Cannabis use and transition to psychosis in people at ultra-high risk

2014 ◽  
Vol 44 (12) ◽  
pp. 2503-2512 ◽  
Author(s):  
L. R. Valmaggia ◽  
F. L. Day ◽  
C. Jones ◽  
S. Bissoli ◽  
C. Pugh ◽  
...  
Keyword(s):  
High Risk ◽  
Early Onset ◽  
Temporal Relationship ◽  
Clinical Presentation ◽  
Late Onset ◽  
Cannabis Use ◽  
Frequent Use ◽  
Increased Risk ◽  
Ultra High Risk ◽  
Continued Use

BackgroundCannabis use is associated with an increased risk of developing a psychotic disorder but the temporal relationship between cannabis use and onset of illness is unclear. The objective of this study was to assess prospectively the influence of cannabis use on transition to psychosis in people at ultra-high risk (UHR) for the disorder.MethodLifetime and continued cannabis use was assessed in a consecutively ascertained sample of 182 people (104 male, 78 female) at UHR for psychosis. Individuals were then followed clinically for 2 years to determine their clinical outcomes.ResultsLifetime cannabis use was reported by 134 individuals (73.6%). However, most of these individuals had stopped using cannabis before clinical presentation (n = 98, 73.1%), usually because of adverse effects. Among lifetime users, frequent use, early-onset use and continued use after presentation were all associated with an increase in transition to psychosis. Transition to psychosis was highest among those who started using cannabis before the age of 15 years and went on to use frequently (frequent early-onset use: 25%; infrequent or late-onset use: 5%; χ21 = 10.971, p = 0.001). However, within the whole sample, cannabis users were no more likely to develop psychosis than those who had never used cannabis (cannabis use: 12.7%; no use: 18.8%; χ21 = 1.061, p = 0.303).ConclusionsIn people at UHR for psychosis, lifetime cannabis use was common but not related to outcome. Among cannabis users, frequent use, early-onset use and continued use after clinical presentation were associated with transition to psychosis.

scholarly journals Epilepsy in Down Syndrome: A Highly Prevalent Comorbidity

2021 ◽  
Vol 10 (13) ◽  
pp. 2776
Author(s):  
Miren Altuna ◽  
Sandra Giménez ◽  
Juan Fortea
Keyword(s):  
Down Syndrome ◽  
Functional Outcomes ◽  
Clinical Presentation ◽  
Late Onset ◽  
Current Knowledge ◽  
Epileptic Seizures ◽  
Myoclonic Epilepsy ◽  
Increased Risk ◽  
Number Of Individuals

Individuals with Down syndrome (DS) have an increased risk for epilepsy during the whole lifespan, but especially after age 40 years. The increase in the number of individuals with DS living into late middle age due to improved health care is resulting in an increase in epilepsy prevalence in this population. However, these epileptic seizures are probably underdiagnosed and inadequately treated. This late onset epilepsy is linked to the development of symptomatic Alzheimer’s disease (AD), which is the main comorbidity in adults with DS with a cumulative incidence of more than 90% of adults by the seventh decade. More than 50% of patients with DS and AD dementia will most likely develop epilepsy, which in this context has a specific clinical presentation in the form of generalized myoclonic epilepsy. This epilepsy, named late onset myoclonic epilepsy (LOMEDS) affects the quality of life, might be associated with worse cognitive and functional outcomes in patients with AD dementia and has an impact on mortality. This review aims to summarize the current knowledge about the clinical and electrophysiological characteristics, diagnosis and treatment of epileptic seizures in the DS population, with a special emphasis on LOMEDS. Raised awareness and a better understanding of epilepsy in DS from families, caregivers and clinicians could enable earlier diagnoses and better treatments for individuals with DS.

Effects of cannabis use on event related potentials in subjects at ultra high risk for psychosis and healthy controls

2013 ◽  
Vol 88 (2) ◽  
pp. 149-156 ◽  
Author(s):  
Mirjam J. van Tricht ◽  
Emma C. Harmsen ◽  
Johannes H.T.M. Koelman ◽  
Lo J. Bour ◽  
Thérèse A. van Amelsvoort ◽  
...  
Keyword(s):  
High Risk ◽  
Event Related Potentials ◽  
Cannabis Use ◽  
Healthy Controls ◽  
Ultra High Risk ◽  
Related Potentials

Early-onset of symptoms predicts conversion to non-affective psychosis in ultra-high risk individuals

2006 ◽  
Vol 84 (1) ◽  
pp. 67-76 ◽  
Author(s):  
G.P. Amminger ◽  
S. Leicester ◽  
A.R. Yung ◽  
L.J. Phillips ◽  
G.E. Berger ◽  
...  
Keyword(s):  
High Risk ◽  
Early Onset ◽  
Affective Psychosis ◽  
Ultra High Risk

