p53 and bcl-2 expression and argyrophilic nucleolar organizer regions in patients with malignant maxillary sinus tumours

1997 ◽  
Vol 111 (1) ◽  
pp. 38-42 ◽  
Author(s):  
Torahiko Nakashima ◽  
Tadashi Nakashima ◽  
Muneyuki Masuda ◽  
Sohtaro Komiyama
Keyword(s):  
Maxillary Sinus ◽  
Clinical Course ◽  
Nucleolar Organizer ◽  
Nucleolar Organizer Regions ◽  
Malignant Tumours ◽  
Clinicopathological Findings ◽  
Significant Difference ◽  
The Mean ◽  
Maxillary Tumours ◽  
Argyrophilic Nucleolar Organizer Regions

AbstractTo investigate the relation between the clinicopathological findings, and the survival of patients with malignant tumours of the maxillary sinus, and the tumour's biological parameters, we examined the expression of p53 and bcl-2 and the number of silver-stainable nucleolar organizer regions (AgNORs) in 23 paraffin-embedded specimens from primary tumours. Fifteen of 23 (65 per cent) maxillary tumours expressed p53 and two of 23 (nine per cent) tumours expressed the bcl-2 gene product. The mean number of AgNORs per nucleus was 5.2 ± 2.4. There was no relationship between the expression of p53 or bcl-2 and the patient's clinical course. In contrast, there was a statistically significant difference in the survival of patients with a high (>6) number of AgNORs and patients with a low (<6) number of AgNORs. These data suggest that the number of AgNORs may be useful in evaluating the prognosis of patients with malignant maxillary sinus tumours.

scholarly journals Usefulness of argyrophilic nucleolar organizer regions in detection of lung cells alterations after benzo[a]pyrene instillation

2006 ◽  
Vol 21 (suppl 4) ◽  
pp. 36-39 ◽  
Author(s):  
Baldomero Antonio Kato da Silva ◽  
Iandara Schettert Silva ◽  
Daniel Martins Pereira ◽  
Ricardo Dutra Aydos ◽  
Paulo de Tarso Camillo de Carvalho
Keyword(s):  
Statistical Tests ◽  
Nucleolar Organizer ◽  
Lung Cells ◽  
Nucleolar Organizer Regions ◽  
Mean Values ◽  
Significant Difference ◽  
The Mean ◽  
Pulmonary Instillation ◽  
The Relationship ◽  
Argyrophilic Nucleolar Organizer Regions

PURPOSE: To verify the relationship between AgNOR expression and lung tissues changes of Wistar rats after pulmonary instillation of benzo[a]pyrene (B[a]P). METHODS: Male Rattus norvegicus albinus,Wistar lineage were given a single intrapulmonary instillation of B[a]P at doses of 10 and 20 mg/kg in a volume of approximately 0,3 ml. After 7 and 21 days the rats were killed and the lung slices submitted to a histological technique of AgNOR. AgNOR dots were quantified and the result analyzed by statistical tests; p <= 0,05 was considered significant. RESULTS: The mean values of AgNOR dots for the experimental groups 10/7 (1,51±0,86) and 10/21 (1,84±0,13) were statistically different (p = 0,009). Among the groups 20/7 (1,63±0,11) and 20/21 (2,48±0,28) was observed statistically significant difference (p = 0,003). CONCLUSION: The AgNOR technique can be useful in identification of cells changes induced by B[a]P.

scholarly journals Evaluating Endoscopic Ipsilateral Endonasal Corridor Approaches to the Anterolateral Wall of the Maxillary Sinus: A Computerized Tomography Study

2021 ◽  
Author(s):  
Navarat Vatcharayothin ◽  
Pornthep Kasemsiri ◽  
Sanguansak Thanaviratananich ◽  
Cattleya Thongrong
Keyword(s):  
Confidence Interval ◽  
Maxillary Sinus ◽  
Inferior Turbinate ◽  
Radial Access ◽  
Sinus Wall ◽  
Nasal Floor ◽  
Significant Difference ◽  
Anterolateral Wall ◽  
The Mean ◽  
Maxillary Sinuses

