Abstract P171: Vitamin D and Cardiometabolic Risk Factors: The Jerusalem Perinatal Study

Circulation ◽  
2012 ◽  
Vol 125 (suppl_10) ◽  
Author(s):  
Amy Moore ◽  
Hagit Hochner ◽  
Colleen Sitlani ◽  
Michelle A Williams ◽  
David S Siscovick ◽  
...  
Keyword(s):  
Risk Factors ◽  
Vitamin D ◽  
Young Adults ◽  
Cardiometabolic Risk ◽  
Hdl Cholesterol ◽  
Cardiometabolic Risk Factors ◽  
P Value ◽  
Total Vitamin ◽  
P Values ◽  
Vitamin D Levels

Background: Vitamin D, a pleotropic hormone, influences cellular and tissue functions that are potentially related to cardiometabolic risk. Vitamin D deficiency and insufficiency have also been related to cardiovascular diseases. However, relationships between vitamin D and cardiometabolic risk factors in young adults are not well-characterized. Methods: We examined associations of vitamin D with cardiometabolic risk factors among a subset of the Jerusalem Perinatal Study (JPS) population, a birth cohort of Jerusalem residents born between 1974 and 1976. Offsprings aged 30-35 years, sampled based on maternal pre-pregnancy body mass index (BMI) and offspring birth weight, and their mothers were recruited as part of the JPS-1 study. Data were collected using interviews and field physical examinations. Fasting blood specimens were obtained for vitamin D and biomarker (glucose, total cholesterol, LDL-cholesterol, HDL-cholesterol, and triglycerides) measurements. We used liquid chromatography-tandem mass spectroscopy to measure total vitamin D (25-[OH] D). Sample-weighted multiple regression models, adjusted for potential confounders, were used to examine associations, and determine coefficients and 95% confidence intervals. Results: Mean total vitamin D levels were 22.27ng/ml, 23.48ng/ml and 21.03ng/ml among all study participants, males (N=617) and females (N=588), respectively. Vitamin D levels were statistically different between males and females (p-value <0.001). Current smokers had higher vitamin D levels compared with non-smokers, even after adjustment for current BMI, ethnicity, occupation and other potential confounders (β=1.41, p-value= 0.039). Overall, higher vitamin D levels were associated with lower BMI (p-values 0.002) and lower diastolic blood pressure (p-values 0.011). Conclusion: Vitamin D is associated with cardiometabolic risk factors in young adults. The unexpected association between current smoking and higher vitamin D in our study needs replication and further investigation.

scholarly journals Vitamin D levels and cardiometabolic risk factors in Portuguese adolescents

2016 ◽  
Vol 220 ◽  
pp. 501-507 ◽  
Author(s):  
Maria Cabral ◽  
Joana Araújo ◽  
Joana Teixeira ◽  
Henrique Barros ◽  
Sandra Martins ◽  
...  
Keyword(s):  
Risk Factors ◽  
Vitamin D ◽  
Cardiometabolic Risk ◽  
Cardiometabolic Risk Factors ◽  
Vitamin D Levels ◽  
Portuguese Adolescents

scholarly journals Association of 25-hydroxyvitamin D with cardiometabolic risk factors and metabolic syndrome: a mendelian randomization study

2019 ◽  
Vol 18 (1) ◽  
Author(s):  
Chi Chen ◽  
Yi Chen ◽  
Pan Weng ◽  
Fangzhen Xia ◽  
Qin Li ◽  
...  
Keyword(s):  
Risk Factors ◽  
Metabolic Syndrome ◽  
Vitamin D ◽  
Cardiometabolic Risk ◽  
Mendelian Randomization ◽  
Cardiometabolic Risk Factors ◽  
Metabolic Traits ◽  
Increased Risk ◽  
Vitamin D Levels ◽  
Genetically Determined

Abstract Background Low circulating vitamin D levels have been associated with increased risk of metabolic syndrome (MS) and cardiometabolic risk factors in multiple epidemiology studies. However, whether this association is causal is still unclear. We aimed to test whether genetically lowered vitamin D levels were associated with MS and its metabolic traits, using mendelian randomization (MR) methodology. Methods Ten thousand six hundred fifty-five participants were enrolled from the SPECT-China study, which was performed in 23 sites in East China during 2014 to 2016. Using four single-nucleotide polymorphisms (SNPs) in the DHCR7, CYP2R1, GC and CYP24A1 genes with known effects on 25(OH) D concentrations, we created a genetic risk score (GRS) as instrumental variable (IV) to estimate the effect of genetically lowered 25(OH) D on MS and cardiometabolic risk factors. MS was defined according to the International Diabetes Federation criteria. Results Lower measured 25(OH)D levels were associated with MS (OR 0.921, 95% CI 0.888, 0.954) after multivariable adjustment. However, the MR-derived odds ratio of genetically determined 25(OH) D for risk of MS was 0.977 (95% CI 0.966, 1.030). The MR-derived estimates for raised fasting plasma glucose was 0.578 (95% CI 0.321, 0.980) per 10 nmol/L GRSsynthesis determined increase of 25(OH) D levels. Conclusions We found no evidence that genetically determined reduction in 25(OH)D conferred an increased risk of MS and its metabolic traits. However, we created our GRS only on the basis of common variants, which represent limited amount of variance in 25(OH)D. MR studies using rare variants, and large-scale well-designed RCTs about the effect of vitamin D supplementation on MS are warranted to further validate the findings.

