Clozapine: the Holywell experience with the first 24 patients

1993 ◽  
Vol 10 (1) ◽  
pp. 30-34 ◽  
Author(s):  
David J King ◽  
Philip J Mills
Keyword(s):  
Antipsychotic Drugs ◽  
Chronic Schizophrenic ◽  
Level Of Functioning ◽  
Duration Of Illness ◽  
Previous Level

AbstractClozapine was substituted for standard antipsychotic drugs in the treatment of 24 chronic schizophrenic inpatients and the response assessed after a mean of ten months. The majority (71%) improved (33.3% markedly), on their previous level of functioning. The response was better in those under 40 years of age, but neither duration of illness nor previous neuroleptic dose appeared to predict response to clozapine. The drug was ultimately discontinued in five (21%) patients – in three because of non-response and intolerance of sedation and in two because of neutropenia.

Suicide in Chronic Schizophrenia

1982 ◽  
Vol 141 (2) ◽  
pp. 171-177 ◽  
Author(s):  
Alec Roy
Keyword(s):  
Suicidal Ideation ◽  
Patient Care ◽  
Past History ◽  
Chronic Schizophrenia ◽  
Controlled Study ◽  
Chronic Schizophrenic ◽  
Duration Of Illness ◽  
History Of ◽  
History Of Depression

SummaryA matched controlled study of 30 chronic schizophrenic suicides is presented. Eighty per cent were male and committed suicide at a mean age of 25.8 years after a mean duration of illness of 4.8 years. Significantly more of the suicides had a chronic relapsing schizophrenic illness; 23.3 per cent committed suicide while in-patients, and 50 per cent of the out-patients committed suicide within three months of discharge from in-patient care. Significantly more of the suicides had a past history of depression (56.6 per cent), were depressed in the last episode of contact (53.3 per cent), had their last admission for depression or suicidal ideation (55.2 per cent) and were unemployed (80 per cent).

Psychogenic paranoid psychosis: an empirical study

1996 ◽  
Vol 11 (4) ◽  
pp. 180-184 ◽  
Author(s):  
N Vicente ◽  
E Ochoa ◽  
B Rios
Keyword(s):  
Empirical Study ◽  
Social Adaptation ◽  
Stress Factors ◽  
Response To Treatment ◽  
Trigger Factors ◽  
Favourable Response ◽  
Level Of Functioning ◽  
Previous Level ◽  
Paranoid Psychosis

SummaryThe present study was aimed at assessing the psychopathological manifestations, stress factors, evolution and social adaptation of 29 patients diagnosed with psychogenic paranoid psychosis. This syndrome is seen as an entity in itself, and is closely related to trigger factors; stability in the symptomatology of each relapse; favourable response to treatment; tendency to relapse, and recovery of the previous level of functioning.

Age and duration of illness as predictors of ventricular brain ratio (VBR) size in chronic schizophrenic patients.

1987 ◽  
Vol 76 (3) ◽  
pp. 256-260 ◽  
Author(s):  
A. Rossi ◽  
P. Stratta ◽  
M. Casacchia ◽  
L. D'Albenzio ◽  
G. Schiazza ◽  
...  
Keyword(s):  
Chronic Schizophrenic ◽  
Duration Of Illness ◽  
Schizophrenic Patients

scholarly journals A Systematic Review of Unexplained Early Regression in Adolescents and Adults with Down Syndrome

2021 ◽  
Vol 11 (9) ◽  
pp. 1197
Author(s):  
Madeleine Walpert ◽  
Shahid Zaman ◽  
Anthony Holland
Keyword(s):  
Down Syndrome ◽  
Current Evidence ◽  
Partial Recovery ◽  
Daily Lives ◽  
Level Of Functioning ◽  
Raising Awareness ◽  
Controlled Treatment ◽  
Previous Level ◽  
Adolescents And Adults ◽  
Potential Trigger

A proportion of young people with Down syndrome (DS) experience unexplained regression that severely impacts on their daily lives. While this condition has been recognised by clinicians, there is a limited understanding of causation and an inconsistent approach to diagnosis and treatment. Varied symptomology and little knowledge of the cause of this regression have impacted on clinician’s ability to prevent or manage this condition. The purpose of this review was to examine the current evidence surrounding unexplained regression in adolescents and young adults, and to establish patterns that may be of use to clinicians, as well as raising awareness of this condition. Four areas were specifically reviewed, (1) terminology used to refer to this condition, (2) the symptoms reported, (3) potential trigger events and, (4) treatments and prognosis. A variety of terminology is used for this condition, which has constrained past attempts to identify patterns. An extensive number of symptoms were reported, however sleep impairment, loss of language and distinct changes in personality and behaviour, such as disinterest and withdrawal, were among the most frequently seen. Life events that were tentatively associated with the onset of a regressive period included a significant change in environmental circumstances or a transition, such as moving home or leaving school. Prognosis for this condition is relatively positive with the majority of individuals making at least a partial recovery. However, few patients were found to make a full recovery to their previous level of functioning and serious adverse effects could persist in those who have made a partial recovery. This is an under-researched condition with significant impacts on people with DS and their families. There are no established treatments for this condition and there is relatively little recognition in the research community. Further studies that focus on the prevention and treatment of this condition with controlled treatment trials are needed.

