individual, is a common phenomenon. Their development is governed by multiple factors, including genetic variation. The current study was set up to look at associations between isolated and comorbid diseases of bronchial asthma and hypertension, on one hand, and single nucleotide polymorphisms associated with regulation of gene expression (eQTL), on the other hand. A total of 96 eQTL SNPs were genotyped in 587 Russian individuals. Bronchial asthma alone was found to be associated with rs1927914 (TLR4), rs1928298 (intergenic variant), and rs1980616 (SERPINA1); hypertension alone was found to be associated with rs11065987 (intergenic variant); rs2284033 (IL2RB), rs11191582 (NT5C2), and rs11669386 (CARD8); comorbidity between asthma and hypertension was found to be associated with rs1010461 (ANG/RNASE4), rs7038716, rs7026297 (LOC105376244), rs7025144 (intergenic variant), and rs2022318 (intergenic variant). The results suggest that genetic background of comorbidity of asthma and hypertension is different from genetic backgrounds of both diseases manifesting isolated.

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Clinical characteristics of a group of deaths with COVID-19 pneumonia in Wuhan, China: retrospective case series

10.21203/rs.3.rs-18090/v1 ◽

2020 ◽

Author(s):

Tao Yao ◽

Yan Gao ◽

Qin Cui ◽

Bo Peng ◽

Yan Chen ◽

...

Keyword(s):

Control Strategies ◽

Antiviral Treatment ◽

Invasive Mechanical Ventilation ◽

Laboratory Data ◽

Case Series ◽

The Elderly ◽

Retrospective Case ◽

Initial Symptoms ◽

Comorbid Diseases ◽

Death Cases

Abstract Background: With the widespread outbreak of novel coronavirus diseases 2019(COVID-19), more and more death cases were reported, however, limited data are available for the patients who died. We aimed to explore the clinial characteristics of deaths with COVID-19 pneumonia Methods: We abstracted and analyzed epidemiological, demographic, clinical, and laboratory data from 83 death cases with COVID-19 pneumonia in East hospital of Wuhan university Renmin hospital,between January 26, 2020, and February 28, 2020.Results: Of the 83 deaths, none was the medical staff. The mean age was 71.8 years (SD 13.2; range, 34-97 years) and 53(63.9%) were male. The median from onset to admission was 10 days (IQR 7-14: range, 2-43 days), to death was 17days (IQR 14-21: range, 6-54 days). Most deaths (66[80%]) had underlying comorbid diseases, the most of which was hypertension [47(57%)]. The main initial symptoms of these 83 deaths were shortness of breath(98.8%), fever(94%) and myalgia or fatigue(90.4%). Laboratory analyses showed the lymphocytopenia in 69(83%) deaths, hypoalbuminemia in 77(93%) deaths, the elevation of lactate dehydrogenase in 79(95%) deaths, procalcitonin in 69(83%) deaths and C-reactive protein in 79(95%) deaths. All 83 patients received antiviral treatment, 81(97.6%) deaths received antibiotic therapy, and 54(65.1%) deaths received glucocorticoid therapy and 20(24.1%) patients received invasive mechanical ventilation.Conclusion: Most of the deaths with COVID-19 pneumonia were elderly patients with underlying comorbid diseases, especially those over 70 years of age. The time of death was mostly 15-21 days after the onset of the disease. More care should be given to the elderly in the further prevention and control strategies of COVID-19.

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