scholarly journals Serum 25-hydroxyvitamin D concentrations and cardiometabolic risk factors in adolescents and young adults

2016 ◽  
Vol 115 (11) ◽  
pp. 1994-2002 ◽  
Author(s):  
Lucinda J. Black ◽  
Sally Burrows ◽  
Robyn M. Lucas ◽  
Carina E. Marshall ◽  
Rae-Chi Huang ◽  
...  
Keyword(s):  
Risk Factors ◽  
Insulin Resistance ◽  
Vitamin D ◽  
Cardiometabolic Risk ◽  
Hdl Cholesterol ◽  
Cardiometabolic Risk Factors ◽  
Inverse Association ◽  
Hydroxyvitamin D ◽  
25 Hydroxyvitamin D ◽  
Over Time

AbstractEvidence associating serum 25-hydroxyvitamin D (25(OH)D) concentrations and cardiometabolic risk factors is inconsistent and studies have largely been conducted in adult populations. We examined the prospective associations between serum 25(OH)D concentrations and cardiometabolic risk factors from adolescence to young adulthood in the West Australian Pregnancy Cohort (Raine) Study. Serum 25(OH)D concentrations, BMI, homoeostasis model assessment for insulin resistance (HOMA-IR), TAG, HDL-cholesterol and systolic blood pressure (SBP) were measured at the 17-year (n 1015) and 20-year (n 1117) follow-ups. Hierarchical linear mixed models with maximum likelihood estimation were used to investigate associations between serum 25(OH)D concentrations and cardiometabolic risk factors, accounting for potential confounders. In males and females, respectively, mean serum 25(OH)D concentrations were 73·6 (sd 28·2) and 75·4 (sd 25·9) nmol/l at 17 years and 70·0 (sd 24·2) and 74·3 (sd 26·2) nmol/l at 20 years. Deseasonalised serum 25(OH)D3 concentrations were inversely associated with BMI (coefficient −0·01; 95 % CI −0·03, −0·003; P=0·014). No change over time was detected in the association for males; for females, the inverse association was stronger at 20 years compared with 17 years. Serum 25(OH)D concentrations were inversely associated with log-HOMA-IR (coefficient −0·002; 95 % CI −0·003, −0·001; P<0·001) and positively associated with log-TAG in females (coefficient 0·002; 95 % CI 0·0008, 0·004; P=0·003). These associations did not vary over time. There were no significant associations between serum 25(OH)D concentrations and HDL-cholesterol or SBP. Clinical trials in those with insufficient vitamin D status may be warranted to determine any beneficial effect of vitamin D supplementation on insulin resistance, while monitoring for any deleterious effect on TAG.

scholarly journals Healthy changes in some cardiometabolic risk factors accompany the higher summertime serum 25-hydroxyvitamin D concentrations in Iranian children: National Food and Nutrition Surveillance

2018 ◽  
Vol 21 (11) ◽  
pp. 2013-2021 ◽  
Author(s):  
Bahareh Nikooyeh ◽  
Zahra Abdollahi ◽  
Majid Hajifaraji ◽  
Hamid Alavi-Majd ◽  
Forouzan Salehi ◽  
...  
Keyword(s):  
Risk Factors ◽  
Vitamin D ◽  
Total Cholesterol ◽  
Cardiometabolic Risk ◽  
Linear Regression Analysis ◽  
Cardiometabolic Risk Factors ◽  
Healthy Children ◽  
Vitamin D Status ◽  
Hydroxyvitamin D ◽  
25 Hydroxyvitamin D

