scholarly journals Red blood cell membrane trans fatty acid levels and risk of non-Hodgkin lymphoma: a prospective nested case–control study

2020 ◽  
Vol 112 (6) ◽  
pp. 1576-1583
Author(s):  
Andres V Ardisson Korat ◽  
Yu-Han Chiu ◽  
Kimberly A Bertrand ◽  
Shumin Zhang ◽  
Mara M Epstein ◽  
...  
Keyword(s):  
Logistic Regression ◽  
Fatty Acid ◽  
Case Control Study ◽  
Positive Association ◽  
Case Control ◽  
Blood Draw ◽  
Non Hodgkin Lymphoma ◽  
Rbc Membrane ◽  
Nested Case Control ◽  
Control Study

ABSTRACT Background Trans fatty acid (TFA) intake persists in much of the world, posing ongoing threats to public health that warrant further elucidation. Published evidence suggests a positive association of self-reported TFA intake with non-Hodgkin lymphoma (NHL) risk. Objectives To confirm those reports, we conducted a prospective study of prediagnosis RBC membrane TFA levels and risk of NHL and common NHL histologic subtypes. Methods We conducted a nested case–control study in Nurses’ Health Study and Health Professionals Follow-Up Study participants with archived RBC specimens and no history of cancer at blood draw (1989–1090 and 1994–1995, respectively). We confirmed 583 incident NHL cases (332 women and 251 men) and individually matched 583 controls on cohort (sex), age, race, and blood draw date/time. We analyzed RBC membrane TFA using GLC (in 2013–2014) and expressed individual TFA levels as a percentage of total fatty acids. We used unconditional logistic regression adjusted for the matching factors to estimate ORs and 95% CIs for overall NHL risk per 1 SD increase in TFA level and assessed histologic subtype-specific associations with multivariable polytomous logistic regression. Results Total and individual TFA levels were not associated with risk of all NHL or most subtypes. We observed a positive association of total TFA levels with diffuse large B cell lymphoma (DLBCL) risk [n = 98 cases; OR (95% CI) per 1 SD increase: 1.30 (1.05, 1.61); P = 0.015], driven by trans 18:1n–9(ω-9)/elaidic acid [OR (95% CI): 1.34 (1.08, 1.66); P = 0.007], trans 18:1n–7/vaccenic acid [OR (95% CI): 1.28 (1.04, 1.58); P = 0.023], and trans 18:2n–6t,t [OR (95% CI): 1.26 (1.01, 1.57); P = 0.037]. Conclusions Our findings extended evidence for TFA intake and DLBCL risk but not for other NHL subtypes. Reduced TFA consumption through dietary choices or health policy measures may support prevention of DLBCL, an aggressive NHL subtype.

A nested case-control study of non-Hodgkin lymphoma and serum organochlorine residues

The Lancet ◽  
1997 ◽  
Vol 350 (9073) ◽  
pp. 240-244 ◽  
Author(s):  
Nathaniel Rothman ◽  
Kenneth P Cantor ◽  
Aaron Blair ◽  
David Bush ◽  
John W Brock ◽  
...  
Keyword(s):  
Hodgkin Lymphoma ◽  
Case Control Study ◽  
Case Control ◽  
Non Hodgkin Lymphoma ◽  
Nested Case Control ◽  
Control Study

scholarly journals Blood fatty acid patterns are associated with prostate cancer risk in a prospective nested case–control study

2016 ◽  
Vol 27 (9) ◽  
pp. 1153-1161 ◽  
Author(s):  
Meng Yang ◽  
Azalea Ayuningtyas ◽  
Stacey A. Kenfield ◽  
Howard D. Sesso ◽  
Hannia Campos ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Fatty Acid ◽  
Cancer Risk ◽  
Case Control Study ◽  
Prostate Cancer Risk ◽  
Case Control ◽  
Fatty Acid Patterns ◽  
Nested Case Control ◽  
Control Study

scholarly journals Associations between metabolites and pancreatic cancer risk in a large prospective epidemiological study

