A twin study of antisocial and neurotic symptoms in childhood

1996 ◽  
Vol 26 (6) ◽  
pp. 1111-1118 ◽  
Author(s):  
Anita Thapar ◽  
Peter McGuffin
Keyword(s):  
Environmental Factors ◽  
Psychiatric Symptoms ◽  
Antisocial Behaviour ◽  
Shared Environment ◽  
Childhood And Adolescence ◽  
Different Types ◽  
Genetic And Environmental Factors ◽  
Using Data ◽  
Variance Explained

SynopsisThere is some evidence to suggest that the role of genetic and environmental influences may vary for different types of psychiatric symptoms in childhood. The aim of this study was to examine to what extent genetic and environmental factors influence parent-rated conduct and neurotic symptoms in childhood and adolescence, using data obtained from a systematically ascertained sample of twins (198 same sex pairs) aged between 8 and 16 years. For symptoms of antisocial behaviour, transmission could be explained entirely by shared environmental factors. Social class effects were also found to have a significant influence on antisocial behaviour, although these effects only accounted for a small proportion of the variance explained by shared environmental factors. In contrast, transmission of neurotic symptoms was best explained by additive genetic influences alone with no contribution from shared environment. Non-shared environmental factors accounted for a substantial component of the variation for both antisocial behaviour and neurotic symptoms.

The etiologic role of genetic and environmental factors in criminal behavior as determined from full- and half-sibling pairs: an evaluation of the validity of the twin method

2014 ◽  
Vol 45 (9) ◽  
pp. 1873-1880 ◽  
Author(s):  
K. S. Kendler ◽  
S. L. Lönn ◽  
H. H. Maes ◽  
J. Sundquist ◽  
K. Sundquist
Keyword(s):  
Environmental Factors ◽  
Age Differences ◽  
Twin Study ◽  
Criminal Behavior ◽  
Shared Environment ◽  
Complex Disorders ◽  
Twin Method ◽  
Heritability Estimates ◽  
Genetic And Environmental Factors

BackgroundTwin studies have shown that criminal behavior (CB) is influenced by both genetic and shared environmental factors. Could these results be replicated using full-siblings and half-siblings?MethodIn 911 009 full-siblings reared together (FSRT), 41 872 half-siblings reared together (HSRT) and 52 590 half-siblings reared apart (HSRA), CB was assessed from the Swedish Crime Register. Modeling, including testing for age differences and rearing status, was performed using the OpenMx package.ResultsFive sibling models were fitted examining FSRT and HSRT 0–2 years different in age, and both FSRT and HSRT, and FSRT, HSRT and HSRA 0–10 years different in age with and without a specified shared environment indexing age differences. Heritability estimates for CB ranged from 33 to 55% in females and 39 to 56% in males, similar to those found in our prior twin study on the same population. Estimates for the shared environment varied from 1 to 14% in females and 10 to 23% in males, lower than those estimated in the twin study. The specified shared environment indexed by sibling age differences was significant in all models tested.ConclusionsHeritability estimates for CB from full- and half-siblings closely approximated those found from twins in the same population, validating the twin method. Shared environmental estimates were lower, suggesting the presence of shared environmental factors for CB specific to twins. When rearing status can be assessed, full- and half-siblings offer an additional method for assessing the role of genetic and environmental factors in complex disorders. However, age differences in siblings may need to be included in the models.

scholarly journals An Unusual Case of “Conjugal” Polymyalgia Rheumatica after SARS-CoV-2 Vaccination

Rheumato ◽  
2021 ◽  
Vol 1 (1) ◽  
pp. 17-21
Author(s):  
Elena Vanni ◽  
Jacopo Ciaffi ◽  
Luana Mancarella ◽  
Francesco Ursini
Keyword(s):  
Environmental Factors ◽  
Polymyalgia Rheumatica ◽  
Temporal Correlation ◽  
Married Couples ◽  
Laboratory Findings ◽  
Immune Mediated ◽  
Asia Syndrome ◽  
Causative Effect ◽  
Genetic And Environmental Factors

The rare occurrence of polymyalgia rheumatica (PMR) in married couples has been reported in the literature. Susceptibility to PMR is contributed by genetic and environmental factors and cases of PMR developing after influenza vaccine have also been described, in a debated phenomenon known as ‘ASIA’ syndrome. We report the case of two cohabitating married patients developing PMR few weeks after the first dose of ChAdOx1-S SARS-CoV-2 vaccine. Both patients presented with typical symptoms suggestive of PMR. Laboratory findings and ultrasound examination confirmed the diagnosis. Glucocorticoid therapy led to rapid improvment of symptoms. Anti-receptor-binding domain IgG titre was tested and, eight weeks after vaccination, both patients showed no antibody response. It has been suggested that vaccines might trigger autoimmune or inflammatory states in predisposed individuals and various hypotheses have been made regarding the pathogenesis of PMR. Although the causative effect of vaccines cannot be determined, the close temporal correlation observed in our case supports the potential role of environmental factors in triggering the onset of PMR. However, the literature indicates that post-COVID19 vaccination immune-mediated or inflammatory adverse events are extremely rare and vaccination should be encouraged since the benefit largely outweighs possible risks.

scholarly journals Eye Rubbing and Keratoconus: A Literature Review

2014 ◽  
Vol 3 (3) ◽  
pp. 118-121 ◽  
Author(s):  
Elizabeth Hawkes ◽  
Mayank A Nanavaty
Keyword(s):  
Environmental Factors ◽  
Literature Review ◽  
Visual Loss ◽  
Current Knowledge ◽  
Common Cause ◽  
Genetic And Environmental Factors ◽  
Developed World

ABSTRACT Keratoconus is a progressive corneal ectactic condition that can lead to visual loss. Despite being the most common cause for keratoplasty in the developed world the aetiology is unknown. It is thought to be multifactorial, with genetic and environmental factors implicated. The association of eye rubbing and pathogenesis of keratoconus has been well documented. In this review, we collate the existing literature and summarize the current knowledge of the role of eye rubbing in the pathogenesis of keratoconus. How to cite this article Hawkes E, Nanavaty MA. Eye Rubbing and Keratoconus: A Literature Review. Int J Kerat Ect Cor Dis 2014;3(3):118-121.

