Assessing the risk of Alzheimer's disease in first-degree relatives of Alzheimer's disease cases

1993 ◽  
Vol 23 (4) ◽  
pp. 915-923 ◽  
Author(s):  
A. E. Korten ◽  
A. F. Jorm ◽  
A. S. Henderson ◽  
G. A. Broe ◽  
H. Creasey ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Family History ◽  
Cumulative Incidence ◽  
Dominant Gene ◽  
Lifetime Risk ◽  
First Degree Relatives ◽  
Familial Form ◽  
The Family ◽  
History Of

SynopsisFamily history of Alzheimer's disease (AD) was investigated using a telephone re-interview of 99 cases and 116 controls selected from a case–control study of 170 matched pairs. It was found that the family history method used in the initial interview was satisfactory in identifying first-degree relatives and assessing their ages of birth and death, but the number of first-degree relatives suffering from AD was probably under-estimated. Family history of AD was confirmed as a risk factor for AD. Higher estimates of cumulative incidence were obtained among case relatives than among control relatives. No evidence was found to support the hypothesis that a familial form of AD is more common in those with earlier onset AD (before age 75) in those who display early, prominent features of aphasia or apraxia, or that an AD gene may be sex-linked. The curves for cumulative incidence showed no tendency to reach an asymptote, as is implied by the theory that some forms of AD are due to the action of an autosomal dominant gene. Estimates of lifetime risk by age 90 were within the range found by other investigators. Much larger samples of the very old are needed to obtain estimates of total lifetime risk with smaller standard errors.

scholarly journals A Structural Connectivity Disruption One Decade before the Typical Age for Dementia: A Study in Healthy Subjects with Family History of Alzheimer’s Disease

2021 ◽  
Author(s):  
F Ramírez-Toraño ◽  
Kausar Abbas ◽  
Ricardo Bruña ◽  
Silvia Marcos de Pedro ◽  
Natividad Gómez-Ruiz ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Family History ◽  
Fractional Anisotropy ◽  
Diffusion Tensor ◽  
Structural Connectivity ◽  
Network Failure ◽  
Structural Connectome ◽  
The Family ◽  
History Of

Abstract The concept of the brain has shifted to a complex system where different subnetworks support the human cognitive functions. Neurodegenerative diseases would affect the interactions among these subnetworks and, the evolution of impairment and the subnetworks involved would be unique for each neurodegenerative disease. In this study, we seek for structural connectivity traits associated with the family history of Alzheimer’s disease, i.e., early signs of subnetworks impairment due to Alzheimer’s disease.3. The sample in this study consisted of 123 first-degree Alzheimer’s disease relatives and 61 non-relatives. For each subject, structural connectomes were obtained using classical diffusion tensor imaging measures and different resolutions of cortical parcellation. For the whole sample, independent structural-connectome-traits were obtained under the framework of connICA. Finally, we tested the association of the structural-connectome-traits with different factors of relevance for Alzheimer’s disease by means of a multiple linear regression. The analysis revealed a structural-connectome-trait obtained from fractional anisotropy associated with the family history of Alzheimer’s disease. The structural-connectome-trait presents a reduced fractional anisotropy pattern in first-degree relatives in the tracts connecting posterior areas and temporal areas. The family history of Alzheimer’s disease structural-connectome-trait presents a posterior–posterior and posterior-temporal pattern, supplying new evidences to the cascading network failure model.

scholarly journals P4-573: PROXIMITY TO PARENTAL ONSET AND APOE ε4 INDEPENDENTLY CONTRIBUTE TO AMYLOID BURDEN IN MIDDLE-AGED ADULTS WITH A FAMILY HISTORY OF SPORADIC ALZHEIMER'S DISEASE

2019 ◽  
Vol 15 ◽  
pp. P1539-P1539
Author(s):  
Eider M. Arenaza-Urquijo ◽  
Gemma Salvadó ◽  
Carolina Minguillón ◽  
Marta Crous-Bou ◽  
Gonzalo Sánchez-Benavides ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Family History ◽  
Amyloid Burden ◽  
Middle Aged ◽  
Sporadic Alzheimer’S Disease ◽  
Apoe Ε4 ◽  
History Of ◽  
Middle Aged Adults

scholarly journals Investigation of the Polymorphic Region in the 5' Flanking Region of the Insulin Gene in Patients with Alzheimer's Disease

1986 ◽  
Vol 13 (S4) ◽  
pp. 471-474
Author(s):  
Michael Fisman ◽  
Valerie M. Watt
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Family History ◽  
Venous Blood ◽  
Insulin Gene ◽  
Restriction Enzyme Digestion ◽  
Polymorphic Region ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
History Of

Abstract:A potential relationship between Alzheimer's Disease (AD) and insulin gene expression was suggested by the observation that patients with AD have altered levels of fasting blood sugar and insulin. Since polymorphisms in the region 5' to the insulin gene have been associated with blood glucose levels, we have studied this polymorphism in AD patients. Subjects were 19 nondiabetic AD patients with symptoms of aphasia and apraxia and a family history of AD; and 20 age and sex-matched nondiabetic controls without family history of AD. The 5' polymorphic region of the insulin gene was analyzed by restriction enzyme digestion of DNA extracted from whole venous blood. We did not observe a correlation between the size of the 5' polymorphic region and AD.

scholarly journals PERSONALITY AND FAMILY HISTORY OF ALZHEIMER’S DISEASE AS PREDICTORS OF OLDER ADULTS’ SELF-REPORTED MEMORY PROBLEMS

2019 ◽  
Vol 3 (Supplement_1) ◽  
pp. S220-S220
Author(s):  
Sakshi Bhargava ◽  
Nikki Hill ◽  
Jacqueline Mogle ◽  
Tyler R Bell ◽  
Rachel Wion
Keyword(s):  
Alzheimer’S Disease ◽  
Older Adults ◽  
Alzheimer's Disease ◽  
Family History ◽  
Multilevel Modeling ◽  
Individual Factors ◽  
Memory Decline ◽  
Memory Problems ◽  
History Of ◽  
One Year

Abstract Understanding individual factors (e.g., personality) associated with self-reported memory problems is important to refine identification of individuals at a higher risk of developing Alzheimer’s disease (AD). Using multilevel modeling, we examined the association of family history of AD and personality traits with self-reported memory problems in older adults (n = 421; 72.21% White; 62.95% female; Mage = 76.69). Results showed that individuals with a family history of AD reported more frequent memory problems and greater one-year memory decline. Similar findings were reported for individuals with higher extraversion scores. Further, older adults with higher neuroticism scores reported greater one- and ten-year memory decline. Neuroticism was positively related to frequency of memory problems, but only among participants with a family history of AD. Findings suggest that higher neuroticism and lower extraversion may increase older adults’ reports of memory problems. Family history of AD may further exacerbate this tendency.

Sign in / Sign up

Export Citation Format

Share Document