Biocompatible implantable antimicrobial release for necrotizing external otitis

1991 ◽  
Vol 105 (4) ◽  
pp. 252-256
Author(s):  
E. J. Ostfeld ◽  
A. Kupferberg
Keyword(s):  
Cardiac Arrest ◽  
Clinical Symptoms ◽  
Sudden Cardiac Arrest ◽  
The Other ◽  
External Otitis ◽  
Therapeutic Modality ◽  
Antibiotic Administration ◽  
Post Implantation ◽  
Necrotizing External Otitis

AbstractThe efficacy of a biocompatible, surgically implantable, antimicrobial release system (IARS) as the exclusive antimicrobial therapy of necrotizing external otitis (NEO) was evaluated in six NEO patients. Gentamicin incorporated polymethyl-methacrylate beads were implanted, following surgical debridement and were removed two months later. Post-implantation alleviation of clinical symptoms: pain, periauricular tissue swelling, otorrhoea, eradication of pseudomonal infection (100 per cent) and substantially shortened hospitalization (4–15 days) were the salient results of this therapeutic modality. Three patients recovered. Two patients who died, one of sudden cardiac arrest and the other of paralytic ileus, 15 and 60 days postoperatively while the beads were still implanted, were symptomless. Recurrence was seen in one patient with early bead extrusion. Ipsilateral sensorineural hearing loss (one patient) and external meatal stenosis were the main complications. IARS appears to offer an effective alternative to long-term systemic antibiotic administration for the eradication of NEO-pseudomonal infection in patients who are sensitive, develop resistance, or when quinolone medical treatment has failed or is contra-indicated.

Abstract 11503: Mindfulness is Inversely Associated with Psychological Symptoms in Long-Term Cardiac Arrest Survivors

Circulation ◽  
2021 ◽  
Vol 144 (Suppl_2) ◽  
Author(s):  
Alex Presciutti ◽  
Jonathan Greenberg ◽  
Ethan Lester ◽  
Mary M Newman ◽  
Jonathan Elmer ◽  
...  
Keyword(s):  
Cardiac Arrest ◽  
Protective Factor ◽  
Psychological Symptoms ◽  
Sudden Cardiac Arrest ◽  
Survey Study ◽  
Present Moment ◽  
Cross Sectional ◽  
Patient Health

Introduction: We sought to identify correlates with psychological symptoms in long-term cardiac arrest (CA) survivors. Mindfulness, or nonjudgmental awareness of the present moment, is a modifiable protective factor against psychological symptoms in various clinical populations and could be a potential treatment target for CA survivors. Methods: We conducted a longitudinal survey study between 10-11/2019 (baseline) and 10-11/2020 (1-year follow-up) with long-term CA survivor members of the Sudden Cardiac Arrest Foundation. We collected demographic and CA characteristics at baseline. At both timepoints, we assessed posttraumatic stress symptoms (PTS) through the PTSD Checklist-5 (PCL-5) and depression and anxiety symptoms through the Patient Health Questionnaire-4 (PHQ-4). At follow-up, we assessed mindfulness through the Cognitive and Affective Mindfulness Scale-Revised (CAMS-R). We used adjusted linear regression to predict 1-year PCL-5 and PHQ-4 scores, with particular consideration of the CAMS-R as a cross-sectional correlate of outcome. Results: We included 129 CA survivors (mean age: 52 years, 52% male, 98% white). At 1-year follow-up, in adjusted models, CAMS-R (β: -0.35, p <0.001) and baseline PCL-5 scores (β: 0.56, p <0.001) were associated with 1-year PCL-5 scores. CAMS-R (β: -0.34, p <0.001) and baseline PHQ-4 scores were associated with 1-year PHQ-4 scores (β: 0.37, p<0.001). Conclusion: Mindfulness was inversely associated with psychological symptoms in long-term CA survivors. Future studies should examine the longitudinal relationship of mindfulness and psychological symptoms after CA.

