Evidence for POT expansion in early Homo: A pretty theory with ugly (or no) paleoneurological facts

1995 ◽  
Vol 18 (1) ◽  
pp. 191-193 ◽  
Author(s):  
Ralph L. Holloway
Keyword(s):  
Selective Pressures ◽  
Early Homo ◽  
The Brain ◽  
Better Than

AbstractIf POT (parieto-occipital-temporal junction) reorganization came earlier in australopithecines than in Homo, it is likely that the selective pressures were different, and not necessarily directed toward language. The brain endocast evidence for the POT in A. afarensis is actually better than it is for early Homo.

scholarly journals Multiple Sclerosis Recognition by Biorthogonal Wavelet Features and Fitness-Scaled Adaptive Genetic Algorithm

2021 ◽  
Vol 15 ◽  
Author(s):  
Shui-Hua Wang ◽  
Xianwei Jiang ◽  
Yu-Dong Zhang
Keyword(s):  
Multiple Sclerosis ◽  
Genetic Algorithm ◽  
Data Augmentation ◽  
Area Under The Curve ◽  
Adaptive Genetic Algorithm ◽  
Biorthogonal Wavelet ◽  
Wide Range ◽  
Wavelet Features ◽  
The Brain ◽  
Better Than

Aim: Multiple sclerosis (MS) is a disease, which can affect the brain and/or spinal cord, leading to a wide range of potential symptoms. This method aims to propose a novel MS recognition method.Methods: First, the bior4.4 wavelet is used to extract multiscale coefficients. Second, three types of biorthogonal wavelet features are proposed and calculated. Third, fitness-scaled adaptive genetic algorithm (FAGA)—a combination of standard genetic algorithm, adaptive mechanism, and power-rank fitness scaling—is harnessed as the optimization algorithm. Fourth, multiple-way data augmentation is utilized on the training set under the setting of 10 runs of 10-fold cross-validation. Our method is abbreviated as BWF-FAGA.Results: Our method achieves a sensitivity of 98.00 ± 0.95%, a specificity of 97.78 ± 0.95%, and an accuracy of 97.89 ± 0.94%. The area under the curve of our method is 0.9876.Conclusion: The results show that the proposed BWF-FAGA method is better than 10 state-of-the-art MS recognition methods, including eight artificial intelligence-based methods, and two deep learning-based methods.

The Effect of Brain Based Learning on Improving Students Critical Thinking Ability and Self Regulated

2020 ◽  
Vol 2 (2) ◽  
pp. 162
Author(s):  
Sarifah Sari Maryati ◽  
Irma Purwanti ◽  
Melinda Putri Mubarika
Keyword(s):  
Critical Thinking ◽  
Thinking Skills ◽  
Critical Thinking Skills ◽  
Learning Approach ◽  
School Students ◽  
Critical Thinking Ability ◽  
Thinking Ability ◽  
Brain Based Learning ◽  
The Brain ◽  
Better Than

This research is motivated by the low ability of mathematical critical thinking and Self Regulated Cimahi 10 Public Middle School students, so that a learning approach is needed to overcome these problems. The alternative approach applied is the Brain Based Learning Model approach.The objectives of this researcher are: 1) to examine students' mathematical critical thinking skills; 2) reviewing the Self Regulated attitude of students who obtain Brain Based Learning learning with students who have expository learning; 3) examine there is a positive correlation between Critical Thinking with Self Regulated students who obtain Brain Based Learning and expository learning. The population in this study was grade VII students of SMP Negeri 10 Cimahi. The samples in this study were class VII-B (Brain Based Learning) and class VII-D (expository). The instruments used in this study were the Critical Thinking test and the student's Self Regulated questionnaire. The test used is a subjective type test (description). The way to analyze data is with IBM SPSS Statistics 18.0 for Windows. The results showed that: 1) the mathematical critical thinking ability of students who obtained learning based on the Brain Based Learning approach was better than students who gained expository learning; 2) Self Regulated  attitude, students who get Brain Based Learning are better than students who get expository approach learning; 3) there is no correlation between critical thinking with Self Regulated students who obtain Brain Based Learning and expository learning.

scholarly journals Human-specific microglial Siglec-11 transcript variant has the potential to affect polysialic acid-mediated brain functions at a distance

Glycobiology ◽  
2020 ◽  
Author(s):  
Masaya Hane ◽  
Dillon Y Chen ◽  
Ajit Varki
Keyword(s):  
Polysialic Acid ◽  
Innate Immune ◽  
Set Domain ◽  
Tissue Macrophage ◽  
Brain Functions ◽  
Functional Consequences ◽  
Molecular Patterns ◽  
The Brain ◽  
Better Than ◽  
Human Specific