AbstractObjectiveTo investigate seasonal variations of vitamin D status at different latitudes and if these changes are accompanied by corresponding variations in certain health parameters in children living in a broad latitudinal range in Iran.DesignLongitudinal study.SubjectsIn total, 530 apparently healthy children aged 5–18 years were randomly selected from six regions of Iran with a latitudinal gradient from 29°N to 37·5°N. All anthropometric and biochemical assessments were performed twice during a year (summer, winter). High BMI (Z-score >1), low HDL cholesterol (<40 mg/dl, males; <50 mg/dl, females) and high TAG (>150 mg/dl) were considered cardiometabolic risk factors.ResultsSerum 25-hydroxyvitamin D (25(OH)D) showed between-season variation, with significantly higher concentrations (mean (sd)) in summer v. winter (43 (29) v. 27 (18) nmol/l; P<0·001). Change of circulating 25(OH)D between summer and winter was negatively correlated with change of BMI (r=−0·16; P<0·001), TAG (r=−0·09; P=0·04) and total cholesterol (r=−0·10; P=0·02) and directly correlated with change of height-for-age Z-score (r=0·09; P=0·04). Multiple stepwise linear regression analysis (β; 95 % CI) showed that winter serum 25(OH)D (−0·3; −0·4, −0·2; P<0·001), gender (boys v. girls: 9·7; 5·2, 14·1; P<0·001) and latitude (>33°N v. <33°N: 4·5; 0·09, 9·0; P=0·04) were predictors of change of serum 25(OH)D between two seasons.ConclusionsSummertime improvement of vitamin D status was accompanied by certain improved cardiometabolic risk factors, notably serum TAG, total cholesterol and BMI, in children.

Vitamin D and Cardio-Metabolic Risk Factors in Overweight Adults: An Overview of the Evidence

2019 ◽  
Vol 25 (22) ◽  
pp. 2407-2420 ◽  
Author(s):  
Ana Valer-Martinez ◽  
J. Alfredo Martinez ◽  
Carmen Sayon-Orea ◽  
Fabio Galvano ◽  
Giuseppe Grosso ◽  
...  
Keyword(s):  
Risk Factors ◽  
Insulin Resistance ◽  
Vitamin D ◽  
Cardiometabolic Risk ◽  
Strong Association ◽  
Cardiometabolic Risk Factors ◽  
Cochrane Library ◽  
Inverse Association ◽  
Cardiometabolic Disorders ◽  
Overweight Adults

Background: Several studies have suggested a potential association between low vitamin D serum levels and several pathological conditions apart from the well-known bone disorders. Thus, vitamin D insufficiency has been linked to cardiometabolic risk factors including obesity, insulin resistance, hypertension, dyslipidemia, as well as type 2 diabetes and cardiovascular disease. Objective: This review intends to provide an overview of recent evidence from clinical studies on vitamin D [25- hydroxyvitamin D (25(OH)D)] and cardiometabolic risk factors in overweight adults. Furthermore, we also discussed potential mechanisms and limits of the retrieved results. Methods: The search process was based on the selection of publications (RCT) listed in PubMed and Cochrane Library databases. Results: Vitamin D status evidenced an inversely strong association with subcutaneous adipose tissue and visceral adiposity, but not significantly related to other bodyweight measures (i.e., body mass index). Studies have shown a potential inverse association of hypovitaminosis D with insulin resistance and cardiovascular risk factors. Conclusion: The mechanisms by which vitamin D deficiency enhances adiposity, as well as putative association with metabolic syndrome features, remain still unclear. Further investigation would be required to conclude whether vitamin D has an independent role in preventing cardiometabolic disorders.

scholarly journals Adequate 25-hydroxyvitamin D levels are inversely associated with various cardiometabolic risk factors in Chinese children, especially obese children

2020 ◽  
Vol 8 (1) ◽  
pp. e000846 ◽  
Author(s):  
Pei Xiao ◽  
Hongbo Dong ◽  
Haibo Li ◽  
Yinkun Yan ◽  
Hong Cheng ◽  
...  
Keyword(s):  
Risk Factors ◽  
Vitamin D ◽  
Cardiometabolic Risk ◽  
Fasting Blood Glucose ◽  
Effect Modification ◽  
Cardiometabolic Risk Factors ◽  
Chinese Children ◽  
Model Assessment ◽  
Hydroxyvitamin D ◽  
25 Hydroxyvitamin D

