Ultrastructural localization of fibronectin in duct cells of human minor salivary glands and its immunochemical detection in minor salivary gland secretion

1984 ◽  
Vol 29 (11) ◽  
pp. 921-925 ◽  
Author(s):  
A Linde ◽  
L.E. Berghem ◽  
H.-A. Hansson ◽  
R. Jonsson ◽  
Ylva Redfors
Keyword(s):  
Salivary Gland ◽  
Salivary Glands ◽  
Minor Salivary Gland ◽  
Ultrastructural Localization ◽  
Gland Secretion ◽  
Minor Salivary Glands ◽  
Duct Cells ◽  
Salivary Gland Secretion ◽  
Immunochemical Detection

Terminal duct adenocarcinomas of the parotid gland

1995 ◽  
Vol 109 (5) ◽  
pp. 466-468 ◽  
Author(s):  
Bonnie L. Kemp ◽  
John G. Batsakis ◽  
Adel K. El-Naggar ◽  
Sophia N. Kotliar ◽  
Mario A. Luna
Keyword(s):  
Salivary Gland ◽  
Parotid Gland ◽  
Salivary Glands ◽  
Minor Salivary Gland ◽  
Low Grade ◽  
Minor Salivary Glands ◽  
Biological Behaviour ◽  
Parotid Neoplasms ◽  
Clinicopathological Study

AbstractThe major salivary glands are considered to rarely be the sites of primary terminal duct adenocarcinomas, a neoplasm with a considerable predilection for origin from intraoral minor salivary glands. We present a clinicopathological study of 22 terminal duct adenocarcinomas of the parotid gland, the largest single series to date. A comparison between the parotid neoplasms and over 200 minor salivary gland terminal duct adenocarcinomas indicates there is little difference in biological behaviour and confirms the low-grade quality of the carcinomas, regardless of site of origin.

scholarly journals An unusual pleomorphic adenoma

2014 ◽  
Vol 62 (3) ◽  
pp. 319-324
Author(s):  
Christiano Sampaio QUEIROZ ◽  
Roberto Almeida de AZEVEDO ◽  
Antonio Irineu TRINDADE NETO ◽  
Caetano Guilherme Carvalho PONTES ◽  
Rafael de Queiroz MOURA
Keyword(s):  
Salivary Gland ◽  
Salivary Glands ◽  
Pleomorphic Adenoma ◽  
Histopathological Examination ◽  
Minor Salivary Gland ◽  
Surgical Excision ◽  
Biological Behavior ◽  
Surgical Removal ◽  
Minor Salivary Glands ◽  
Recommended Treatment

Pleomorphic adenoma is the most common neoplasm in major and minor salivary glands. It constitutes approximately 90% of all benign salivary gland lesions and the parotid is the most affected location. When the minor salivary glands are affected, it mostly occurs at the junction of the hard and soft palates. The diagnosis is complex because of the great histological variety and biological behavior of this tumor, a histopathological examination being essential. The recommended treatment is surgical excision. For lesions located superficially in the parotid gland, superficial parotidectomy - identifying and preserving the facial nerve - is necessary. Lesions in the palate or gums sometimes demand a margin of safety, being excised below the periosteum, including the overlying mucosa. With correct surgical removal, the prognosis is excellent. The aim of this study is to report a case of an unusual minor salivary gland pleomorphic adenoma in the hard palate, describing the most important aspects of this pathology.

