First report of Echinococcus granulosus sensu stricto (G1) in Nigeria, West Africa

Abstract Echinococcus granulosus sensu stricto is regarded to have the highest zoonotic potential of all Echinococcus taxa. Globally, human infection due to this species constitutes over 88.44% of the total cystic echinococcosis (CE) burden. Here, we report a CE infection in a Nigerian camel caused by E. granulosus G1 genotype. To the best of our knowledge, this report is the first encounter of the G1 genotype in the West Africa sub-region where the G6 genotype is reportedly prevalent, suggesting that the epidemiology of this highly zoonotic group could have a wider host range and distribution in the sub-region, and emphasizes the need for further investigation into the genetic diversity of Echinococcus spp. in Nigeria and across the sub-region.

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Microdiversity of Echinococcus granulosus sensu stricto in Australia

Parasitology ◽

10.1017/s0031182016000445 ◽

2016 ◽

Vol 143 (8) ◽

pp. 1026-1033 ◽

Cited By ~ 13

Author(s):

C. A. ALVAREZ ROJAS ◽

D. EBI ◽

C. G. Gauci ◽

J. P. SCHEERLINCK ◽

M. WASSERMANN ◽

...

Keyword(s):

Host Range ◽

Cryptic Species ◽

Host Specificity ◽

Echinococcus Granulosus ◽

Cystic Echinococcosis ◽

Sensu Stricto ◽

Echinococcus Granulosus Sensu Stricto ◽

The World ◽

Geographic Regions ◽

Morphology Development

SUMMARYEchinococcus granulosus (sensu lato) is now recognized as an assemblage of cryptic species, which differ considerably in morphology, development, host specificity (including infectivity/pathogenicity for humans) and other aspects. One of these species, E. granulosus sensu stricto (s.s.), is now clearly identified as the principal agent causing cystic echinococcosis in humans. Previous studies of a small section of the cox1 and nadh1 genes identified two variants of E. granulosus s.s. to be present in Australia; however, no further work has been carried out to characterize the microdiversity of the parasite in its territory. We have analysed the sequence of the full length of the cox1 gene (1609 bp) from 37 isolates of E. granulosus from different hosts and geographic regions of Australia. The analysis shows that seven haplotypes of E. granulosus s.s. not previously described were found, together with five haplotypes known to be present in other parts of the world, including the haplotype EG01 which is widespread and present in all endemic regions. These data extend knowledge related to the geographical spread and host range of E. granulosus s.s. in a country such as Australia in which the parasite established around 200 years ago.

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Investigating the genetic diversity of Echinococcus granulosus sensu stricto with new microsatellites

Parasitology Research ◽

10.1007/s00436-018-5963-y ◽

2018 ◽

Vol 117 (9) ◽

pp. 2743-2755 ◽

Cited By ~ 2

Author(s):

Gérald Umhang ◽

Frédéric Grenouillet ◽

Vanessa Bastid ◽

Selim M’Rad ◽

Benoît Valot ◽

...

Keyword(s):

Genetic Diversity ◽

Echinococcus Granulosus ◽

Sensu Stricto ◽

Echinococcus Granulosus Sensu Stricto

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First molecular evidence of the simultaneous human infection with two species of Echinococcus granulosus sensu lato: Echinococcus granulosus sensu stricto and Echinococcus canadensis

Parasitology Research ◽

10.1007/s00436-015-4836-x ◽

2015 ◽

Vol 115 (3) ◽

pp. 1065-1069 ◽

Cited By ~ 8

Author(s):

Myriam Oudni-M’rad ◽

Selim M’rad ◽

Amine Ksia ◽

Rachida Lamiri ◽

Mongi Mekki ◽

...

Keyword(s):

Echinococcus Granulosus ◽

Sensu Stricto ◽

Human Infection ◽

Molecular Evidence ◽

Echinococcus Canadensis ◽

Echinococcus Granulosus Sensu Stricto ◽

Echinococcus Granulosus Sensu Lato

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Genetic diversity of Echinococcus granulosus sensu stricto infecting humans in western Algeria

Parasitology Research ◽

10.1007/s00436-021-07223-7 ◽

2021 ◽

Author(s):

Daouia Moussa ◽

Kheira Senouci ◽

Nori Midoun ◽

Mohamed Lacheheb ◽

Benali Tabeti ◽

...

Keyword(s):

Genetic Diversity ◽

Echinococcus Granulosus ◽

Sensu Stricto ◽

Echinococcus Granulosus Sensu Stricto ◽

Western Algeria

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Phylogeography and Genetic Diversity of Human Hydatidosis in Bordering the Caspian Sea, Northern Iran by Focusing on Echinococcus granulosus Sensu Stricto Complex

Iranian Journal of Public Health ◽

10.18502/ijph.v49i9.4097 ◽

2020 ◽

Author(s):

Abolghasem SIYADATPANAH ◽

Ahmad DARYANI ◽

Shahabeddin SARVI ◽

Adel SPOTIN ◽

Mehdi SHARIF ◽

...

Keyword(s):

Genetic Diversity ◽

Echinococcus Granulosus ◽

Haplotype Diversity ◽

Taxonomic Status ◽

Sensu Stricto ◽

Ffpe Tissue ◽

Cox1 Gene ◽

Northern Iran ◽

Tissue Samples ◽

Echinococcus Granulosus Sensu Stricto

Background: Human Echinococcosisis a cyclo-zoonotic infection caused by tapeworms of the Echinococcus granulosus sensu stricto complex. The detection of mitochondrial genome data of genus Echinococcus can reflect the taxonomic status, genetic diversity, and population structure genetics. Methods: Totally, 52 formalin-fixed paraffin-embedded (FFPE) tissue samples from patients with histologically confirmed CE were collected from Mazandaran province, Iran in the period of Mar 1995 to May 2018. All extracted DNAs from (FFPE) tissue samples were subjected to amplify by polymerase chain reactions method targeting cytochrome c oxidase subunit 1 (cox1) gene. All PCR amplicons were sequenced to phylogenetic analysis and genetic diversity. Results: Molecular analysis showed that 50(96.1%) and 2 (3.84%) isolates were identified as G1 andG3 E. granulosus genotypes, respectively. DNA sequence analyses indicated a high gene diversity for G1 (Haplotype diversity: 0.830) and G3 genotypes (Hd: 1.00). Based on multiple sequence alignment analyses, 7 (13.46%; G1 genotype) and 2 (3.84%; G3 genotype) new haplotypes were unequivocally identified. Conclusion: G3 genotype (Buffalo strain) was identified from two human hydatidosis isolates in the region. Present study strengthens our knowledge about taxonomic status, transmission patterns of Echinococcus parasite to human and heterogeneity aspects of this parasite in clinical CE isolates of Northern Iran.

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