Abstract Introduction The endoscopic access to lesions in the anterolateral wall of the maxillary sinus is a challenging issue; therefore, the evaluation of access should be performed. Objective To assess the accessibility of three endoscopic ipsilateral endonasal corridors. Methods Three corridors were created in each of the 30 maxillary sinuses from 19 head cadavers. Accessing the anterolateral wall of the maxillary sinus was documented with a straight stereotactic navigator probe at the level of the nasal floor and of the axilla of the inferior turbinate. Results At level of the nasal floor, the prelacrimal approach, the modified endoscopic Denker approach, and the endoscopic Denker approach allowed mean radial access to the anterolateral maxillary sinus wall of 42.6 ± 7.3 (95% confidence interval [CI]: 39.9–45.3), 56.0 ± 6.1 (95%CI: 53.7–58.3), and 60.1 ± 6.2 (95%CI: 57.8–62.4), respectively. Furthermore, these approaches provided more lateral access to the maxillary sinus at the level of the axilla of the inferior turbinate, with mean radial access of 45.8 ± 6.9 (95%CI: 43.3–48.4) for the prelacrimal approach, 59.8 ± 4.7 (95% CI:58.1–61.6) for the modified endoscopic Denker approach, and 63.6 ± 5.5 (95%CI: 61.6–65.7) for the endoscopic Denker approach. The mean radial access in each corridor, either at the level of the nasal floor or the axilla of the inferior turbinate, showed a statistically significant difference in all comparison approaches (p < 0.05). Conclusions The prelacrimal approach provided a narrow radial access, which allows access to anteromedial lesions of the maxillary sinus, whereas the modified endoscopic Denker and the endoscopic Denker approaches provided more lateral radial access and improved operational feasibility on far anterolateral maxillary sinus lesions.

Number of Nucleoli and Nucleolar Organizer Regions per Nucleus and Nucleolus — Prognostic Value in Canine Mammary Tumors

1996 ◽  
Vol 33 (5) ◽  
pp. 527-532 ◽  
Author(s):  
M. BratuliĆ ◽  
Ž GrabareviĆ ◽  
B. ArtukoviĆ ◽  
D. Capak
Keyword(s):  
Malignant Tumors ◽  
Organizer Region ◽  
Nucleolar Organizer Region ◽  
Nucleolar Organizer ◽  
Staining Technique ◽  
Mammary Tumors ◽  
World Health ◽  
Nucleolar Organizer Regions ◽  
Canine Mammary Tumors ◽  
Significant Difference

Twenty-eight canine mammary tumors were evaluated for histopathologic classification as recommended by the World Health Organization and silver-binding nucleolar organizer region (AgNOR) and nucleolus counts. Samples of surgically excised tumors and tumors taken at necropsy were fixed in neutral formalin, embedded in paraffin, and cut into 1-3-μm-thick sections. Two sections were taken from each tumor: one was stained with hematoxylin and eosin and the other was treated with the silver staining technique for the demonstration of AgNORs. After histopathologic classification, the number of nucleoli and the number of AgNORs/nucleus and AgNORs/nucleolus were determined. Statistical analysis (Student's t-test) showed a significant difference in the mean number of nucleoli ( P < 0.005), mean number of AgNORs/nucleolus ( P < 0.001), and mean number of AgNORs/nucleus ( P < 0.005) between benign and malignant canine mammary tumors. There was no significant differences between metastatic and nonmetastatic malignant tumors.

Argyrophilic nucleolar organizer regions in oral mucosa cells of crack and cocaine users: a cross-sectional study

2020 ◽  
Vol 27 (30) ◽  
pp. 37920-37926
Author(s):  
Rosângela Góes Rabelo ◽  
Arthur Pias Salgueiro ◽  
Fernanda Visioli ◽  
Viviane Palmeira da Silva ◽  
Maria das Graças Alonso Oliveira ◽  
...  
Keyword(s):  
Oral Mucosa ◽  
Nucleolar Organizer ◽  
Cross Sectional Study ◽  
Nucleolar Organizer Regions ◽  
Sectional Study ◽  
Cross Sectional ◽  
Cocaine Users ◽  
Argyrophilic Nucleolar Organizer Regions

Argyrophilic nucleolar organizer regions in benign hyperplastic and cancerous human prostates

The Prostate ◽  
1992 ◽  
Vol 20 (1) ◽  
pp. 1-13 ◽  
Author(s):  
Motoyuki Masai ◽  
Kouichi Abe ◽  
Susumu Akimoto ◽  
Jun Shimazaki ◽  
Ryuichi Yatani
Keyword(s):  
Nucleolar Organizer ◽  
Nucleolar Organizer Regions ◽  
Argyrophilic Nucleolar Organizer Regions
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