An Established Epithelial Cell Line (NPC/HK1) from a Nasopharyngeal Carcinoma - I. A Tem Study

1982 ◽  
Vol 40 ◽  
pp. 222-223
Author(s):  
C.L. Li ◽  
E.C. Chew ◽  
D.P. Huang ◽  
H.C. Ho ◽  
M. Lui ◽  
...  
Keyword(s):  
Nasopharyngeal Carcinoma ◽  
Epithelial Cell ◽  
Cell Line ◽  
Squamous Carcinoma ◽  
Carcinoma Cells ◽  
Epithelial Cell Line ◽  
Original Tumour ◽  
Tumour Biopsy ◽  
Fine Structures ◽  
Well Differentiated

An epithelial cell line, NPC/HK1, has recently been successfully established from a moderately to well differentiated squamous carcinoma of the nasopharynx. This communication reports on the fine structures observed in the carcinoma cells of the original tumour biopsy and those of the NPC/HK1 cells from different culture generations derived from it.

An Established Epithelial Cell Line (NPC/HK1) from a Nasopharyngeal Carcinoma - II. A Sem Study

1982 ◽  
Vol 40 ◽  
pp. 224-225
Author(s):  
Li C.L. ◽  
Chew E.C. ◽  
Huang D.P. ◽  
Ho H.C. ◽  
Mak L.S. ◽  
...  
Keyword(s):  
Nasopharyngeal Carcinoma ◽  
Epithelial Cell ◽  
Surface Morphology ◽  
Cell Line ◽  
Epithelial Cell Line ◽  
Present Communication ◽  
Cells In Culture ◽  
Sem Study ◽  
Well Differentiated

An epithelial cell line, NPC/HK1, has recently been successfully established from a nasopharyngeal carcinoma of the moderately to well differentiated squamous type. The present communication reports on the surface morphology of the NPC/HK1 cells in culture.

Ultrastructure of NPC/HK1 cells heterotransplanted in athymic nude mice

1982 ◽  
Vol 40 ◽  
pp. 236-237
Author(s):  
E.C. Chew ◽  
C.L. Li ◽  
D.P. Huang ◽  
H.C. Ho ◽  
L.S. Mak ◽  
...  
Keyword(s):  
Cell Line ◽  
Nude Mice ◽  
Biopsy Specimen ◽  
Epithelial Cell Line ◽  
Present Communication ◽  
Recurrent Tumour ◽  
Athymic Nude Mice ◽  
Cell Line Establishment ◽  
Fine Structures ◽  
Well Differentiated

An epithelial cell line, NPC/HK1, has recently been established from a biopsy specimen of a recurrent tumour of the nasopharynx which was histologically diagnosed as a moderately to well differentiated squamous cell carcinoma. A definite decrease in the amount of tonofilaments and desmosomes in the NPC/HK1 cells during the cell line establishment was observed. The present communication reports on the fine structures of the NPC/HK1 cells heterotraneplanted in athymic nude mice.

scholarly journals The anticancer effects of Levonorgestrel on human esophageal squamous carcinoma cells

2021 ◽  
Author(s):  
Liangying Yan ◽  
Zhongyu Wang ◽  
Huimin Wang ◽  
Chengwei Zhang ◽  
Wenbo Cao ◽  
...  
Keyword(s):  
Cell Line ◽  
Drug Repositioning ◽  
Squamous Carcinoma ◽  
Carcinoma Cells ◽  
Cancer Drug ◽  
Epithelial Cell Line ◽  
Apoptotic Pathway ◽  
Cancer Drug Discovery ◽  
Squamous Carcinoma Cells ◽  
Anticancer Effects

Abstract Drug repositioning is a better way to cancer drug discovery. As a common used oral contraceptive, Levonorgestrel (LNG) was found to play important anticancer roles in several cancers, but its role in human esophageal squamous cell carcinoma (ESCC) was little known. Using ESCC cell line of Ec1 and human normal esophageal epithelial cell line of Het-1A, this study was aim to investigate the effect and molecular mechanism of LNG on the ESCC. The results showed that LNG inhibit the cell proliferation; LNG also induced the cell apoptosis of ESCC related to mitochondrial apoptotic pathway for its disruption of mitochondrial capacity and upregulation of cleaved-Caspase 3 and the declining of the ratio of Bcl-2/Bax; LNG can inhibit the cell migration of ESCC with the E-cadherin overexpression. The anticancer effect of LNG on ESCC mainly associated with Wnt/β-catenin signaling pathway through up-regulation the phosphorylation level of β-catenin. At last, the study declared that LNG combined with cisplatin (CDDP) significantly suppressed the proliferation of Ec1. In conclusions, the LNG serves as efficient anticancer drug in ESCC cells and maybe used for drug repositioning to adjunctive therapy ESCC.

scholarly journals Episialin (MUC1) overexpression inhibits integrin-mediated cell adhesion to extracellular matrix components.

1995 ◽  
Vol 129 (1) ◽  
pp. 255-265 ◽  
Author(s):  
J Wesseling ◽  
S W van der Valk ◽  
H L Vos ◽  
A Sonnenberg ◽  
J Hilkens
Keyword(s):  
Extracellular Matrix ◽  
Epithelial Cell ◽  
Cell Surface ◽  
Cell Line ◽  
Carcinoma Cells ◽  
Breast Epithelial Cell ◽  
Epithelial Cell Line ◽  
High Avidity ◽  
Apical Side ◽  
Extracellular Matrix Components

Episialin (MUC1) is a transmembrane molecule with a large mucin-like extracellular domain protruding high above the cell surface. The molecule is located at the apical side of most glandular epithelial cells, whereas in carcinoma cells it is often present at the entire surface and it is frequently expressed in abnormally large quantities. We have previously shown that overexpression of episialin reduces cell-cell interactions. Here we show that the integrin-mediated adhesion to extracellular matrix of transfectants of a melanoma cell line (A375), a transformed epithelial cell line (MDCK-ras-e) and a human breast epithelial cell line (HBL-100) is reduced by high levels of episialin. This reduction can be reversed by inducing high avidity of the beta 1 integrins by mAb TS2/16 (at least for beta 1-mediated adhesion). The adhesion can also be restored by redistribution of episialin on the cell surface by monoclonal antibodies into patches or caps. Similarly, capping of episialin on ZR-75-1 breast carcinoma cells, growing in suspension, caused adherence and spreading of these cells. We propose that there is a delicate balance between adhesion and anti-adhesion forces in episialin expressing cells, which can be shifted towards adhesion by strengthening the integrin-mediated adhesion, or towards anti-adhesion by increasing the level of expression of episialin.

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