5-HT-stimulated arachidonic acid release from labeled phosphatidylinositol in blowfly salivary glands

1982 ◽  
Vol 243 (5) ◽  
pp. C222-C226 ◽  
Author(s):  
I. Litosch ◽  
Y. Saito ◽  
J. N. Fain
Keyword(s):  
Arachidonic Acid ◽  
Salivary Gland ◽  
Salivary Glands ◽  
Gland Secretion ◽  
Appreciable Effect ◽  
Arachidonic Acid Release ◽  
Salivary Gland Secretion ◽  
Hormone Sensitive ◽  
Acid Release ◽  
Ca2 Channels

In blowfly salivary glands, breakdown of phosphatidylinositol has been linked to the activation of hormone-sensitive Ca2+ channels. Addition of 5-hydroxytryptamine to blowfly salivary glands stimulated the breakdown of phosphatidylinositol prelabeled with 32P or [3H]arachidonic acid. This was associated with a transient accumulation of [3H]arachidonic-labeled diglyceride. There was no appreciable effect of 5-hydroxytryptamine on breakdown of phosphatidylethanolamine or phosphatidylcholine labeled with 32P or [3H]arachidonic acid, indicating that phosphatidylinositol was the immediate source of diglyceride. Extracellular Ca2+ was necessary for [3H]arachidonic acid but not 32P loss from phosphatidylinositol. Addition of arachidonic acid to salivary glands did not stimulate salivary gland secretion or 45Ca flux. In contrast, 5-hydroxytryptamine stimulated both salivary gland secretion and 45Ca flux. These results indicate that, although [3H]arachidonic acid is incorporated into phosphatidylinositol and its release from this phospholipid is increased by 5-hydroxytryptamine, the liberated arachidonic acid does not stimulate salivary gland secretion or 45Ca flux.

scholarly journals Pleomorphic Adenoma of Minor Salivary Gland in Buccal Mucosa: an Uncommon Finding

2015 ◽  
Vol 03 (01) ◽  
pp. 047-050
Author(s):  
Gourav Ahuja ◽  
Jaideep Marya ◽  
Poonam Sood
Keyword(s):  
Salivary Gland ◽  
Salivary Glands ◽  
Pleomorphic Adenoma ◽  
Buccal Mucosa ◽  
Minor Salivary Gland ◽  
Salivary Gland Tumors ◽  
Benign Tumors ◽  
Minor Salivary Glands ◽  
Diverse Range ◽  
Neck Tumors

AbstractSalivary gland tumors account for less than 3% of the head and neck tumors. Among various salivary gland tumors, pleomorphic adenoma is most common and accounts for 60- 70% of the benign tumors of salivary glands. However, the involvement of minor salivary glands of buccal mucosa is extremely uncommon and reported to be 4% only. Salivary glands may present with a diverse range of lesions presenting a challenge to even the most experienced clinician. We report two rare cases of pleomorphic adenoma of minor salivary glands of buccal mucosa in a 45 year old female and 70 years old male respectively. It includes clinical features, diagnosis and treatment of the tumor.

scholarly journals Clinicopathological profile of adenoid cystic carcinoma of minor salivary gland tumour: our experience at a tertiary care centre

2020 ◽  
Vol 6 (8) ◽  
pp. 1460
Author(s):  
Prakash Mylanahalli Doddrangaiah ◽  
Bharath Kanna Karunakaran ◽  
Roopa S. Mallali ◽  
Afshan Fathima
Keyword(s):  
Salivary Gland ◽  
Adenoid Cystic Carcinoma ◽  
Salivary Glands ◽  
Hard Palate ◽  
Minor Salivary Gland ◽  
Salivary Gland Tumour ◽  
Minor Salivary Glands ◽  
Adenoid Cystic ◽  
Minor Salivary Gland Tumour ◽  
Gland Tumour