Abstract CD33-related Siglecs are often found on innate immune cells and modulate their reactivity by recognition of sialic acid-based “self-associated molecular patterns” and signaling via intracellular tyrosine-based cytosolic motifs. Previous studies have shown that Siglec-11 specifically binds to the brain-enriched polysialic acid (polySia/PSA) and that its microglial expression in the brain is unique to humans. Furthermore, human microglial Siglec-11 exists as an alternate splice form missing the exon encoding the last (fifth) Ig-like C2-set domain of the extracellular portion of the protein, but little is known about the functional consequences of this variation. Here, we report that the recombinant soluble human microglial form of Siglec-11 (hSiglec-11(4D)-Fc) binds endogenous and immobilized polySia better than the tissue macrophage form (hSiglec-11(5D)-Fc) or the chimpanzee form (cSiglec-11(5D)-Fc). The Siglec-11 protein is also prone to aggregation, potentially influencing its ligand-binding ability. Additionally, Siglec-11 protein can be secreted in both intact and proteolytically cleaved forms. The microglial splice variant has reduced proteolytic release and enhanced incorporation into exosomes, a process that appears to be regulated by palmitoylation of cysteines in the cytosolic tail. Taken together, these data demonstrate that human brain specific microglial hSiglec-11(4D) has different molecular properties and can be released on exosomes and/or as proteolytic products, with the potential to affect polySia-mediated brain functions at a distance.

The evolutionary paths to collective rituals: An interdisciplinary perspective on the origins and functions of the basic social act

2019 ◽  
Vol 41 (3) ◽  
pp. 224-252 ◽  
Author(s):  
Martin Lang
Keyword(s):  
Collective Action ◽  
Evolutionary Theory ◽  
Psychology Of Religion ◽  
Early Career ◽  
Evolutionary Analysis ◽  
Hunter Gatherers ◽  
Selective Pressures ◽  
Early Homo ◽  
Underlying Mechanisms ◽  
Evolutionary Paths

The present article is an elaborated and upgraded version of the Early Career Award talk that I delivered at the IAPR 2019 conference in Gdańsk, Poland. In line with the conference’s thematic focus on new trends and neglected themes in psychology of religion, I argue that psychology of religion should strive for firmer integration with evolutionary theory and its associated methodological toolkit. Employing evolutionary theory enables to systematize findings from individual psychological studies within a broader framework that could resolve lingering empirical contradictions by providing an ultimate rationale for which results should be expected. The benefits of evolutionary analysis are illustrated through the study of collective rituals and, specifically, their purported function in stabilizing risky collective action. By comparing the socio-ecological pressures faced by chimpanzees, contemporary hunter-gatherers, and early Homo, I outline the selective pressures that may have led to the evolution of collective rituals in the hominin lineage, and, based on these selective pressures, I make predictions regarding the different functions and their underlying mechanisms that collective rituals should possess. While examining these functions, I echo the Early Career Award and focus mostly on my past work and the work of my collaborators, showing that collective rituals may stabilize risky collective action by increasing social bonding, affording to assort cooperative individuals, and providing a platform for reliable communication of commitment to group norms. The article closes with a discussion of the role that belief in superhuman agents plays in stabilizing and enhancing the effects of collective rituals on trust-based cooperation.

scholarly journals Efficient inverse graphics in biological face processing

2020 ◽  
Vol 6 (10) ◽  
pp. eaax5979 ◽  
Author(s):  
Ilker Yildirim ◽  
Mario Belledonne ◽  
Winrich Freiwald ◽  
Josh Tenenbaum
Keyword(s):  
Face Processing ◽  
Three Dimensional ◽  
Generative Models ◽  
Neural Data ◽  
Primate Brain ◽  
Scene Structure ◽  
Analysis By Synthesis ◽  
The Brain ◽  
Processing Circuit ◽  
Better Than

Vision not only detects and recognizes objects, but performs rich inferences about the underlying scene structure that causes the patterns of light we see. Inverting generative models, or “analysis-by-synthesis”, presents a possible solution, but its mechanistic implementations have typically been too slow for online perception, and their mapping to neural circuits remains unclear. Here we present a neurally plausible efficient inverse graphics model and test it in the domain of face recognition. The model is based on a deep neural network that learns to invert a three-dimensional face graphics program in a single fast feedforward pass. It explains human behavior qualitatively and quantitatively, including the classic “hollow face” illusion, and it maps directly onto a specialized face-processing circuit in the primate brain. The model fits both behavioral and neural data better than state-of-the-art computer vision models, and suggests an interpretable reverse-engineering account of how the brain transforms images into percepts.

