ELEVATED MACROPHAGE EXPRESSED MARKER PROGNOSTICATE THE LONG-TERM FUNCTIONAL RECOVERY IN SURVIVORS OF OUT OF HOSPITAL SUDDEN CARDIAC ARREST

Introduction: To assess the long-term functional recovery and health related quality-of-life (HRQoL) outcomes for out-of-hospital cardiac arrest (OHCA) survivors stratified by shock provider. Methods: We included adult OHCA in initial shockable rhythms between 2010-2019. Those surviving to 12 months post arrest were invited to participate in telephone interviews to identify functional recovery and HRQoL outcomes, using the following assessment tools, Glasgow Outcome Scale-Extended (GOS-E), EuroQol-5D (EQ-5D), and 12-Item Short Form (SF-12). Results: Of the 1,581 patients surviving to 12 months, 1,325 (85.5%) responded to the interviews, of these, 227 (17.1%) and 144 (10.9%) were initially shocked by bystanders and first responders, respectively. A higher proportion of patients shocked by bystanders were located in public (p<0.001), received bystander CPR (p<0.001) and received initial defibrillation faster from time of collapse (P<0.001). Survivors receiving bystander defibrillation reported higher rates of living at home without care (p=0.004), upper good recovery (GOS-E) (p=0.008) and EQ-5D index score of 1 (perfect health) (p=0.023). After adjustment, bystander defibrillation was associated with a 64% increase in the odds of an EQ-5D current Visual Analogue Scale ≥ 80 (AOR 1.64, 95%CI: 1.17-2.31; p=0.004) and a 45% increase in the odds of a good functional recovery (GOS-E ≥ 7) (AOR 1.45, 95% CI: 1.02-2.06; p=0.037), than those initially shocked by paramedics. No improvement in adjusted outcomes were observed for survivors initially defibrillated by first responders. Conclusion: Patients receiving bystander defibrillation reported better functional recovery and HRQol outcomes at 12 months compared to those defibrillated by first responders and paramedics.

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Abstract 11503: Mindfulness is Inversely Associated with Psychological Symptoms in Long-Term Cardiac Arrest Survivors

Circulation ◽

10.1161/circ.144.suppl_2.11503 ◽

2021 ◽

Vol 144 (Suppl_2) ◽

Author(s):

Alex Presciutti ◽

Jonathan Greenberg ◽

Ethan Lester ◽

Mary M Newman ◽

Jonathan Elmer ◽

...

Keyword(s):

Cardiac Arrest ◽

Protective Factor ◽

Psychological Symptoms ◽

Sudden Cardiac Arrest ◽

Survey Study ◽

Present Moment ◽

Cross Sectional ◽

Patient Health

Introduction: We sought to identify correlates with psychological symptoms in long-term cardiac arrest (CA) survivors. Mindfulness, or nonjudgmental awareness of the present moment, is a modifiable protective factor against psychological symptoms in various clinical populations and could be a potential treatment target for CA survivors. Methods: We conducted a longitudinal survey study between 10-11/2019 (baseline) and 10-11/2020 (1-year follow-up) with long-term CA survivor members of the Sudden Cardiac Arrest Foundation. We collected demographic and CA characteristics at baseline. At both timepoints, we assessed posttraumatic stress symptoms (PTS) through the PTSD Checklist-5 (PCL-5) and depression and anxiety symptoms through the Patient Health Questionnaire-4 (PHQ-4). At follow-up, we assessed mindfulness through the Cognitive and Affective Mindfulness Scale-Revised (CAMS-R). We used adjusted linear regression to predict 1-year PCL-5 and PHQ-4 scores, with particular consideration of the CAMS-R as a cross-sectional correlate of outcome. Results: We included 129 CA survivors (mean age: 52 years, 52% male, 98% white). At 1-year follow-up, in adjusted models, CAMS-R (β: -0.35, p <0.001) and baseline PCL-5 scores (β: 0.56, p <0.001) were associated with 1-year PCL-5 scores. CAMS-R (β: -0.34, p <0.001) and baseline PHQ-4 scores were associated with 1-year PHQ-4 scores (β: 0.37, p<0.001). Conclusion: Mindfulness was inversely associated with psychological symptoms in long-term CA survivors. Future studies should examine the longitudinal relationship of mindfulness and psychological symptoms after CA.

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Diagnostic yield and long-term outcome of nonischemic sudden cardiac arrest survivors and their relatives: Results from a tertiary referral center

Heart Rhythm ◽

10.1016/j.hrthm.2020.06.030 ◽

2020 ◽

Vol 17 (10) ◽

pp. 1679-1686

Author(s):

Elisabeth Mütze Jacobsen ◽

Benjamin Lautrup Hansen ◽

Amalie Kjerrumgaard ◽

Jacob Tfelt-Hansen ◽

Christian Hassager ◽

...

Keyword(s):

Cardiac Arrest ◽

Diagnostic Yield ◽

Sudden Cardiac Arrest ◽

Tertiary Referral ◽

Term Outcome ◽

Long Term Outcome ◽

Tertiary Referral Center ◽

Referral Center

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GALECTIN-3 AS A RISK PREDICTOR OF LONG-TERM MORTALITY IN THE RESUSCITATED COHORTS OF SUDDEN CARDIAC ARREST

Journal of the American College of Cardiology ◽

10.1016/s0735-1097(19)31100-3 ◽

2019 ◽

Vol 73 (9) ◽

pp. 492

Author(s):

Sharma Kattel ◽

Hardik Bhatt ◽

Wassim Mosleh ◽

Milind Chaudhari ◽

Zaid Al-Jebaje ◽

...

