Dietary flavonoid intake and colorectal cancer: a case–control study

Diets rich in flavonoids may reduce the risk of developing colorectal cancer. Flavonoids are widely distributed in foods of plant origin, though in the UK tea is the main dietary source. Our objective was to evaluate any independent associations of total dietary and non-tea intake of four flavonoid subclasses and the risk of developing colorectal cancer in a tea-drinking population with a high colorectal cancer incidence. A population-based case–control study (264 cases with histologically confirmed incident colorectal cancer and 408 controls) was carried out. Dietary data gathered by FFQ were used to calculate flavonoid intake. Adjusted OR and 95 % CI were estimated by logistic regression. No linear association between risk of developing colorectal cancer and total dietary flavonol, procyanidin, flavon-3-ol or flavanone intakes was found, but non-tea flavonol intake was inversely associated with colorectal cancer risk (OR 0·6; 95 % CI 0·4, 1·0). Stratification by site of cancer and assessment of individual flavonols showed a reduced risk of developing colon but not rectal cancer with increasing non-tea quercetin intake (OR 0·5; 95 % CI 0·3, 0·8; Ptrend < 0·01). We concluded that flavonols, specifically quercetin, obtained from non-tea components of the diet may be linked with reduced risk of developing colon cancer.

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Levothyroxine use and the risk of colorectal cancer: a large population-based case-control study

Endocrine Connections ◽

10.1530/ec-21-0463 ◽

2021 ◽

Author(s):

Josephina G. Kuiper ◽

Aline C. Fenneman ◽

Anne H. van der Spek ◽

Elena Rampanelli ◽

Max Nieuwdorp ◽

...

Keyword(s):

Colorectal Cancer ◽

Odds Ratio ◽

Treatment Duration ◽

Case Control Study ◽

Significant Risk ◽

Population Based ◽

Case Control ◽

Colorectal Cancer Patients ◽

Control Study ◽

Reduced Risk

Objective: Whether an association between oral levothyroxine use, leading to supraphysiological exposure of the colon to thyroid hormones, and risk of colorectal cancer exists in humans is unclear. We therefore aimed to assess whether the use of levothyroxine is associated with a reduced risk of colorectal cancer in a linked cohort of pharmacy and cancer data. Design: Population-based matched case-control study. Methods: A total of 28,121 patients diagnosed with colorectal cancer between 1998-2014 were matched to 106,086 controls. Multivariable logistic regression was used to estimate the association between levothyroxine use and occurrence of colorectal cancer, adjusted for potential confounders. Results were stratified by gender, age, tumour subtype and staging as well as treatment duration and dosing. Results: A total of 1066 colorectal cancer patients (4%) and 4024 (4%) controls had used levothyroxine at any point before index date (adjusted odds ratio 0.95 [0.88-1.01]). Long-term use of levothyroxine was seen in 323 (30%) colorectal cancer patients and 1111 (28%) controls (adjusted odds ratio 1.00 [0.88-1.13]). Stratification by tumour subsite showed a borderline significant risk reduction of rectal cancer, while this was not seen for proximal colon cancer or distal colon cancer. There was no relationship with treatment duration or with levothyroxine dose. Conclusions: In this study, no reduced risk of colorectal cancer was seen in levothyroxine users. When stratifying by tumour subsite, a borderline significant risk reduction of rectal cancer was found and may warrant further research.

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Dietary flavonoid intake and lung cancer-A population-based case-control study

Cancer ◽

10.1002/cncr.23398 ◽

2008 ◽

Vol 112 (10) ◽

pp. 2241-2248 ◽

Cited By ~ 93

Author(s):

Yan Cui ◽

Hal Morgenstern ◽

Sander Greenland ◽

Donald P. Tashkin ◽

Jenny T. Mao ◽

...

Keyword(s):

Lung Cancer ◽

Case Control Study ◽

Population Based ◽

Case Control ◽

Flavonoid Intake ◽

Dietary Flavonoid ◽

Control Study

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Gene-diet interactions in the aetiology of colorectal cancer: results from a population-based case-control study in north-east Scotland

Endoscopy ◽

10.1055/s-2005-922879 ◽

2006 ◽

Vol 37 (12) ◽

Author(s):

L Sharp ◽

LF Masson ◽

J Little ◽

NT Brockton ◽

SC Cotton ◽

...

Keyword(s):

Colorectal Cancer ◽

Case Control Study ◽

Population Based ◽

Case Control ◽

North East ◽

Control Study

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Faculty Opinions recommendation of Tea drinking and the risk of biliary tract cancers and biliary stones: a population-based case-control study in Shanghai, China.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.14785.472314 ◽

2006 ◽

Author(s):

Suzanne C Ho

Keyword(s):

Biliary Tract ◽

Case Control Study ◽

Population Based ◽

Case Control ◽

Biliary Stones ◽

Biliary Tract Cancers ◽

Tea Drinking ◽

Control Study

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Tea drinking and the risk of biliary tract cancers and biliary stones: A population-based case–control study in Shanghai, China

International Journal of Cancer ◽

10.1002/ijc.21748 ◽

2006 ◽

Vol 118 (12) ◽

pp. 3089-3094 ◽

Cited By ~ 24

Author(s):

Xue-Hong Zhang ◽

Gabriella Andreotti ◽

Yu-Tang Gao ◽

Jie Deng ◽

Enju Liu ◽

...

