scholarly journals A Structural Connectivity Disruption One Decade before the Typical Age for Dementia: A Study in Healthy Subjects with Family History of Alzheimer’s Disease

2021 ◽  
Author(s):  
F Ramírez-Toraño ◽  
Kausar Abbas ◽  
Ricardo Bruña ◽  
Silvia Marcos de Pedro ◽  
Natividad Gómez-Ruiz ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Family History ◽  
Fractional Anisotropy ◽  
Diffusion Tensor ◽  
Structural Connectivity ◽  
Network Failure ◽  
Structural Connectome ◽  
The Family ◽  
History Of

Abstract The concept of the brain has shifted to a complex system where different subnetworks support the human cognitive functions. Neurodegenerative diseases would affect the interactions among these subnetworks and, the evolution of impairment and the subnetworks involved would be unique for each neurodegenerative disease. In this study, we seek for structural connectivity traits associated with the family history of Alzheimer’s disease, i.e., early signs of subnetworks impairment due to Alzheimer’s disease.3. The sample in this study consisted of 123 first-degree Alzheimer’s disease relatives and 61 non-relatives. For each subject, structural connectomes were obtained using classical diffusion tensor imaging measures and different resolutions of cortical parcellation. For the whole sample, independent structural-connectome-traits were obtained under the framework of connICA. Finally, we tested the association of the structural-connectome-traits with different factors of relevance for Alzheimer’s disease by means of a multiple linear regression. The analysis revealed a structural-connectome-trait obtained from fractional anisotropy associated with the family history of Alzheimer’s disease. The structural-connectome-trait presents a reduced fractional anisotropy pattern in first-degree relatives in the tracts connecting posterior areas and temporal areas. The family history of Alzheimer’s disease structural-connectome-trait presents a posterior–posterior and posterior-temporal pattern, supplying new evidences to the cascading network failure model.

Assessing the risk of Alzheimer's disease in first-degree relatives of Alzheimer's disease cases

1993 ◽  
Vol 23 (4) ◽  
pp. 915-923 ◽  
Author(s):  
A. E. Korten ◽  
A. F. Jorm ◽  
A. S. Henderson ◽  
G. A. Broe ◽  
H. Creasey ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Family History ◽  
Cumulative Incidence ◽  
Dominant Gene ◽  
Lifetime Risk ◽  
First Degree Relatives ◽  
Familial Form ◽  
The Family ◽  
History Of

SynopsisFamily history of Alzheimer's disease (AD) was investigated using a telephone re-interview of 99 cases and 116 controls selected from a case–control study of 170 matched pairs. It was found that the family history method used in the initial interview was satisfactory in identifying first-degree relatives and assessing their ages of birth and death, but the number of first-degree relatives suffering from AD was probably under-estimated. Family history of AD was confirmed as a risk factor for AD. Higher estimates of cumulative incidence were obtained among case relatives than among control relatives. No evidence was found to support the hypothesis that a familial form of AD is more common in those with earlier onset AD (before age 75) in those who display early, prominent features of aphasia or apraxia, or that an AD gene may be sex-linked. The curves for cumulative incidence showed no tendency to reach an asymptote, as is implied by the theory that some forms of AD are due to the action of an autosomal dominant gene. Estimates of lifetime risk by age 90 were within the range found by other investigators. Much larger samples of the very old are needed to obtain estimates of total lifetime risk with smaller standard errors.

Using Fractional Anisotropy Imaging to Detect Mild Cognitive Impairment and Alzheimer’s Disease among Mexican Americans and Non-Hispanic Whites: A HABLE Study

2021 ◽  
pp. 1-8
Author(s):  
James R. Hall ◽  
Leigh A. Johnson ◽  
Fan Zhang ◽  
Melissa Petersen ◽  
Arthur W. Toga ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Fractional Anisotropy ◽  
Mexican Americans ◽  
Diffusion Tensor ◽  
Characteristic Curve ◽  
Aging Brain ◽  
Community Based

<b><i>Introduction:</i></b> Alzheimer’s disease (AD) is the most frequently occurring neurodegenerative disease; however, little work has been conducted examining biomarkers of AD among Mexican Americans. Here, we examined diffusion tensor MRI marker profiles for detecting mild cognitive impairment (MCI) and dementia in a multi-ethnic cohort. <b><i>Methods:</i></b> 3T MRI measures of fractional anisotropy (FA) were examined among 1,636 participants of the ongoing community-based Health &amp; Aging Brain among Latino Elders (HABLE) community-based study (Mexican American <i>n</i> = 851; non-Hispanic white <i>n</i> = 785). <b><i>Results:</i></b> The FA profile was highly accurate in detecting both MCI (area under the receiver operating characteristic curve [AUC] = 0.99) and dementia (AUC = 0.98). However, the FA profile varied significantly not only between diagnostic groups but also between Mexican Americans and non-Hispanic whites. <b><i>Conclusion:</i></b> Findings suggest that diffusion tensor imaging markers may have a role in the neurodiagnostic process for detecting MCI and dementia among diverse populations.

scholarly journals Brain Structural and Amyloid Correlates of Recovery From Semantic Interference in Cognitively Normal Individuals With or Without Family History of Late-Onset Alzheimer’s Disease

