scholarly journals Altered Autonomic Nervous System Reactivity to Pain in Trigeminal Neuralgia

2015 ◽  
Vol 42 (2) ◽  
pp. 125-131 ◽  
Author(s):  
Guillaume Léonard ◽  
Philippe Chalaye ◽  
Philippe Goffaux ◽  
David Mathieu ◽  
Isabelle Gaumond ◽  
...  
Keyword(s):  
Heart Rate ◽  
Nervous System ◽  
Autonomic Nervous System ◽  
Trigeminal Neuralgia ◽  
Cold Pressor Test ◽  
Cardiac Activity ◽  
Cold Pressor ◽  
Healthy Controls ◽  
P Values ◽  
Autonomic Nervous

AbstractBackground: In the past two decades, there has been increasing evidence to suggest that trigeminal neuralgia (TN) may be linked to a dysfunction of the autonomic nervous system (ANS). The aim of the present study was to formally test this hypothesis by comparing the reactivity of the ANS to experimental pain in a population of TN patients and healthy controls. Methods: Twelve patients diagnosed with classical TN and 12 healthy controls participated in the study. Cardiac activity was assessed while participants were instructed to rest and again during a cold pressor test (CPT). Heart rate variability analyses were performed off-line to obtain parasympathetic (high-frequency) and sympathetic (low-frequency) indices. Results: At baseline, ANS measures did not differ between healthy controls and TN patients, and both groups showed a similar increase in heart rate during the CPT (all p values >0.05). However, TN patients showed a greater increase in cardiac sympathetic activity and a greater decrease in cardiac parasympathetic activity during CPT compared with healthy controls (all p values <0.05). Importantly, changes in sympathetic reactivity, from baseline to CPT, were negatively associated with the number of pain paroxysms experienced each day by TN patients in the preceding week (r=−.58, p<0.05). Conclusions: These results suggest that TN, like many other short-lasting, unilateral facial pain conditions, is linked to ANS alterations. Future studies are required to determine if the altered ANS response observed in TN patients is a cause or a consequence of TN pain

scholarly journals Evaluation of Autonomic Nervous System Changes Using Short-term Heart Rate Variability During Apnea

2020 ◽  
Author(s):  
Baolin He ◽  
Wenyu Li ◽  
Xiaotong Zhang ◽  
Yanan Wu ◽  
Jing Liu ◽  
...  
Keyword(s):  
Heart Rate ◽  
Heart Rate Variability ◽  
Nervous System ◽  
Autonomic Nervous System ◽  
Physiological State ◽  
Cardiac Activity ◽  
Normal Function ◽  
Short Term ◽  
Autonomic Nervous ◽  
Respiratory State

Abstract Background: Frequent cessations of respiration can greatly increase the prevalence rate of arrhythmia. It has been confirmed that cardiac activity is regulated by autonomic nervous system (ANS). And heart rate variability (HRV) is widely used as a method to evaluate the function of ANS. Therefore, we analyzed whether apnea can affect the balance and normal function of ANS using short-term HRV indices. Methods: Forty-five healthy subjects were asked to breathe normally and hold their breathing to simulate 10 times apnea. Thirty-six patients from the dataset of a sleep laboratory for the diagnosis of sleep disorders with 10 times apnea were included in analysis. We calculated short-term HRV indices of subjects in normal respiratory and apneic states, respectively. Results: Compared with normal respiratory state, respiration cease would lead to the values of the mean-RR, nLF, LF/HF, and α1 were significantly increase whereas the values of rMSSD and nHF were significantly decrease. Conclusions: Cessations of respiration would lead to an imbalance in function of ANS, as well as an increase in fractal characteristics of the heart. These changes in physiological state are likely to induce and cause the occurrence of arrhythmia, which is regulated by ANS.

scholarly journals A method to quantify autonomic nervous system function in healthy, able-bodied individuals

2020 ◽  
Author(s):  
Shubham Debnath ◽  
Todd J. Levy ◽  
Mayer Bellehsen ◽  
Rebecca M. Schwartz ◽  
Douglas P. Barnaby ◽  
...  
Keyword(s):  
Heart Rate ◽  
Nervous System ◽  
Autonomic Nervous System ◽  
Pupil Diameter ◽  
Electrodermal Activity ◽  
Cold Pressor Test ◽  
Healthy Population ◽  
Individual Response ◽  
Autonomic Nervous ◽  
Organ Systems