Financial cost of treating out-patients with schizophrenia in Nigeria

1997 ◽  
Vol 171 (4) ◽  
pp. 364-368 ◽  
Author(s):  
Toyin G. Suleiman ◽  
Jude U. Ohaeri ◽  
Rahman A. Lawal ◽  
Adam Y. Haruna ◽  
O. B. Orija
Keyword(s):  
Antipsychotic Drugs ◽  
Indirect Costs ◽  
Financial Cost ◽  
Total Cost ◽  
Duration Of Illness ◽  
Government Hospitals ◽  
Insulin Dependent ◽  
The Mean ◽  
Cost Of Drugs ◽  
The Cost

BackgroundAn assessment of the monetary costs of treating a group of Nigerian out-patients with schizophrenia, in comparison with insulin-dependent diabetics, was made.MethodFifty out-patients with schizophrenia (mean age 42.9) and 40 with diabetes (mean age 41.9), attending government hospitals in Lagos, were assessed at six-monthly intervals, for direct and indirect costs (US$=82 naira; minimum monthly wage=500 naira)ResultsTwenty (40%) of those with schizophrenia and eight (20%) of the diabetics had no income at all. The mean total cost of schizophrenia in six months (2951.4 naira) or US$ 35.9) was significantly less than that of diabetes (11 791 naira or US$ 143). The cost of antipsychotic drugs accounts for 52.8% of the cost of schizophrenia; insulin injections accounted for 92.8% of the total cost of diabetes. Patients with schizophrenia and their relatives suffered significantly more loss of working days. Cost of illness was not significantly correlated with age and duration of illness.ConclusionsBecause of drastic currency devaluation, and lack of disability benefits and nursing homes, the findings contrast with Western reports where cost of drugs constitutes 2–5%, and indirect costs constitute over 50% of the total cost of schizophrenia.

scholarly journals A FRAMEWORK FOR DEVELOPING PHARMACOTHERAPY FOR AGITATION IN ALZHEIMER’S DISEASE: RECOMMENDATIONS OF THE ISCTM* WORKING GROUP

2020 ◽  
pp. 1-9
Author(s):  
C. O’Gorman ◽  
R. Khoury ◽  
A. Anderson ◽  
M. Carter ◽  
F. DiCesare ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Executive Function ◽  
Working Group ◽  
Significant Decline ◽  
Significant Deterioration ◽  
Cognitive Domains ◽  
Level Of Functioning ◽  
Previous Level

Dementia is characterized by a significant decline in one of several cognitive domains such as memory, language and executive function, affecting independence and representing a significant deterioration from a previous level of functioning (1). Alzheimer’s Disease (AD) represents the most common form of dementia and contributes up to 70% of the almost 50 million dementia cases worldwide, a number that is projected to double in 20 years (2).

scholarly journals Dyspraxia and Agnosia in Schizophrenia

1993 ◽  
Vol 6 (1) ◽  
pp. 49-54 ◽  
Author(s):  
P. F. Liddle ◽  
S. Haque ◽  
D. L. Morris ◽  
T. R. E. Barnes
Keyword(s):  
Cognitive Impairment ◽  
Strong Correlation ◽  
Spontaneous Movement ◽  
Abnormal Involuntary Movements ◽  
Involuntary Movements ◽  
Chronic Schizophrenic ◽  
Flat Affect ◽  
Neurological Signs ◽  
Duration Of Illness ◽  
Schizophrenic Patients

A battery of tests for dyspraxia and agnosia was administered to 51 chronic schizophrenic patients to test the hypothesis that these cortical neurological signs are associated with psychomotor poverty syndrome (poverty of speech, flat affect, decreased spontaneous movement), disorganization syndrome (various disorders of the form of thought, inappropriate affect), abnormal involuntary movements, cognitive impairment, and duration of illness. The findings supported all elements of the hypothesis, and in particular, demonstrated a strong correlation of cortical signs with psychomotor poverty and with cognitive impairment.

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