Life-threatening and major cardiac events during long-distance races: updates from the prospective RACE PARIS registry with a systematic review and meta-analysis

2020 ◽  
pp. 204748732094300
Author(s):  
Benoît Gerardin ◽  
Paul Guedeney ◽  
Anne Bellemain-Appaix ◽  
Thomas Levasseur ◽  
Hazrije Mustafic ◽  
...  
Keyword(s):  
Cardiac Arrest ◽  
Clinical Symptoms ◽  
Meta Analysis ◽  
Heat Stroke ◽  
Sudden Cardiac Arrest ◽  
Cardiac Events ◽  
Long Distance ◽  
Exertional Heat Stroke ◽  
Life Threatening ◽  
Long Distance Race

Aims Limited data exist regarding the incidence and aetiology of life-threatening events such as major cardiac events or exertional heat stroke during long-distance races. We aimed to provide an updated incidence, etiology and prognosis of life-threatening events during long-distance races. Methods The prospective RACE PARIS registry recorded all life-threatening events/fatal events occurring during 46 marathons, half-marathons and other long-distance races in the Paris area between 2006 and 2016, comprising 1,073,722 runners. Event characteristics were determined by review of medical records and interviews with survivors. Results The incidence of life-threatening events, exertional heat stroke and major cardiac events was 3.35 per 100,000, 1.02 per 100,000 and 2.33 per 100,000, respectively, including 18 sudden cardiac arrests (1.67 per 100,000). The main aetiology of sudden cardiac arrest was myocardial ischaemia (11/18), due to acute coronary thrombosis (6/11), stable atherosclerotic coronary artery disease (2/11), coronary dissection (1/11), anomalous connection (1/11) or myocardial bridging (1/11). A third of participants with ischaemia-related major cardiac events presented with pre-race clinical symptoms. Major cardiac events were more frequent in the case of a high pollution index (6.78 per 100,000 vs. 2.07 per 100,000, odds ratio 3.27, 95% confidence interval 1.12–9.54). Case fatality was low (0.19 per 100,000). Similarly, we report in a meta-analysis of eight long-distance race registries comprising 16,223,866 runners a low incidence of long-distance race-related sudden cardiac arrest (0.82 per 100,000) and fatality (0.39 per 100,000). Death following sudden cardiac arrest was strongly associated with initial asystole or pulseless rhythm. Conclusion Long-distance race-related life-threatening events remain rare although serious events. Better information for runners on the risk of pre-race clinical symptoms, outside air pollution and temperature may reduce their incidence.

Diagnostic yield and long-term outcome of nonischemic sudden cardiac arrest survivors and their relatives: Results from a tertiary referral center

Heart Rhythm ◽  
2020 ◽  
Vol 17 (10) ◽  
pp. 1679-1686
Author(s):  
Elisabeth Mütze Jacobsen ◽  
Benjamin Lautrup Hansen ◽  
Amalie Kjerrumgaard ◽  
Jacob Tfelt-Hansen ◽  
Christian Hassager ◽  
...  
Keyword(s):  
Cardiac Arrest ◽  
Diagnostic Yield ◽  
Sudden Cardiac Arrest ◽  
Tertiary Referral ◽  
Term Outcome ◽  
Long Term Outcome ◽  
Tertiary Referral Center ◽  
Referral Center

GALECTIN-3 AS A RISK PREDICTOR OF LONG-TERM MORTALITY IN THE RESUSCITATED COHORTS OF SUDDEN CARDIAC ARREST

2019 ◽  
Vol 73 (9) ◽  
pp. 492
Author(s):  
Sharma Kattel ◽  
Hardik Bhatt ◽  
Wassim Mosleh ◽  
Milind Chaudhari ◽  
Zaid Al-Jebaje ◽  
...  
Keyword(s):  
Cardiac Arrest ◽  
Sudden Cardiac Arrest ◽  
Galectin 3 ◽  
Risk Predictor ◽  
Long Term Mortality

scholarly journals Long‐term electro‐clinical profile of sudden cardiac arrest survivors

