Maternal Age and Parity as Predictors of Human Twinning

1990 ◽  
Vol 39 (3) ◽  
pp. 329-334 ◽  
Author(s):  
B. Bønnelykke
Keyword(s):  
Logistic Regression ◽  
Regression Analysis ◽  
Random Sample ◽  
Maternal Age ◽  
Case Control Study ◽  
Positive Association ◽  
Case Control ◽  
Negative Association ◽  
Medical Birth Register ◽  
Control Study

AbstractA case-control study was conducted to evaluate the association between maternal age and parity and dizygotic (DZ) and monozygotic (MZ) twinning, respectively. Mothers of all twins born alive in Denmark in 1984 or 1985 were included into the study as cases, and a random sample of mothers of singletons were controls. Data on maternal age at delivery and number of previous births were collected from the Danish Medical Birth Register. By means of logistic regression analysis, a significant and positive association was found betwen maternal age and DZ twinning, and a significant and negative association between parity and MZ twinning. No association was found for parity and DZ twinning, nor for maternal age and MZ twinning. The study suggests that human MZ twinning has predictors too, as has DZ twinning. The finding has implications for zygosity classification in future twin research.

scholarly journals Red blood cell membrane trans fatty acid levels and risk of non-Hodgkin lymphoma: a prospective nested case–control study

2020 ◽  
Vol 112 (6) ◽  
pp. 1576-1583
Author(s):  
Andres V Ardisson Korat ◽  
Yu-Han Chiu ◽  
Kimberly A Bertrand ◽  
Shumin Zhang ◽  
Mara M Epstein ◽  
...  
Keyword(s):  
Logistic Regression ◽  
Fatty Acid ◽  
Case Control Study ◽  
Positive Association ◽  
Case Control ◽  
Blood Draw ◽  
Non Hodgkin Lymphoma ◽  
Rbc Membrane ◽  
Nested Case Control ◽  
Control Study

ABSTRACT Background Trans fatty acid (TFA) intake persists in much of the world, posing ongoing threats to public health that warrant further elucidation. Published evidence suggests a positive association of self-reported TFA intake with non-Hodgkin lymphoma (NHL) risk. Objectives To confirm those reports, we conducted a prospective study of prediagnosis RBC membrane TFA levels and risk of NHL and common NHL histologic subtypes. Methods We conducted a nested case–control study in Nurses’ Health Study and Health Professionals Follow-Up Study participants with archived RBC specimens and no history of cancer at blood draw (1989–1090 and 1994–1995, respectively). We confirmed 583 incident NHL cases (332 women and 251 men) and individually matched 583 controls on cohort (sex), age, race, and blood draw date/time. We analyzed RBC membrane TFA using GLC (in 2013–2014) and expressed individual TFA levels as a percentage of total fatty acids. We used unconditional logistic regression adjusted for the matching factors to estimate ORs and 95% CIs for overall NHL risk per 1 SD increase in TFA level and assessed histologic subtype-specific associations with multivariable polytomous logistic regression. Results Total and individual TFA levels were not associated with risk of all NHL or most subtypes. We observed a positive association of total TFA levels with diffuse large B cell lymphoma (DLBCL) risk [n = 98 cases; OR (95% CI) per 1 SD increase: 1.30 (1.05, 1.61); P = 0.015], driven by trans 18:1n–9(ω-9)/elaidic acid [OR (95% CI): 1.34 (1.08, 1.66); P = 0.007], trans 18:1n–7/vaccenic acid [OR (95% CI): 1.28 (1.04, 1.58); P = 0.023], and trans 18:2n–6t,t [OR (95% CI): 1.26 (1.01, 1.57); P = 0.037]. Conclusions Our findings extended evidence for TFA intake and DLBCL risk but not for other NHL subtypes. Reduced TFA consumption through dietary choices or health policy measures may support prevention of DLBCL, an aggressive NHL subtype.