<p class="abstract"><strong>Background:</strong> Adenoid cystic carcinoma (ACC) is a rare malignant tumour originating from minor salivary glands. It is known for perineural spread, local recurrences and distant metastasis. The minor salivary gland tumour represents 3% of all head and neck neoplasms, whereas ACC constitutes about 0.5% of all malignant salivary gland neoplasms. This study was done to evaluate the clinical presentation and histopathological findings of minor salivary gland tumour.</p><p class="abstract"><strong>Methods:</strong> This study was done in the department of ENT, Bangalore Medical College and Research Institute from May 2017 to July 2019. Of the 25 patients with minor salivary gland tumour, 10 patients with ACC were considered for the present study. A detailed clinical and histopathological evaluation was done. Results were documented and tabulated in excel sheet.  </p><p class="abstract"><strong>Results:</strong> We analysed data of 25 (16 female, 9 male) patients in the age group of 30-60 years, of which 10 patients had adenoid cystic carcinoma of minor salivary gland tumour. The most frequent site of tumour occurrence was noted in the hard palate (6 patients), followed by retromolar trigone (2 patients), floor of mouth (1 patient) and tongue (1 patient). The histopathological pattern noted most commonly in our study: cribriform pattern (6 cases), tubular (1 case) and solid (3 cases).</p><p class="abstract"><strong>Conclusions:</strong> ACC of minor salivary glands is rare. The otorhinolaryngologist should bear this clinical entity in mind when encountered with a painless swelling over the hard palate. This would lead to an early diagnosis and prompt management in such patients.</p>

Peculiar histopathological features in minor salivary gland in lupus erythematosus

Lupus ◽  
2018 ◽  
Vol 27 (10) ◽  
pp. 1706-1711 ◽  
Author(s):  
S B Bologna ◽  
M M S Nico ◽  
G Florezi ◽  
W S Cavalcante ◽  
S V Lourenço
Keyword(s):  
Salivary Gland ◽  
Salivary Glands ◽  
Lupus Erythematosus ◽  
Inflammatory Infiltrate ◽  
Minor Salivary Gland ◽  
Control Group ◽  
Minor Salivary Glands ◽  
Vacuolar Degeneration ◽  
Ductal Cells ◽  
American College Of Rheumatology

Salivary glands (SGs) can be affected by lupus erythematosus (LE). Many authors debate whether this condition is a secondary manifestation of Sjögren syndrome (SS) or a glandular aspect of LE. The present study investigated the histopathological aspects of biopsied minor salivary glands from LE patients to analyze their peculiar features that lead to xerostomia. Twenty-three minor labial salivary gland (MLSG) cases were included in the study; the diagnosis of LE was rendered according to the American College of Rheumatology criteria. Twenty-three healthy MLSGs were used as a control, for comparison. Regarding lupus MLSG, the presence of hyalinization and thickening of ductal basement membrane, perivascular inflammatory infiltrate, epithelial spongiosis with no ductal lymphocytic aggression, vacuolar degeneration of the ductal cells and acinar serous metaplasia were statistically significant compared to the control group. In the LE group, there was a statistically significant correlation between acinar atrophy and acinar fibrosis; acinar atrophy and ductal ectasia; acinar fibrosis and ductal ectasia; ductal atrophy and ductal spongiosis with no lymphocytic focus, interstitial inflammatory infiltrate intensity and vasculitis as well as vascular thrombi and vasculitis. There were no morphological differences between the three subtypes of lupus analyzed. Minor salivary glands from patients diagnosed with LE present peculiar histopathological changes and may be a multisystemic presentation.

Minor salivary gland inflammation in Devic’s disease and longitudinally extensive myelitis

2008 ◽  
Vol 14 (6) ◽  
pp. 809-814 ◽  
Author(s):  
A Javed ◽  
R Balabanov ◽  
BGW Arnason ◽  
TJ Kelly ◽  
NJ Sweiss ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Salivary Glands ◽  
Minor Salivary Gland ◽  
Connective Tissue Diseases ◽  
Transverse Myelitis ◽  
Minor Salivary Glands ◽  
Minor Salivary Gland Biopsy ◽  
Devic’S Disease ◽  
Devic's Disease ◽  
Sjögren’S Disease