2019 ◽  
Vol 31 (1) ◽  
pp. 25-36 ◽  
Author(s):  
Carolina Abulafia ◽  
David Loewenstein ◽  
Rosie Curiel-Cid ◽  
Bárbara Duarte-Abritta ◽  
Stella M. Sánchez ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Family History ◽  
Late Onset ◽  
Semantic Interference ◽  
Cognitively Normal ◽  
Normal Individuals ◽  
History Of

Identification of a novel PSEN1 mutation (Leu232Pro) in a Korean patient with early-onset Alzheimer's disease and a family history of dementia

2017 ◽  
Vol 56 ◽  
pp. 212.e11-212.e17 ◽  
Author(s):  
Jiyun Park ◽  
Seong Soo A. An ◽  
Vo Van Giau ◽  
Kyuhwan Shim ◽  
Young Chul Youn ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Family History ◽  
Early Onset ◽  
Korean Patient ◽  
Psen1 Mutation ◽  
History Of ◽  
Early Onset Alzheimer’S Disease

scholarly journals Functional and structural connectome properties in the 5XFAD transgenic mouse model of Alzheimer’s disease

2018 ◽  
Vol 2 (2) ◽  
pp. 241-258 ◽  
Author(s):  
Shelli R. Kesler ◽  
Paul Acton ◽  
Vikram Rao ◽  
William J. Ray
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Mouse Model ◽  
Transgenic Mice ◽  
Transgenic Mouse ◽  
Amyloid Beta ◽  
Molecular Mechanisms ◽  
Diffusion Tensor ◽  
Transgenic Mouse Model ◽  
Structural Connectome

Neurodegeneration in Alzheimer’s disease (AD) is associated with amyloid-beta peptide accumulation into insoluble amyloid plaques. The five-familial AD (5XFAD) transgenic mouse model exhibits accelerated amyloid-beta deposition, neuronal dysfunction, and cognitive impairment. We aimed to determine whether connectome properties of these mice parallel those observed in patients with AD. We obtained diffusion tensor imaging and resting-state functional magnetic resonance imaging data for four transgenic and four nontransgenic male mice. We constructed both structural and functional connectomes and measured their topological properties by applying graph theoretical analysis. We compared connectome properties between groups using both binarized and weighted networks. Transgenic mice showed higher characteristic path length in weighted structural connectomes and functional connectomes at minimum density. Normalized clustering and modularity were lower in transgenic mice across the upper densities of the structural connectome. Transgenic mice also showed lower small-worldness index in higher structural connectome densities and in weighted structural networks. Hyper-correlation of structural and functional connectivity was observed in transgenic mice compared with nontransgenic controls. These preliminary findings suggest that 5XFAD mouse connectomes may provide useful models for investigating the molecular mechanisms of AD pathogenesis and testing the effectiveness of potential treatments.

scholarly journals P4-573: PROXIMITY TO PARENTAL ONSET AND APOE ε4 INDEPENDENTLY CONTRIBUTE TO AMYLOID BURDEN IN MIDDLE-AGED ADULTS WITH A FAMILY HISTORY OF SPORADIC ALZHEIMER'S DISEASE

2019 ◽  
Vol 15 ◽  
pp. P1539-P1539
Author(s):  
Eider M. Arenaza-Urquijo ◽  
Gemma Salvadó ◽  
Carolina Minguillón ◽  
Marta Crous-Bou ◽  
Gonzalo Sánchez-Benavides ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Family History ◽  
Amyloid Burden ◽  
Middle Aged ◽  
Sporadic Alzheimer’S Disease ◽  
Apoe Ε4 ◽  
History Of ◽  
Middle Aged Adults

scholarly journals Investigation of the Polymorphic Region in the 5' Flanking Region of the Insulin Gene in Patients with Alzheimer's Disease

1986 ◽  
Vol 13 (S4) ◽  
pp. 471-474
Author(s):  
Michael Fisman ◽  
Valerie M. Watt
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Family History ◽  
Venous Blood ◽  
Insulin Gene ◽  
Restriction Enzyme Digestion ◽  
Polymorphic Region ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
History Of

Abstract:A potential relationship between Alzheimer's Disease (AD) and insulin gene expression was suggested by the observation that patients with AD have altered levels of fasting blood sugar and insulin. Since polymorphisms in the region 5' to the insulin gene have been associated with blood glucose levels, we have studied this polymorphism in AD patients. Subjects were 19 nondiabetic AD patients with symptoms of aphasia and apraxia and a family history of AD; and 20 age and sex-matched nondiabetic controls without family history of AD. The 5' polymorphic region of the insulin gene was analyzed by restriction enzyme digestion of DNA extracted from whole venous blood. We did not observe a correlation between the size of the 5' polymorphic region and AD.

P2-278: TRANSCALLOSAL CONDUCTION AND CENTRAL MOTOR CONDUCTION IN PEOPLE WITH A FAMILY HISTORY OF AUTOSOMAL-DOMINANT ALZHEIMER'S DISEASE

2006 ◽  
Vol 14 (7S_Part_14) ◽  
pp. P785-P785
Author(s):  
Yi-Ling Kuo ◽  
John M. Ringman ◽  
Yannick Darmon ◽  
Connor Holzke ◽  
Beth E. Fisher
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Family History ◽  
Autosomal Dominant ◽  
Autosomal Dominant Alzheimer’S Disease ◽  
History Of
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