AbstractThe autonomic nervous system (ANS), which maintains physiological homeostasis in various organ systems via parasympathetic and sympathetic branches, is altered in common diffuse and focal conditions. Sensitive, quantitative biomarkers could detect changes in ANS function, first here in healthy participants and eventually in patients displaying dysautonomia. This framework combines controlled autonomic testing with feature extraction from physiological responses. Twenty-one individuals were assessed in two morning and two afternoon sessions over two weeks. Each session included five standard clinical tests probing autonomic function: squat test, cold pressor test, diving reflex test, deep breathing, and Valsalva maneuver. Noninvasive sensors captured continuous electrocardiography, blood pressure, breathing, electrodermal activity, and pupil diameter. Heart rate, heart rate variability, mean arterial pressure, electrodermal activity, and pupil diameter responses to the perturbations were extracted, and averages across participants were computed. A template matching algorithm calculated scaling and stretching features that optimally fit the average to an individual response. These features were grouped based on test and modality to derive sympathetic and parasympathetic indices for this healthy population. A significant positive correlation (p = 0.000377) was found between sympathetic amplitude response and body mass index. Additionally, longer duration and larger amplitude sympathetic and longer duration parasympathetic responses occurred in afternoon testing sessions; larger amplitude parasympathetic responses occurred in morning sessions. These results demonstrate the robustness and sensitivity of an algorithmic approach to extract multimodal responses from standard tests. This novel method of quantifying ANS function can be used for early diagnosis, measurement of disease progression, or treatment evaluation.

Autonomic nervous system in euthymic patients with bipolar affective disorder

2011 ◽  
Vol 26 (S2) ◽  
pp. 222-222
Author(s):  
K. Latalova ◽  
T. Diveky ◽  
A. Grambal ◽  
D. Kamaradova ◽  
H. Velartova ◽  
...  
Keyword(s):  
Heart Rate ◽  
Heart Rate Variability ◽  
Nervous System ◽  
Autonomic Nervous System ◽  
Age Of Onset ◽  
Bipolar Affective Disorder ◽  
Cardiac Activity ◽  
Diagnostic Systems ◽  
Autonomic Nervous ◽  
Bipolar Patients

BackgroundAutonomic nervous system (ANS) dysfunction and reduced heart rate variability (HRV) have been reported in a wide variety of psychiatric disorders, but have not been well characterized in bipolar patiens in remission. We recorded cardiac activity and assessed HRV in bipolar outpatients in remission.AimsAscertain if ANS decrease with the age of the patient; ascertain relation between activity of ANS and level of dissociation, and other components (age of patients, and age of disorder, dosage of psychotropic medication)MethodsAutonomic nervous system (ANS) has been evaluated during orthostatic change in three positions (1- lie down 5 minutes, 2 – stand up 5 minutes, 3 – lie down 5 minutes). The functioning of the ANS has been measured by the diagnostic systems that are using the power spectral analysis which quantifies the heart rate variability (HRV) was assessed using time domain, frequency domain, and nonlinear analyses in 23 bipolar patients in remission.ResultsWe found highly statistically significant negative correlations between level of dissociation measured by DES and most of parameters of ANS. We found negative correlations between the age of the patient and activity of ANS, and negative correlations between activity of ANS and duration and onset of disorder.ConclusionsAutonomic dysregulation is associated with bipolar disorder in remission and has relation to level of dissociation and probably to age of patiens and age of onset and duration of disorder.Supported by grant IGA MZ ČR NT11047

scholarly journals The Assessment of Autonomic Nervous System Activity Based on Photoplethysmography in Healthy Young Men

2021 ◽  
Vol 12 ◽  
Author(s):  
Binbin Liu ◽  
Zhe Zhang ◽  
Xiaohui Di ◽  
Xiaoni Wang ◽  
Lin Xie ◽  
...  
Keyword(s):  
Nervous System ◽  
Autonomic Nervous System ◽  
Mental Arithmetic ◽  
Cold Pressor Test ◽  
Young Men ◽  
Cold Pressor ◽  
Sympathetic Activation ◽  
Pulse Rate Variability ◽  
Activation Patterns ◽  
Autonomic Nervous

Noninvasive assessment of autonomic nervous system (ANS) activity is of great importance, but the accuracy of the method used, which is primarily based on electrocardiogram-derived heart rate variability (HRV), has long been suspected. We investigated the feasibility of photoplethysmography (PPG) in ANS evaluation. Data of 32 healthy young men under four different ANS activation patterns were recorded: baseline, slow deep breathing (parasympathetic activation), cold pressor test (peripheral sympathetic activation), and mental arithmetic test (cardiac sympathetic activation). We extracted 110 PPG-based features to construct classification models for the four ANS activation patterns. Using interpretable models based on random forest, the main PPG features related to ANS activation were obtained. Results showed that pulse rate variability (PRV) exhibited similar changes to HRV across the different experiments. The four ANS patterns could be better classified using more PPG-based features compared with using HRV or PRV features, for which the classification accuracies were 0.80, 0.56, and 0.57, respectively. Sensitive features of parasympathetic activation included features of nonlinear (sample entropy), frequency, and time domains of PRV. Sensitive features of sympathetic activation were features of the amplitude and frequency domain of PRV of the PPG derivatives. Subsequently, these sensitive PPG-based features were used to fit the improved HRV parameters. The fitting results were acceptable (p &lt; 0.01), which might provide a better method of evaluating ANS activity using PPG.

