The epidemiology of psychiatrist-ascertained depression and DSM-III depressive disorders Results from the Eastern Baltimore Mental Health Survey Clinical

1992 ◽  
Vol 22 (3) ◽  
pp. 629-655 ◽  
Author(s):  
A. J. Romanoski ◽  
M. F. Folstein ◽  
G. Nestadt ◽  
R. Chahal ◽  
A. Merchant ◽  
...  
Keyword(s):  
Major Depression ◽  
Life Events ◽  
Depressive Disorders ◽  
Multiple Logistic Regression ◽  
Adverse Life Events ◽  
Future Studies ◽  
Symptom Profiles ◽  
Examination Method ◽  
Treatment Of Depression ◽  
History Of

SynopsisPsychiatrists used a semi-structured Standardized Psychiatric Examination method to examine 810 adults drawn from a probability sample of eastern Baltimore residents in 1981. Of the population, 5·9% was found to be significantly depressed. DSM-III major depression (MD) had a prevalence of 1·1% and ‘non-major depression’ (nMD), our collective term for the other depressive disorder categories in DSM-III, had a prevalence of 3·4%. The two types of depression differed by sex ratio, age-specific prevalence, symptom severity, symptom profiles, and family history of suicide. Analyses using a multiple logistic regression model discerned that both types of depression were influenced by adverse life events, and that nMD was influenced strongly by gender, marital status, and lack of employment outside the home. Neither type of depression was influenced by income, education, or race. This study validates the concept of major depression as a clinical entity. Future studies of the aetiology, mechanism, and treatment of depression should distinguish between these two types of depression.

scholarly journals Factors related to age at depression onset: the role of SLC6A4 methylation, sex, exposure to stressful life events and personality in a sample of inpatients suffering from major depression

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Simon Sanwald ◽  
◽  
Katharina Widenhorn-Müller ◽  
Carlos Schönfeldt-Lecuona ◽  
Christian Montag ◽  
...  
Keyword(s):  
Major Depression ◽  
Life Events ◽  
Depressive Disorders ◽  
Stressful Life Events ◽  
Depressive Symptomatology ◽  
Age At Onset ◽  
Stressful Life ◽  
Entire Group ◽  
Affective Neuroscience ◽  
Depression Severity

Abstract Background An early onset of depression is associated with higher chronicity and disability, more stressful life events (SLEs), higher negative emotionality as described by the primary emotion SADNESS and more severe depressive symptomatology compared to depression onset later in life. Additionally, methylation of the serotonin transporter gene (SLC6A4) is associated with SLEs and depressive symptoms. Methods We investigated the relation of SLEs, SLC6A4 methylation in peripheral blood, the primary emotions SADNESS and SEEKING (measured by the Affective Neuroscience Personality Scales) as well as depressive symptom severity to age at depression onset in a sample of N = 146 inpatients suffering from major depression. Results Depressed women showed higher SADNESS (t (91.05) = − 3.17, p = 0.028, d = − 0.57) and higher SLC6A4 methylation (t (88.79) = − 2.95, p = 0.02, d = − 0.55) compared to men. There were associations between SLEs, primary emotions and depression severity, which partly differed between women and men. The Akaike information criterion (AIC) indicated the selection of a model including sex, SLEs, SEEKING and SADNESS for the prediction of age at depression onset. SLC6A4 methylation was not related to depression severity, age at depression onset or SLEs in the entire group, but positively related to depression severity in women. Conclusions Taken together, we provide further evidence that age at depression onset is associated with SLEs, personality and depression severity. However, we found no associations between age at onset and SLC6A4 methylation. The joint investigation of variables originating in biology, psychology and psychiatry could make an important contribution to understanding the development of depressive disorders by elucidating potential subtypes of depression.

FKBP5 polymorphisms moderate the influence of adverse life events on the risk of anxiety and depressive disorders in preschool children

2016 ◽  
Vol 72 ◽  
pp. 30-36 ◽  
Author(s):  
Sandra Scheuer ◽  
Marcus Ising ◽  
Manfred Uhr ◽  
Yvonne Otto ◽  
Kai von Klitzing ◽  
...  
Keyword(s):  
Preschool Children ◽  
Life Events ◽  
Depressive Disorders ◽  
Adverse Life Events

scholarly journals Association between anxiety but not depressive disorders and leukocyte telomere length after 2 years of follow-up in a population-based sample

2012 ◽  
Vol 43 (4) ◽  
pp. 689-697 ◽  
Author(s):  
P. W. Hoen ◽  
J. G. M. Rosmalen ◽  
R. A. Schoevers ◽  
J. Huzen ◽  
P. van der Harst ◽  
...  
Keyword(s):  
Anxiety Disorders ◽  
Telomere Length ◽  
Life Events ◽  
Educational Level ◽  
Depressive Disorders ◽  
Population Based ◽  
Lifestyle Factors ◽  
Adverse Life Events ◽  
Antidepressant Use