Dyslexia: A Very Short Introduction

2019 ◽  
Author(s):  
Margaret J. Snowling
Keyword(s):  
Risk Factors ◽  
Environmental Factors ◽  
Short Introduction ◽  
Learning To Read ◽  
Innovative Research ◽  
Genetic And Environmental Factors ◽  
Associated Risk Factors

Dyslexia: A Very Short Introduction provides an accessible overview of the innovative research surrounding dyslexia, beginning with its history, and drawing on the experiences of children and adults with dyslexia today. Considering the skills involved in learning to read, and looking at the role of genetic and environmental factors including the language of learning, this VSI discusses the causes of dyslexia and its associated risk factors. Discussing the various brain-scanning techniques that have been used to find out if the brains of people with dyslexia differ in structure or function from those of typical readers, it moves on to weigh up various strategies and interventions that can help people living with dyslexia today.

Exploring Genetic and Environmental Influences on Miscarriage Rates: A Twin Study

2010 ◽  
Vol 13 (2) ◽  
pp. 201-206 ◽  
Author(s):  
Andrea V. Burri ◽  
Lynn Cherkas ◽  
Timothy D. Spector
Keyword(s):  
Environmental Factors ◽  
Twin Study ◽  
Variance Components ◽  
Model Fitting ◽  
Genetic Influence ◽  
Shared Environment ◽  
Pair Correlations ◽  
Relative Contribution ◽  
Genetic And Environmental Factors ◽  
Common Variable

AbstractMiscarriage is the most common type of pregnancy loss, occurring in up to 15% of clinically recognized pregnancies. Our understanding of the etiology is still limited but is believed to be multifactorial, including endocrine and anatomical abnormalities, immunologic, genetic and lifestyle factors. The aim of this study was to explore whether genetic variability in miscarriage is under any genetic influence. 3234 MZ and DZ female twins completed postal self-completion questionnaires on pregnancies. Rates were adjusted for total number of pregnancies. The relative contribution of genetic and environmental factors to variation in miscarriage was assessed using twin intra-pair correlations and quantified using a variance components model fitting approach. We found 22.7% of our twins reporting having suffered at least one miscarriage. Current age, age at first pregnancy and higher number of pregnancies all had a significant influence on reported miscarriage. The concordance of miscarriage was similar in identical and non-identical twins, 26% and 27%, respectively. Shared environment and predominantly random error and unique environment rather than genetic factors best explained the total variation of miscarriage. To our knowledge, this is the first large twin study exploring heritability of miscarriage which unlike the vast majority of common variable traits, shows no significant genetic influence. In the absence of clear environmental factors, these results suggest the influence of random factors.

Genes, environments and depressions in young people

2015 ◽  
Vol 100 (11) ◽  
pp. 1064-1069 ◽  
Author(s):  
Ian M Goodyer
Keyword(s):  
Young People ◽  
Environmental Factors ◽  
Mental Illnesses ◽  
Childhood And Adolescence ◽  
The Common ◽  
Genetic And Environmental Factors

Among the common mental illnesses in childhood and adolescence, the unipolar depressions are the most concerning. These mental illnesses are aetiologically and clinically heterogeneous and little is known about their pathophysiology. This selected review considers the contribution of genetic and environmental factors in the emergence of these illnesses in the second decade of life.

Genetic and Cultural Transmission of Antisocial Behavior: An Extended Twin Parent Model

2007 ◽  
Vol 10 (1) ◽  
pp. 136-150 ◽  
Author(s):  
Hermine H. Maes ◽  
Judy L. Silberg ◽  
Michael C. Neale ◽  
Lindon J. Eaves
Keyword(s):  
Environmental Factors ◽  
Antisocial Behavior ◽  
Assortative Mating ◽  
Cultural Transmission ◽  
Shared Environment ◽  
Simultaneous Estimation ◽  
Adoption Studies ◽  
Expression Of Genes ◽  
Genes And Environment ◽  
Genetic And Environmental Factors

AbstractConsiderable evidence from twin and adoption studies indicates that both genetic and shared environmental factors play a substantial role in the liability to antisocial behavior. Although twin and adoption designs can resolve genetic and environmental influences, they do not provide information about assortative mating, parent–offspring transmission, or the contribution of these factors to trait variation. We examined the role of genetic and environmental factors for conduct disorder (CD) using a twin–parent design. This design allows the simultaneous estimation of additive genetic, shared and individual-specific environmental effects, as well as sex differences in the expression of genes and environment in the presence of assortative mating and combined genetic and cultural transmission. A retrospective measure of CD was obtained from twins and their parents or guardians in the Virginia Twin Study of Adolescent Behavior Development and its Young Adult Follow up sample. Both genetic and environmental factors play a significant role in the liability to CD. Major influences on individual differences appeared to be additive genetic (38%–40%) and unique environmental (39%–42%) effects, with smaller contributions from the shared environment (18%–23%), assortative mating (~2%), cultural transmission (~2%) and resulting genotype-environment covariance. This study showed significant heritability, which is slightly increased by assortative mating, and significant effects of primarily nonparental shared environment on CD.

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