Gut ◽  
2020 ◽  
Vol 69 (11) ◽  
pp. 2008-2015 ◽  
Author(s):  
Rachael Stolzenberg-Solomon ◽  
Andriy Derkach ◽  
Steven Moore ◽  
Stephanie J Weinstein ◽  
Demetrius Albanes ◽  
...  
Keyword(s):  
Fixed Effects ◽  
Case Control Study ◽  
Conditional Logistic Regression ◽  
Case Control ◽  
Ductal Adenocarcinoma ◽  
Blood Collection ◽  
Blood Draw ◽  
Metabolite Level ◽  
Nested Case Control ◽  
Control Study

ObjectiveTo assess whether prediagnostic metabolites were associated with incident pancreatic ductal adenocarcinoma (PDAC) in a prospective cohort study.DesignWe conducted an untargeted analysis of 554 known metabolites measured in prediagnostic serum (up to 24 years) to determine their association with incident PDAC in a nested case-control study of male smokers (372 matched case-control sets) and an independent nested case-control study that included women and non-smokers (107 matched sets). Metabolites were measured using Orbitrap Elite or Q-Exactive high-resolution/accurate mass spectrometers. Controls were matched to cases by age, sex, race, date of blood draw, and follow-up time. We used conditional logistic regression adjusted for age to calculate ORs and 95% CIs for a 1 SD increase in log-metabolite level separately in each cohort and combined the two ORs using a fixed-effects meta-analysis.ResultsThirty-one metabolites were significantly associated with PDAC at a false discovery rate <0.05 with 12 metabolites below the Bonferroni-corrected threshold (p<9.04×10–5). Similar associations were observed in both cohorts. The dipeptides glycylvaline, aspartylphenylalanine, pyroglutamylglycine, phenylalanylphenylalanine, phenylalanylleucine and tryptophylglutamate and amino acids aspartate and glutamate were positively while the dipeptides tyrosylglutamine and α-glutamyltyrosine, fibrinogen cleavage peptide DSGEGDFXAEGGGVR and glutathione-related amino acid cysteine-glutathione disulfide were inversely associated with PDAC after Bonferroni correction. Five top metabolites demonstrated significant time-varying associations (p<0.023) with the strongest associations observed 10–15 years after participants’ blood collection and attenuated thereafter.ConclusionOur results suggest that prediagnostic metabolites related to subclinical disease, γ-glutamyl cycle metabolism and adiposity/insulin resistance are associated with PDAC.

Maternal Age and Parity as Predictors of Human Twinning

1990 ◽  
Vol 39 (3) ◽  
pp. 329-334 ◽  
Author(s):  
B. Bønnelykke
Keyword(s):  
Logistic Regression ◽  
Regression Analysis ◽  
Random Sample ◽  
Maternal Age ◽  
Case Control Study ◽  
Positive Association ◽  
Case Control ◽  
Negative Association ◽  
Medical Birth Register ◽  
Control Study

AbstractA case-control study was conducted to evaluate the association between maternal age and parity and dizygotic (DZ) and monozygotic (MZ) twinning, respectively. Mothers of all twins born alive in Denmark in 1984 or 1985 were included into the study as cases, and a random sample of mothers of singletons were controls. Data on maternal age at delivery and number of previous births were collected from the Danish Medical Birth Register. By means of logistic regression analysis, a significant and positive association was found betwen maternal age and DZ twinning, and a significant and negative association between parity and MZ twinning. No association was found for parity and DZ twinning, nor for maternal age and MZ twinning. The study suggests that human MZ twinning has predictors too, as has DZ twinning. The finding has implications for zygosity classification in future twin research.

scholarly journals N-6 and N-3 Fatty Acid Cholesteryl Esters in Relation to Fatal CHD in a Dutch Adult Population: A Nested Case-Control Study and Meta-Analysis

PLoS ONE ◽  
2013 ◽  
Vol 8 (5) ◽  
pp. e59408 ◽  
Author(s):  
Janette de Goede ◽  
W. M. Monique Verschuren ◽  
Jolanda M. A. Boer ◽  
Lisa D. M. Verberne ◽  
Daan Kromhout ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Case Control Study ◽  
Meta Analysis ◽  
Adult Population ◽  
Case Control ◽  
Cholesteryl Esters ◽  
Nested Case Control ◽  
Control Study
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