Effects of Cannabis Use in Those at Ultra-High Risk for Psychosis

2018 ◽  
pp. 167-181 ◽  
Author(s):  
Brian O'Donoghue ◽  
Meredith McHugh ◽  
Barnaby Nelson ◽  
Patrick McGorry
Keyword(s):  
High Risk ◽  
Cannabis Use ◽  
Ultra High Risk

scholarly journals Relationships between Problematic Cannabis Use and Risky Behaviors in Spanish Adolescents

2019 ◽  
Vol 16 (17) ◽  
pp. 3029
Author(s):  
Raquel Alarcó-Rosales ◽  
Miriam Sánchez-SanSegundo ◽  
Rosario Ferrer-Cascales ◽  
Natalia Albaladejo-Blázquez ◽  
Nicolás Ruiz-Robledillo ◽  
...  
Keyword(s):  
High Risk ◽  
Motor Vehicle ◽  
Motor Vehicle Accident ◽  
Risky Behaviors ◽  
Cannabis Use ◽  
Physical Assault ◽  
Cannabis Abuse ◽  
The Past ◽  
Vehicle Accident ◽  
Increased Risk

This study examined the relations between problematic cannabis use, physical assault, and getting involved in a motor vehicle accident under the influence of cannabis in a sample of adolescents randomly selected from 25 public and semiprivate high schools in Alicante (Spain). Participants (n = 648) completed The Spanish National Standardized Survey about drug use in high school adolescents (ESTUDES, 2017), which includes the cannabis abuse screening test (CAST). Prevalence of cannabis use across the life-span and within the past 30 days was 37.5% and 17.4%, respectively. CAST scores were associated with an increased risk of driving under the effects of cannabis, riding shotgun, and physical assault, but not with an increased risk of having a motor vehicle accident. There were no differences between boys and girls in the association of problematic cannabis use with risky behaviors. This result highlights the importance of comprehensive prevention and education strategies for adolescents at high risk of cannabis use.

Maternal Partner Criminality and Cannabis use in Young Adulthood: Prospective Study

2007 ◽  
Vol 41 (6) ◽  
pp. 546-553 ◽  
Author(s):  
Mohammad R. Hayatbakhsh ◽  
Stuart A. Kinner ◽  
Konrad Jamrozik ◽  
Jake M. Najman ◽  
Abdullah A. Mamun
Keyword(s):  
Young Adults ◽  
Young Adulthood ◽  
Early Adulthood ◽  
Cannabis Use ◽  
Birth Cohort Study ◽  
Mater Hospital ◽  
Frequent Use ◽  
Increased Risk ◽  
History Of

Objectives: The present study examined whether the experience of the arrest or incarceration of a mother's partner before a child reached 14 years of age was associated with use of cannabis in early adulthood and, if so, whether this association was confounded or mediated by other factors. Method: Data were from the Mater Hospital University of Queensland Study of Pregnancy, a prospective birth cohort study in Brisbane, Australia. The history of partner arrest and incarceration was reported by mothers at the 14 year follow up. Mothers were divided into four groups: mothers whose partner had no history of arrest or incarceration, mothers reporting partner arrest, mothers reporting partner incarceration, and unpartnered mothers. Young adults’ cannabis use was assessed at 21 years. Other covariates were prospectively measured between birth and 14 years. Results: After controlling for potential confounding and mediating factors, frequent use of cannabis at age 21 was more likely among young adults with a history of maternal partner arrest (odds ratio=2.3; 95% confidence interval: 1.4–3.8). There was no significant association between maternal partner incarceration or single motherhood, and cannabis use at age 21. Conclusions: Arrest of the mother's partner before the child is 14 is associated with that child's increased cannabis use at age 21 but this does not appear to be the case for children whose fathers have been imprisoned. It appears that for children whose fathers have been arrested, the father's ongoing presence in the family may result in worse outcomes for the child, including an increased risk of cannabis use in young adulthood.

scholarly journals Comprehensive Assessment of Diet Quality and Risk of Precursors of Early-Onset Colorectal Cancer

2020 ◽  
Author(s):  
Xiaobin Zheng ◽  
Jinhee Hur ◽  
Long H Nguyen ◽  
Jie Liu ◽  
Mingyang Song ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
High Risk ◽  
Diet Quality ◽  
Early Onset ◽  
Strong Support ◽  
Healthy Eating Index ◽  
Malignant Potential ◽  
Poor Diet ◽  
Increased Risk