Keyword(s):

Biliary Tract ◽

Case Control Study ◽

Population Based ◽

Case Control ◽

Biliary Stones ◽

Biliary Tract Cancers ◽

Tea Drinking ◽

Control Study

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0058 Colorectal cancer risk and shift work in a population-based case-control study in Spain (MCC-Spain)

Occupational and Environmental Medicine ◽

10.1136/oemed-2014-102362.16 ◽

2014 ◽

Vol 71 (Suppl 1) ◽

pp. A5.3-A6 ◽

Cited By ~ 5

Author(s):

Kyriaki Papantoniou ◽

Manolis Kogevinas ◽

Vicente Martin Sanchez ◽

Victor Moreno ◽

Marina Pollan ◽

...

Keyword(s):

Colorectal Cancer ◽

Cancer Risk ◽

Shift Work ◽

Case Control Study ◽

Population Based ◽

Case Control ◽

Colorectal Cancer Risk ◽

Control Study

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Population-based case-control study: chemoprotection of colorectal cancer with non-aspirin nonsteroidal anti-inflammatory drugs and other drugs for pain control

Alimentary Pharmacology & Therapeutics ◽

10.1111/apt.15333 ◽

2019 ◽

Vol 50 (3) ◽

pp. 295-305 ◽

Cited By ~ 1

Author(s):

Antonio Rodríguez-Miguel ◽

Luis A. García-Rodríguez ◽

Miguel Gil ◽

Diana Barreira-Hernández ◽

Sara Rodríguez-Martín ◽

...

Keyword(s):

Colorectal Cancer ◽

Pain Control ◽

Case Control Study ◽

Population Based ◽

Case Control ◽

Inflammatory Drugs ◽

Anti Inflammatory ◽

Control Study

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The Association Between Sleep Disorders and the Risk of Colorectal Cancer in Patients: A Population-based Nested Case–Control Study

In Vivo ◽

10.21873/invivo.11513 ◽

2019 ◽

Vol 33 (2) ◽

pp. 573-579 ◽

Cited By ~ 7

Author(s):

CHIA-LING LIN ◽

TA-CHUN LIU ◽

YA-NI WANG ◽

CHI-HSIANG CHUNG ◽

WU-CHIEN CHIEN

Keyword(s):

Colorectal Cancer ◽

Sleep Disorders ◽

Case Control Study ◽

Population Based ◽

Case Control ◽

Nested Case Control ◽

Control Study

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Association between shiftwork and the risk of colorectal cancer in females: a population-based case–control study

Occupational and Environmental Medicine ◽

10.1136/oemed-2017-104657 ◽

2018 ◽

Vol 75 (5) ◽

pp. 344-350 ◽

Cited By ~ 11

Author(s):

Wa Mwenga Walasa ◽

Renee N Carey ◽

Si Si ◽

Lin Fritschi ◽

Jane S Heyworth ◽

...

Keyword(s):

Colorectal Cancer ◽

Cancer Risk ◽

Case Control Study ◽

Early Morning ◽

Population Based ◽

Case Control ◽

Colorectal Cancer Risk ◽

Adverse Health Outcomes ◽

Increased Risk ◽

Control Study

ObjectiveResearch indicates that shiftwork may be associated with increased risks of adverse health outcomes, including some cancers. However, the evidence of an association between shiftwork and colorectal cancer risk is limited and inconclusive. Further, while several possible pathways through which shiftwork might result in cancer have been proposed, few studies have taken these factors into account. We investigated the association between two types of shiftwork (graveyard shiftwork and early-morning shiftwork) and six mechanistic shiftwork variables (including light at night and phase shift) and the risk of colorectal cancer among females in an Australian population-based case–control study. Graveyard shiftwork was the primary exposure of interest.MethodsParticipants (350 cases and 410 controls) completed a lifetime occupational history, and exposure to each of the eight shiftwork variables was assigned to participants through a job exposure matrix. We used logistic regression to calculate odds ratios (OR) and corresponding 95% confidence intervals (CI) for the association between different shiftwork variables and the risk of colorectal cancer, adjusting for potential demographic, lifestyle and medical confounders.ResultsWorking in an occupation involving long-term exposure (>7.5 years) to graveyard shiftwork was not associated with colorectal cancer risk (adjusted OR 0.95, 95% CI 0.57 to 1.58). Similarly, no increased risks of colorectal cancer were seen for any of the other seven shiftwork variables examined.ConclusionsNo evidence of an increased risk of colorectal cancer among females who had worked in occupations involving shiftwork was observed in this study.

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