2336 Novel PGF2a synthesis pathway in epithelial ovarian cancer
2018 ◽
Vol 2
(S1)
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pp. 22-22
Keyword(s):
OBJECTIVES/SPECIFIC AIMS: To understand the role of PGF2a and to characterize a novel cyclooxyrgenase (COX)-independent prostaglandin synthesis pathway in epithelial ovarian cancer. METHODS/STUDY POPULATION: We used high grade epithelial ovarian cancer cell line (OVCAR3) as a model to study our pathway. Our main mode of PGF2a detection is through mass spectrometry. RESULTS/ANTICIPATED RESULTS: Our current results suggest the OVCAR3 cells may synthesize PGF2a independently of COX enzymes. We anticipate this novel pathway may be dependent on the TGFb pathway. DISCUSSION/SIGNIFICANCE OF IMPACT: Understanding the role and synthesis pathway of PGF2a may allow us to uncover a novel therapeutic pathway for high grade ovarian cancer.
2016 ◽
Vol 14
(12)
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pp. 2179
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2001 ◽
Vol 86
(5)
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pp. 2144-2152
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1999 ◽
Vol 57
(7)
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pp. 753-762
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2002 ◽
Vol 87
(8)
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pp. 3721-3727
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2005 ◽
Vol 275
(1-2)
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pp. 25-55
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