Cardiovascular Consequences of a Mutant Thyroid Hormone Receptor α1

2010 ◽  
Vol 6 (2) ◽  
pp. 51 ◽  
Author(s):  
Jens Mittag ◽  
Keyword(s):  
Heart Rate ◽  
Nervous System ◽  
Autonomic Nervous System ◽  
Thyroid Hormone ◽  
Cardiovascular System ◽  
Hormone Receptor ◽  
Thyroid Hormone Receptor ◽  
Cardiac Activity ◽  
Autonomic Nervous

Thyroid hormone has long been known for its profound direct effects on the cardiovascular system, but its interactions with the autonomic nervous system controlling cardiac activity still remain enigmatic. Recently, mice heterozygous for a mutant thyroid hormone receptor α1 (TRα1+/m) have been generated and their analysis has provided new insights into the actions of thyroid hormone on the cardiovascular system. The mutant TRα1 caused many symptoms resembling hypothyroidism, such as bradycardia, as well as reduced contraction and delayed relaxation time of isolated cardiomyocytes. While no abnormalities were detected in the autonomic regulation of the basal heart rate using pharmacological denervation, an impaired adjustment of the autonomic nervous system could be observed in TRα1+/m mice on activity, stress or increased temperature. The results thus confirm the important role of TRα1 in maintaining the intrinsic properties of the heart and demonstrate a novel role for TRα1 in the adaptations of the autonomic nervous system controlling the heart rate under non-baseline conditions.

Cardiovascular Consequences of a Mutant Thyroid Hormone Receptor α1

2011 ◽  
Vol 07 (01) ◽  
pp. 55
Author(s):  
Jens Mittag ◽  
Keyword(s):  
Heart Rate ◽  
Nervous System ◽  
Autonomic Nervous System ◽  
Thyroid Hormone ◽  
Cardiovascular System ◽  
Hormone Receptor ◽  
Thyroid Hormone Receptor ◽  
Cardiac Activity ◽  
Autonomic Nervous

Thyroid hormone has long been known for its profound direct effects on the cardiovascular system, but its interactions with the autonomic nervous system controlling cardiac activity still remain enigmatic. Recently, mice heterozygous for a mutant thyroid hormone receptor 〈1 (TR〈1+/m) have been generated and their analysis has provided new insights into the actions of thyroid hormone on the cardiovascular system. The mutant TR〈1 caused many symptoms resembling hypothyroidism, such as bradycardia, as well as reduced contraction and delayed relaxation time of isolated cardiomyocytes. While no abnormalities were detected in the autonomic regulation of the basal heart rate using pharmacologic denervation, an impaired adjustment of the autonomic nervous system could be observed in TR〈1+/m mice on activity, stress, or increased temperature. The results thus confirm the important role of TR〈1 in maintaining the intrinsic properties of the heart and demonstrate a novel role for TR〈1 in the adaptations of the autonomic nervous system controlling the heart rate under non-baseline conditions.

Effect of a Motivational Song on the Autonomic Nervous System and the Heart of Indian Male Volunteers

2018 ◽  
pp. 299-317 ◽  
Author(s):  
Gitika Yadu ◽  
Suraj Kumar Nayak ◽  
Debasisha Panigrahi ◽  
Sirsendu Sekhar Ray ◽  
Kunal Pal
Keyword(s):  
Heart Rate ◽  
Nervous System ◽  
Autonomic Nervous System ◽  
Electrical Activity ◽  
Stimulus Condition ◽  
Cardiac Activity ◽  
Ecg Signals ◽  
Autonomic Nervous ◽  
Cardiac Electrical Activity ◽  
Hrv Analysis

This chapter investigates the effect of a motivational song (stimulus) on the physiology of the autonomic nervous system and the electrical activity of the heart. Five min electrocardiogram (ECG) signals were acquired from 19 volunteers during the resting and the post-stimulus conditions. The RR intervals (RRIs) were extracted. Recurrence analysis of the RRI time series indicated a higher alteration (acceleration or deceleration) in the heart rate along with the reduction of the causality and patterned behavior of the RRIs. The exact alteration in the ANS physiology was examined using heart rate variability (HRV) analysis. The results of the HRV analysis suggested an increase in the parasympathetic activity in the post-stimulus condition. The alteration in the cardiac activity was analyzed using time domain and joint time-frequency domain analyses of ECG signals. The results suggested an alteration in the cardiac electrical activity of the heart in the post-stimulus condition.

scholarly journals Studies on the Raynaud's Phenomenon of Occupational Origin : II. The Function of the Autonomic Nervous System and the Cold Pressor Test

Sangyo Igaku ◽  
1967 ◽  
Vol 9 (2) ◽  
pp. 60-63
Author(s):  
Akira OKADA ◽  
Takamasa YAMASHITA ◽  
Akira KATSUTA ◽  
Minoru KASUYA ◽  
Teruo KITAZAWA ◽  
...  
Keyword(s):  
Nervous System ◽  
Autonomic Nervous System ◽  
Raynaud’S Phenomenon ◽  
Cold Pressor Test ◽  
Cold Pressor ◽  
Raynaud's Phenomenon ◽  
Autonomic Nervous ◽  
Pressor Test
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