scholarly journals Cerebrospinal fluid p-tau217 performs better than p-tau181 as a biomarker of Alzheimer’s disease

2020 ◽  
Vol 11 (1) ◽  
Author(s):  
Shorena Janelidze ◽  
Erik Stomrud ◽  
Ruben Smith ◽  
Sebastian Palmqvist ◽  
Niklas Mattsson ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cerebrospinal Fluid ◽  
Amyloid Β ◽  
Pet Tracer ◽  
Positron Emission ◽  
Diagnostic Work ◽  
Work Up ◽  
The Brain ◽  
Better Than

AbstractCerebrospinal fluid (CSF) p-tau181 (tau phosphorylated at threonine 181) is an established biomarker of Alzheimer’s disease (AD), reflecting abnormal tau metabolism in the brain. Here we investigate the performance of CSF p-tau217 as a biomarker of AD in comparison to p-tau181. In the Swedish BioFINDER cohort (n = 194), p-tau217 shows stronger correlations with the tau positron emission tomography (PET) tracer [18F]flortaucipir, and more accurately identifies individuals with abnormally increased [18F]flortaucipir retention. Furthermore, longitudinal increases in p-tau217 are higher compared to p-tau181 and better correlate with [18F]flortaucipir uptake. P-tau217 correlates better than p-tau181 with CSF and PET measures of neocortical amyloid-β burden and more accurately distinguishes AD dementia from non-AD neurodegenerative disorders. Higher correlations between p-tau217 and [18F]flortaucipir are corroborated in an independent EXPEDITION3 trial cohort (n = 32). The main results are validated using a different p-tau217 immunoassay. These findings suggest that p-tau217 might be more useful than p-tau181 in the diagnostic work up of AD.

The Failure of Mirabeau's Political Ideas

1951 ◽  
Vol 13 (1) ◽  
pp. 88-107
Author(s):  
J. J. Chevallier
Keyword(s):  
Constitutional Law ◽  
The Other ◽  
English School ◽  
Political Theorist ◽  
Political Ideas ◽  
Other Hand ◽  
The Brain ◽  
Better Than ◽  
The Revolution

“Mirabeau and Sieyès are the two strongest minds of the Revolution,” said Talleyrand who knew both of them well. This is no doubt true. It is likewise true that Mirabeau and Sieyes were at opposite poles from each other intellectually. Sieyès was a political theorist; they called him the brain. Mirabeau, on the other hand, was the least theoretical of men. When the Estates General opened he had no draft of a Constitution; Sieyès, on the other hand, had thought of one and even several.For the whole course of the Revolution until his death in April, 1791, Mirabeau cannot be described by an invariable formula. He cannot be classified in the pro-English school. He wrote to a minister before the Revolution: “the executive life” suited him better than “the speculative life.” Sieyès, and even Mounier, would have been wonderful professors of Constitutional Law. Not Mirabeau. His culture was enormous but disorganized. An omnivorous reader and always with pen in hand, he had made innumerable excerpts from all sorts of books, and drew upon them with no scruples about plagiarism when he wrote his own works. One must be careful to avoid the temptation, to which some have succumbed, of seeing in these plagiarisms the expression of Mirabeau's own ideas.

Visual Organization Ability in Brain-Damaged Adults

1977 ◽  
Vol 45 (3) ◽  
pp. 723-728 ◽  
Author(s):  
Paul L. Wang
Keyword(s):  
Left Hemisphere ◽  
Right Hemisphere ◽  
Functional Dynamics ◽  
Visual Organization ◽  
Bilateral Lesions ◽  
The Brain ◽  
Better Than

49 brain-damaged patients (15 with left-hemisphere lesions, 19 with right-hemisphere lesions, and 15 with bilateral lesions) and 17 non-brain-damaged patients were administered the Hooper Visual Organization Test. Non-brain-damaged patients performed significantly better than the brain-damaged patients; however, the differences among the brain-damaged patients were not significant. Hooper Visual Organization Test seems valuable for identifying organicity but its usefulness for determining lateralization is limited. It is also suggested that both hemispheres form a close functional loop in subserving visual organization ability. A hypothetical diagram has been proposed to describe the functional dynamics of the visual synthesis ability measured by the Visual Organization Test.

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