A Case-Control Study of the Association of the Polymorphisms of MTHFR and APOE with Risk Factors and the Severity of Coronary Artery Disease

Cardiology ◽  
2019 ◽  
Vol 142 (3) ◽  
pp. 149-157 ◽  
Author(s):  
Yan Long ◽  
Xiao-Tao Zhao ◽  
Chang Liu ◽  
Yuan-Yuan Sun ◽  
Yin-Ting Ma ◽  
...  
Keyword(s):  
Risk Factors ◽  
Logistic Regression ◽  
Regression Analysis ◽  
Logistic Regression Analysis ◽  
Sanger Sequencing ◽  
Case Control Study ◽  
Case Control ◽  
Chinese Han ◽  
Han Population ◽  
Control Study

Objectives: To explore the association between single-nucleotide polymorphisms (SNPs) in MTHFR and APOE and the risk of CAD and, more importantly, the severity of CAD and the profile of serum lipids, we performed a case-control study in a Chinese Han population. Methods: A total of 1,207 cases of consecutive CAD-suspected inpatients were recruited, and 406 CAD cases and 231 non-CAD controls were enrolled for the final analysis after screening for exclusion criteria. All subjects had undergone coronary angiography, and the severity of CAD was evaluated by 2 cardiologists according to the Gensini scores. The genotypes of MTHFR and APOEwere detected using real-time PCR, and then verified by Sanger sequencing. Environmental risk factors, such as age, sex, smoking, alcohol consumption, hypertension, diabetes, dyslipidemia, and BMI were collected. Statistical analyses (the χ2 test, binary logistic regression analysis, and ordinal polytomous logistic regression analysis) were performed with SPSS v16.0. Results: The genotypes ofall the subjects included in the CAD and non-CAD groups in this study were successfully detected, with an agreement of 100% with Sanger sequencing. The distributions of genotypes CT and TT at MTHFR C667T were higher in CAD cases than in non-CAD controls (OR 1.99, 95% CI 1.34–2.95; OR 1.77, 95% CI 1.18–2.67; p < 0.05), whereas genotype AC at MTHFR A1298Cwas lower in CAD cases (OR 0.71, 95% CI 0.50–1.02; p < 0.05). A significant association was observed in genotypes CT and TT at MTHFR C667T and the risk of CAD (OR 1.44, 95% CI 1.27–3.67; OR 1.56, 95% CI 0.88–2.78; p < 0.05). Both genotypes and alleles of APOE were comparable in the CAD cases and non-CAD controls (p > 0.05). The genotype TT at MTHFR C667T and ε4+ at APOE were more likely to be found in the CAD subgroup with a Gensini score ≥72 (p = 0.040 and p = 0.028, respectively). Meanwhile, in the patients with genotype TT,a higher level of serum Hcy was detected, while genotype ε4+ patients possessed higher levels of serum apolipoprotein E (ApoE) and low-density lipoprotein cholesterol (LDL-C) than other genotypes. Conclusion: This study revealed that the SNP site of MTHFR C667Tis associatedwith the risk of CAD in this Chinese Han population. In addition, the genotypes of TT in MTHFR C667T and ε4+in APOE may increase the severity of CAD, and higher Hcy, LDL-C, and ApoE levels may be involved in this pathogenic process.

scholarly journals Siesta and Risk for Ischemic Stroke: Results from a Case-Control Study

Medicina ◽  
2020 ◽  
Vol 56 (5) ◽  
pp. 222
Author(s):  
Yousef Mohammad
Keyword(s):  
Logistic Regression ◽  
Regression Analysis ◽  
Ischemic Stroke ◽  
Protective Effect ◽  
Case Control Study ◽  
Multivariate Logistic Regression Analysis ◽  
Case Control ◽  
Multivariate Logistic Regression ◽  
Neurology Clinic ◽  
Control Study

