scholarly journals Commercial factor VIII associated hepatitis, 1974–75, in the United Kingdom: a retrospective survey

1978 ◽  
Vol 80 (3) ◽  
pp. 327-336 ◽  
Author(s):  
J. Craske ◽  
P. Kirk ◽  
B. Cohen ◽  
Elise M. Vandervelde
Keyword(s):  
United Kingdom ◽  
Hepatitis B ◽  
Factor Viii ◽  
Incubation Period ◽  
Hepatitis A ◽  
Retrospective Survey ◽  
Factors Affecting ◽  
The United Kingdom ◽  
Surface Antibody

SummaryA retrospective survey of transfusion hepatitis associated with a brand of commercial Factor VIII was carried out in 24 Haemophilia Centres from January 1974 until December 1975. Of 371 patients who were transfused with this product, and were followed up, 78 cases of hepatitis affecting 66 patients were found (17·7%). Two types of hepatitis were observed: hepatitis B and non-B hepatitis, the latter with an incubation period of between 8 and 60 days. Twelve patients contracted two types of hepatitis, non-B followed by hepatitis B. Only one patient died after contracting hepatitis B. Four of the suspect batches of concentrate were found to be positive for HBsAg by radioimmunoassay.There was evidence that the presence of hepatitis B surface antibody in a patient's serum prior to exposure was associated with immunity to hepatitis B. Evidence was presented suggesting that the non-B hepatitis observed was not due to hepatitis A. The factors affecting the incidence of transfusion hepatitis in haemophiliacs were discussed.

Incidence of factor VIII inhibitors throughout life in severe hemophilia A in the United Kingdom

Blood ◽  
2011 ◽  
Vol 117 (23) ◽  
pp. 6367-6370 ◽  
Author(s):  
Charles R.M. Hay ◽  
Ben Palmer ◽  
Elizabeth Chalmers ◽  
Ri Liesner ◽  
Rhona Maclean ◽  
...  
Keyword(s):  
United Kingdom ◽  
Factor Viii ◽  
Hemophilia A ◽  
Interquartile Range ◽  
Severe Hemophilia ◽  
The United Kingdom ◽  
Potential Risk Factors ◽  
History Of ◽  
Previously Treated Patients ◽  
Adjusted Incidence

Abstract The age-adjusted incidence of new factor VIII inhibitors was analyzed in all United Kingdom patients with severe hemophilia A between 1990 and 2009. Three hundred fifteen new inhibitors were reported to the National Hemophilia Database in 2528 patients with severe hemophilia who were followed up for a median (interquartile range) of 12 (4-19) years. One hundred sixty (51%) of these arose in patients ≥ 5 years of age after a median (interquartile range) of 6 (4-11) years' follow-up. The incidence of new inhibitors was 64.29 per 1000 treatment-years in patients < 5 years of age and 5.31 per 1000 treatment-years at age 10-49 years, rising significantly (P = .01) to 10.49 per 1000 treatment-years in patients more than 60 years of age. Factor VIII inhibitors arise in patients with hemophilia A throughout life with a bimodal risk, being greatest in early childhood and in old age. HIV was associated with significantly fewer new inhibitors. The inhibitor incidence rate ratio in HIV-seropositive patients was 0.32 times that observed in HIV-seronegative patients (P < .001). Further study is required to explore the natural history of later-onset factor VIII inhibitors and to investigate other potential risk factors for inhibitor development in previously treated patients.

Acceptance of hepatitis B vaccine by general dental practitioners in the United Kingdom

BDJ ◽  
1986 ◽  
Vol 161 (10) ◽  
pp. 371-373 ◽  
Author(s):  
R W Matthews ◽  
C Scully ◽  
T B Dowell
Keyword(s):  
United Kingdom ◽  
Hepatitis B ◽  
Hepatitis B Vaccine ◽  
The United Kingdom ◽  
Dental Practitioners

scholarly journals Prevalence of HIV/hepatitis B and HIV/hepatitis C coinfection among people of East, South, Central and West African ancestry in the United Kingdom

AIDS ◽  
2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Rachel Hung ◽  
Nisha Patel ◽  
Julie Fox ◽  
Catherine Cosgrove ◽  
Sarah L. Pett ◽  
...  
Keyword(s):  
United Kingdom ◽  
Hepatitis C ◽  
Hepatitis B ◽  
African Ancestry ◽  
West African ◽  
The United Kingdom ◽  
South Central ◽  
West African Ancestry

scholarly journals A Conceptual Framework Outlining Factors Affecting the Acceptance of Earth as a Sustainable Building Material in the United Kingdom

2020 ◽  
Vol 9 (3) ◽  
pp. 241
Author(s):  
Mohammad Sharif Zami
Keyword(s):  
United Kingdom ◽  
Conceptual Framework ◽  
Co2 Emissions ◽  
Environmental Sustainability ◽  
Building Material ◽  
Review Of Literature ◽  
Factors Affecting ◽  
Earth Construction ◽  
The United Kingdom ◽  
The Uk

Despite the fact that contemporary earth construction may open up new avenues to cutting down CO2 emissions, a review of literature reveals that there is sparse research to date identifying reasons behind why there may be resistance to earth construction as a sustainable construction material in the United Kingdom. The aim of this paper is to formulate a conceptual framework that facilitates a clearer understanding of factors affecting the acceptance of earth as a sustainable material in the UK. To achieve this aim, this study adopted a research methodological framework comprising of an extensive review of literature, the Delphi technique, and in-depth interviews. The conceptual framework provides insight into factors related to the UK context specifically including a lack of technological innovation, resources, well-established supply chain networks, training facilities in universities and building codes. These issues may be addressed through the promotion of earthen architecture as a method of cutting CO2 emissions and introducing earth construction modules in relevant degree programs. Keywords: conceptual framework, factors, building material, earth, environmental sustainability

Hepatitis B in a West Indian population in the United Kingdom

BMJ ◽  
1986 ◽  
Vol 292 (6525) ◽  
pp. 957-958
Author(s):  
M J Godley ◽  
P W Laidler ◽  
J E Banatvala
Keyword(s):  
United Kingdom ◽  
Hepatitis B ◽  
Indian Population ◽  
West Indian ◽  
The United Kingdom

scholarly journals Hepatitis in dialysis units in the United Kingdom: a Public Health Laboratory Service Survey

1981 ◽  
Vol 87 (3) ◽  
pp. 443-451 ◽  
Author(s):  
S. Polakoff
Keyword(s):  
Public Health ◽  
United Kingdom ◽  
Hepatitis B ◽  
Prospective Study ◽  
Type B ◽  
Single Patient ◽  
Hepatitis Viruses ◽  
Laboratory Service ◽  
The United Kingdom ◽  
A Prospective Study

SummaryA prospective study of hepatitis that began in 1968 and continues to include more than half the dialysis units in the United Kingdom shows that type B infection has been completely controlled in such units since the last outbreak ended in 1973. Though occasionally a single patient has developed hepatitis B surface antigenaemia in the course of dialysis or after transplantation, the infection has not spread to other patients or staff in the survey units.A detailed analysis of the results in 1974–75 shows clustering of patients with raised aminotransferase levels in about one-fifth of the units but, unlike past outbreaks of hepatitis B, these clusters are not accompanied by clinical hepatitis among staff. The possibility that some of the clusters are caused by hepatitis viruses other than type A or B is discussed. It is concluded that, when reliable tests for type non-A non-B infections become available, the continued existence of the survey will allow prompt assessment of any viral hepatitis problems that may still exist in UK units.

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