scholarly journals Serum 25-hydroxyvitamin D concentrations and cardiometabolic risk factors in adolescents and young adults

2016 ◽  
Vol 115 (11) ◽  
pp. 1994-2002 ◽  
Author(s):  
Lucinda J. Black ◽  
Sally Burrows ◽  
Robyn M. Lucas ◽  
Carina E. Marshall ◽  
Rae-Chi Huang ◽  
...  
Keyword(s):  
Risk Factors ◽  
Insulin Resistance ◽  
Vitamin D ◽  
Cardiometabolic Risk ◽  
Hdl Cholesterol ◽  
Cardiometabolic Risk Factors ◽  
Inverse Association ◽  
Hydroxyvitamin D ◽  
25 Hydroxyvitamin D ◽  
Over Time

AbstractEvidence associating serum 25-hydroxyvitamin D (25(OH)D) concentrations and cardiometabolic risk factors is inconsistent and studies have largely been conducted in adult populations. We examined the prospective associations between serum 25(OH)D concentrations and cardiometabolic risk factors from adolescence to young adulthood in the West Australian Pregnancy Cohort (Raine) Study. Serum 25(OH)D concentrations, BMI, homoeostasis model assessment for insulin resistance (HOMA-IR), TAG, HDL-cholesterol and systolic blood pressure (SBP) were measured at the 17-year (n 1015) and 20-year (n 1117) follow-ups. Hierarchical linear mixed models with maximum likelihood estimation were used to investigate associations between serum 25(OH)D concentrations and cardiometabolic risk factors, accounting for potential confounders. In males and females, respectively, mean serum 25(OH)D concentrations were 73·6 (sd 28·2) and 75·4 (sd 25·9) nmol/l at 17 years and 70·0 (sd 24·2) and 74·3 (sd 26·2) nmol/l at 20 years. Deseasonalised serum 25(OH)D3 concentrations were inversely associated with BMI (coefficient −0·01; 95 % CI −0·03, −0·003; P=0·014). No change over time was detected in the association for males; for females, the inverse association was stronger at 20 years compared with 17 years. Serum 25(OH)D concentrations were inversely associated with log-HOMA-IR (coefficient −0·002; 95 % CI −0·003, −0·001; P<0·001) and positively associated with log-TAG in females (coefficient 0·002; 95 % CI 0·0008, 0·004; P=0·003). These associations did not vary over time. There were no significant associations between serum 25(OH)D concentrations and HDL-cholesterol or SBP. Clinical trials in those with insufficient vitamin D status may be warranted to determine any beneficial effect of vitamin D supplementation on insulin resistance, while monitoring for any deleterious effect on TAG.

scholarly journals Association between physical activity, cardiometabolic risk factors and vitamin D in children and adolescents: a systematic review

2019 ◽  
Vol 24 ◽  
pp. 1-12
Author(s):  
Patricia Ribeiro Paes Corazza ◽  
Maiara Cristina Tadiotto ◽  
Derick Andrade Michel ◽  
Jorge Mota ◽  
Neiva Leite
Keyword(s):  
Physical Activity ◽  
Risk Factors ◽  
Systematic Review ◽  
Vitamin D ◽  
Children And Adolescents ◽  
Cardiometabolic Risk ◽  
Density Lipoprotein ◽  
Cardiometabolic Risk Factors ◽  
Cross Sectional ◽  
Vitamin D Levels

This systematic review aimed to synthesize evidence of cross-sectional studies on the associations between physical activity, cardiometabolic risk factors and vitamin D concentrations in children and adolescents. The search was performed in PubMed, SciELO, LILACS, Scopus, MEDLINE and SPORTDiscus. Cardiometabolic risk factors included obesity, insulin resistance, systemic arterial hypertension and unfavorable changes in the lipid profile (low levels of high-density lipoprotein, elevated low-density lipoprotein and triglycerides). Cross-sectional design studies published between 2007 and 2019 were included whether they evaluated the relationship between vitamin D and physical activity and/or vitamin D and cardiometabolic risk factors. Fourteen studies were selected, involving 8340 children and adolescents. The main results found were a significant inverse relationship between vitamin D levels and cardiometabolic risk factors. All studies (n = 8) that tested association between physical activity and 25-hydroxyvitamin D (25 (OH) D) concentrations showed a significant and direct relationship between them. In addition, nine out of eleven studies that tested the association between 25 (OH) D and body mass index reported an inverse and significant relationship between 25 (OH) D and obesity. In conclusion, sufficient concentrations of vitamin D are related to a more favorable cardiometabolic profile, and children and adolescents who are obese or insufficiently active have a higher risk of present hypovitaminosis D.