Background and objectives: Siesta, which is a short afternoon nap, is a habit that is commonly practiced in the Mediterranean and tropical areas. Data on the association between siesta and coronary artery disease has been conflicting. A protective effect has been demonstrated in the countries that commonly practice siesta, but a harmful effect has been observed in the countries that infrequently practice the siesta habit. Information on the association between siesta and ischemic stroke has been, however, lacking. Hence, the purpose of our study was to determine the effect of siesta on ischemic stroke. Materials and Methods: This was a case-control study, conducted on the patients with acute ischemic stroke who came for their first follow-up visit to the neurology clinic. Controls were randomly selected from the patients visiting the neurology clinic on the same day as the patients with ischemic stroke. In addition to basic demographics and the occurrence of established stroke risk factors, information about siesta practice was also collected from both groups. A multivariate logistic regression analysis was utilized to determine the relationship between siesta practice and ischemic stroke. Results: A total of 206 patients were recruited from the neurology clinic of King Khalid university hospital; of which only 194 subjects were included in the analysis (98 ischemic stroke cases and 96 controls). The mean age of the participants was 59.68 ± 13.75 years and 98 (50.52%) were male. Interestingly, 43% of the whole study cohort practiced regular siesta. However, when compared to the stroke population, the control group practiced siesta more frequently (30% vs. 56%). In a multivariate logistic regression analysis, hypertension, diabetes mellitus, excess body weight (body mass index > 25 kg/m2) and dyslipidemia were found to increase the risk of ischemic stroke (OR 2.12, 95% CI: 1.02–4.66, p = 0.005; OR 2.72, 95% CI: 1.94–4.88, p = 0.014; OR 2.94, 95% CI: 1.5164–5.7121 p = 0.0014; OR 3.27, 95% CI: 2.42–5.199, p ≤ 0.001, respectively). On the contrary, the practice of regular siesta lowered the risk of ischemic stroke (OR 0.58, 95% CI: 0.3551–0.9526, p = 0.031). Conclusions: Siesta was associated with a reduced risk for the occurrence of ischemic stroke. Large prospective longitudinal studies should be conducted to verify the protective effect of siesta on stroke.

scholarly journals Determinants of postnatal care non-utilization among women in Demba Gofa rural district, southern Ethiopia: a community-based unmatched case-control study

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Markos Manote ◽  
Tsegaye Gebremedhin
Keyword(s):  
Logistic Regression ◽  
Regression Analysis ◽  
Postnatal Care ◽  
Case Control Study ◽  
Care Service ◽  
Case Control ◽  
Rural District ◽  
Southern Ethiopia ◽  
Community Based ◽  
Control Study

Abstract Background Maternal and neonatal mortality remain a significant problem across much of the developing world, especially in sub-Saharan Africa countries. In Ethiopia, most maternal and neonatal deaths occur during the postpartum period; this is a critical time for monitoring the health of women and newborns, but the most neglected period for care. In rural communities of Ethiopia, the utilization of postnatal care service is very low and evidence on which factors contribute to the non-utilization of postnatal care (PNC) is insufficient. Consequently, this study was designed to identify the determinants of postnatal service non-utilization among women who gave birth in Demba Gofa rural district, Southern Ethiopia. Methods A community-based unmatched case-control study was conducted among 186 cases (postnatal care non-utilizers) and 186 controls (postnatal care utilizers) in Demba Gofa rural district from March 1 to April 10, 2019. A previously tested interviewer-administered structured questionnaire was used for data collection. Binary logistic regression analysis was performed. In the final multivariable logistic regression analysis model, a p-value of less than 0.05 and an Adjusted Odd Ratio (AOR) with a 95% confidence interval (CI) was used to determine variables for postnatal care non-utilization. Results In this study, women who delivered recently were incorporated within 186 cases and 186 controls. Not knowing the availability of PNC services (AOR: 4.33, 95% CI: 1.71–10.99), having a home delivery (AOR: 7.06, 95% CI: 3.71–13.44), ANC non-attendance (AOR: 6.14, 95% CI: 3.01–12.50), unable to make an independent decision (AOR: 9.31, 95% CI: 3.29–26.35), and not participating in the Women’s Development Army (WDA) (AOR: 5.09, 95% CI: 2.73–9.53) comprised the determinants which were assessed for non-utilization of postnatal care services. Conclusions Encouraging institutional delivery along with integrated health education about postnatal care and postnatal danger signs, empowering women to execute independent decisions, accessing PNC services and strengthening participation in the Model Families will likely improve postnatal care service utilization in the district of Ethiopia.

scholarly journals Analysis of the causes and influencing factors of fetal loss in advanced maternal age: a nested case-control study