ObjectiveVitamin D deficiency has recently evolved as a major public health issue worldwide. But the relationship between vitamin D and cardiovascular health in children remains unclear. Accordingly, we aimed to examine the associations between 25-hydroxyvitamin D (25(OH)D) concentrations and cardiometabolic risk factors, and to assess the possible effect modification of obesity on the associations in a Chinese pediatric population.Research design and methodsA cross-sectional sample of 6091 children aged 6–18 years was obtained using a cluster sampling method. The 25(OH)D concentrations, and metabolic risk factors, including waist to height ratio, blood pressure, blood lipids, fasting blood glucose (FBG), and insulin were measured. Adjusted ORs and multiplicative or additive interaction were calculated to assess the associations and effect modification, respectively.ResultsTriglycerides, FBG, insulin, and homeostasis model assessment of insulin resistance were inversely associated with 25(OH)D concentrations (p<0.05) in both sexes. The OR of hyperglycemia among individuals with insufficient vitamin D was higher than those with adequate vitamin D after adjusting for covariates (OR: 1.47; 95% CI 1.26 to 1.70). Moreover, girls with insufficient vitamin D had significantly higher odds for hypertension and high total cholesterol than those with adequate vitamin D, which was not observed in boys. Thirty-two percent (95% CI 14% to 51%) of the increased odds of hyperglycemia can be explained by the interaction between insufficient vitamin D and obesity.ConclusionsVitamin D insufficiency is associated with increased odds of various cardiometabolic risk factors in Chinese children and has a synergistic effect on hyperglycemia with obesity.

Association between Serum 25-Hydroxyvitamin D Levels and Cardiometabolic Risk Factors in Young Korean Adults

2018 ◽  
Vol 8 (6) ◽  
pp. 841-847
Author(s):  
Shorry Lea ◽  
Miso Jang ◽  
Yeji Kim ◽  
Hee-Kyung Joh ◽  
Cheol Min Lee ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiometabolic Risk ◽  
Cardiometabolic Risk Factors ◽  
Hydroxyvitamin D ◽  
Korean Adults ◽  
25 Hydroxyvitamin D

Abstract P171: Vitamin D and Cardiometabolic Risk Factors: The Jerusalem Perinatal Study

Circulation ◽  
2012 ◽  
Vol 125 (suppl_10) ◽  
Author(s):  
Amy Moore ◽  
Hagit Hochner ◽  
Colleen Sitlani ◽  
Michelle A Williams ◽  
David S Siscovick ◽  
...  
Keyword(s):  
Risk Factors ◽  
Vitamin D ◽  
Young Adults ◽  
Cardiometabolic Risk ◽  
Hdl Cholesterol ◽  
Cardiometabolic Risk Factors ◽  
P Value ◽  
Total Vitamin ◽  
P Values ◽  
Vitamin D Levels

Background: Vitamin D, a pleotropic hormone, influences cellular and tissue functions that are potentially related to cardiometabolic risk. Vitamin D deficiency and insufficiency have also been related to cardiovascular diseases. However, relationships between vitamin D and cardiometabolic risk factors in young adults are not well-characterized. Methods: We examined associations of vitamin D with cardiometabolic risk factors among a subset of the Jerusalem Perinatal Study (JPS) population, a birth cohort of Jerusalem residents born between 1974 and 1976. Offsprings aged 30-35 years, sampled based on maternal pre-pregnancy body mass index (BMI) and offspring birth weight, and their mothers were recruited as part of the JPS-1 study. Data were collected using interviews and field physical examinations. Fasting blood specimens were obtained for vitamin D and biomarker (glucose, total cholesterol, LDL-cholesterol, HDL-cholesterol, and triglycerides) measurements. We used liquid chromatography-tandem mass spectroscopy to measure total vitamin D (25-[OH] D). Sample-weighted multiple regression models, adjusted for potential confounders, were used to examine associations, and determine coefficients and 95% confidence intervals. Results: Mean total vitamin D levels were 22.27ng/ml, 23.48ng/ml and 21.03ng/ml among all study participants, males (N=617) and females (N=588), respectively. Vitamin D levels were statistically different between males and females (p-value <0.001). Current smokers had higher vitamin D levels compared with non-smokers, even after adjustment for current BMI, ethnicity, occupation and other potential confounders (β=1.41, p-value= 0.039). Overall, higher vitamin D levels were associated with lower BMI (p-values 0.002) and lower diastolic blood pressure (p-values 0.011). Conclusion: Vitamin D is associated with cardiometabolic risk factors in young adults. The unexpected association between current smoking and higher vitamin D in our study needs replication and further investigation.

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