Keyword(s):

Cardiac Arrest ◽

Sudden Cardiac Arrest ◽

Galectin 3 ◽

Risk Predictor ◽

Long Term Mortality

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Biocompatible implantable antimicrobial release for necrotizing external otitis

The Journal of Laryngology & Otology ◽

10.1017/s0022215100115543 ◽

1991 ◽

Vol 105 (4) ◽

pp. 252-256

Author(s):

E. J. Ostfeld ◽

A. Kupferberg

Keyword(s):

Cardiac Arrest ◽

Clinical Symptoms ◽

Sudden Cardiac Arrest ◽

The Other ◽

External Otitis ◽

Therapeutic Modality ◽

Antibiotic Administration ◽

Post Implantation ◽

Necrotizing External Otitis

AbstractThe efficacy of a biocompatible, surgically implantable, antimicrobial release system (IARS) as the exclusive antimicrobial therapy of necrotizing external otitis (NEO) was evaluated in six NEO patients. Gentamicin incorporated polymethyl-methacrylate beads were implanted, following surgical debridement and were removed two months later. Post-implantation alleviation of clinical symptoms: pain, periauricular tissue swelling, otorrhoea, eradication of pseudomonal infection (100 per cent) and substantially shortened hospitalization (4–15 days) were the salient results of this therapeutic modality. Three patients recovered. Two patients who died, one of sudden cardiac arrest and the other of paralytic ileus, 15 and 60 days postoperatively while the beads were still implanted, were symptomless. Recurrence was seen in one patient with early bead extrusion. Ipsilateral sensorineural hearing loss (one patient) and external meatal stenosis were the main complications. IARS appears to offer an effective alternative to long-term systemic antibiotic administration for the eradication of NEO-pseudomonal infection in patients who are sensitive, develop resistance, or when quinolone medical treatment has failed or is contra-indicated.

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Long‐term electro‐clinical profile of sudden cardiac arrest survivors

Epilepsia Open ◽

10.1002/epi4.12516 ◽

2021 ◽

Author(s):

Hussam Shaker ◽

Anna Milan ◽

Faisal Alsallom ◽

Christopher Newey ◽

Stephen Hantus ◽

...

Keyword(s):

Cardiac Arrest ◽

Sudden Cardiac Arrest ◽

Clinical Profile

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Angiographic characteristics and long-term prognostic impact of coronary artery disease in survivors after sudden cardiac arrest with a non-diagnostic electrocardiogram

Catheterization and Cardiovascular Interventions ◽

10.1002/ccd.27713 ◽

2018 ◽

Vol 93 (1) ◽

pp. 9-15 ◽

Cited By ~ 1

Author(s):

María Teresa Nogales-Romo ◽

Carlos Ferrera ◽

Pablo Salinas ◽

Pedro Martínez-Losas ◽

Luis Nombela-Franco ◽

...

Keyword(s):

Coronary Artery Disease ◽

Cardiac Arrest ◽

Coronary Artery ◽

Sudden Cardiac Arrest ◽

Prognostic Impact ◽

Artery Disease

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Positron-Emission-Tomography Imaging of Long-Term Expression of the 18kDa Translocator Protein After Sudden Cardiac Arrest in Rats

Shock ◽

10.1097/shk.0000000000001546 ◽

2020 ◽

Vol Publish Ahead of Print ◽

Author(s):

Daniel C. Schroeder ◽

Erik Popp ◽

Cathrin Rohleder ◽

Stefanie Vus ◽

David de la Puente Bethencourt ◽

...

Keyword(s):

Positron Emission Tomography ◽

Cardiac Arrest ◽

Sudden Cardiac Arrest ◽

Positron Emission Tomography Imaging ◽

Translocator Protein ◽

Emission Tomography ◽

Tomography Imaging ◽

Positron Emission

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Cardiopulmonary Resuscitation

AACN Advanced Critical Care ◽

10.4037/15597768-2009-4011 ◽

2009 ◽

Vol 20 (4) ◽

pp. 373-383

Author(s):

Cindy Goodrich

Keyword(s):

Cardiac Arrest ◽

Cardiopulmonary Resuscitation ◽

Survival Rates ◽

Sudden Cardiac Arrest ◽

Heart Association ◽

New Techniques ◽

Cardiac Assist ◽

Mechanical Devices

Dismal survival statistics associated with sudden cardiac arrest have led to the development of new strategies and mechanical devices aimed at improving the quality of cardiopulmonary resuscitation (CPR). The most recent American Heart Association guidelines for cardiopulmonary resuscitation and emergency cardiovascular care were published in 2005. Major changes included revisions to current practices related to airway and ventilation, circulation, and defibrillation management. Greater emphasis is placed on providing simple, high-quality, effective CPR. New techniques and mechanical devices have been developed to augment CPR, hopefully improving survival rates and long-term outcomes. These include active compression-decompression CPR, Lund University Cardiac Assist System, LifeBelt, AutoPulse, and the impedance threshold device. This article focuses on current strategies aimed at improving survival rates for patients with sudden cardiac arrest. New techniques and mechanical devices developed to augment cardiopulmonary resuscitation will be discussed. These strategies will most likely shape future resuscitation practices.

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