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Xiaomei Wang ◽  
Yuan Lin ◽  
Zhaozhen Liu ◽  
Xinxin Huang ◽  
Rongxin Chen ◽  
...  
Keyword(s):  
Logistic Regression ◽  
Maternal Age ◽  
Case Control Study ◽  
Fetal Loss ◽  
Advanced Maternal Age ◽  
Case Control ◽  
High School Education ◽  
Factors Influencing ◽  
Nested Case Control ◽  
Control Study

Abstract Background The risk of fetal loss is higher among ≥35-year-olds than younger women. The present study aimed to explore the causes and factors influencing fetal loss in advanced maternal age (AMA). Methods AMA women with singleton fetuses (< 14 gestational weeks) who underwent their first prenatal examination in the Obstetrics Department of Fujian Maternity and Child Health Hospital from December 2018 to June 2020 were included in this cohort study. Those who terminated the pregnancy before 14 gestational weeks were excluded. A baseline survey was conducted, and follow-up was carried out until the termination of the pregnancy. Clinical data were extracted to analyse the causes of fetal loss among them. In the nested case-control study, the AMA women with fetal loss were enrolled as the case group, and women without fetal loss in the same period were enrolled as the control group, in a 1:2 ratio matched by age and gestational weeks. Logistic regression models were used to analyse the factors influencing fetal loss. Results A total of 239 women with fetal loss and 478 controls were enrolled. The causes of fetal loss were most often fetal factors, followed by maternal factors, umbilical cord factors, and placental factors. Multivariate logistic regression analysis indicated that junior high school education and below (adjusted odds ratio (aOR) = 5.13, 95% confidence interval (CI): 2.19–12.02), senior high school education (aOR = 4.91, 95% CI: 2.09–11.54), residence in a rural area (aOR = 2.85, 95% CI: 1.92–4.25), unemployment (aOR = 1.81, 95% CI: 1.20–2.71), spontaneous abortion history (aOR = 1.88, 95% CI: 1.26–2.80), preterm birth history (aOR = 11.08, 95% CI: 2.90–42.26), hypertensive disorders of pregnancy (aOR = 7.20, 95% CI: 2.24–23.12), and preterm premature rupture of membranes (aOR = 4.12, 95% CI: 1.53–11.11) were risk factors for fetal loss. Conclusions Low educational level, unemployment, abnormal pregnancy/labor history, and pregnancy complications were correlated with the incidence of fetal loss in AMA. Thus, early identification as well as a targeted intervention, should be conducted.

scholarly journals A Retrospective Case-control Study on a Triad of Risk Predictors Associated With Periodontitis; a Regression Analysis

2021 ◽  
Author(s):  
HINA MAHMOOD ◽  
SEHAR NAEEM ◽  
UZMA SAEED ◽  
BATOOL ZARA
Keyword(s):  
Regression Analysis ◽  
Case Control Study ◽  
Positive Association ◽  
Case Control ◽  
Binary Logistic Regression Analysis ◽  
Retrospective Case ◽  
Dental Visits ◽  
Education Status ◽  
Risk Predictors ◽  
Control Study

Abstract AIMS: This case-control study was conducted to analyze the association of periodontitis with risk predictors i.e. education status, brushing habits and past dental visits in systemically healthy patients. MATERIALS AND METHODS: A total of 1097 systemically healthy, non-tobacco using patients with age ≥18 years who reported to periodontology department were included. The demographic details and dental care pattern of the patients were extracted from the records of periodontology department and their frequencies were formulated. The association of three predicting factors i.e. education status, brushing habits and past dental visits was assessed on SPSS using binary logistic regression analysis. RESULTS: A total of 471(42.9%) patients were diagnosed with periodontitis. Higher frequency of periodontitis was observed in patients who were male and >50 years of age. Subjects with ≥ 12 years of education, regular brushing habits and regular past dental visits showed greater odds of being safe from periodontitis. CONCLUSIONS: A positive association between the study variables and periodontitis was observed, which will help the clinicians in prediction of periodontitis in systemically healthy, non-smoking individuals. It also indicates a need of tailor made dental educational and awareness programs for prevention and control of periodontitis in systemically healthy individuals.

scholarly journals Coffee consumption and the risk of polycystic ovary syndrome: evidence from a case-control study

