Sinonasal inverted papilloma: narrative review

2010 ◽  
Vol 124 (7) ◽  
pp. 705-715 ◽  
Author(s):  
S Anari ◽  
S Carrie
Keyword(s):  
Malignant Transformation ◽  
Current Knowledge ◽  
Biological Marker ◽  
Staging System ◽  
Inverted Papilloma ◽  
Narrative Review ◽  
Future Research ◽  
Surgical Removal ◽  
Benign Condition ◽  
Sinonasal Inverted Papilloma

AbstractBackground:Sinonasal inverted papilloma is a benign condition with the potential for recurrence and malignant change. Over the past few decades, numerous studies and reviews have addressed different aspects of this condition.Objective:To amalgamate the current literature on inverted papilloma, in order to review the evidence and consider the gaps in current knowledge.Methods:Retrospective, narrative review.Results:The reported incidence of inverted papilloma varies between centres and is affected by selection bias. The exact aetiology of inverted papilloma is not fully understood. Currently, there is no reliable histological or biological marker to predict the probability of recurrence or malignant transformation. There is no universally accepted staging system available for sinonasal inverted papilloma. Complete surgical removal of the tumour is the mainstay of treatment, but the method of choice depends on the extent of the disease, the skill of the surgeon and the technology available.Conclusion:In order to compare different studies and to enable meta-analysis of the literature, there should be a universally accepted staging and classification system for sinonasal inverted papilloma. Further research on the aetiology of sinonasal inverted papilloma, and on biological markers for its recurrence and malignant transformation, is required. To enable meaningful future research, we would encourage multicentre participation with a consensus on management.

New Staging System for Sinonasal Inverted Papilloma in the Endoscopic Era

2007 ◽  
Vol 117 (7) ◽  
pp. 1283-1287 ◽  
Author(s):  
Steven B. Cannady ◽  
Pete S. Batra ◽  
Nathan B. Sautter ◽  
Hwan-Jung Roh ◽  
Martin J. Citardi
Keyword(s):  
Staging System ◽  
Inverted Papilloma ◽  
Sinonasal Inverted Papilloma

Clinical Implications of Carcinoma In Situ in Sinonasal Inverted Papilloma

2019 ◽  
Vol 161 (6) ◽  
pp. 1036-1042 ◽  
Author(s):  
Ivy W. Maina ◽  
Charles C. L. Tong ◽  
Esther Baranov ◽  
Neil N. Patel ◽  
Vasiliki Triantafillou ◽  
...  
Keyword(s):  
Malignant Transformation ◽  
Recurrence Rate ◽  
Carcinoma In Situ ◽  
Inverted Papilloma ◽  
Sinonasal Inverted Papilloma ◽  
Definitive Surgery ◽  
Severe Degree ◽  
Multiple Recurrences

Objective Sinonasal inverted papilloma (IP) is a typically benign sinonasal tumor with a tendency to recur and the potential for malignant transformation. Varying degrees of dysplasia may be present, of which carcinoma in situ (CIS) is most advanced. We hereby describe the biological and clinical behavior of IP with CIS (IPwCIS). Study Design Retrospective cohort. Setting Tertiary academic referral center. Subjects and Methods Patients who underwent surgical resection for IP between 2002 and 2017. Pertinent clinical data were obtained, and all IPwCIS cases were histologically confirmed. Results In total, 37 of 215 cases (17.2%) were identified with IPwCIS. Mean age was 57 years and 86.5% of patients were male. Median follow-up was 82 months, and the recurrence rate was 27%. The maxillary sinus was the most common primary site (37.8%) and 14 tumors (37.8%) demonstrated multifocal attachment, which was associated with recurrence (odds ratio [OR], 9.7; 95% confidence interval [CI], 1.4-112.8; P = .028). IPwCIS was also associated with multiple recurrences (OR, 2.71; 95% CI, 1.246-5.814; P = .021). Most patients were treated with surgery alone (89.1%) and 4 patients received adjuvant radiotherapy (8.1%). Only 1 patient (2.7%) demonstrated malignant transformation after definitive surgery. Conclusions IPwCIS represents the most severe degree of dysplasia prior to malignant transformation and is associated with higher recurrence rate and multifocal involvement but low rate of conversion to invasive carcinoma. The need for adjuvant therapy remains controversial, and further research into the etiology of the disease is warranted.

scholarly journals Endoscopic approach of sinonasal inverted papilloma – our 15 years’ experience on 162 cases

2015 ◽  
Vol 5 (17) ◽  
pp. 31-36 ◽  
Author(s):  
Vlad Budu ◽  
Alexandra Schnaider ◽  
Ioan Bulescu
Keyword(s):  
Surgical Treatment ◽  
Inverted Papilloma ◽  
Malignant Degeneration ◽  
Surgical Removal ◽  
Endoscopic Techniques ◽  
Sinonasal Inverted Papilloma ◽  
Radiologic Imaging ◽  
Retrospective Clinical Study ◽  
Long Term Follow Up