BackgroundTelomere length is considered an emerging marker of biological aging. Depression and anxiety are associated with excess mortality risk but the mechanisms remain obscure. Telomere length might be involved because it is associated with psychological distress and mortality. The aim of this study was to test whether anxiety and depressive disorders predict telomere length over time in a large population-based sample.MethodAll analyses were performed in a longitudinal study in a general population cohort of 974 participants. The Composite International Diagnostic Interview (CIDI) was used to measure the presence of anxiety and depressive disorders. Telomere length was measured using monochrome multiplex polymerase chain reaction (PCR) at approximately 2 years of follow-up. We used linear multivariable regression models to evaluate the association between anxiety and depressive disorders and telomere length, adjusting for adverse life events, lifestyle factors, educational level and antidepressant use.ResultsThe presence of anxiety disorders predicted shorter telomeres at follow-up (β = –0.073, t = –2.302, p = 0.022). This association was similar after controlling for adverse life events, lifestyle factors, educational level and antidepressant use (β = –0.077, t = –2.144, p = 0.032). No association was found between depressive disorders and shorter telomeres at follow-up (β = 0.010, t = 0.315, p = 0.753).ConclusionsThis study found that anxiety disorders predicted shorter telomere length at follow-up in a general population cohort. The association was not explained by adverse life events, lifestyle factors, educational level and antidepressant use. How anxiety disorders might lead to accelerated telomere shortening and whether this might be a mediator explaining the excess mortality risk associated with anxiety deserve further investigation.

I’m Not Crazy!

2002 ◽  
Author(s):  
Daniel J. Wallace ◽  
Janice Brock Wallace
Keyword(s):  
Major Depression ◽  
Life Events ◽  
Musculoskeletal Pain ◽  
Minnesota Multiphasic Personality Inventory ◽  
Office Visit ◽  
Endogenous Depression ◽  
Reactive Depression ◽  
Medical Centers ◽  
Historical Factors ◽  
History Of

“You look fine, and I can’t find anything wrong with you. Maybe you’re just depressed or stressed out.” Nearly all of my patients have heard this before. And they start to wonder: Am I really crazy? How could it all be in my mind? This chapter will summarize the small number of behavioral surveys that rheumatologists and psychiatrists have performed on fibromyalgia patients. The treatment of fibromyalgia will be reviewed in Parts VI and VII. Why are there so few studies that we can rely upon? First, most research is conducted at university medical centers, where fibromyalgia patients tend to be more symptomatic and have not responded to interventions by community physicians. Second, depression itself is associated with high rates of musculoskeletal pain. Also, few people have had comprehensive psychological evaluations before they became ill that can be used for comparison. Finally, instruments of psychological assessment were devised before we knew what fibromyalgia was, and popular tests such as the Minnesota Multiphasic Personality Inventory (MMPI) cannot distinguish between pain from a disease and pain from depression. Is fibromyalgia a manifestation of depression or the reverse? Well-designed studies have addressed this issue, but many used different methods, populations, ethnic groupings, referral sources, and geographical distributions. In any case, the results were reasonably similar. On average, these studies showed that about 18 percent of fibromyalgia patients have evidence of a major depression at any office visit and 58 percent have a history of major depression in their lifetime. What does this mean? At any point in time, the overwhelming majority of fibromyalgia patients are not seriously depressed. And if they are depressed, it’s usually because they do not feel well. This condition is called reactive depression and is reversible with treatment, as opposed to endogenous depression, which is caused by chemical imbalances and is much harder to treat. A well-designed study of depressed patients demonstrated that fewer than 10 percent had two or more tender points. Certain life events or historical factors are statistically present more often in fibromyalgia patients than in those without the disorder.

Resilience

2011 ◽  
Vol 20 (6) ◽  
pp. 390-394 ◽  
Author(s):  
Mark D. Seery
Keyword(s):  
Mental Health ◽  
Health Care ◽  
Life Events ◽  
Chronic Back Pain ◽  
Well Being ◽  
Care Utilization ◽  
Negative Consequences ◽  
Adverse Life Events ◽  
History Of ◽  
Health And Well Being

When adverse life events occur, people often suffer negative consequences for their mental health and well-being. More adversity has been associated with worse outcomes, implying that the absence of life adversity should be optimal. However, some theory and empirical evidence suggest that the experience of facing difficulties can also promote benefits in the form of greater propensity for resilience when dealing with subsequent stressful situations. I review research that demonstrates U-shaped relationships between lifetime adversity exposure and mental health and well-being, functional impairment and health care utilization in chronic back pain, and responses to experimentally induced pain. Specifically, a history of some lifetime adversity predicts better outcomes than not only a history of high adversity but also a history of no adversity. This has important implications for understanding resilience, suggesting that adversity can have benefits.