Abstract P416: Low Vitamin D does not correlate with Cardiometabolic Risk in African Immigrants

Circulation ◽  
2014 ◽  
Vol 129 (suppl_1) ◽  
Author(s):  
Anne E Sumner ◽  
Caroline K Thoreson ◽  
Michelle Y O'Connor ◽  
Madia Ricks ◽  
Stephanie T Chung
Keyword(s):  
Risk Factors ◽  
Vitamin D ◽  
Cardiometabolic Risk ◽  
African Descent ◽  
African Immigrants ◽  
Cardiometabolic Risk Factors ◽  
Cardiometabolic Disease ◽  
Oral Glucose ◽  
Sensitivity Index ◽  
Vitamin D Levels

Controversy exists as to whether low vitamin D levels contribute to the development of cardiometabolic disease. As African descent populations have a high prevalence of low vitamin D levels and cardiometabolic disease, clarification is important. However, current cross-sectional studies linking low vitamin D concentrations to cardiometabolic disease not only provide conflicting results, data specifically on people of African descent is very limited. Therefore, we evaluated the association between vitamin D levels, measured as 25(OH)D, and cardiometabolic risk factors in 78 African immigrants (77% male, age 35±y (mean±SD) age range 22-63y). Participants had oral glucose tolerance tests, insulin sensitivity index (S I ) determined with the minimal model and abdominal computerized tomographic scans to measure visceral adipose tissue (VAT). Cardiometabolic risk factors were related to 25(OH)D levels by Pearson correlations and one-way ANOVA across quartiles of 25(OH)D. Mean 25(OH)D levels were 22±7, range 10-36 ng/mL. BMI was 27.9±4.4 kg/m2 and 74% of Africans were either overweight or obese. Nine percent had newly identified diabetes and 33% had pre-diabetes. Mean arterial BP was 88±10 mmHg and 44% of Africans had either pre-hypertension or hypertension. Cardiometabolic variables did not change across quartiles of 25(OH)D (Table). In addition, there were no significant correlations between 25(OH)D and the cardiometabolic variables listed in the Table (all r<0.2, all P >0.1). As cardiometabolic risk factors do not become more severe as 25(OH)D levels decline, vitamin D may not modulate cardiometabolic risk in people of African descent.

scholarly journals Association between Cardiometabolic risk factor and responsiveness to vitamin D supplementation: a new approach using artificial neural network analysis

BMC Nutrition ◽  
2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Elahe Allahyari ◽  
Parichehr Hanachi ◽  
Seyed Jamal Mirmoosavi ◽  
Gordon A.Ferns ◽  
Afsane Bahrami ◽  
...  
Keyword(s):  
Risk Factors ◽  
Vitamin D ◽  
Cardiometabolic Risk ◽  
Serum Vitamin ◽  
Vitamin D Supplementation ◽  
Cardiometabolic Risk Factors ◽  
Baseline Serum ◽  
Serum Vitamin D ◽  
Vitamin D Levels ◽  
Artificial Neural

Abstract Background There are increasing data highlighting the effectiveness of vitamin D supplementation in the treatment of vitamin D deficiency. But individuals vary in their responsiveness to vitamin D supplementation. In this study, the association between several cardiometabolic risk factors and the magnitude of response to vitamin D supplementation (change in vitamin D level) was investigated using a novel artificial neural networks (ANNs) approach. Methods Six hundred eight participants aged between 12 to 19 years old were recruited to this prospective interventional study. Nine vitamin D capsules containing 50,000 IU vitamin D/weekly were given to all participants over the 9 week period. The change in serum 25(OH) D level was calculated as the difference between post-supplementation and basal levels. Suitable ANNs model were selected between different algorithms in the hidden and output layers and different numbers of neurons in the hidden layer. The major determinants for predicting the response to vitamin D supplementation were identified. Results The sigmoid in both the hidden and output layers with 4 hidden neurons had acceptable sensitivity, specificity and accuracy, assessed as the area under the ROC curve, was determined in our study. Baseline serum vitamin D (30.4%), waist to hip ratio (10.5%), BMI (10.5%), systolic blood pressure (8%), heart rate (6.4%), and waist circumference (6.1%) were the most important factors in predicting the response to serum vitamin D levels. Conclusion We provide the first attempt to relate anthropometric specific recommendations to attain serum vitamin D targets. With the exception of cardiometabolic risk factors, the relative importance of other factors and the mechanisms by which these factors may affect the response requires further analysis in future studies (Trial registration: IRCT201509047117N7; 2015-11-25; Retrospectively registered).

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