Abstract Background The role of poor diet quality in the rising incidence of colorectal cancer (CRC) diagnosed under age 50 has not been explored. Based on molecular features of early-onset CRC, early-onset adenomas are emerging surrogate endpoints. Methods In a prospective cohort study (Nurses’ Health Study II), we evaluated two empirical dietary patterns (Western and prudent) and three recommendation-based indexes (Dietary Approaches to Stop Hypertension [DASH], Alternative Mediterranean Diet [AMED], and Alternative Healthy Eating Index [AHEI]-2010) with risk of early-onset adenoma overall and by malignant potential (high-risk: ≥1 cm, tubulovillous/villous histology, high-grade dysplasia, or ≥ 3 adenomas), among 29474 women with ≥1 lower endoscopy before age 50 (1991-2011). Multivariable logistic regressions were used to estimate odds ratios (ORs) and 95% confidence intervals (CIs). Results We documented 1157 early-onset adenomas with 375 of high-risk. Western diet was positively, whereas prudent diet, DASH, AMED, and AHEI-2010 were inversely associated with risk of early-onset adenoma. The associations were largely confined to high-risk adenomas (OR [95% CI] for the highest versus lowest quintile: Western = 1.67 [1.18 to 2.37]; prudent = 0.69 [0.48 to 0.98]; DASH = 0.65 [0.45 to 0.93]; AMED = 0.55 [0.38 to 0.79]; AHEI-2010 = 0.71 [0.51 to 1.01]; all P  trend≤.03), driven by those identified in the distal colon and rectum (all P  trend≤.04 except AMED: Ptrend=.14). Conclusion Poor diet quality was associated with an increased risk of early-onset distal and rectal adenomas of high malignant potential. These findings provide preliminary but strong support to the role of diet in early-onset CRC.

scholarly journals Atrial Fibrillation Increases the Risk of Early-Onset Dementia in the General Population: Data from a Population-Based Cohort

2020 ◽  
Vol 9 (11) ◽  
pp. 3665
Author(s):  
Dongmin Kim ◽  
Pil-Sung Yang ◽  
Gregory Y.H. Lip ◽  
Boyoung Joung
Keyword(s):  
Atrial Fibrillation ◽  
Early Onset ◽  
Late Onset ◽  
Population Data ◽  
The Elderly ◽  
Population Based ◽  
Early Onset Dementia ◽  
Increased Risk ◽  
Late Onset Dementia

Atrial fibrillation (AF) is considered a risk factor for dementia, especially in the elderly. However, the association between the two diseases is not well identified in different age subgroups. The association of incident AF with the development of dementia was assessed from 1 January 2005, to 31 December 2013, in 428,262 participants from a longitudinal cohort (the Korea National Health Insurance Service-Health Screening cohort). In total, 10,983 participants were diagnosed with incident AF during the follow-up period. The incidence of dementia was 11.3 and 3.0 per 1000 person-years in the incident-AF and without-AF groups, respectively. After adjustment for clinical variables, the risk of dementia was significantly elevated by incident AF, with a hazard ratio (HR) of 1.98 (95% confidence interval [CI]: 1.80–2.17, p < 0.001), even after censoring for stroke (HR: 1.74, 95% CI: 1.55–1.94, p < 0.001). The HRs of incident AF for dementia onset before the age of 65 (early-onset dementia) and for onset after the age of 65 (late-onset dementia) were 2.91 (95% CI: 1.93–4.41) and 1.67 (95% CI: 1.49–1.87), respectively. Younger participants with AF were more prone to dementia development than older participants with AF (p for trend < 0.001). AF was associated with an increased risk of both early- and late-onset dementia, independent of clinical stroke.

scholarly journals Interaction between asthma and smoking increases the risk of adult airway obstruction

2014 ◽  
Vol 45 (3) ◽  
pp. 635-643 ◽  
Author(s):  
Marianne Aanerud ◽  
Anne-Elie Carsin ◽  
Jordi Sunyer ◽  
Julia Dratva ◽  
Thorarinn Gislason ◽  
...  
Keyword(s):  
Airway Obstruction ◽  
Early Onset ◽  
Linear Models ◽  
Late Onset ◽  
Smoking Status ◽  
Random Effect ◽  
Chronic Obstructive ◽  
Lung Function Decline ◽  
Increased Risk ◽  
Never Smokers

The aim of the present study was to analyse the interaction between asthma and smoking in the risk of adult airway obstruction, accounting for atopy.In the European Community Respiratory Health Survey, 15 668 persons aged 20–56 years underwent spirometry in 1991–1993 and 9 years later (n=8916). Risk of airway obstruction and lung function decline associated with smoking and early-onset (<10 years of age) and late-onset (>10 years of age) asthma were analysed with generalised estimating equation models and random-effect linear models, adjusting for covariates. Interaction of asthma with smoking was expressed as relative excess risk due to interaction (RERI).A 20-fold increase in adult airway obstruction was found among those with early-onset asthma independently of smoking status (never-smokers: OR 21.0, 95% CI 12.7–35; current smokers: OR 23.7, 95% CI 13.9–40.6). Late-onset asthma was associated with airway obstruction, with a stronger association among current smokers (OR 25.6, 95% CI 15.6–41.9) than among never-smokers (OR 11.2, 95% CI 6.8–18.6) (RERI 12.02, 95% CI 1.96–22.07). Stratifying by atopy, the association between smoking and asthma was most pronounced among nonatopics.Early- and late-onset asthma were associated with 10–20-fold increased risk of adult airway obstruction. Smoking increased the risk of adult airway obstruction in subjects with asthma onset after age 10 years. Investigation of measures potentially preventive of chronic obstructive pulmonary disease development following asthma is urgently needed.

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