2021 ◽  
Author(s):  
Yue Wang ◽  
Yin Yang ◽  
Hui Deng ◽  
Xiao-Qing Bu ◽  
Tian Li ◽  
...  
Keyword(s):  
Logistic Regression ◽  
Regression Analysis ◽  
Polycystic Ovary Syndrome ◽  
Case Control Study ◽  
Polycystic Ovary ◽  
Coffee Consumption ◽  
Case Control ◽  
Confounding Factors ◽  
Ovary Syndrome ◽  
Control Study

Abstract Background Coffee has become one of the most common beverages worldwide. Some components in coffee have been reported to be beneficial to the regulation of hormones related to polycystic ovary syndrome(PCOS), and therefore may limit the development of PCOS. However, epidemiological evidence on the relationship between coffee consumption and PCOS is limited. In this study, we aimed at investigating the association between coffee consumption and PCOS risk. Methods The study was a hospital-based case-control study conducted at Chongqing Hospital of Traditional Chinese Medicine, China, from July 2018 to January 2020. Data was collected from 206 women with PCOS and 206 healthy women. A self-designed structured questionnaire was employed to collect relevant information from study participants. Sleep quality was evaluated by Pittsburgh Sleep Quality Index (PSQI). Logistic regression analysis was used to calculate odds ratios (ORs) and 95% confidence intervals (95% CI), adjusted for other confounding factors. Results A statistically significant inverse correlation was observed between coffee consumption and PCOS. After adjusting all potential confounding factors, the results of logistic regression analysis showed that compared to non-drinker, the ORs(95%CI) for ≤ 1 cup/week, 2–3 cups/week and > 3 cups/week were 0.322(0.180–0.574), 0.263(0.104–0.664) and 0.152(0.046–0.563), respectively, and the linear trend was also statistically significant(P for trend < 0.01). Conclusions Coffee consumption was found to be associated with a reduced risk of PCOS. Given the scarcity of studies on coffee consumption and PCOS, as well as the inherent limitations of our study, the prospective cohort studies in the future are needed to verify our results.

scholarly journals Predictors of postoperative acute exacerbation of interstitial lung disease: a case–control study

2020 ◽  
Vol 7 (1) ◽  
pp. e000634
Author(s):  
Keisuke Hosoki ◽  
Yu Mikami ◽  
Hirokazu Urushiyama ◽  
Kunihiko Souma ◽  
Gaku Kawamura ◽  
...  
Keyword(s):  
Logistic Regression ◽  
Regression Analysis ◽  
Interstitial Lung Disease ◽  
Lung Disease ◽  
Acute Exacerbation ◽  
Case Control Study ◽  
Conditional Logistic Regression ◽  
Case Control ◽  
Conditional Logistic Regression Analysis ◽  
Control Study

IntroductionPatients with interstitial lung disease (ILD) are known to develop an acute exacerbation (AE) after surgery. Previous studies have evaluated the predictors of postoperative AE. However, it remains unclear whether the results of those studies can be generalised to patients with different types of ILD and/or extrapolated to those who undergo non-pulmonary surgery. This study aimed to elucidate the predictors of the development of AE after surgery with general anaesthesia in patients with ILD.MethodsWe conducted a nested matched case–control study of 700 patients from an initial cohort of 50 840 patients. We excluded those who underwent solid organ or bone marrow transplantation. The cases were patients with ILD who developed AE within 30 days postoperatively, whereas the controls did not develop AE. Each case (n=28) was matched with four controls (n=112) for sex, year of surgery and multiple operations within 30 days. Furthermore, a multivariable conditional logistic regression analysis was used to identify significant predictors, as indicated by a p value of <0.05.ResultsAfter adjusting for potential confounders, the multivariable conditional logistic regression analysis identified honeycombing on CT (OR 3.09; 95% CI 1.07 to 8.92), a per cent predicted FVC <80% (OR 4.21; 95% CI 1.46 to 12.2) and an ARISCAT score ≥45 (OR 6.14; 95% CI 2.10 to 18.0) significantly associated with the development of postoperative AE.ConclusionsWe found that the three factors were independent predictors for the development of postoperative AE in patients with ILD. These predictors are advantageous because they can be readily evaluated before surgery by surgeons and anaesthesiologists even without consulting experienced pulmonologists.

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