2021 ◽  
Author(s):  
Hussam Shaker ◽  
Anna Milan ◽  
Faisal Alsallom ◽  
Christopher Newey ◽  
Stephen Hantus ◽  
...  
Keyword(s):  
Cardiac Arrest ◽  
Sudden Cardiac Arrest ◽  
Clinical Profile

Angiographic characteristics and long-term prognostic impact of coronary artery disease in survivors after sudden cardiac arrest with a non-diagnostic electrocardiogram

2018 ◽  
Vol 93 (1) ◽  
pp. 9-15 ◽  
Author(s):  
María Teresa Nogales-Romo ◽  
Carlos Ferrera ◽  
Pablo Salinas ◽  
Pedro Martínez-Losas ◽  
Luis Nombela-Franco ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Cardiac Arrest ◽  
Coronary Artery ◽  
Sudden Cardiac Arrest ◽  
Prognostic Impact ◽  
Artery Disease

Abstract 227: Sudden Cardiac Arrest During Exercise Occurs Infrequently and With Few Warning Symptoms

Circulation ◽  
2019 ◽  
Vol 140 (Suppl_2) ◽  
Author(s):  
Katherine S Allan ◽  
Brian E Grunau ◽  
Morgan Haines ◽  
Armin Nowroozpoor ◽  
James Christenson ◽  
...  
Keyword(s):  
Cardiac Arrest ◽  
Metropolitan Areas ◽  
Sudden Cardiac Arrest ◽  
The Other ◽  
Future Research ◽  
Moderate Exercise ◽  
Metabolic Equivalent ◽  
Shockable Rhythm ◽  
Future Events ◽  
Bystander Cpr

Introduction: The incidence and details of sudden cardiac arrest (SCA) during exercise in the general population are not well described. We describe a cohort ages 2-85 who experienced an SCA within ≤ 1 hour of moderate to vigorous activity in 4 metropolitan areas of British Columbia, Canada. Methods: We reviewed prehospital records of consecutive out-of-hospital cardiac arrests (OHCAs) in the provincial BC OHCA Registry from June 17 2017 to August 16 2018. We included non-traumatic OHCAs treated by EMS occurring within ≤ 1 hour of exercise. We defined SCA as an OHCA of no obvious cause, witnessed/unwitnessed, survived/died. We assigned an estimated metabolic equivalent (MET) score to each type of physical activity. We defined moderate exercise as a MET score of 3-5.9 and vigorous as ≥6. Results: A total of 2674 OHCAs occurred during the study period of which 56 SCAs (2.1%) occurred within ≤1 hour of participation in 23 types of exercise (Figure 1). The incidence of SCA during exercise was 1.45 (95% CI 1.10-1.88) per 100,000 population. The median age was 56.5 [IQR 45-69] and 87.5% (49/56) were male. Most exercise related SCAs occurred in public (49/56 87.5%), 83.3% (45/54) were bystander witnessed and 85% (46/54) received bystander CPR. Over 70% (40/56) had a shockable rhythm. The survival rate was 55.4% (31/56). Half of the SCAs collapsed during exercise (49.1%; 26/53) while the other half collapsed within ≤1 hour after exercising (51%; 27/53). Symptom data were available in 46% of patients (23/50) with most experiencing chest pain, dizziness, feeling unwell or seizure just prior to collapse. Conclusions: SCAs during exercise are rare and frequently occur in a public location. Survival is high and may be related to witnessed and public location status. Equal numbers of SCAs collapsed during or ≤ 1 hour of exercising and symptoms were present in almost half. Future research is needed to determine what factors could predict those at highest risk for SCA in order to prevent future events.

Positron-Emission-Tomography Imaging of Long-Term Expression of the 18kDa Translocator Protein After Sudden Cardiac Arrest in Rats

Shock ◽  
2020 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Daniel C. Schroeder ◽  
Erik Popp ◽  
Cathrin Rohleder ◽  
Stefanie Vus ◽  
David de la Puente Bethencourt ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Cardiac Arrest ◽  
Sudden Cardiac Arrest ◽  
Positron Emission Tomography Imaging ◽  
Translocator Protein ◽  
Emission Tomography ◽  
Tomography Imaging ◽  
Positron Emission
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