AN ASSOCIATION BETWEEN ADVERSE EVENTS, ANXIETY AND BODY SIZE OF ADOLESCENTS

2013 ◽  
Vol 46 (1) ◽  
pp. 122-138 ◽  
Author(s):  
TOMASZ HANĆ ◽  
KLAUDIA JANICKA ◽  
MAGDALENA DURDA ◽  
JOACHIM CIEŚLIK
Keyword(s):  
Adverse Events ◽  
Chronic Diseases ◽  
Life Events ◽  
Body Height ◽  
Biological Traits ◽  
General Tendency ◽  
Adverse Life Events ◽  
Anxiety Trait ◽  
History Of ◽  
High Level

SummaryThe aim of the study was to assess the relationship between adverse life events, a tendency to respond with a high level of anxiety, and height and adiposity of adolescents. The sample included 575 persons (309 girls and 266 boys) aged 10–15 (mean 12.73) from the Wielkopolska region of Poland. The influence of adverse events during the 6 months before the examination and anxiety trait, as assessed with a STAIC questionnaire, on body height and BMI was analysed. Also sex, age, chronic diseases and socioeconomic status indicators were assessed. One-way and two-way ANOVA was used for assessment of relationships. Adverse events had no influence on body height and BMI. Subjects with a high level of anxiety trait (>34 score) were shorter (difference z=0.21) than subjects with a normal level of anxiety trait (≤34 score). The association of anxiety trait and body height was significant after adjustment for sex, age, chronic diseases and history of adverse life events. The analysis showed no statistically significant influence of adverse life events on height and BMI and a significant relationship between the general tendency to respond with anxiety and body height of adolescents. This suggests that psychological characteristics associated with the cognitive tendency to interpret events as threatening, and consequently, to respond with stress, may be involved in the variability of biological traits regardless of the objective harmfulness of the situation.

The Symptom Structure of Panic Attacks in Depressed and Anxious Patients

1993 ◽  
Vol 38 (3) ◽  
pp. 181-184 ◽  
Author(s):  
Brian J. Cox ◽  
Gary Hasey ◽  
Richard P. Swinson ◽  
Klaus Kuch ◽  
Robert Cooke ◽  
...  
Keyword(s):  
Major Depression ◽  
Panic Disorder ◽  
Major Depressive Episode ◽  
Structured Interview ◽  
Panic Attacks ◽  
Major Depressive ◽  
Symptom Profiles ◽  
History Of ◽  
Depressive Episodes ◽  
Panic Symptom

This study examined the panic symptom profiles of three diagnostic groups: those with panic disorder and no history of major depression; those with panic disorder with a history of major depressive episode but no current depression; and those current major depression with panic disorder. Patients were compared on the frequency of specific panic attack symptoms based on structured interview responses. The symptom profiles of all three groups were significantly correlated. The patients with past and current depressive episodes had the most similar symptom structure.

History of Depression

2016 ◽  
pp. 10-23 ◽  
Author(s):  
Allan V. Horwitz ◽  
Jerome C. Wakefield ◽  
Lorenzo Lorenzo-Luaces
Keyword(s):  
Seventeenth Century ◽  
Major Depression ◽  
Depressive Disorders ◽  
Diagnostic System ◽  
Adaptive Responses ◽  
Dsm 5 ◽  
Different Types ◽  
Use Context ◽  
History Of ◽  
History Of Depression

The symptoms that define depressive conditions have been recognized for millennia of medical history. The earliest Hippocratic writings not only define depression in similar ways as current works but also use context to differentiate ordinary sadness from depressive disorder. Sadness was understood as a natural reaction to loss; symptoms indicated a disorder only if they were not attributable to an identifiable trigger or if they displayed disproportionate intensity or duration to their triggers. The first serious approaches to subcategorize different types of depressive disorders developed in the seventeenth century. Despite agreement that a melancholic or psychotic form of depression existed, researchers debated the categorization of neurotic or nonpsychotic depressions until 1980 when the DSM- III introduced major depression as a unitary category. The DSM’s diagnostic system was historically anomalous because its diagnoses did not consider the context in which symptoms arose. The only exception within the DSM, for uncomplicated symptoms that follow bereavement, was removed from the DSM-5 in 2013 so that depressive diagnoses now thoroughly conflate adaptive responses to loss with pathological depressions.

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