AbstractBACKGROUND. Inverted papilloma is a benign tumor of the nose and sinuses, with a high risk of recurrence and malignant degeneration. The inverted papilloma is a slow growing tumor that can be approached through an endoscopic or external approach, depending on its stage.OBJECTIVE. The aims of the study are to identify the particularities of diagnosis of the inverted papilloma, to establish the correct steps in surgical treatment of this tumor and to open the access for other steps of treatment.MATERIAL AND METHODS. The authors present their experience in managing the sinonasal inverted papilloma in a 15-year retrospective clinical study, which included 162 patients. The preoperative protocol consisted in clinical examination, nasal endoscopy, radiologic imaging (CT scan) and biopsy with histopathology results and immunohistochemistry findings. Surgical removal of the inverted papilloma was performed by endoscopic techniques, according to the stage of the tumor. We were interested in the recurrence rate of the tumor and its malignancy after a long-term follow-up.RESULTS. In our series, we included 162 patients and we had 26 (16.04%) recurrences and 12 (7.40%) malignant degenerations. All our patients were diagnosed in Krouse stages I, II and III and underwent endoscopic resection of the tumor.CONCLUSION. In order not to have any leftover tumor (the most important factor of recurrence and malignant transformation), it is mandatory to have a complete diagnosis of the inverted papilloma, a precise surgical technique and a rigorous followup. In some cases, the surgical treatment is associated with other type of treatment (antiviral, antiangiogenetic).

Malignant transformation of sinonasal inverted papilloma and related genetic alterations: a systematic review

2017 ◽  
Vol 274 (8) ◽  
pp. 2991-3000 ◽  
Author(s):  
M. Re ◽  
F. M. Gioacchini ◽  
A. Bajraktari ◽  
M. Tomasetti ◽  
S. Kaleci ◽  
...  
Keyword(s):  
Systematic Review ◽  
Malignant Transformation ◽  
Genetic Alterations ◽  
Inverted Papilloma ◽  
Sinonasal Inverted Papilloma

scholarly journals Risk Factors of Recurrence and Malignant Transformation of Sinonasal Inverted Papilloma

2017 ◽  
Vol 2017 ◽  
pp. 1-7 ◽  
Author(s):  
Marta Gamrot-Wrzoł ◽  
Paweł Sowa ◽  
Grażyna Lisowska ◽  
Wojciech Ścierski ◽  
Maciej Misiołek
Keyword(s):  
Malignant Transformation ◽  
Clinical Medicine ◽  
Surgical Techniques ◽  
Diagnostic Techniques ◽  
Postoperative Management ◽  
Inverted Papilloma ◽  
Surgical Approaches ◽  
Ki 67 ◽  
Wnt Proteins ◽  
Sinonasal Inverted Papilloma

Sinonasal inverted papilloma is a relatively rare disease; however, it is prevalent enough for every ENT practitioner to encounter it several times throughout medical routines. Despite the developments in experimental and clinical medicine as well as surgical techniques, our knowledge of this disease is still inadequate. With improved imaging and better diagnostic techniques, proper diagnosis and qualification for surgical approaches leave no doubt. Although the endoscopic approach seems to be the gold standard for such condition, some cases may additionally require an external approach. Regardless of the type of surgery, postoperative management is crucial for both healing and long-term follow-up. Unfortunately, the procedures are still lacking in explicit and standardized postoperative management guidelines. Moreover, an important issue is still the need for a biomarker indicative of inverted papilloma and its malignant transformation. Several particles, within the spotlight of the researchers, have been SCCA, Ki-67, Bcl-2, Wnt proteins, and many more. Nevertheless, the topic requires further investigations.

scholarly journals Sinonasal Inverted Papilloma and the Dilemma of Treatments

2013 ◽  
Vol 6 (2) ◽  
pp. 61-63
Author(s):  
Bandar Al Qahtani ◽  
Mariam S Al-Amro
Keyword(s):  
Malignant Transformation ◽  
Recent Literature ◽  
Inverted Papilloma ◽  
Sinonasal Inverted Papilloma

ABSTRACT This is a review of most recent literature to find the best methods for management of sinonasal inverted papilloma and if there is any standardized modality/modalities. Also there is concern about the advancement in the management of sinonasal inverted papilloma based on recent literature revision. Inverted papilloma has to be managed aggressively from the beginning putting in mind its ability to recur and malignant transformation. Until now days there is no single verified modality of treatment and the choice of the best approach is tailored to every case. How to cite this article Al-Qahtani BM, Al-Amro MS. Sinonasal Inverted Papilloma and the Dilemma of Treatments. Clin Rhinol An Int J 2013;6(2):61-63.

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