Devic’s disease is often considered as a variant of multiple sclerosis (MS). However, evidence suggests that Devic’s disease may be distinct from MS. Devic’s disease can coexist with connective tissue diseases, particularly Sjögren’s disease, but this association is rare with MS. Diagnosis of Sjögren’s disease in patients with neurological symptoms is often difficult. During early stages of Sjögren’s disease, patients may not fulfill all criteria for Sjögren’s disease. A high percentage of patients with Sjögren’s disease have inflammatory infiltrates in minor salivary glands, and this may be a reliable indicator of early or subclinical disease. We show high prevalence (80%) of salivary gland inflammation in Devic’s disease and longitudinally extensive transverse myelitis (LETM). We diagnosed 16 patients with Devic’s disease, and 2 of these satisfied criteria for Sjögren’s disease as did 2 of 9 patients with LETM. Anti-SSA/B titers were infrequently elevated. Although most did not satisfy criteria for Sjögren’s disease. 9 of 12 Devic’s disease patients and 7 of 8 LETM patients had severe salivary gland inflammation. Thus: (1) patients with Devic’s disease or with LETM who have positive labial biopsies but do not satisfy criteria for Sjögren’s disease could have subclinical Sjögren’s diseases. Alternatively, (2) as patients with Devic’s disease have elevated titers of several autoantibodies, so there may exist a set of antibodies that react with antigens in minor salivary glands and cause inflammation. Minor salivary gland biopsy is more sensitive than anti-SSA/B serology in providing histological evidence for possible Sjögren’s disease with CNS lesions.

scholarly journals Forskolin as an activator of cyclic AMP accumulation and secretion in blowfly salivary glands

1982 ◽  
Vol 204 (1) ◽  
pp. 147-151 ◽  
Author(s):  
I Litosch ◽  
Y Saito ◽  
J N Fain
Keyword(s):  
Salivary Gland ◽  
Cyclic Amp ◽  
Adenylate Cyclase ◽  
Salivary Glands ◽  
Mammalian Cells ◽  
Salivary Secretion ◽  
Gland Secretion ◽  
Cyclic Amp Accumulation ◽  
Salivary Gland Secretion ◽  
Stimulation Of

Forskolin is a diterpene that activates adenylate cyclase in a variety of mammalian cells. In addition of forskolin to blowfly salivary glands increased cyclic AMP accumulation and salivary secretion. There was a small increase in transepithelial movement of labelled Ca2+. Forskolin did not induce breakdown of labelled phosphatidylinositol or inhibit the stimulation of phosphatidylinositol breakdown caused by 5-hydroxytryptamine. These data indicate that forskolin can mimic all the effects of 5-hydroxytryptamine on salivary-gland secretion that have been attributed to cyclic AMP.

scholarly journals Secondary Sjögren's in patients with systemic scleroderma

2019 ◽  
Vol 3 (23) ◽  
pp. 37-39
Author(s):  
E. I. Selifanova ◽  
M. S. Esayan
Keyword(s):  
Salivary Gland ◽  
Salivary Glands ◽  
Minor Salivary Gland ◽  
Systemic Scleroderma ◽  
Minor Salivary Glands ◽  
Minor Salivary Gland Biopsy ◽  
European Consensus ◽  
Salivary Gland Biopsy ◽  
Morphological Differences ◽  
Lymphoid Infiltration

The aim of the study was to investigate the morphological differences of the minor salivary glands in patients with secondary Sjögren's syndrome associated with systemic scleroderma (Scl-SS). Total of 40 patients were grouped according to the American–European Consensus Group criteria. Information about the duration of the disease was taken from the patients records. Sections of the minor salivary gland biopsy were reevaluated, and the lymphocyte focus score (FS), plasma cell focus, and fibrosis rates were all evaluated. The groups were formed according to the duration of the disease: less than and over 5 years.Results. Scl-SS leads to changes in both in the large salivary glands and in the MSG, manifested in the form of mucoid swelling, fibrinoid changes, hyalinosis and sclerosis. In patients with Scl-SS the progression of the process leads to the destruction of the duct wall and to the focal and diffuse lymphoid infiltration.

Sign in / Sign up

Export Citation Format

Share Document